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Investigative urology最新文献

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Ephraim McDowell (1771-1830). The President's lithotomist. 以法莲·麦克道尔(1771-1830)。总统的石匠。
Investigative urology Pub Date : 1981-11-01
S D Graham
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引用次数: 0
A fundamental study of regional chemotherapy given by intraarterial infusion with concomitant hemodialysis and hemoperfusion. 动脉内灌注局部化疗伴血液透析和血液灌流的基础研究。
Investigative urology Pub Date : 1981-11-01
S Kamidono, G Hamami, A Fujii, J Ishigami
{"title":"A fundamental study of regional chemotherapy given by intraarterial infusion with concomitant hemodialysis and hemoperfusion.","authors":"S Kamidono,&nbsp;G Hamami,&nbsp;A Fujii,&nbsp;J Ishigami","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the intraarterial infusion of anticancer drugs, the majority of systemic side effects are caused by the systemic circulation of the infused drug. If the extraregional infusate could be removed by hemodialysis (HD) or direct hemoperfusion (DHP), side effects in the intraarterial infusion therapies could be mitigated and regional administration of anticancer drugs in large doses would than be possible. To substantiate this postulate, the authors carried out in vivo experiments using mongrel dogs, and obtained the results evidencing removal of extra regional anticancer drugs by HD and DHP. The maximum mitomycin C clearance of HD was 35.7 ml per min, whereas that of DHP was 119.7 ml per min. The results show the usefulness of concomitant use of HD or DHP in the intraarterial infusion of anticancer drugs via internal iliac artery in the treatment of cancer of the urinary bladder.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 3","pages":"176-8"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17846634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transplantation and cell culture of rat urinary bladder carcinoma. 大鼠膀胱癌移植及细胞培养。
Investigative urology Pub Date : 1981-11-01
S M Cohen, J P Yang, J B Jacobs, M Arai, S Fukushima, G H Friedell
{"title":"Transplantation and cell culture of rat urinary bladder carcinoma.","authors":"S M Cohen,&nbsp;J P Yang,&nbsp;J B Jacobs,&nbsp;M Arai,&nbsp;S Fukushima,&nbsp;G H Friedell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 3","pages":"136-41"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18309991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma lipid bound sialic acid in patients with prostate and bladder cancer. 血浆脂质结合唾液酸在前列腺癌和膀胱癌患者中的作用。
Investigative urology Pub Date : 1981-11-01
U Dunzendorfer, N Katopodis, A M Dnistrian, C C Stock, M K Schwartz, W F Whitmore
{"title":"Plasma lipid bound sialic acid in patients with prostate and bladder cancer.","authors":"U Dunzendorfer,&nbsp;N Katopodis,&nbsp;A M Dnistrian,&nbsp;C C Stock,&nbsp;M K Schwartz,&nbsp;W F Whitmore","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Plasma lipid bound sialic acid (LSA) was measured in patients with prostate and bladder cancer to determine the usefulness of this biochemical marker in teh staging of malignant disease and in monitoring the efficacy of therapy. Patients with advanced stages of prostate cancer with bone metastases exhibited LSA levels significantly higher than normal subjects. Patients with bladder cancer showed elevations in LSA both in early noninvasive and in advanced stages of the disease. In both types of cancer, patients treated successfully and clinically free of disease did not have elevated LSA levels, whereas patients failing to respond to treatment had persistently high values.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 3","pages":"194-6"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18311706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum levels of follicle stimulating hormone, luteinizing hormone, prolactin, testosterone, 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha, 17 beta-diol, 5 alpha-androstane-3 beta, 17 beta-diol, and 17 beta-estradiol from male beagles with spontaneous or induced benign prostatic hyperplasia. 自发性或诱发性良性前列腺增生的雄性比格犬血清促卵泡激素、促黄体生成素、催乳素、睾酮、5 -二氢睾酮、5 -雄烷-3 α、17 - β -二醇、5 - α -雄烷-3 β、17 - β -二醇和17 - β -雌二醇水平。
Investigative urology Pub Date : 1981-11-01
R C Cochran, L L Ewing, G D Niswender
{"title":"Serum levels of follicle stimulating hormone, luteinizing hormone, prolactin, testosterone, 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha, 17 beta-diol, 5 alpha-androstane-3 beta, 17 beta-diol, and 17 beta-estradiol from male beagles with spontaneous or induced benign prostatic hyperplasia.","authors":"R C Cochran,&nbsp;L L Ewing,&nbsp;G D Niswender","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The serum concentration of testosterone (T) 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol), 5 alpha-androstane-3 beta , 17 beta-diol (3 beta-diol), luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin in young (less than 40 months) beagles with spontaneous benign prostatic hyperplasia (BPH) were not significantly (P greater than 0.25) different from serum hormone levels of age matched controls, or old (greater than 60 months) beagles with BPH. However, the serum hormone levels of age matched controls, or with BPH (2.46 +/- 0.51 pg per ml) was significantly (P less than 0.05) lower than that of age matched controls (3.93 +/- 0.35 pg per ml) and of old beagles with BPH is not associated with increased serum concentrations of androgens, or changes in serum levels of gonadotropins, but may be related to some change in estrogen biosynthesis or metabolism. In the second part of the experiment, castrate and intact beagles were treated for 4 months with three weekly injections of T, DHT, 3 alpha-diol, estradiol, T + estradiol, DHT + estradiol, or 3 alpha-diol + estradiol. As expected, the serum concentration of T, DHT, 3 alpha-diol, estradiol, LH, and FSH varied dramatically depending on the steroid regimen used. Analysis of these results showed that prostate weight was increased by steroid treatments which elevated the serum DHT concentration. However, glandular hyperplasia, indistinguishable from that seen in dogs with BPH, occurred only when estradiol was added to those steroid treatments which caused elevated serum DHT concentration.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 3","pages":"142-7"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17236239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Initiation and propagation of stimulus from the renal pelvic pacemaker in pig kidney. 猪肾盆腔起搏器刺激的启动和传播。
Investigative urology Pub Date : 1981-11-01
T Morita, G Ishizuka, S Tsuchida
{"title":"Initiation and propagation of stimulus from the renal pelvic pacemaker in pig kidney.","authors":"T Morita,&nbsp;G Ishizuka,&nbsp;S Tsuchida","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new in vitro method was used to examine the initiation and the propagation of the peristaltic contraction in the renal pelvis and ureter of the pig. The method enabled the direct observation of peristalsis, both microscopically and electrophysiologically. A microscopic ripplelike contraction of a constant frequency was generated spontaneously at the border between the upper, middle, and lower major calyces and their minor calyces. At the same time, electromyograms were recorded in the same regions, with a constant discharge interval that suggested to us that these might be pacemaker potentials. The waves originating from the upper calyx, middle calyx, and lower calyx propagated at different times toward the ureter. Pressure changes of an almost constant interval were recorded in each calyx and corresponded in a 1:1 ratio to the action potentials at the same calyx. Pelvic pressure changes reflected the electrical activity of the renal pelvis, but did not reflect the pacemaker activity of the renal calyx.U</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 3","pages":"157-60"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18309993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of a density gradient column in the analysis of urinary calculi. 密度梯度柱在尿路结石分析中的应用。
Investigative urology Pub Date : 1981-11-01
A L Rodgers, L R Nassimbeni, K J Mulder, J Mullins
{"title":"Use of a density gradient column in the analysis of urinary calculi.","authors":"A L Rodgers,&nbsp;L R Nassimbeni,&nbsp;K J Mulder,&nbsp;J Mullins","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 3","pages":"154-6"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18309992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post ischemic renal bleeding from fenal puncture site. 肾穿刺后缺血性出血。
Investigative urology Pub Date : 1981-11-01
D A Myers, G Oldani, B Finlayson
{"title":"Post ischemic renal bleeding from fenal puncture site.","authors":"D A Myers,&nbsp;G Oldani,&nbsp;B Finlayson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 3","pages":"214-5"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18311711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of dyes used to evaluate the in situ, ex-vivo, and perfused kidney. 染料用于评估原位、离体和灌注肾的效果。
Investigative urology Pub Date : 1981-11-01
R L Burleson, R Kasulke, D B Jones, P Marbarger, J DeRito, C DeVoe
{"title":"The effect of dyes used to evaluate the in situ, ex-vivo, and perfused kidney.","authors":"R L Burleson,&nbsp;R Kasulke,&nbsp;D B Jones,&nbsp;P Marbarger,&nbsp;J DeRito,&nbsp;C DeVoe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Methylene blue, indigo carmine, and fluorescein dyes were evaluated to determine their effect on the dog kidney. Methylene blue and indigo carmine were administered intravenously and intraarterially to the in situ vascularized kidney and serial histologic appearance of the kidney was determined. The three dyes were administered intraarterially to excised kidneys that were then preserved for 1 hour in the cold and autotransplanted; and finally the three dyes were administered to the perfusate of excised kidneys that were perfused for 18 hours by cryoperfusion with an albumin perfusate and then autotransplanted. Renal function and histology were determined 5 days after autotransplantation. Methylene blue dye did not damage the in situ vascularized kidney as judged by renal histology. However, administration of methylene blue to the ex vivo kidney that was subsequently short term cold stored or perfusion stored was associated with marked apparent ischemic damage of the organ. Indigo carmine dye did not adversely affect either the in situ vascularized kidney or the short term cold stored kidney. However, with perfusion storage, indigo carmine produced apparent vasoconstriction that led to perfusion failure. Fluorescein dye was not harmful to the kidney either during short term cold storage or during perfusion preservation. It is concluded that fluorescein is the dye of choice for evaluating the vascular anatomy or macroperfusion status of the kidney.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 3","pages":"165-8"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18309995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemoimmunotherapy of murine bladder cancer. 小鼠膀胱癌的化学免疫治疗。
Investigative urology Pub Date : 1981-11-01
B J Stogdill, D L Lamm, R B Livingston
{"title":"Chemoimmunotherapy of murine bladder cancer.","authors":"B J Stogdill,&nbsp;D L Lamm,&nbsp;R B Livingston","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The lethality of invasive transitional cell carcinoma (TCC) has prompted a search for effective, minimally toxic, adjuvant therapy. Such agents were evaluated in a murine bladder cancer (MBT2) model which parallels the clinical disease. One hundred C3H/He mice were inoculated i.d. with 2.5 x 10(4) viable MBT2 tumor cells and randomized to receive either normal saline (control), cis-Platinum (CPT), cyclophosphamide (CY), methotrexate (MTX), BCG, (CY + MTX), or (CY + MTX + BCG). Chemotherapy was given intraperitoneally weekly starting on day 7 after inoculation. Immunotherapy was given intralesionally on days 1 and 10 only. All mice were treated for 5 weeks followed by 5 weeks of observation. At 5 weeks, tumors of mice receiving cyclophosphamide alone or either of the combinations of therapy were smaller (P less than 0.01) than tumors of controls or other single agents alone. Each regimen increased survival, but only the combination regimen increase survival significantly (P less than 0.01). In the doses and schedule used in this model. Combination chemotherapy and chemoimmunotherapy significantly delay tumor growth and increase duration of survival (P less than 0.01) when compared with controls or single agent groups.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"19 3","pages":"179-81"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18311702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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