Investigative urology最新文献

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Studies on the mechanism of compensatory renal hypertrophy and hyperplasia in a nephrectomized animal model. I. Evidence for a renotropic growth stimulating factor in uninephrectomized rabbit sera using tissue culture. 肾切除动物模型代偿性肾肥大和增生机制的研究。利用组织培养在未切除肾的兔血清中发现嗜肾性生长刺激因子的证据。
Investigative urology Pub Date : 1981-03-01
H Kanetake, N Yamamoto
{"title":"Studies on the mechanism of compensatory renal hypertrophy and hyperplasia in a nephrectomized animal model. I. Evidence for a renotropic growth stimulating factor in uninephrectomized rabbit sera using tissue culture.","authors":"H Kanetake,&nbsp;N Yamamoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>When synchronized primary rabbit kidney confluent monolayer cell cultures were incubated with a medium that contained uninephrectomized rabbit serum, the incorporation of tritiated thymidine into DNA was much greater than that with a medium that contained normal rabbit serum. The maximal growth stimulating activity of uninephrectomized serum on thymidine incorporation into sparsely cultured cells was increased approximately 5 fold above that of normal serum. We conclude that uninephrectomized sera contain a growth stimulating factor. Uninephrectomized rabbit sera showed no increased stimulation of DNA synthesis in primary rabbit skin cultured cells above that by normal rabbit serum, indicating that the growth stimulating factor in uninephrectomized serum shows renotropic specificity in tissue culture. A transformed rabbit kidney cell line RK-13 did not respond to the renotropic growth stimulating factor. However, primary and the transformed rabbit kidney cells absorbed the renotropic growth stimulating factor from uninephrectomized sera. Thus, the cell line RK-13 has receptors for adsorption of the renotropic growth factor but is unable to respond further to the growth stimulating process. The renotropic growth stimulating factor is heat unstable and undialyzable by dialysis tubings with pore size up to 12,000 molecular weight. Thus the renotropic growth factor seems to be a macromolecule, probably a protein.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"18 5","pages":"326-30"},"PeriodicalIF":0.0,"publicationDate":"1981-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18219299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of manipulation of the prostate gland on serum prostate-specific acid phosphatase measured by radioimmunoassay. 前列腺推拿对放射免疫法测定血清前列腺特异性酸性磷酸酶的影响。
Investigative urology Pub Date : 1981-03-01
P Vihko, O Lukkarinen, M Kontturi, R Vihko
{"title":"The effect of manipulation of the prostate gland on serum prostate-specific acid phosphatase measured by radioimmunoassay.","authors":"P Vihko,&nbsp;O Lukkarinen,&nbsp;M Kontturi,&nbsp;R Vihko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We investigated the effects of digital prostatic palpation, cystoscopy, and biopsy of the prostate on the concentrations of serum prostate-specific acid phosphatase (PAP) measured by radioimmunoassay. Serum concentrations of PAP in patients with normal or hyperplastic prostates did not exceed the upper limit of our reference range (4 microgram per liter) during the 48 hr after digital prostatic palpation. The serum concentrations of PAP did not significantly increase in patients with carcinomatous prostates after digital examination of the prostate. Serum PAP did increase in patients with benign prostatic hyperplasia soon after cystoscopy of biopsy of the prostate. No diurnal variation in the serum concentrations of PAP during the follow-up of 48 hr was detected in the patient groups with normal, benign hyperplastic, or carcinomatous prostates not subjected to rectal examination.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"18 5","pages":"334-6"},"PeriodicalIF":0.0,"publicationDate":"1981-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17228630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histochemical observation of F 1881 binding protein in human benign prostatic hypertrophy. f1881结合蛋白在人良性前列腺肥大组织中的组织化学观察。
Investigative urology Pub Date : 1981-03-01
H Naito, H Ito, M Wakisaka, A Kambegawa, J Shimazaki
{"title":"Histochemical observation of F 1881 binding protein in human benign prostatic hypertrophy.","authors":"H Naito,&nbsp;H Ito,&nbsp;M Wakisaka,&nbsp;A Kambegawa,&nbsp;J Shimazaki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 3-carboxymethyloxime conjugate of R 1881 was conjugated with bovine serum albumin and reacted with fluorescein isothiocyanate. Tissue sections from patients with benign prostatic hypertrophy were incubated with this compound. Fluorescence was observed in the cytoplasm of gland cells, although both positive and negative cells were distributed evenly in some areas. Neither the stroma nor the nuclei of epithelial cells were fluorescent. Preincubation with a 20 fold molar excess of R 1881-carboxymethyloxime-bovine serum albumin, 1 microM of R 1881, or 1 microM of triamcinolone acetonide diminished fluorescence of the section. Bovine serum albumin conjugated with fluorescein isothiocyanate did not stain the section. Therefore, the fluorescence observed in the sections seems to be attributable to the high affinity binding of R 1881. The intensity and number of fluorescent cells and the R 1881 binding estimated by a biochemical method were well correlated.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"18 5","pages":"337-40"},"PeriodicalIF":0.0,"publicationDate":"1981-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17228633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Charles Horace Mayo (1865-1939). 查尔斯·霍勒斯·梅奥(1865-1939)。
Investigative urology Pub Date : 1981-01-01
C C Carson
{"title":"Charles Horace Mayo (1865-1939).","authors":"C C Carson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"18 4","pages":"313-4"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18053793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of antiestrogen, antiandrogen, and the prolactin inhibitor 2 bromo-alpha-ergocriptine on the stromal tissue of human benign prostatic hyperplasia. Correlation of stereological data and plasma hormones. 抗雌激素、抗雄激素及催乳素抑制剂2溴-麦角隐亭对人良性前列腺增生间质组织的影响。体视学数据与血浆激素的相关性。
Investigative urology Pub Date : 1981-01-01
G Bartsch, M Oberholzer, H P Rohr
{"title":"The effect of antiestrogen, antiandrogen, and the prolactin inhibitor 2 bromo-alpha-ergocriptine on the stromal tissue of human benign prostatic hyperplasia. Correlation of stereological data and plasma hormones.","authors":"G Bartsch,&nbsp;M Oberholzer,&nbsp;H P Rohr","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In an attempt to shed light on the action of endogenous androgens and estrogens on the stromal tissue of the human prostate, we studied the effect of selective androgen (cyproterone acetate), estrogen (tamoxifen), and prolactin (bromocriptine) antagonists. The application of cyproterone acetate led to a reduced relative volumetric amount of the smooth muscle cell organelles, whereas the administration of tamoxifen effected no alteration as compared to pretreatment values. The administration of bromocriptine led to further activation of the smooth muscle cells in benign prostatic hyperplasia. Hormones, such as leutinizing hormone, follicle stimulating hormone, testosterone, 17-beta-estradiol, and prolactin were measured to assess alterations of the pituitary gonadal axis.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"18 4","pages":"308-12"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17227241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal function during and after a temporary complete unilateral ureter obstruction in rats. 大鼠暂时性完全性单侧输尿管梗阻期间及后的肾功能。
Investigative urology Pub Date : 1981-01-01
A P Provoost, J C Molenaar
{"title":"Renal function during and after a temporary complete unilateral ureter obstruction in rats.","authors":"A P Provoost,&nbsp;J C Molenaar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We studied changes in the glomerular filtration rate (GFR) and in the distribution of the renal blood flow over the left and right kidney during and after unilateral ureteral obstruction in rats. The fraction of the total renal blood flow to the obstructed kidney slowly decreased with the duration of obstruction. The fraction of the total GFR decreased at a much faster rate. After the removal of an obstruction of 7, 14, or 21 days, the kidney resumed glomerular filtration with or without an intact contralateral kidney. The degree of recovery diminished with the duration of the obstruction. We conclude that recovery of the GFR, in the case of a complete unilateral ureteral obstruction, depends upon the duration of the obstruction and not on the presence of the intact contralateral kidney.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"18 4","pages":"242-6"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18460865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of active peptides on the isolated muscle of the human urinary bladder. 活性肽对人膀胱离体肌肉的影响。
Investigative urology Pub Date : 1981-01-01
V Erspamer, G Ronzoni, G Falconieri Erspamer
{"title":"Effects of active peptides on the isolated muscle of the human urinary bladder.","authors":"V Erspamer,&nbsp;G Ronzoni,&nbsp;G Falconieri Erspamer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We studied the effect of 29 active peptides, six biogenic amines, and two prostaglandins on isolated preparations of the longitudinal muscle of the human urinary bladder. The peptide that had the most potent stimulant action was angiotensin II, followed by eledoisin and kassinin (substance P-like peptides), and by bombesin and litorin. The threshold dose of angiotensin was frequently as low as 0.3 to 0.5 ng per ml. Eledoisin showed approximately 10 per cent of the activity of angiotensin II. All peptides had a direct stimulant effect on vesical smooth muscle. Further studies are required to determine if angiotensin and/or substance P-like peptides are involved in the control of motility of the human urinary bladder, as constituents of the secretion of peptidergic nerves.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"18 4","pages":"302-4"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18459872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Segmental replacement of the ureter using tapered and nontapered ileum. 采用锥形和非锥形回肠进行节段性输尿管置换术。
Investigative urology Pub Date : 1981-01-01
W B Waters, W F Whitmore, A L Lage, R F Gittes
{"title":"Segmental replacement of the ureter using tapered and nontapered ileum.","authors":"W B Waters,&nbsp;W F Whitmore,&nbsp;A L Lage,&nbsp;R F Gittes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We attempted to reduce the absorptive surface area and maintain the natural antireflux mechanism of the distal ureter by using ileum as an interposed segment rather than a total ureteral substitute in six dogs. In each dog we compared the physiologic effects of a longitudinally tapered ileal segment versus a simple nontapered segment. Information from the intravenous pyelogram, renal function tests, and the pressure flow studies showed preservation of renal function and parenchyma, no secondary dilation of the upper tracts, continued peristaltic activity, no evidence of obstruction or stone formation secondary to mucus production, no early pyelographic abnormalities, and no differences in pressure flow characteristics between the tapered and nontapered segments. We believe that incorporating ileum into the urinary tract to bridge a ureteral defect is a safe and effective clinical alternative.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"18 4","pages":"258-61"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18460867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimal parameters of electrical stimulation in the treatment of urinary incontinence. 电刺激治疗尿失禁的最佳参数。
Investigative urology Pub Date : 1981-01-01
C J Godec, R Fravel, A S Cass
{"title":"Optimal parameters of electrical stimulation in the treatment of urinary incontinence.","authors":"C J Godec,&nbsp;R Fravel,&nbsp;A S Cass","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We evaluated five types of electrical stimulation (continuous, intermittent pseudorandomized, randomized (stochastic), and intermittent randomized) for their effects on muscle contraction and muscle fatigue in 12 patients with urinary incontinence. Continuous stimulation, used in the available commercial stimulators, was not optimal. Randomized (stochastic) stimulation seems to be optimal although this conclusion was not statistically confirmed.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"18 4","pages":"239-41"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18019759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detrusor dynamics. I. Effect of prostaglandin f2 alpha on tension-length relationship. 逼尿肌动力学。1 .前列腺素f2 α对张力-长度关系的影响。
Investigative urology Pub Date : 1981-01-01
M Abdel-Rahman, A Coulombe, M M Elhilali
{"title":"Detrusor dynamics. I. Effect of prostaglandin f2 alpha on tension-length relationship.","authors":"M Abdel-Rahman,&nbsp;A Coulombe,&nbsp;M M Elhilali","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We used 50 detrusor strips to evaluate the possible modulatory effect of prostaglandin F2 alpha on the dynamics of bladder wall during stretch. Prostaglandin F2 alpha showed a positive excitatory effect on the total mural tension in doses up to 2 micrograms per ml within muscle lengths up to 140 per cent of the equilibrium length. At higher doses and greater lengths a mild inhibitory effect was evident. In contrast, the excitatory effect of urecholine continued up to double the equilibrium length.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"18 4","pages":"278-80"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18459867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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