Investigative and Clinical Urology最新文献

The role of Uro-Vaxom in reducing infectious adverse effects and improving outcomes in bacillus Calmette-Guérin therapy for non-muscle-invasive bladder cancer. urovaxom在减少卡介苗-谷氨酰胺治疗非肌肉侵袭性膀胱癌的感染不良反应和改善预后中的作用

IF 2.5 3区医学

Investigative and Clinical Urology Pub Date : 2025-07-01 DOI: 10.4111/icu.20250060

Sookyung Cho, Ho Seok Chung, Seung Il Jung, Do Gyeong Lim, Eu Chang Hwang, Dong Deuk Kwon

{"title":"The role of Uro-Vaxom in reducing infectious adverse effects and improving outcomes in bacillus Calmette-Guérin therapy for non-muscle-invasive bladder cancer.","authors":"Sookyung Cho, Ho Seok Chung, Seung Il Jung, Do Gyeong Lim, Eu Chang Hwang, Dong Deuk Kwon","doi":"10.4111/icu.20250060","DOIUrl":"10.4111/icu.20250060","url":null,"abstract":"Purpose: Intravesical bacillus Calmette-Guerin (BCG) instillation is a cornerstone treatment for non-muscle-invasive bladder cancer (NMIBC) but is frequently associated with significant local and systemic adverse effects. This study aimed to investigate the effects of Uro-Vaxom (UVX) on BCG-related infectious adverse events and oncologic outcomes in patients with NMIBC.Materials and methods: This retrospective cohort study included 251 NMIBC patients who underwent BCG induction therapy following transurethral resection of bladder tumors at a single institution. Patients were stratified into two groups: those not receiving UVX (non-UVX group, n=142) and those receiving UVX (UVX group, n=109). Clinical and oncologic parameters, including the frequency of antibiotic use, treatment discontinuation rates, and early recurrence rates following BCG therapy, were compared between the groups.Results: Antibiotic use during BCG treatment was significantly lower in the UVX group compared to the non-UVX group (p<0.001). Furthermore, BCG discontinuation due to urinary tract infection (UTI) was observed exclusively in the non-UVX group (p=0.003). Although tumor recurrence rates within one year were lower in the UVX group, this difference did not reach statistical significance (p=0.212). Multivariate analysis did not identify UVX use as a significant predictor of early recurrence or bacteriuria.Conclusions: The administration of UVX during BCG therapy in NMIBC patients was associated with reduced antibiotic use and a lower BCG discontinuation rate due to UTI, thereby improving treatment adherence. These findings highlight the potential role of UVX as a valuable adjunct to BCG therapy to optimize patient outcomes.","PeriodicalId":14522,"journal":{"name":"Investigative and Clinical Urology","volume":"66 4","pages":"344-351"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor: Combination of intrarectal heated lidocaine gel and periprostatic nerve block for pain control during transrectal ultrasound-guided prostate biopsy: A prospective randomized trial. 致编辑：一项前瞻性随机试验：经直肠超声引导前列腺活检时，直肠内加热利多卡因凝胶和前列腺周围神经阻滞联合用于疼痛控制。

IF 2.5 3区医学

Investigative and Clinical Urology Pub Date : 2025-07-01 DOI: 10.4111/icu.20250085

An Minh Nguyen, Long Hoang Vo

引用次数: 0

Letter to the editor: Multi-center, prospective, non-interventional, observational study on the efficacy and safety of Mirabek^® in adult patients with overactive bladder. 致编辑：多中心、前瞻性、非介入性、观察性研究Mirabek®治疗成人膀胱过动症的疗效和安全性。

IF 2.5 3区医学

Investigative and Clinical Urology Pub Date : 2025-07-01 DOI: 10.4111/icu.20250056

An Minh Nguyen, Long Hoang Vo

引用次数: 0

Comparing the accuracy of the urinary tract infection symptom assessment and the acute cystitis symptom score questionnaires in diagnosis of acute uncomplicated cystitis in women. 比较尿路感染症状评估与急性膀胱炎症状评分问卷对女性急性无并发症膀胱炎诊断的准确性。

IF 2.5 3区医学

Investigative and Clinical Urology Pub Date : 2025-07-01 DOI: 10.4111/icu.20240380

Yi-Ju Chou, Shang-Jen Chang, Stephen Shei-Dei Yang

{"title":"Comparing the accuracy of the urinary tract infection symptom assessment and the acute cystitis symptom score questionnaires in diagnosis of acute uncomplicated cystitis in women.","authors":"Yi-Ju Chou, Shang-Jen Chang, Stephen Shei-Dei Yang","doi":"10.4111/icu.20240380","DOIUrl":"10.4111/icu.20240380","url":null,"abstract":"Purpose: The purpose of this study is to compare the accuracy of two commonly used questionnaires in diagnosing acute cystitis, i.e., the urinary tract infection symptom assessment (UTISA) and the acute cystitis symptom score (ACSS) questionnaires.Materials and methods: From April 2021 to December 2022, we enrolled female patients with suspected symptoms of acute cystitis as the patient group. As a control group, we included asymptomatic females who came to the hospital for health check-ups. We calculated the accuracy of the two questionnaires in diagnosing acute cystitis and compared the difference in the area under the curve (AUC) of the two through the DeLong test.Results: A total of 89 and 43 participants were recruited for the patient and control groups, respectively. Both questionnaires include six symptoms: frequency, urgency, dysuria, incomplete bladder emptying, lower abdominal pain, and hematuria to diagnose acute cystitis. However, UTISA includes lower back pain as the 7th symptom. The sensitivity, specificity, and AUC of UTISA and ACSS were 85.4% versus 75.3% (p=0.091), 93.0% versus 93.0% (p>0.999), and 0.96 (95% CI 0.92-0.99) versus 0.90 (95% CI 0.83-0.94) (p<0.001), respectively.Conclusions: UTISA questionnaire demonstrates higher diagnostic accuracy compared to ACSS questionnaire. ACSS has lower sensitivity probably due to its limited assessment of low back pain and the objective definition of the severity of frequency that prevents patients from responding based on subjective severity.","PeriodicalId":14522,"journal":{"name":"Investigative and Clinical Urology","volume":"66 4","pages":"352-358"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of tumor invasion patterns on intravesical bacillus Calmette-Guérin response for stage T1 high-grade non-muscle-invasive bladder cancer. 肿瘤侵袭模式对膀胱内calmette - gusamrin反应对T1期高级别非肌侵性膀胱癌的预测价值。

IF 2.5 3区医学

Investigative and Clinical Urology Pub Date : 2025-07-01 DOI: 10.4111/icu.20250124

Ismail Ulus, Şule Özsoy, Selçuk Cin, Mehmet Yilmaz, Gokhan Cil, İbrahim Oğulcan Canitez, Atilla Semercioz

{"title":"Predictive value of tumor invasion patterns on intravesical bacillus Calmette-Guérin response for stage T1 high-grade non-muscle-invasive bladder cancer.","authors":"Ismail Ulus, Şule Özsoy, Selçuk Cin, Mehmet Yilmaz, Gokhan Cil, İbrahim Oğulcan Canitez, Atilla Semercioz","doi":"10.4111/icu.20250124","DOIUrl":"10.4111/icu.20250124","url":null,"abstract":"Purpose: Parameters predicting intravesical bacillus Calmette-Guerin (BCG) treatment response in non-muscle-invasive bladder cancer (NMIBC) are limited. This study investigated the effectiveness of tumor invasion patterns in predicting intravesical BCG treatment response, which are known to have prognostic value for NMIBC.Materials and methods: Data of 167 primary, stage T1 high-grade NMIBC patients evaluated retrospectively. All transurethral resection samples were re-evaluated for confirmation of pathological variables and determination of invasion patterns. Binary logistic regression analysis applied to obtain determinants of BCG response. Kaplan-Meier curves and log-rank test used to assess relationship between variables and time to recurrence and time to progression.Results: Tumor invasion pattern was nodular in 83 (49.7%), trabecular in 20 (12.0%) and infiltrative in 64 patients (38.3%). Multivariate analysis revealed multifocality (p=0.001), trabecular invasion (p=0.001) and infiltrative invasion (p=0.001) were independent predictors of poor BCG response. Log-rank test determined infiltrative invasion has higher impact on time to recurrence (p<0.001) and nodular invasion has significantly lower risk for time to progression (p=0.013), during the median follow-up period of 15 months.Conclusions: Invasion patterns are significantly correlated with BCG response. Assessment of this easily applicable parameter can differ patients who may benefit from BCG treatment and can be used as a prognostic indicator.","PeriodicalId":14522,"journal":{"name":"Investigative and Clinical Urology","volume":"66 4","pages":"295-301"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient-reported outcome measures for pain and tolerability of transperineal prostate biopsy under local anaesthesia using the PrecisionPoint™ transperineal access system: A prospective study for a real-world patient experience. 使用PrecisionPoint™经会阴准入系统，局部麻醉下经会阴前列腺活检疼痛和耐受性的患者报告结果测量：一项真实患者体验的前瞻性研究。

IF 2.5 3区医学

Investigative and Clinical Urology Pub Date : 2025-07-01 DOI: 10.4111/icu.20250077

Ahmed Tarek Albnhawy, Ayman Mostafa, Eslam Hussain, George Hanna, Shweta Das, Asmita Hossain, Moumn Abdalla, Jordan Durrant, Panagiotis Papikinos

{"title":"Patient-reported outcome measures for pain and tolerability of transperineal prostate biopsy under local anaesthesia using the PrecisionPoint™ transperineal access system: A prospective study for a real-world patient experience.","authors":"Ahmed Tarek Albnhawy, Ayman Mostafa, Eslam Hussain, George Hanna, Shweta Das, Asmita Hossain, Moumn Abdalla, Jordan Durrant, Panagiotis Papikinos","doi":"10.4111/icu.20250077","DOIUrl":"10.4111/icu.20250077","url":null,"abstract":"Purpose: Prostate biopsy remains the key step in prostate cancer detection. In recent years, the PrecisionPoint™ Transperineal Access System (PPTAS) has been described as an effective and safe method for performing transperineal biopsy under local anaesthesia (LA). The authors report on the real-world experience of the procedure.Materials and methods: Following introduction and familiarity with the PPTAS biopsy method, patients undergoing prostate biopsy for suspected prostate cancer were provided with validated questionnaires to rate their pain and discomfort following the procedure. The experience of LA administration and the experience of the biopsies were rated separately and prospectively. In addition, the number of cores, maximum core length (MCL), detection rate, and complication rate were retrospectively collected.Results: One hundred three patients were recruited to the study, and a final number of 86 completed patient-reported outcome measures (PROMs) forms were analysed. The procedure was described as tolerable by 97.7%, causing discomfort in 70.9%-88.4%. The grade of pain or discomfort in 73.3%-87.2% was <4 on the pain scale, with only 5.8%-9.3% describing a pain grade >5 on the pain scale. The number of cores, MCL, detection rate, and complication rate were within accepted rates.Conclusions: In a real-world setting, the procedure showed satisfactory PROMs with good patient tolerability and a low grade of pain. Also, it showed a good biopsy quality, detection rate, and complications rate, meaning PPTAS should be considered by centers seeking to streamline the prostate cancer detection pathway for patients.","PeriodicalId":14522,"journal":{"name":"Investigative and Clinical Urology","volume":"66 4","pages":"311-319"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of regular cystoscopy on prognosis in non-muscle-invasive bladder cancer: A nationwide study. 定期膀胱镜检查对非肌肉浸润性膀胱癌预后的影响：一项全国性研究。

IF 2.5 3区医学

Investigative and Clinical Urology Pub Date : 2025-07-01 DOI: 10.4111/icu.20240362

Jeong-Soo Kim, Jooyoung Lee, Chung Un Lee, Tuan Thanh Nguyen, Se Young Choi

{"title":"Impact of regular cystoscopy on prognosis in non-muscle-invasive bladder cancer: A nationwide study.","authors":"Jeong-Soo Kim, Jooyoung Lee, Chung Un Lee, Tuan Thanh Nguyen, Se Young Choi","doi":"10.4111/icu.20240362","DOIUrl":"10.4111/icu.20240362","url":null,"abstract":"Purpose: Transurethral resection of bladder tumors (TUR-BT) requires follow-up evaluation by cystoscopy. We sought to evaluate the prognosis of non-muscle-invasive bladder cancer (NMIBC) patients within 6 months of surgery to identify the optimal timing for the first cystoscopy after TUR-BT.Materials and methods: In this retrospective analysis, patients newly diagnosed with NMIBC were divided into two groups according to whether they underwent cystoscopy within 6 months after TUR-BT. We considered four outcomes: recurrence, progression, cancer-specific mortality, and all-cause mortality. Inverse probability treatment weighting (IPTW)-adjusted Kaplan-Meier analysis was performed to identify the difference in survival for each outcome stratified by cystoscopy status within 6 months after the first TUR-BT. We employed Cox regression models with IPTW to estimate the hazard ratios (HRs) of each outcome according to cystoscopy status.Results: Among 40,678 patients, 11,940 (29.4%) did not undergo cystoscopy within 6 months. The risk of recurrence was higher for patients who underwent cystoscopy than those who did not (HR 1.32, 95% confidence interval [CI] 1.26-1.38, p<0.001). By contrast, the cystoscopy group had a lower risk of progression compared to the non-cystoscopy group (HR 0.70, 95% CI 0.65-0.76, p<0.001), with lower cancer-specific mortality (HR 0.62, 95% CI 0.56-0.68, p<0.001) and all-cause mortality (HR 0.58, 95% CI 0.56-0.60, p<0.001).Conclusions: Cystoscopy within 6 months was associated with a higher risk of recurrence but a lower risk of progression and death. Therefore, regular cystoscopy after the first TUR-BT for NMIBC is essential to ensure favorable survival outcomes.","PeriodicalId":14522,"journal":{"name":"Investigative and Clinical Urology","volume":"66 4","pages":"302-310"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel T-shaped incision of the tunica vaginalis for managing adhesions during vasoepididymostomy. 一种新型的阴道膜t形切口用于处理附睾血管吻合术中的粘连。

IF 2.5 3区医学

Investigative and Clinical Urology Pub Date : 2025-07-01 DOI: 10.4111/icu.20250011

Zhuojie Liu, Jiarong Feng, Karl H Pang, Hao Zhang, Yan Zhang

{"title":"A novel T-shaped incision of the tunica vaginalis for managing adhesions during vasoepididymostomy.","authors":"Zhuojie Liu, Jiarong Feng, Karl H Pang, Hao Zhang, Yan Zhang","doi":"10.4111/icu.20250011","DOIUrl":"10.4111/icu.20250011","url":null,"abstract":"Purpose: To propose a novel surgical approach for managing inflammatory adhesions of the tunica vaginalis (TV) during vasoepididymostomy (VE), and to report surgical outcomes.Materials and methods: A T-shaped incision of the TV was used to expose the epididymis and vas deferens in cases with adhesions between the TV and the testis. We retrospectively analyzed data from five patients who underwent microsurgical VE for obstructive azoospermia (OA) secondary to epididymal obstruction. Operative time, postoperative patency rate and semen analysis, and natural pregnancy rates were recorded. For comparison, 50 patients who underwent conventional longitudinal TV incision were included to assess operative time, while 46 and 36 of these patients were used to compare patency and pregnancy rates, respectively, with the T-shaped incision group.Results: The T-shaped incision involves a longitudinal incision of the TV at the epididymal-testicular junction followed by an incision (T) in the direction towards the epididymis and vas deferens area. Among the five patients who underwent this approach, four (80.0%) had sperm detected in semen two months postoperatively, and their partners achieved natural pregnancy (4/5, 80.0%) within one year after VE. No postoperative wound infections occurred. No statistically significant differences were observed in mean operative time, patency rates, or pregnancy rates between the T-shaped and longitudinal incision groups.Conclusions: The T-shaped TV incision is a feasible approach for VE in OA patients with inflammatory TV-testis adhesions, providing adequate epididymal access without compromising operative time or surgical outcomes.","PeriodicalId":14522,"journal":{"name":"Investigative and Clinical Urology","volume":"66 4","pages":"329-335"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connecting the dots: How functional bladder capacity may reflect cardiovascular risk. 连接点：膀胱功能容量如何反映心血管风险。

IF 2.5 3区医学

Investigative and Clinical Urology Pub Date : 2025-07-01 DOI: 10.4111/icu.20240405

Momina Ahmed, Hafiz Muhammad Haris, Hafsa Zareen

引用次数: 0

Letter to the editor: Computerized metric assessment of glandular tissue volume within the peripheral zone of the prostate using combined magnetic resonance imaging and histopathology: Possible pathophysiological implications on prostate cancer development. 致编辑的信：结合磁共振成像和组织病理学对前列腺外周区腺体组织体积的计算机度量评估：前列腺癌发展的可能病理生理意义。

IF 2.5 3区医学

Investigative and Clinical Urology Pub Date : 2025-07-01 DOI: 10.4111/icu.20250045

Kuo-Jen Lin, Po-Ting Lin, Yu-Hsiang Lin

引用次数: 0