Iranian journal of allergy, asthma, and immunology最新文献_第6页

Comprehensive Analysis of Core Genes, Key Pathways, and Immune Infiltration in Intervertebral Disc Degeneration Using Machine Learning and Experimental Validation. 利用机器学习和实验验证综合分析椎间盘退变的核心基因、关键通路和免疫浸润。

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21260

Haoju Lo, Chunhao Tsai, Tsanwen Huang

引用次数: 0

Effects of Combination Therapy with Empagliflozin and Metformin on Interleukin-1β and Interleukin-6 Secretion in Type 2 Diabetes Patients. 恩格列净联合二甲双胍对2型糖尿病患者白细胞介素-1β和白细胞介素-6分泌的影响

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21258

Amir Pedram Moghis, Mehdi Behzad, Alireza Soltanian, Shiva Borzouei

{"title":"Effects of Combination Therapy with Empagliflozin and Metformin on Interleukin-1β and Interleukin-6 Secretion in Type 2 Diabetes Patients.","authors":"Amir Pedram Moghis, Mehdi Behzad, Alireza Soltanian, Shiva Borzouei","doi":"10.18502/ijaai.v25i3.21258","DOIUrl":"10.18502/ijaai.v25i3.21258","url":null,"abstract":"Type 2 diabetes (T2D) is defined by persistent inflammatory processes. This study evaluated the anti-inflammatory properties of empagliflozin in combination with metformin therapy in patients with T2D. In this prospective cohort study, 50 individuals with type 2 diabetes were non-randomly assigned to receive metformin (MTF, n = 25) or empagliflozin (10 mg/day) and metformin (EMPA+MTF, n = 25) and followed for 6 months. Fasting blood glucose (FPG), HbA1c, body mass index (BMI), glomerular filtration rate (GFR), and urinary albumin were measured at baseline and then 6 months later. Interleukin-1beta (IL-1β) and interleukin-6 (IL-6) secretion from isolated and stimulated peripheral blood mononuclear cells were measured using ELISA and compared in the different study groups. The MTF+EMPA group showed significantly decreased levels of FPG, HbA1C, and body mass index compared to the baseline. FPG and HbA1c in the MTF+EMPA group showed a significant decrease six months after treatment versus the MTF group. A significant reduction in IL-1β levels was observed at the six months post-treatment compared to baseline and in relation to the MTF group after six months. The levels of IL-6 exhibited no significant differences, both within and between the study groups. Significant direct correlations were observed between IL-1β levels and FPG as well as HbA1c within the MTF+EMPA group following six months of treatment. Incorporating empagliflozin (10 mg/day) into metformin treatment markedly enhanced glycemic regulation and lowered IL-1β secretions, indicating a possible anti-inflammatory benefit in overweight individuals with T2D following six months of treatment.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 3","pages":"355-362"},"PeriodicalIF":1.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of a Prognostic Model for Hepatocellular Carcinoma Based on Cell Death-related Genes and Characterization of Immune Microenvironment. 基于细胞死亡相关基因及免疫微环境表征的肝癌预后模型构建

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21259

Wei Wu, Yingji Wang, Xiaocheng Zhao, Ke Dong, Maode Li, Xiang An, Yingyan Xu, Shuai Wang, Dexin Li

{"title":"Construction of a Prognostic Model for Hepatocellular Carcinoma Based on Cell Death-related Genes and Characterization of Immune Microenvironment.","authors":"Wei Wu, Yingji Wang, Xiaocheng Zhao, Ke Dong, Maode Li, Xiang An, Yingyan Xu, Shuai Wang, Dexin Li","doi":"10.18502/ijaai.v25i3.21259","DOIUrl":"10.18502/ijaai.v25i3.21259","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the predominant type of primary liver cancer. This study aimed to elucidate the involvement of genes associated with 25 cell-death modalities in HCC development and progression. HCC transcriptomic datasets were integrated with curated cell death-related genes. Candidate genes were screened by differential expression analysis and protein-protein interaction network construction. Prognostic genes were identified using univariate Cox regression, proportional hazards assumption testing, and stepwise multivariate Cox regression. A risk score model and a nomogram were established, followed by risk stratification and analyses of immune infiltration, immune checkpoints, somatic mutations, and in silico drug sensitivity. Single-cell RNA sequencing was used to identify key cell types, infer temporal dynamics, and characterize intercellular communication, and findings were validated by quantitative real-time PCR (qRT-PCR). MAPT, CDKN2A, NQO1, CHGA, SERPINE1, and RET were identified as prognostic genes, and the risk model and nomogram showed good prognostic performance. Immune profiling revealed significant differences in multiple immune cell subsets between risk groups, including activated CD4+ T cells. Notably, CDKN2A correlated with activated CD4+ T cells, NQO1 with natural killer cells, RET with CD4+ central memory cells, and SERPINE1 with activated dendritic cells; RET also showed the strongest positive correlation with HAVCR2. Mutation spectra differed across risk groups, and ten drugs displayed significant predicted IC50 differences; all six genes were negatively correlated with KIN001.135. Single-cell analyses highlighted hepatocytes as a key cell type with strong hepatocyte-epithelial communication. qRT-PCR confirmed higher MAPT, CDKN2A, NQO1, and SERPINE1 expression in HCC tissues than in normal tissues.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 3","pages":"363-392"},"PeriodicalIF":1.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study of Dexmedetomidine Administration Routes in Pediatric Patients Receiving Endoscopic Low-temperature Plasma Adenotonsillar Ablation. 右美托咪定给药途径在儿童内镜下低温等离子体腺扁桃体消融中的比较研究。

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21256

Kaiying Song, Ling Li, Peijun Li, Xuetao Yan, Yongmei Zhao, Huiqin Lu, Zigang Liu

{"title":"Comparative Study of Dexmedetomidine Administration Routes in Pediatric Patients Receiving Endoscopic Low-temperature Plasma Adenotonsillar Ablation.","authors":"Kaiying Song, Ling Li, Peijun Li, Xuetao Yan, Yongmei Zhao, Huiqin Lu, Zigang Liu","doi":"10.18502/ijaai.v25i3.21256","DOIUrl":"10.18502/ijaai.v25i3.21256","url":null,"abstract":"This study aimed to explore the effects of different dexmedetomidine (DEX) administration routes on anesthesia quality in pediatric patients undergoing endoscopic low-temperature plasma adenotonsillar ablation. We selected 120 children with obstructive sleep apnea hypopnea syndrome scheduled for surgery between May and December 2023. Participants were divided into four groups (n=30 each): a control group (Group S) receiving standard anesthesia without DEX; a local anesthesia group (Group L) receiving ropivacaine infiltration with 0.3 µg·kg-1 DEX; an intravenous group (Group T) receiving 0.6 µg·kg-1 DEX infusion post-induction; and a nasal drip group (Group N) receiving 0.6 µg·kg-1 DEX intranasally upon room entry. We compared operation/extubation/recovery times, and scores from the Observer Assessment of Alertness and Sedation (OAA/S), Objective Pain Scale (OPS), and Pediatric Anesthesia Emergence Delirium (PAED) scales. Rescue sedation and safety were also assessed. Group T showed lower heart rates at specific timepoints, while Group L had lower blood pressures. Recovery time (Steward score ≥4) was longer in Groups L and T compared to Group S, but not in Group N. Groups T and N showed increased OAA/S scores post-awakening, with Group N having the highest scores. OPS and PAED scores decreased in all DEX groups, with Group N demonstrating the lowest scores, followed by Group L and then Group T. No significant differences were found in operation time, extubation time, or the incidence of rescue sedation/complications among groups. Intranasal DEX emerged as the optimal route, providing effective analgesia and sedation without prolonging recovery time.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 3","pages":"330-344"},"PeriodicalIF":1.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Value of the Combination of Serum TH1/TH2 Cytokines, Procalcitonin, and High-sensitivity C-reactive Protein for Predicting the Severity of Pneumonia. 血清TH1/TH2细胞因子、降钙素原、高敏c反应蛋白联合检测预测肺炎严重程度的诊断价值

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21257

Huadong Zeng, Xuan Huang, Guansheng Zeng, Xian Qiu, Xiaoli Li, Dandan Zhang, Shaoqiang Zheng

{"title":"Diagnostic Value of the Combination of Serum TH1/TH2 Cytokines, Procalcitonin, and High-sensitivity C-reactive Protein for Predicting the Severity of Pneumonia.","authors":"Huadong Zeng, Xuan Huang, Guansheng Zeng, Xian Qiu, Xiaoli Li, Dandan Zhang, Shaoqiang Zheng","doi":"10.18502/ijaai.v25i3.21257","DOIUrl":"10.18502/ijaai.v25i3.21257","url":null,"abstract":"T helper 1 (TH1) and T helper 2 (TH2) cells can secrete various proinflammatory and anti-inflammatory factors, which can serve as indicators for predicting the severity of pneumonia. However, they are rarely used in combination with procalcitonin (PCT) and high-sensitivity C-reactive protein (hsCRP) detection to predict the severity of pneumonia. The purpose of this study is to investigate the combination of serum TH1/TH2 cytokines, PCT, and hsCRP for predicting the severity of community-acquired pneumonia (CAP). This study observed 58 inpatients with CAP. Analyses were conducted on the serum levels of TH1/TH2 cytokines, PCT, and hsCRP; imaging examination results; underlying diseases; pathogens; and the pneumonia severity index (PSI). The severe pneumonia group showed significantly higher PSI scores, age, and complication rates. Serum IL-2 was notably elevated in severe cases, while a combination of PCT, IL-4, TNF-α, and IFN-γ effectively predicted severe pneumonia, with an AUC of 0.712. Specific alterations in cytokines and biomarkers were identified as risk factors for higher PSI, complications, and prolonged hospitalization. The combined detection of PCT, IL-4, TNF-α, and IFN-γ provides a potential tool for predicting severe CAP, and distinct biomarker profiles are associated with different clinical outcomes.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 3","pages":"345-354"},"PeriodicalIF":1.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling Post-cholecystitis Complication Risk from Perioperative Liver Function and Immune-inflammation Indicators. 围手术期肝功能和免疫炎症指标对胆囊炎并发症风险的影响

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21254

Yuan Zhang, Yijiang Zhou, Liyuan Hou, Yingxue Liu

{"title":"Modeling Post-cholecystitis Complication Risk from Perioperative Liver Function and Immune-inflammation Indicators.","authors":"Yuan Zhang, Yijiang Zhou, Liyuan Hou, Yingxue Liu","doi":"10.18502/ijaai.v25i3.21254","DOIUrl":"10.18502/ijaai.v25i3.21254","url":null,"abstract":"Acute calculous cholecystitis (ACC) often triggers transient perioperative elevations in liver enzymes and systemic inflammation, yet existing complication-prediction tools seldom incorporate dynamic biomarker changes. Our goal was to establish and develop, using internal validation, a multivariable risk model that incorporates perioperative variations in liver function tests (LFTs) and the Systemic Immune-Inflammation Index (SII) in order to predict Clavien-Dindo grade ≥II complications following cholecystectomy for ACC. In this retrospective cohort study at a tertiary academic center (January 2022-December 2024), we analyzed 260 adult patients undergoing laparoscopic or open cholecystectomy for ACC. We calculated Δ-values (day 1 minus baseline) for alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, and SII (platelet × neutrophil/lymphocyte). Multivariable logistic regression with backward stepwise selection was used to derive the final model, which included ΔALT, ΔAST, Δbilirubin, ΔSII, age, American Society of Anesthesiologists (ASA) status, and operative duration. Internal validation employed 1 000 bootstrap replications. The model demonstrated good discrimination (optimism-corrected area under the curve, 0.82; 95% CI, 0.77-0.87) and excellent calibration (slope, 0.95; intercept, -0.02). Significant predictors included ΔALT, ΔAST, Δbilirubin, and ΔSII, along with age, ASA III status, and longer operative duration. The decision-curve analysis demonstrated net benefit across threshold probabilities of 5% to 40%, with 15 additional true positives per 1 000 at the 20% threshold. Integrating dynamic perioperative changes in LFTs and SII with key clinical factors yields a robust risk prediction model for postoperative complications after ACC surgery.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 3","pages":"303-316"},"PeriodicalIF":1.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Efficacy of Immunotherapy in Combination with Surgical Resection in High-risk Muscle-invasive Bladder Cancer. 探讨免疫治疗联合手术切除治疗高危肌浸润性膀胱癌的疗效。

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21255

Zeping Li, Caimei Liu, Houqing Wang

{"title":"Exploring the Efficacy of Immunotherapy in Combination with Surgical Resection in High-risk Muscle-invasive Bladder Cancer.","authors":"Zeping Li, Caimei Liu, Houqing Wang","doi":"10.18502/ijaai.v25i3.21255","DOIUrl":"10.18502/ijaai.v25i3.21255","url":null,"abstract":"Traditional radical cystectomy has a high recurrence rate, a high probability of metastasis, and a reduced quality of life for patients. This study aimed to explore the efficacy of combining immunotherapy and surgical resection for high-risk muscle-invasive bladder cancer. In a retrospective study, 231 patients with high-risk muscle-invasive bladder cancer admitted to Yueyang People's Hospital between January 2019 and May 2024 were selected. After exclusions, 200 cases were analyzed and divided into two groups according to the treatment modality: the control group (surgical resection alone, n=100) and the intervention group (combination of immunotherapy and surgical resection, n=100). The cellular immune function indexes (CD3+, CD4+/CD8+, and natural killer cell levels), tumor markers (carcinoembryonic antigen, carbohydrate antigen 125, cytokeratin 21-1, and neuron-specific enolase), serum cytokines (basic fibroblast growth factor, vascular endothelial growth factor, and tumor necrosis factor-α), pathological complete remission (pCR), 1-year survival, and Functional Assessment of Cancer Therapy-Bladder (FACT-BL) quality-of-life scores were assessed in the two groups. After 1 year of treatment, the indicators of the two groups of patients were statistically significant in comparison with each other. Patients in the intervention group had substantial improvements in immune function indexes, pCR, 1-year survival rate, and FACT-BL scores in comparison with the control group. Tumor markers and serum cytokines were lower than those in the control group. The combination of immunotherapy and surgical resection can enhance clinical efficacy, providing a scientific basis for optimizing the clinical treatment plan.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 3","pages":"317-329"},"PeriodicalIF":1.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Immune-Related Diagnostic Genes and Subtypes of Active Ulcerative Colitis. 活动性溃疡性结肠炎免疫相关诊断基因和亚型的鉴定

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21262

Tianlong Tang, Xinquan Zan, Fei Liu, Xiao Shi, Qiaoming Zhi, Ye Han

{"title":"Identification of Immune-Related Diagnostic Genes and Subtypes of Active Ulcerative Colitis.","authors":"Tianlong Tang, Xinquan Zan, Fei Liu, Xiao Shi, Qiaoming Zhi, Ye Han","doi":"10.18502/ijaai.v25i3.21262","DOIUrl":"10.18502/ijaai.v25i3.21262","url":null,"abstract":"Ulcerative colitis (UC) is a chronic immune-mediated disease with a growing global burden. In this study, bioinformatics analysis and machine learning methods were employed to screen the potential immune microenvironment-related feature genes. We identified 4 immune-related genes that are consistently dysregulated in UC and correlate with immune infiltration, including APOBEC3B (Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3B), CXCL11, PLA2G2A, and TMEM173. Their diagnostic performance was verified in an external cohort and in our clinical samples. Then, the proportion of ambiguous clustering (PAC) successfully classified UC patients into 2 molecular subtypes, including subtype 1 (metabolism-related subtype) and subtype 2 (immune-related subtype). The single sample gene set enrichment analysis (ssGSEA) algorithm revealed that subtype 2, with a higher score, of the majority of immune cells presented a worse inflammatory response. In addition, we assessed scores of partial novel drugs querying the cMAP database and found that the efficacy of clinical small-molecule compounds presented different results across UC subtypes. These findings identify biomarkers, establish a concise immune-based classification of UC, and support subtype-guided therapy.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 3","pages":"415-435"},"PeriodicalIF":1.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alternaria Alternata Sensitization in Asthma: A Cross-sectional Study of Prevalence and Demographic Risk Factors. 交替菌致敏在哮喘中的作用：患病率和人口危险因素的横断面研究。

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21250

Seyed Hesamodin Nabavizadeh, Aida Askarisarvestani, Elham Amini, Fardin Karbakhsh Ravari, Golnoosh Karimi

{"title":"Alternaria Alternata Sensitization in Asthma: A Cross-sectional Study of Prevalence and Demographic Risk Factors.","authors":"Seyed Hesamodin Nabavizadeh, Aida Askarisarvestani, Elham Amini, Fardin Karbakhsh Ravari, Golnoosh Karimi","doi":"10.18502/ijaai.v25i3.21250","DOIUrl":"10.18502/ijaai.v25i3.21250","url":null,"abstract":"Alternaria alternata is one of the most potent fungal allergens associated with allergic respiratory diseases, particularly asthma. Sensitization to A alternata has been linked to poor asthma control and increased morbidity, yet its prevalence varies widely across populations due to environmental and methodological differences. This study aimed to determine the prevalence and demographic predictors of A alternata sensitization among patients with moderate to severe asthma. A cross-sectional study was conducted from March to September 2024 among 80 patients with physician-diagnosed moderate or severe asthma in Shiraz, Iran. Participants underwent skin prick testing (SPT) for A. alternata. Demographic and clinical data were collected and analyzed using descriptive statistics, χ2 tests, and logistic regression. Among the 80 patients (mean age 29.03 ± 20.45 years; 53.8% male), 28.8% tested positive for Alternaria sensitization. Sensitization was significantly more prevalent in patients younger than 18 years (44.1%) compared to adults (17.4%). No significant difference was observed based on sex. Although sensitization was more frequent in patients with severe asthma (40.6%) than moderate asthma (20.8%), this trend was not statistically significant. Logistic regression identified younger age as the only independent predictor of sensitization. Alternaria alternata sensitization is common among individuals with moderate to severe asthma, particularly in younger patients. These findings underscore the importance of routine fungal allergen screening in asthmatics, especially children, to inform targeted management strategies and potentially reduce asthma-related morbidity.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 3","pages":"279-285"},"PeriodicalIF":1.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hsa-miR-23a-5p: A Potential Prognostic Biomarker in Diffuse Large B-cell Lymphoma. Hsa-miR-23a-5p：弥漫性大b细胞淋巴瘤的潜在预后生物标志物

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21263

Yunfei Zhao, Anna Su, Rui Bai, Gulimire Adili, Laxin Sabitjan, Xun Li

{"title":"Hsa-miR-23a-5p: A Potential Prognostic Biomarker in Diffuse Large B-cell Lymphoma.","authors":"Yunfei Zhao, Anna Su, Rui Bai, Gulimire Adili, Laxin Sabitjan, Xun Li","doi":"10.18502/ijaai.v25i3.21263","DOIUrl":"10.18502/ijaai.v25i3.21263","url":null,"abstract":"This study aimed to identify a novel microRNA (miRNA)-related circulating biomarker that is easily accessible for clinical use and can dynamically monitor the biological characteristics of diffuse large B-cell lymphoma (DLBCL). We analyzed miRNA expression profiles in DLBCL from the Gene Expression Omnibus (GEO) (GSE171272 and GSE173080) and The Cancer Genome Atlas (TCGA). The immune microenvironment and immune-related gene differences associated with hsa-miR-23a-5p were assessed through the single-sample gene set enrichment analysis and CIBERSORT. Gene set enrichment analysis identified expression trends related to hsa-miR-23a-5p. The 50% inhibitory concentration of chemotherapy agents was estimated for hsa-miR-23a-5p. Potential miRNA targets were identified using TargetScan, miRWalk, and RNA22, and validated with miRTarBase, DIANA-TarBase, and NPInter. Gene functions and associated pathways were analyzed through Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes. Protein-Protein Interaction networks were built using Cytoscape. SNRPD1-related analysis was conducted using TCGA and GEO data. Hsa-miR-23a-5p was significantly overexpressed in the tumor tissues and serum exosomes of patients with DLBCL. The expression levels of hsa-miR-23a-5p were associated with distinct prognostic outcomes, immune landscapes, chemoresistance, and biological processes, serving as potential risk factors. The target gene SNRPD1 was an independent prognostic factor significantly associated with patient survival. This study identifies hsa-miR-23a-5p and its target SNRPD1 as potential prognostic factors for DLBCL. Specifically, the overexpression of hsa-miR-23a-5p in serum exosomes of patients with DLBCL suggests that it could serve as a convenient, non-invasive biomarker for clinical evaluation of DLBCL. However, further research and validation are necessary to confirm these findings.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 3","pages":"436-454"},"PeriodicalIF":1.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0