Iraqi Journal of Pharmaceutical Sciences最新文献

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Evaluation of Anti-inflammatory Effects of Cinnamic Acid Against Dextran Sodium Sulfate Induced Ulcerative Colitis in Male Mice 肉桂酸对右旋糖酐硫酸钠诱导的雄性小鼠溃疡性结肠炎的抗炎作用评价
Iraqi Journal of Pharmaceutical Sciences Pub Date : 2023-09-27 DOI: 10.31351/vol32iss2pp33-40
Maysam Habboby, None Munaf Hashim Abdulrazzaq
{"title":"Evaluation of Anti-inflammatory Effects of Cinnamic Acid Against Dextran Sodium Sulfate Induced Ulcerative Colitis in Male Mice","authors":"Maysam Habboby, None Munaf Hashim Abdulrazzaq","doi":"10.31351/vol32iss2pp33-40","DOIUrl":"https://doi.org/10.31351/vol32iss2pp33-40","url":null,"abstract":"Inflammatory bowel disease (IBD) is a common chronic inflammatory disease of the gastrointestinal tract, including ulcerative colitis and Crohn's disease. ulcerative colitis (UC) disease is characterized by chronic, persistent, recurrent, and nonspecific intestinal ulcers and mucosal inflammation. This study investigated the protective effects of cinnamic acid on dextran sodium sulfate (DSS) induced ulcerative colitis in mice. Forty adult male mice were collected and randomly divided into five groups, group Ӏ received a suspension of distill water and poloxamer, and group ӀӀ received 3% DSS in drinking water for 7 consecutive days. Two treatment groups received an oral suspension of cinnamic acid 50 and 25 mg/kg respectively and 3% DSS in drinking water, for 7 consecutive days and the final group received an oral suspension of cinnamic acid 50mg/kg for 7 days without DSS in drinking water. after All the animals were euthanized on day eight. The sample was collected for analysis. DSS with cinnamic acid 50 mg/kg group revealed a significant (p<0.05) reduction in Tumor necrosis factor α, interleukin 6, nuclear factor-κB ,cinnamic acid 25mg/kg revealed a significant (p<0.05) reduction in Tumor necrosis factor α and nuclear factor-κB but not significant (p>0.05)reduction in IL-6 when compared to the model group. Histopathological examination showed a significant reduction of inflammatory signs in all cinnamic acid-treated groups when compared to the DSS model group.&#x0D; In conclusion, the treatment with cinnamic acid significantly decreased the levels of DSS-associated oxidative stress. This finding supports the idea that the use of this substance could be used as a potential therapy for patients with ulcerative colitis.","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135586538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Assessment of Serum Levels of Advanced Oxidation Protein Products in Type 2 Diabetic Patients with and without Retinopathy Taking Different Antidiabetic Treatments 2型糖尿病伴视网膜病变和不伴视网膜病变患者不同抗糖尿病治疗后血清高级氧化蛋白产物水平的评估
Iraqi Journal of Pharmaceutical Sciences Pub Date : 2023-09-27 DOI: 10.31351/vol32iss2pp74-82
None Sara Asaad Kadhim, None Eman Saadi Saleh, None Aymen Dheaa Jaafer
{"title":"Assessment of Serum Levels of Advanced Oxidation Protein Products in Type 2 Diabetic Patients with and without Retinopathy Taking Different Antidiabetic Treatments","authors":"None Sara Asaad Kadhim, None Eman Saadi Saleh, None Aymen Dheaa Jaafer","doi":"10.31351/vol32iss2pp74-82","DOIUrl":"https://doi.org/10.31351/vol32iss2pp74-82","url":null,"abstract":"The goal of this study was to investigate the protein peroxidation role by measuring serum levels of advanced oxidation protein products (AOPP) in type 2 diabetic patients with or without retinopathy and comparing them to controls to see if circulating AOPP levels can be used as a detection biomarker for DR. And see which of the two widely used antidiabetic treatment groups had the most impact on this oxidative stress marker. The groups were divided into two subgroups: 1) 70 type 2 diabetic patients (36 male, 34 female), 35 with diabetic retinopathy (DR) and 35 with no evidence of DR, and 2) non-diabetic controls (11 male, 9 female) were chosen from Ibn AL-Haitham Hospital for Ophthalmology and a Specialized Center for Endocrinology and Diabetes. AOPP levels were significantly higher in diabetic patients with (12.5±5.6 ng/ml) or without DR (5.1±4 ng/ml) when compared to those of controls (1.45 0.8 ng/ml) (p<0.05). AOPP levels were higher in the late stage of DR compared to the early stage(14 3.15 ng/ml ) and ( 10 2.13 ng/ml) respectively so. Furthermore, Dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) cause a better reduction in AOPP levels compared to Sulfonylureas (SUs) in the NDR group. Increased protein oxidation may involve in the pathogenesis and severity of DR and the serum AOPP levels have the prospect to become a marker for the diagnosis of DR. DPP-4 inhibitors were better in slowing the progression of the disease compared to SUs.","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135586534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential Activity of Serunai Leaf Ethanol Extract (Chromolaena Odorata L.) Against the Healing of Burns 秋葵叶乙醇提取物的潜在活性研究反对烧伤的愈合
Iraqi Journal of Pharmaceutical Sciences Pub Date : 2023-09-27 DOI: 10.31351/vol32iss2pp91-95
Rusdiati Helmidanora, Heri Wijaya, None Musakir
{"title":"Potential Activity of Serunai Leaf Ethanol Extract (Chromolaena Odorata L.) Against the Healing of Burns","authors":"Rusdiati Helmidanora, Heri Wijaya, None Musakir","doi":"10.31351/vol32iss2pp91-95","DOIUrl":"https://doi.org/10.31351/vol32iss2pp91-95","url":null,"abstract":"Wounds are a problem that everyone often experiences, especially burns, so they need to be addressed. In South Sulawesi, chrysanthemum leaves are believed to heal wounds. This study aimed to determine whether there was an effect of healing burns on the backs of mice by administering ethanol extract of Serunai leaves (Chromolaena odorata L.). The research conducted is experimental. The object under study is the process of healing burns on the back of male white mice. The study was conducted on 25 male white mice divided into five groups of test animals, each group consisting of 5 male white mice. The first group was given positive control (+) branded ointment, and the second group was given negative control (-) vaseline flavum, the third group was given ethanol extract of Serunai leaves with a concentration of 5%, the fourth group was given ethanol extract of Serunai leaves with a concentration of 10%. The fifth group was given ethanol extract. Serunai leaves with a concentration of 20%, and each group was replicated five times. Data were obtained from observing burns until the skin's surface on the back of the mice was covered and calculated using AUC and analyzed by the OneWay Anova test. The results showed that the ethanol extract of Serunai leaves had the potential for healing burns. Each concentration has a burn healing power of 5% (48.76%), 10% (60.34%), and 20% (67.54%) concentration.","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135586535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Polymorphism in TNF-α Promoter Region: Its Association with Severity and Susceptibility to Rheumatoid Arthritis in Iraqi Patients with Active Disease TNF-α启动子区域的遗传多态性:与伊拉克活动性疾病患者类风湿关节炎的严重程度和易感性相关
Iraqi Journal of Pharmaceutical Sciences Pub Date : 2023-09-27 DOI: 10.31351/vol32iss2pp46-57
Khalid abdulhussein Abdulameer, Zainab Hashim
{"title":"Genetic Polymorphism in TNF-α Promoter Region: Its Association with Severity and Susceptibility to Rheumatoid Arthritis in Iraqi Patients with Active Disease","authors":"Khalid abdulhussein Abdulameer, Zainab Hashim","doi":"10.31351/vol32iss2pp46-57","DOIUrl":"https://doi.org/10.31351/vol32iss2pp46-57","url":null,"abstract":"Objectives: To study the prevalence of rs1799964 (-1031 T/C) and rs361525 (- 238 G/A) SNPs and their effect on the disease activity, severity, and cytokines production in newly diagnosed Iraqi rheumatoid arthritis patients.&#x0D; Patients and Methods: sixty-three patients were diagnosed by a specialist physician while attending the rheumatology unit and twenty control participated. The inflammatory markers were measured and PCR amplification and sequencing were performed to demonstrate TNF-α SNPs.&#x0D; Results: Regarding (-1031 C/T) SNP, the TT genotype and allele C were significantly present in the controls, and the CT genotype was distributed significantly in the patients. The TT genotype was mostly distributed in the mild-moderate group, while the CT genotype and allele C were significantly distributed in the severe group. DAS28, TNF-α, IL-1, and ACPA were significantly associated with this SNP. While non-significant differences appeared in the analysis of -238 G/A SNP.&#x0D; Conclusion: The presence of the CT genotype and C allele of) -1031 C/T( was associated with susceptibility to RA. While the CT genotype and C allele were associated with more severe disease. Also, TT genotype was associated with less severe disease. Furthermore, an association between -1031 C/T and the inflammatory markers and DAS28 was reported.","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135586537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Genotoxicity of the Aerial Parts of Iraqi Euphorbia cyathophora on Bone Marrow and Spleen Cells in Mice 伊拉克大戟空中部分对小鼠骨髓和脾脏细胞的遗传毒性评价
Iraqi Journal of Pharmaceutical Sciences Pub Date : 2023-09-27 DOI: 10.31351/vol32iss2pp41-45
Noor Sabah Jaafar, None Ali F Hassan, None Maha N Hamad
{"title":"Evaluation of the Genotoxicity of the Aerial Parts of Iraqi Euphorbia cyathophora on Bone Marrow and Spleen Cells in Mice","authors":"Noor Sabah Jaafar, None Ali F Hassan, None Maha N Hamad","doi":"10.31351/vol32iss2pp41-45","DOIUrl":"https://doi.org/10.31351/vol32iss2pp41-45","url":null,"abstract":"The aim of the study was extraction of arial part of Euphorbia cyathophora constituents with methanol and evaluate its effect on mitotic index and total chromosomal aberration bone marrow cell and spleen cell in mice&#x0D; 200 gm of E. cyathophora fine powder was defatted then extracted by cold maceration 80% ethanol for seven days. The extract was filtered and dried in a rotary evaporator then the dried extract was suspended with water and consecutively extracted using chloroform, ethyl acetate for each. The aqueous layer was then mixed with 100ml methanol. These fractions are dried under reduced pressure to obtain the dry extract. Twenty-four Albino mice were used for the experiment. The animals were divided into four groups: Group 1: Mice were treated with distilled water. The dose was given daily for seven successive days. Group 2: Mice were treated with a single dose (20mg/kg) of methotrexate (positive control). Group 3: Mice were treated with (100mg/kg) of menthol fraction for seven successive days. Group 4: Mice were treated with (200mg/kg) of methanol fraction for seven successive days. Mice were sacrificed by (spinal dislocation). Samples of bone marrow cells and spleen cells were taken and genotoxic analyses.&#x0D; Methanol fraction of Euphorbia cyathophora at a dose of 100mg/kg demonstrated a significant decrease in mitotic index and a significant increase in total chromosomal aberrations as compared to distilled water in both bone marrow cells and spleen cells&#x0D; (p<0.05). 100 mg/kg and 200 mg/kg of methanol fraction of Euphorbia cyathophora that showed to be significantly higher in mitotic index and significantly lower in total chromosomal aberration as compared to methotrexate (p<0.05).&#x0D; In conclusion the current study revealed that the methanol fraction of aerial parts of Euphorbia cyathophora is genotoxic but its genotoxicity is less than that of methotrexate.","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135586533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Type 2 Diabetes Mellitus on Pulmonary Function Tests 2型糖尿病对肺功能试验的影响
Iraqi Journal of Pharmaceutical Sciences Pub Date : 2023-09-25 DOI: 10.31351/vol32iss2pp25-32
Ruaa Abdulsaid, Azza Sajid, Talib Kadhim Akar
{"title":"Impact of Type 2 Diabetes Mellitus on Pulmonary Function Tests","authors":"Ruaa Abdulsaid, Azza Sajid, Talib Kadhim Akar","doi":"10.31351/vol32iss2pp25-32","DOIUrl":"https://doi.org/10.31351/vol32iss2pp25-32","url":null,"abstract":"Background: Diabetes mellitus is a chronic metabolic disorder that may affect different organs including the lungs. Different studies have been published on the effects of diabetes mellitus on pulmonary function. A restrictive pattern of lung disorder was reported in some studies, whereas an obstructive pattern was suggested in others. The study aims to determine the impact of type 2 diabetes on pulmonary function tests (PFTs) and the type of respiratory disorder. Material and Methods: This observational study was conducted in Basrah City, Iraq. One hundred and eighty-two participants were enrolled and divided into 2 groups: 100 healthy (group1) and 82 patients with type2 diabetes mellitus (group 2).PFTs were estimated by a medical spirometer and measurements of several hematological tests were done for each individual. Results: We found a significant decline (p &gt;0.05) in each of FEV1, FVC, PEF, and MVV and a significant increase in ELA in group 2. The restrictive pulmonary disorder was a higher percentage (24.39%) than obstruction (10.9%) and combined (2.43%). Conclusion: Pulmonary function tests were significantly affected by type2 DM and the percentages of different respiratory disorders were higher among group 2 than in group 1, with an increase in restrictive pattern.","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135865398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung function disorders among sickle cell disease patients in Basra City, Iraq 伊拉克巴士拉市镰状细胞病患者的肺功能障碍
Iraqi Journal of Pharmaceutical Sciences Pub Date : 2023-09-25 DOI: 10.31351/vol32iss2pp18-24
Azza Sajid, Abeer Mohammed, Nawal Ibrahim
{"title":"Lung function disorders among sickle cell disease patients in Basra City, Iraq","authors":"Azza Sajid, Abeer Mohammed, Nawal Ibrahim","doi":"10.31351/vol32iss2pp18-24","DOIUrl":"https://doi.org/10.31351/vol32iss2pp18-24","url":null,"abstract":"Background: In sickle cell disease (SCD), lung function impairments might be obstructive, restrictive, or both. Due to a lack of extensive epidemiological investigations, the exact prevalence of sickle cell chronic lung illnesses and the way to identify them have yet to be determined. The aim of this study is to determine the impact of SCD on pulmonary function tests (PFTs) in adult patients in Basrah, Iraq, as well as to describe the patients' respiratory disorder .Materials and Methods: This a cross-sectional study conducted in Basrah City, Iraq, in which two groups of individual were enrolled: 110 healthy subjects (group1) and 102 sickle cell disease patients (group 2).Measurements of PFTs and several hematological tests were done for each individual of the two groups. Results: Significant decline (p &gt; 0.05) in different tests of pulmonary function (FEV1; FVC; FEV1%PEF and MVV) were found in SCD patients with a significant elevation in estimated lung age. Several hematological tests (WBC;RBC;HGB; Neutrophils and lymphocytes were also showed significant changes(p &gt;0.05)in the patients.&#x0D; In conclusion: Lung functions differ significantly in patients with SCD compared with matched healthy control individuals of a similar age, gender and standing height. This study has also shown that PFT abnormality in SCD patients was restrictive disease pattern.","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135865397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of pharmacist interventions on pulmonary function parameters of Iraqi asthmatic patients: A comparative study 药师干预对伊拉克哮喘患者肺功能参数影响的比较研究
Iraqi Journal of Pharmaceutical Sciences Pub Date : 2023-09-23 DOI: 10.31351/vol32iss2pp9-17
None Marwan S. Ibrahim, Mohammed Mahmood Mohammed
{"title":"Effect of pharmacist interventions on pulmonary function parameters of Iraqi asthmatic patients: A comparative study","authors":"None Marwan S. Ibrahim, Mohammed Mahmood Mohammed","doi":"10.31351/vol32iss2pp9-17","DOIUrl":"https://doi.org/10.31351/vol32iss2pp9-17","url":null,"abstract":"Background: Despite the fact that asthma is a long-term disease that may be treated, many people are unable to control their symptoms due to a lack of knowledge about their condition. The study's purpose was to find out if a pharmacist intervention improved asthma management because of this.&#x0D; Objective: this study designed to assess the effect of pharmaceutical care on pulmonary functions test.&#x0D; Method: The study was completed in three months. The patients who were enrolled were divided into two groups: Group 1 consists of 23 asthma patients who were randomly assigned to receive conventional therapy for chronic bronchial asthma based on disease stage and severity, as well as a pharmaceutical care plan that includes patient care and education, for three months. Group 2: Included in the study were 21 asthma patients who were randomly randomized to receive only conventional therapy for chronic bronchial asthma based on illness stage and severity for three months. All individuals included in this trial had their ACT and PFT levels checked at the start and three months later.&#x0D; Result: the conclusion of the study, patients who received a verbal and written pharmaceutical implementation plan significantly improved their asthma control by increasing medication adherence, which was accompanied by an improvement in mean ACT and PFT scores for the interventional group when compared to the control group after 3 months of follow up.&#x0D; Conclusion: The results of the study approved the important role of the pharmacist in asthma control to improve medication adherence and enhancing PFT and this mean increase asthma control","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136011461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Clinical Pharmacist in Reducing Drug Related Problems in Decompensated Liver cirrhosis patients 临床药师在减少失代偿期肝硬化患者用药相关问题中的作用
Iraqi Journal of Pharmaceutical Sciences Pub Date : 2023-09-23 DOI: 10.31351/vol32iss2pp1-8
Ameer Alobeidi, None Mohammed Y. Jamal
{"title":"The Role of Clinical Pharmacist in Reducing Drug Related Problems in Decompensated Liver cirrhosis patients","authors":"Ameer Alobeidi, None Mohammed Y. Jamal","doi":"10.31351/vol32iss2pp1-8","DOIUrl":"https://doi.org/10.31351/vol32iss2pp1-8","url":null,"abstract":"Patients with decompensated cirrhosis have typically prescribed a combination of therapeutic and prophylactic medications. Polypharmacy increases the probability of medication errors and drug related problems. Clinical pharmacists are highly effective at identifying, resolving, and preventing clinically important drug-related problems in their patients' care. The objectives of the study were the identification and classification of drug-related problems, as well as the discussion of these problems with health care providers (physicians, pharmacists, and nurses) and patients. Reduce their incidence as effectively as possible and educate all research participants on the significance of following their prescribed drug regimen. Prospective, interventional, clinical study for 80 hospitalized decompensated liver cirrhosis patients was designed in two phases, an observational phase to identify drug related problems and classify them according to the Pharmaceutical Care Network Europe classification version 9.1, and an interventional phase to increase the awareness of patients and the health care providers about those problems and to propose a proper solution for each one. The majority of drug-related problems were attributable to the Effect of drug treatment not optimal in 41.5%, Adverse drug events (possibly) occurring in 41.5 %, and Untreated symptoms or indications in 17%. Causes were Drug dose too high in 30.2%, Patient unintentionally using the drug in the wrong way in 22.6%, and Prescribed drug not available in 13.2%. Omeprazole and lactulose were the most common medications causing problems. Acceptance and full implementation were high and observed in 71.7% of pharmacist interventions while 15.1% of the intervention have no agreement. Significant numbers of Iraqi patients with decompensated liver cirrhosis have drug-related problems, and the use of proton pump inhibitors in too high dose was accountable for a large number of problems. Physicians and clinical pharmacists collaborated exceptionally well","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136011635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and Identification of Salmosamonella typhi from clinical samples with molecular detection of O-antigen encoded genes 用o抗原编码基因的分子检测从临床标本中分离和鉴定伤寒沙门氏菌
Iraqi Journal of Pharmaceutical Sciences Pub Date : 2023-06-16 DOI: 10.31351/vol32iss1pp156-159
Huda Jassim
{"title":"Isolation and Identification of Salmosamonella typhi from clinical samples with molecular detection of O-antigen encoded genes","authors":"Huda Jassim","doi":"10.31351/vol32iss1pp156-159","DOIUrl":"https://doi.org/10.31351/vol32iss1pp156-159","url":null,"abstract":"Abstract &#x0D; Antibiotic treatment of S.typhi is difficult as compared to treatment of acute infection. Antibiotic resistance carried against S.typhi by using 6 kinds of antibiotics from different classes, their results showed that all isolates were high resistance to Ampicillin (99%), Gentamicin (98%), Amikacin (79%) and less resistances Trimethoprim (55%) , Imipenem (60%) and Ceftriaxone(66%) .&#x0D; The present study focused on the molecular detection of Wzx flippase, Wzy polymerase genes in some Salmonella typhi isolates, Samples were collected from typhoid patients by classical lab work. Antibiotics susceptibility were investigated using disc diffusion method. The DNA and molecular Wzx flippase, Wzy polymerase were implemented using specific primers. The results showed that there was 33.33% having Wzy gene. The Wzx gene didn’t observed in any Salmonella isolates. The present study concluded that there was an important of the genetic diversity of O-antigen encoded genes included Wzx and Wzy which may be effect in typhoid diagnosis and treatment types.","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"179 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135571649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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