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Investigative urology最新文献

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Immunology of pyelonephritis in the primate model. II. Effect on immunosuppression. 灵长类动物肾盂肾炎的免疫学研究。2免疫抑制作用。
Investigative urology Pub Date : 1981-11-01
J A Roberts, G J Domingue, L N Martin, J C Kim, S R Rangan
{"title":"Immunology of pyelonephritis in the primate model. II. Effect on immunosuppression.","authors":"J A Roberts,&nbsp;G J Domingue,&nbsp;L N Martin,&nbsp;J C Kim,&nbsp;S R Rangan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nonobstructive pyelonephritis was produced in the rhesus monkey (Macaca mulatta) by means of retrograde inoculation of Escherichia coli to the point of pyelotubular backflow. The effects of treatment with cyclophosphamide or azathioprine were determined. Commensal renal viruses were not activated by the immunosuppression, and thus did not complicate our results. Both cyclophosphamide and azathioprine prolonged the bacteriuria and produced more severe pathology. Cyclophosphamide decreased the leukocytic response and partically suppressed the antibody response. The increased amount of acute pyelonecytic response and partially suppressed the antibody response. The increased amount of acute pyelonephritic lesions after treatment with this drug suggest that the antibody and inflammatory responses may be important protective mechanisms, particularly regarding prevention of abscesses. In contrast, azathioprine did not decrease the leukocytosis nor the antibody responses, but resulted in decreased in vitro responsiveness of lymphocytes to mitogens. The increased severity of chronic pyelonephritic lesions after azathioprine treatment suggests that the cellular immune response also may be an important protective mechanism during late stages of the disease. The results thus indicate that the immune response is protective and is not directly responsible for the chronic scarring of pyelonephritis.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 3","pages":"148-53"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17334424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healing properties of the renal papilla. Animal model II. 肾乳头的愈合特性。动物模型II。
Investigative urology Pub Date : 1981-09-01
R T Webb, J M Russell, W H Boyce
{"title":"Healing properties of the renal papilla. Animal model II.","authors":"R T Webb,&nbsp;J M Russell,&nbsp;W H Boyce","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 2","pages":"126-9"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18289267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of penile erection. 阴茎勃起的机制。
Investigative urology Pub Date : 1981-09-01
G S Benson
{"title":"Mechanisms of penile erection.","authors":"G S Benson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 2","pages":"65-9"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17182763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal metabolic changes relating to calculogenesis in an experimental model of calcium containing renal stone formation in rabbits. 兔含钙肾结石形成实验模型中与肾结石发生相关的肾脏代谢变化。
Investigative urology Pub Date : 1981-09-01
H Itatani, H Itoh, T Yoshioka, M Namiki, T Koide, A Okuyama, T Sonoda
{"title":"Renal metabolic changes relating to calculogenesis in an experimental model of calcium containing renal stone formation in rabbits.","authors":"H Itatani,&nbsp;H Itoh,&nbsp;T Yoshioka,&nbsp;M Namiki,&nbsp;T Koide,&nbsp;A Okuyama,&nbsp;T Sonoda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In histochemical studies it was shown that sulfated acid glycosaminoglycans (AGAGS) were produced and secreted into the tubular lumen in renal papilla, but not in the renal cortex of muddy stone forming kidney. There was no secretion of sulfated AGAGS in renal papilla histochemically during hydronephrosis before stone formation. On autoradiographic study with the use of 45Ca and 35S for labeling of sulfated AGAGS, we found that 45Ca accumulated in renal papilla of muddy stone forming kidney, but not in the other. 35S apparently accumulated into muddy stones. Measurement of calcium content of the renal papilla and cortex proved the results of autoradiographic studies, and measurement of uronic acid in the urine showed increased secretion of AGAGS in the urine from muddy stone forming kidney. From these results it was proposed that the sulfate AGAGS secreted in the urine could bind calcium crystals to each other amd make crystals aggregate massively.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 2","pages":"119-22"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18287358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soft agar clonogenic assay for primary human renal carcinoma: in vitro chemotherapeutic drug sensitivity testing. 原发性人肾癌的软琼脂克隆测定:体外化疗药物敏感性试验。
Investigative urology Pub Date : 1981-09-01
M M Lieber, J S Kovach
{"title":"Soft agar clonogenic assay for primary human renal carcinoma: in vitro chemotherapeutic drug sensitivity testing.","authors":"M M Lieber,&nbsp;J S Kovach","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dispersed tumor cells from primary human renal adenocarcinomas showed typical clonogenic growth in soft agar in seven of 31 instances. In vitro chemotherapy sensitivity testing was performed successfully for five of the seven clonogenic tumors. Extensive inherent resistance to the cytotoxic effects of many standard and experimental chemotherapeutic agents were observed. Occasionally, a single drug showed marked cytotoxicity. Similar results were obtained with soft agar clonogenic chemotherapeutic drug sensitivity assays performed on cells from human renal carcinoma xenografts. These in vitro results agree with clinical experience in the chemotherapy of advanced renal carcinoma. It remains to be determined if the sensitivity or resistance to chemotherapeutic drugs of human renal carcinomas noted in vitro reflects the characteristics of the tumors in vivo. Our results show that it is feasible to evaluate the soft agar assay as a method for selecting drugs for individual patients with renal carcinoma, a disease for which no chemotherapeutic treatment can be recommended at present.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 2","pages":"111-4"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18287355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphologic and biochemical characteristics of human kidney cells in vitro. 体外培养人肾细胞的形态学和生化特征。
Investigative urology Pub Date : 1981-09-01
M Matsuda, M Osafune, M Ishibashi, E Nakano, M Takaha, T Sonoda, A Hiraoka, T Hada, S Watanabe, K Higashino, S Morimoto
{"title":"Morphologic and biochemical characteristics of human kidney cells in vitro.","authors":"M Matsuda,&nbsp;M Osafune,&nbsp;M Ishibashi,&nbsp;E Nakano,&nbsp;M Takaha,&nbsp;T Sonoda,&nbsp;A Hiraoka,&nbsp;T Hada,&nbsp;S Watanabe,&nbsp;K Higashino,&nbsp;S Morimoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In vitro cultivated cells derived from normal human renal cortex were characterized morphologically and biochemically. Although the epithelial monolayer was composed of heterogeneous cells, it included cells with a surface structure similar to microvilli as well as some resembling the desmosome between neighboring cells. Enzymatic studies revealed a marked decrease in alkaline phosphatase activity, and the activity of gamma-glutamyl transpeptidase was also reduced to about one-fifth of that in the original tissue. The electrophoretic mobility of the enzyme was not identical with that of normal kidney or of the novel enzyme in renal neoplastic tissue. Lactate dehydrogenase activity was similar to that of normal kidney tissue but the isozyme pattern was completely inverted. These cells responded to the addition of 10 ng per ml of parathyroid hormone in culture medium and there was a 33 fold increase in intracellular cyclic adenosine monophosphate. Estrogen specific binding protein was not detectable in the monolayer cells. These results clearly indicated that the biologic transformation observed in the cultivated normal cells was not attributable to simple fetalism or dedifferentiation, but was a more complicated process.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 2","pages":"104-8"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17182762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The pathogenesis of renal dysplasia. III. Complete and incomplete urinary obstruction. 肾发育不良的发病机制。3完全和不完全尿路梗阻。
Investigative urology Pub Date : 1981-09-01
R D Schwarz, F D Stephens, L J Cussen
{"title":"The pathogenesis of renal dysplasia. III. Complete and incomplete urinary obstruction.","authors":"R D Schwarz,&nbsp;F D Stephens,&nbsp;L J Cussen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We graded obstructed kidneys of infants on the hypodysplasia scale to assess the influence of complete and partial obstruction on the pathogenesis of hypodysplasia. Kidneys with complete obstruction exhibited severe grades; those with partial ureteral obstruction had near normal grades. Those kidneys subjected to partial urethral obstruction ranged from mild to severe grades which correlated with degrees of lateral ectopy of the urethral office. Renal parenchymal development was impaired by complete obstruction but was tolerant to incomplete obstruction. Abnormal orifice positions associated with urethral obstructions were considered to be manifestations of ectopic ureteric buds and the hypodysplasia to be evidence of abnormal induction of abnormal renal blastema.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 2","pages":"101-3"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18210284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The clinical implications of epididymal levels of tetracycline. 附睾四环素水平的临床意义。
Investigative urology Pub Date : 1981-09-01
J J Warner, B I Turner, R H Alford, R K Rhamy
{"title":"The clinical implications of epididymal levels of tetracycline.","authors":"J J Warner,&nbsp;B I Turner,&nbsp;R H Alford,&nbsp;R K Rhamy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 2","pages":"92-3"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18289272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory plasma cell infiltration of the urinary bladder in the aging C57BL/Icrfa(t) mouse. 衰老C57BL/Icrfa(t)小鼠膀胱炎性浆细胞浸润。
Investigative urology Pub Date : 1981-09-01
J I Phillips
{"title":"Inflammatory plasma cell infiltration of the urinary bladder in the aging C57BL/Icrfa(t) mouse.","authors":"J I Phillips","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An age related increased cellularity in the lamina propria of the mouse bladder is described. The identified cell types involved are plasma cells, lymphocytes, and eosinophilic leukocytes, and probably represent an inflammatory plasma cell infiltration. Two rare unidentified cell types were also seen. The cause of the inflammatory reaction is unknown, but the failure to detect a causative microorganism suggests that it might be an autoimmune response, possibly related to the clinical condition of interstitial cystitis. From foci of increased cellularity, located in the close proximity of blood vessels, lymphocytes migrate to the urothelium which otherwise shows no ultrastructural changes with age.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 2","pages":"75-8"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18210285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrarenal surgery, Animal model I. 肾内手术，动物模型I。
Investigative urology Pub Date : 1981-09-01
J M Russell, R T Webb, W H Boyce
{"title":"Intrarenal surgery, Animal model I.","authors":"J M Russell,&nbsp;R T Webb,&nbsp;W H Boyce","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 2","pages":"123-5"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18289266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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