Iraqi Journal of Pharmaceutical Sciences最新文献_第4页

Natural Products as A Promising Therapy for SARS COV-2; An Overview 天然产物治疗SARS COV-2的前景概述

Iraqi Journal of Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.31351/vol30iss1pp29-40

N. Jaafar, I. Jaafar

{"title":"Natural Products as A Promising Therapy for SARS COV-2; An Overview","authors":"N. Jaafar, I. Jaafar","doi":"10.31351/vol30iss1pp29-40","DOIUrl":"https://doi.org/10.31351/vol30iss1pp29-40","url":null,"abstract":"Recently emerging pandemic SARS CoV-2 conquered our world since December 2019. Continuous efforts have been done to find out effective immunization and precise treatment stetratigies. A way from therapeutic options that were tried in SARS CoV-2, an increased attention is directed to predict natural products and mainly phytochemicals as collaborative measures for this crisis. In this review, most of the mentioned compounds specially flavonoids (biacalin, hesperidin, quercetin, luteolin, and phenolic (resveratrol, curcumin, and theaflavin) exert their effect through interfering with the action of one or more of this proteins (spike protein, papain-like protease, 3-chymotrypsin-like cysteine protease, and RNA-dependent RNA polymerase) that are involved in viral life cycle beside the anti-inflammatory effect of these compounds. The triterpenoids (celastrol, escin and glycyrrhizin) and the alkaloids (lycorine and cepharanthine) mediated their effect mainly through anti-inflammatory activity. Glycyrrhetinic acid (glycyrrhizin metabolite) dawn regulates ACE-2, and reduces protease expression, thus reduce viral entry. This review may be representing an initial step in long path for designing the successful and effective treatment or vaccine for this pandemic. © 2021 University of Baghdad - College of Pharmacy. All rights reserved.","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69297431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Structure, Transmission, Clinical Characteristics, Diagnosis, Treatment and Prevention of Coronavirus Disease 2019 (COVID-19): A Review 冠状病毒病2019 (COVID-19)的遗传结构、传播、临床特征、诊断、治疗和预防:综述

Iraqi Journal of Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.31351/vol30iss1pp56-65

Rawaa S. Al-Mayyahi, W. A. Al-Tumah

引用次数: 4

Docking Study of Naringin Binding with COVID-19 Main Protease Enzyme 柚皮苷与新冠病毒主要蛋白酶对接研究

Iraqi Journal of Pharmaceutical Sciences Pub Date : 2020-12-30 DOI: 10.31351/vol29iss2pp231-238

Narmin H. Amin Huseen

引用次数: 9

Preparation and Characterization of Topical Letrozole Nanoemulsion for Breast Cancer 乳腺癌外用来曲唑纳米乳的制备与表征

Iraqi Journal of Pharmaceutical Sciences Pub Date : 2020-06-25 DOI: 10.31351/vol29iss1pp195-206

Ihab D. Hammodi, S. N. A. Alhammid

引用次数: 5

Effects of Omega-3 Co-Administered with Therapeutic Dose of lornoxicam on Male Rats' Liver Omega-3与氯诺昔康对雄性大鼠肝脏的影响

Iraqi Journal of Pharmaceutical Sciences Pub Date : 2019-12-23 DOI: 10.31351/vol28iss2pp159-164

Isra Majeed, N. Al-Shawi

{"title":"Effects of Omega-3 Co-Administered with Therapeutic Dose of lornoxicam on Male Rats' Liver","authors":"Isra Majeed, N. Al-Shawi","doi":"10.31351/vol28iss2pp159-164","DOIUrl":"https://doi.org/10.31351/vol28iss2pp159-164","url":null,"abstract":"The purpose of this study was to investigate the effect of omega-3 poly unsaturated fatty-acids co-administered with the therapeutic dose of lornoxicam on liver of healthy rats. Twenty-eight adults male rats weighing 180-200g were used in this study and the animals were randomly divided into four groups of seven rats each. Group I: negative control/rats intraperitoneally injected with normal saline in a dose 5ml/kg/day; Group II: rats intraperitoneally injected with lornoxicam at dose 0.7 mg/kg/day; Group III: rats orally-administered omega-3 only at a dose 185mg/kg/day; Group IV: rats co-administered omega-3 (185mg/kg/day) orally and intra-peritoneal injection of lornoxicam (0.7 mg/kg/day). Duration of treatment was 14-day; and at day 15 of the study, the liver of each rat was excised for the preparation of tissue-homogenate to be utilized for the estimation of ALT, AST, TNF-alpha and IL-10. Omega-3 can reduce signs of inflammation through the reduction- of TNF-alpha level and elevation of IL-10 with a significant reduction in ALT enzyme activity level in rats' liver tissue homogenate. In conclusion, Omega-3 poly-unsaturated fatty-acids may have a protective effect against hepatocytes inflammation when co-administered with lornoxicam.","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"28 1","pages":"159-164"},"PeriodicalIF":0.0,"publicationDate":"2019-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48108301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Solubility and Dissolution Enhancement of Atorvastatin Calcium using Solid Dispersion Adsorbate Technique 固体分散吸附技术增强阿托伐他汀钙的溶解度和溶出度

Iraqi Journal of Pharmaceutical Sciences Pub Date : 2019-12-22 DOI: 10.31351/vol28iss2pp105-114

S. K. Ali, Eman B. H. Al-Khedairy

{"title":"Solubility and Dissolution Enhancement of Atorvastatin Calcium using Solid Dispersion Adsorbate Technique","authors":"S. K. Ali, Eman B. H. Al-Khedairy","doi":"10.31351/vol28iss2pp105-114","DOIUrl":"https://doi.org/10.31351/vol28iss2pp105-114","url":null,"abstract":"Atorvastatin (ATR) is poorly soluble anti-hyperlipidemic drug; it belongs to the class II group according to the biopharmaceutical classification system (BCS) with low bioavailability due to its low solubility. Solid dispersions adsorbate is an effective technique for enhancing the solubility and dissolution of poorly soluble drugs. \u0000 The present study aims to enhance the solubility and dissolution rate of ATR using solid dispersion adsorption technique in comparison with ordinary solid dispersion. polyethylene glycol 4000 (PEG 4000), polyethylene glycol 6000 (PEG 6000), Poloxamer188 and Poloxamer 407were used as hydrophilic carriers and Aerosil 200, Aerosil 300 and magnesium aluminium silicate (MAS) as adsorbents. \u0000 All solid dispersion adsorbate (SDA) formulas were prepared in ratios of 1:1:1 (drug: carrier: adsorbent) and evaluated for their water solubility, percentage yield, drug content, , dissolution, crystal structure using X-ray powder diffraction (XRD) and Differential Scanning Calorimetry (DSC) studies and Fourier Transform Infrared Spectroscopy (FTIR) for determination the drug-carrier- adsorbate interaction. \u0000 The prepared (SDA) showed significant improvement of drug solubility in all prepared formula. Best result was obtained with formula SDA12(ATR :Poloxamer407 : MAS 1:1:1) that showed 8.07 and 5.38 \u0000fold increase in solubility compared to solubility of pure ATR and solid dispersion(SD4) (Atorvastatin: Poloxamer 407 1:1) respectively due to increased wettability and reduced crystallinity of the drug which leads to improve drug solubility and dissolution .","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"28 1","pages":"105-114"},"PeriodicalIF":0.0,"publicationDate":"2019-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41361997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Evaluation of Knowledge, Attitudes and Experience of off-label Drug Prescribing Practice among Physicians in Baghdad City Hospitals 巴格达市医院医师对超说明书用药实践的知识、态度和经验评价

Iraqi Journal of Pharmaceutical Sciences Pub Date : 2019-12-22 DOI: 10.31351/vol28iss2pp115-123

A. M. Shanshal, Ahmed H. Ataimish

{"title":"Evaluation of Knowledge, Attitudes and Experience of off-label Drug Prescribing Practice among Physicians in Baghdad City Hospitals","authors":"A. M. Shanshal, Ahmed H. Ataimish","doi":"10.31351/vol28iss2pp115-123","DOIUrl":"https://doi.org/10.31351/vol28iss2pp115-123","url":null,"abstract":"Abstract \u0000The present study aims to assess the knowledge, attitude, and experience of off-label prescribing practice among physicians in Baghdad city hospitals. This cross-sectional study was performed through the period from November 1st 2018 to March 2019 at 17 hospitals, a self-administered questionnaire was utilized to collect data from the physicians, and the targeted hospitals were randomly selected at different regions in Baghdad City area. Out of the 400 distributed questionnaires to the physicians, 383 of them were returned completed, 57.2% indicated that they were reasonably familiar with the term “off label drug”, 57.7% mentioned that the most common medical reasons for the prescribing off-label drugs were unavailability of alternatives, 67.6%, 65.5% had concerns regarding its safety and efficacy respectively, 62.7% agreed that the (MOH) authority should provide an incentive to stimulate pharmaceutical companies to perform clinical trials in Iraqi patients, 49.1% believed that clinical trials that recruit volunteers involve ethical issues. Extensive efforts are required to implant programs, regulations and guidelines to control the off-label prescribing practice among the Iraqi healthcare providers who are authorized to prescribe medications at different healthcare settings.","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"28 1","pages":"115-123"},"PeriodicalIF":0.0,"publicationDate":"2019-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69297373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Investigation of Corchorus olitorius L. Leaves Cultivated in Iraq and it’s In Vitro Antiviral Activity 伊拉克凤尾草叶的植物化学研究及其体外抗病毒活性

Iraqi Journal of Pharmaceutical Sciences Pub Date : 2018-12-07 DOI: 10.31351/vol27iss2pp115-122

Hayder T. Hasan, Eman J. Kadhim

{"title":"Phytochemical Investigation of Corchorus olitorius L. Leaves Cultivated in Iraq and it’s In Vitro Antiviral Activity","authors":"Hayder T. Hasan, Eman J. Kadhim","doi":"10.31351/vol27iss2pp115-122","DOIUrl":"https://doi.org/10.31351/vol27iss2pp115-122","url":null,"abstract":"The aim of our study was to investigate the antiviral activity of the Corchorus olitorius family Tiliaceae cultivated in Iraq against measles virus, and to demonstrate an overview about chemical constituents and pharmacological activity of Corchorus olitorius L. \u0000About150 gm Leaves of Corchorus. olitorius were defatted by maceration in hexane for 24 hrs. The defatted plant materials were subjected for extraction after filtration using Soxhlet apparatus, with aqueous methanol 85% as a solvent extraction for 24 hours, the extract was filtered, and the solvent was evaporated under reduced pressure using a rotary evaporator to get a dry extract of about 12 gm. About 4 gm from the residue was suspended in 100ml water, about 3-4ml of 5% sodium hydroxide was added to obtain a basic solution having PH 10 and partitioned with ethyl acetate (3x100ml), the aqueous layer collected and evaporated to dryness. MTT-cell viability assay (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) was conducted on 96-well plates (Falcon), Vero cells were seeded at 1× 104 cells/well to obtain a multiplicity of infection (MOI 10), and at 5 × 103 cells/well to obtain a multiplicity of infection (MOI 5). \u0000Different statistical result revealed a significant antiviral activity of the aqueous layer of Corchorus olitorius leaves against measles virus. The preliminary phytochemical tests showed the presence of phenols and flavonoids in the aqueous layer of Corchorus olitorius leaves. \u0000The antiviral activity of Corchorus olitorius leaves is mainly due to the phenolics and flavonoids that detected in the aqueous layer.","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69297369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Spectrophotometric Determination of Cefixime Following Simple Diazotization and Coupling with ?-Naphthol 头孢克肟的简单重氮化-？偶联分光光度法测定-萘酚

Iraqi Journal of Pharmaceutical Sciences Pub Date : 2017-12-25 DOI: 10.1234/ijps.v26i2.726

S. A. Darweesh

引用次数: 2

Preparation and Evaluation of Ketoprofen Nanosuspension Using Solvent Evaporation Technique 溶剂蒸发法制备酮洛芬纳米混悬液及评价

Iraqi Journal of Pharmaceutical Sciences Pub Date : 2017-12-25 DOI: 10.1234/IJPS.V26I2.727

Hayder K. Abbas, F. M. H. Wais, A. N. Abood

{"title":"Preparation and Evaluation of Ketoprofen Nanosuspension Using Solvent Evaporation Technique","authors":"Hayder K. Abbas, F. M. H. Wais, A. N. Abood","doi":"10.1234/IJPS.V26I2.727","DOIUrl":"https://doi.org/10.1234/IJPS.V26I2.727","url":null,"abstract":" \u0000 \u0000The effective surface area of drug particle is increased by a reduction in the particle size. Since dissolution takes place at the surface of the solute, the larger the surface area, the further rapid is the rate of drug dissolution. Ketoprofen is class II type drug according to (Biopharmaceutics Classification System BCS) with low solubility and high permeability. The aim of this investigation was to increase the solubility and hence the dissolution rate by the preparation of ketoprofen nanosuspension using solvent evaporation method. Materials like PVP K30, poloxamer 188, HPMC E5, HPMC E15, HPMC E50, Tween 80 were used as stabilizers in perpetration of different formulas of Ketoprofen nanosuspensions. These formulas were evaluated for particle size, entrapment efficiency of drug (EE), effect of stabilizer type, effect of stabilizer concentration and in-vitro dissolution studies. All of the prepared Ketoprofen nanosuspensions formulas showed a particle size result within Nano range. The average particle size of Ketoprofen nanosuspensions formulas was observed from 9.4 nm to 997 nm. Entrapment efficiency was ranged from 79.23% to 95.41 %. The in vitro dissolution studies showed a significant (p<0.01) enhancement in dissolution rate of nanosuspension formulas compared to pure drug (drug alone) and physical mixture (drug and stabilizer). The results indicate the suitability of solvent evaporation method for Ketoprofen with improved in vitro dissolution rate and thus perhaps enhance fast onset of action for drug.","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66008384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14