Iranian Journal of Basic Medical Sciences最新文献

{"title":"Psoriasis: Immunological and genetic blueprints driving pathogenesis and potential for personalized therapies.","authors":"Mohamed J Saadh, Omer Qutaiba B Allela, Radhwan Abdul Kareem, Gaurav Sanghvi, G PadmaPriya, Rishabh Thakur, Mukesh Kumari, Sofia Gupta, Kakhramon Khaitov, Hayder Naji Sameer, Ahmed Yaseen, Zainab H Athab, Mohaned Adil","doi":"10.22038/ijbms.2025.85335.18442","DOIUrl":"https://doi.org/10.22038/ijbms.2025.85335.18442","url":null,"abstract":"<p><p>Psoriasis is a long-lasting inflammatory skin condition that impacts millions globally. The occurrence of this disorder differs significantly across various areas, resulting from a complex interplay of genetic and environmental influences. In psoriasis, the pathogenesis represents a complex interaction of innate and adaptive immunity that plays a significant role in the disease manifestation process. Many genetic factors predispose to psoriasis, which is considered a polygenic disease. Several genes concerning pathways like NF-κB and PI3K/Akt that modulate the amplification of inflammatory response and keratinocyte dysregulation have been elaborated in the light of their differential expression, susceptibility loci, and polymorphisms. Such genetic insights could open a whole new avenue for precision medicine in which biomarkers and gene-targeting therapies are promising options for personalized treatment. This review emphasizes the need for complex investigations into psoriasis, from molecular mechanisms to clinical manifestations, to bridge the gap between basic research and therapeutic development by furthering the understanding of psoriasis and paving the way for innovative treatments addressing skin lesions and systemic effects.</p>","PeriodicalId":14495,"journal":{"name":"Iranian Journal of Basic Medical Sciences","volume":"28 6","pages":"680-690"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scopolamine-induced memory impairment in mice: Soursop leaf extract and fractions protect the hippocampus and prefrontal cortex.","authors":"Faith Afolabi, Babatunde Adebola Alabi, Joseph Ayo Badejo, Okim Okim Nsor, Sodiq Kolawole Lawal, Ezekiel Olugbenga Iwalewa","doi":"10.22038/ijbms.2024.80289.17379","DOIUrl":"10.22038/ijbms.2024.80289.17379","url":null,"abstract":"<p><strong>Objectives: </strong><i>Annona muricata</i>\" (soursop) is a medicinal plant with diverse ornamental, consumptive, and pharmacological importance. This study was designed for its anti-amnesic potential in mice.</p><p><strong>Materials and methods: </strong>The crude extract was fractionated with n-hexane, ethyl acetate, and aqueous methanol. The crude and fractions were tested <i>in vitro</i> for the anti-oxidant radical scavenging activity (DPPH), total flavonoid and phenolic content, and their acetylcholinesterase inhibitory activity. Thin-layer chromatography was used to determine the phytochemicals contained in the fractions and their purity. Neurobehavioral models like the Open Field Test, Novel Object Recognition Test, Y-Maze, and Morris Water Maze were used to evaluate the action of AMME (<i>Annona muricata</i> methanol extract) and AMAMF (<i>Annona muricata</i> aqueous methanol fraction).</p><p><strong>Results: </strong>The AMME and AMAMF significantly reduced the serum levels of myeloperoxidase and arginine (<i>P</i><0.05). They also modulate the hippocampal and prefrontal acetylcholinesterase and glutamic acid decarboxylase activities (<i>P</i><0.05). The 25 mg/kg AMAMF significantly affected short-term memory (<i>P</i><0.05). The AMAMF and AMME significantly enhanced the prefrontal and hippocampal tissue levels of glutathione and superoxide dismutase. During the <i>in vitro</i> AchE assay on all fractions, the AMME and AMAMF consistently showed the greatest percentage of inhibitory activity. They inhibited 50% of the AchE enzymes with the lowest concentration.</p><p><strong>Conclusion: </strong>The study showed the neuroprotective effects of AMME and AMAMF in memory impairment models. The extracts showed potent AChE inhibition and positive effects on memory and anti-oxidant enzyme levels.</p>","PeriodicalId":14495,"journal":{"name":"Iranian Journal of Basic Medical Sciences","volume":"28 3","pages":"355-365"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory role of circular RNAs in the development of therapeutic resistance in the glioma: A double-edged sword.","authors":"Negin Masoomabadi, Ali Gorji, Tahereh Ghadiri, Safieh Ebrahimi","doi":"10.22038/ijbms.2024.81644.17669","DOIUrl":"10.22038/ijbms.2024.81644.17669","url":null,"abstract":"<p><p>Gliomas are the most common lethal tumors of the brain associated with a poor prognosis and increased resistance to chemo-radiotherapy. Circular RNAs (circRNAs), newly identified noncoding RNAs, have appeared as critical regulators of therapeutic resistance among multiple cancers and gliomas. Since circRNAs are aberrantly expressed in glioma and may act as promoters or inhibitors of therapeutic resistance, we categorized alterations of these specific RNAs expression in therapy resistant-glioma in three different classes, including chemoresistance, radioresistance, and glioma stem cell (GSC)-regulation. circRNAs act as competing endogenous RNA, sponging target microRNA and consequently affecting the expression of genes related to glioma tumorigenesis and resistance. By doing so, circRNAs can modulate the critical cellular pathways and processes regulating glioma resistance, including DNA repair pathways, GSC, epithelial-mesenchymal transition, apoptosis, and autophagy. Considering the poor survival and increased resistance to currently approved treatments for glioma, it is crucial to increase the knowledge of the resistance regulatory effects of circRNAs and their underlying molecular mechanisms. Herein, we conducted a comprehensive search and discussed the existing knowledge regarding the important role eof circRNAs in the emergence of resistance to therapeutic interventions in glioma. This knowledge may serve as a basis for enhancing the effectiveness of glioma therapeutic strategies.</p>","PeriodicalId":14495,"journal":{"name":"Iranian Journal of Basic Medical Sciences","volume":"28 1","pages":"3-15"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary supplements for prevention of Alzheimer's disease: <i>In vivo</i> and <i>in silico</i> molecular docking studies.","authors":"Doha Abdou Mohamed, Rasha Salah Mohamed, Karem Fouda, Hoda Bakr Mabrok","doi":"10.22038/ijbms.2024.79960.17320","DOIUrl":"10.22038/ijbms.2024.79960.17320","url":null,"abstract":"<p><strong>Objectives: </strong>Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in people over 65. The present research aimed to investigate the potential of different dietary supplements (DS) in preventing AD in an experimental animal model and <i>in silico</i> study.</p><p><strong>Materials and methods: </strong>Three DS containing a mixture of wheat-germ oil and black pepper extract/or turmeric extract were prepared. Total phenolic content, HPLC-phenolic profile, phytosterols content, fatty-acids profile, and anti-oxidant activity were evaluated in all DS. The protective effect of the prepared DS was assessed through their impact on cholinergic neurotransmission and the gene expression of GSK3β, APP, and Akt. Oxidative stress and inflammatory markers were evaluated. The inhibition activities against acetylcholinesterase (AChE) and reduction of amyloid-β aggregation of the major phytochemicals present in the studied DS were evaluated using <i>in silico</i> molecular docking study.</p><p><strong>Results: </strong>Molecular docking revealed that rosmarinic acid and β-Sitosterol exhibited the strongest binding affinities for AChE and Amyloid-β, respectively. The results showed that all DS reduced cholinergic neurotransmission, decreased TNF-α as an inflammatory marker, and improved oxidative stress status. All DS down-regulated the expression of GSK3β and APP while significantly up-regulating the expression of the Akt gene.</p><p><strong>Conclusion: </strong>The present study concluded that all DS enhanced cholinergic neurotransmission, reduced inflammation, and improved oxidative stress status by impacting the expression of GSK3β, Akt, and APP genes. Rosmarinic acid and β-sitosterol showed promising effects for treating AD, according to an <i>in silico</i> molecular docking study. The studied dietary supplements were considered promising candidates for the prevention of AD.</p>","PeriodicalId":14495,"journal":{"name":"Iranian Journal of Basic Medical Sciences","volume":"28 2","pages":"170-180"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal medicine approach to relieving dyspnea: A narrative review of efficacy and mechanisms.","authors":"Mahboobeh Ghasemzadeh Rahbardar, Mohammad Hossein Boskabady","doi":"10.22038/ijbms.2025.85518.18486","DOIUrl":"10.22038/ijbms.2025.85518.18486","url":null,"abstract":"<p><p>Dyspnea, a distressing symptom characterized by difficult or labored breathing, can be caused by a variety of underlying processes, including respiratory and cardiovascular problems. Despite advancements in medicine, a need remains for more effective dyspnea therapies. Herbal therapy has emerged as a viable approach in this field, with potential therapeutic benefits. The purpose of this narrative review is to assess the efficacy of herbal medication in reducing dyspnea. A comprehensive search was undertaken without time constraints utilizing Google Scholar, PubMed, and Scopus databases up to December 2024 to collect relevant clinical trials. Herbal medicine (<i>Allium sativum</i> L., <i>Carum copticum </i>(L.) Benth. & Hook.f., <i>Crocus sativus </i>L., <i>Curcuma longa</i> L., <i>Eucalyptus globulus</i> Labill., <i>Mentha</i> × <i>piperita</i> L., <i>Nigella sativa</i> L., <i>Rosmarinus officinalis</i> L., <i>Thymus vulgaris</i> L., and <i>Zataria multiflora</i> Boiss.) and their main components have been shown to reduce dyspnea through multiple mechanisms of disease, including anti-inflammatory, bronchodilatory, and anti-oxidant properties. The findings indicate that herbal remedies may be a useful complement or alternative therapy for managing dyspnea. It could be concluded that herbal therapy offers an effective approach to managing dyspnea, providing a natural and potentially beneficial option for people experiencing respiratory distress. More research and clinical trials are needed to understand the exact mechanisms of action and maximize the use of herbal therapies in the treatment of dyspnea.</p>","PeriodicalId":14495,"journal":{"name":"Iranian Journal of Basic Medical Sciences","volume":"28 9","pages":"1140-1162"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12340407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144846512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial protection and anti-inflammatory effect of curcumin in inhibiting reproductive toxicity induced by sodium valproate in male mice.","authors":"Moein Shaneh, Milad Chahardori, Fereshte Talebpour Amiri, Nahid Amani, Fatemeh Shaki","doi":"10.22038/ijbms.2025.82254.17791","DOIUrl":"10.22038/ijbms.2025.82254.17791","url":null,"abstract":"<p><strong>Objectives: </strong>Sodium valproate (VPA) has harmful effects on the male reproductive system. The present study aimed to investigate the influence of curcumin (CUR) in mitigating the VPA-induced reproductive toxicity in male mice.</p><p><strong>Materials and methods: </strong>The male mice (mean weight 20 g and 8 weeks old) were divided into six groups (n=6): control, VPA only (500 mg/kg, IP), VPA plus different doses of CUR (25, 50, and 100 mg/kg, IP), CUR alone (100 mg/kg, IP). After treatment for eight consecutive weeks, the mice were sacrificed, testicle tissues were separated, and mitochondria were isolated with different centrifuge techniques. Various biomarkers were evaluated in testis tissue, including the concentration of lipid peroxidation, glutathione, protein carbonyl, nitric oxide, IL-6, and TNF-alpha. Also, mitochondrial toxicity, swelling, and membrane potential were assessed. Furthermore, sperm analysis and histopathological examination were done on testicular tissue.</p><p><strong>Results: </strong>VPA injection increased the amount of nitric oxide, inflammatory factors, mitochondrial toxicity, and oxidative stress markers (<i>P<</i>0.05). Also, histopathological and sperm analysis showed significant damage to testis tissue and a significant reduction in sperm count, motility, and normal morphology after VPA administration. CUR led to a substantial reduction of the inflammatory and oxidative stress parameters(<i>P<</i>0.05), restored the VPA-induced testis toxicity, and increased sperm count and motility (<i>P<</i>0.05).</p><p><strong>Conclusion: </strong>Our study demonstrates CUR's ameliorative effects on mitochondrial oxidative damage and inflammation caused by VPA-induced reproductive toxicity, which can be suggested as a strategy for reducing the side effects caused by VPA.</p>","PeriodicalId":14495,"journal":{"name":"Iranian Journal of Basic Medical Sciences","volume":"28 8","pages":"1027-1036"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-obesity and hepatoprotective effects of pyridoxal phosphate in rats with metabolic syndrome by raising anti-oxidant potential in both serum and liver tissue, while also decreasing hepatic nuclear factor expression.","authors":"Sina Mahdavifard, Amir Hasani","doi":"10.22038/ijbms.2025.81836.17702","DOIUrl":"10.22038/ijbms.2025.81836.17702","url":null,"abstract":"<p><strong>Objectives: </strong>Insulin resistance is the primary trigger of metabolic syndrome, carbonyl stress, and vitamin B6 deficiency, while the nuclear factor (NF-κB) pathway is a pivotal factor in its development. Hence, we investigated the impact of pyridoxal phosphate (PLP) on liver and kidney functions, carbonyl stress, and inflammatory markers in serum and liver tissue.</p><p><strong>Materials and methods: </strong>The study involved four groups of rats, each consisting of eight rats: untreated normal rats (N), rats induced to have metabolic syndrome (MetS), and rats treated with PLP, labeled as N (PLP) and MetS (PLP), respectively. Metabolic syndrome was induced in rats by administering a concentrated sucrose solution for four months. The treated groups received daily PLP at 180 mg/l in their drinking water. Subsequently, the metabolic profile, NF-κB expression, indicators of gly-oxidation, inflammation, and organ function markers were evaluated.</p><p><strong>Results: </strong>PLP significantly reduced gly-oxidation, carbonyl stress, and inflammatory indicators (in both serum and liver tissue) as well as NF-κB expression, glycation, carbonyl stress, liver fat levels, glycemia, insulin resistance, and body weight (<i>P</i><0.001). The treatment also prevented acute hepatitis.</p><p><strong>Conclusion: </strong>PLP had beneficial effects in the metabolic syndrome rat model, showing anti-obesity and hepato-renal protective effects. It improved metabolism and organ (liver and kidney) functions by modulating NF-κB expression, glutathione metabolism, carbonyl stress, and oxidative stress.</p>","PeriodicalId":14495,"journal":{"name":"Iranian Journal of Basic Medical Sciences","volume":"28 8","pages":"1012-1018"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>A20</i> inhibits doxorubicin-induced macrophage maturation and apoptosis through mTOR signaling in classical Hodgkin lymphoma.","authors":"Nguyen Xuan Canh, Phan Thi Hoai Trang, Pham Thi Huong, Do Thi Trang, Pham Viet Nhat, Nguyen Tien Manh, Lê Duy Thành, Nguyen Trung Nam, Nguyen Ba Vuong, Nguyen Thi Xuan","doi":"10.22038/ijbms.2025.86862.18767","DOIUrl":"10.22038/ijbms.2025.86862.18767","url":null,"abstract":"<p><strong>Objectives: </strong>Classical Hodgkin lymphoma (cHL) is identified by the appearance of Hodgkin and Reed-Sternberg cells. <i>A20</i> and <i>CYLD</i> are deubiquitinating enzymes involved in negatively regulating NF-κB-mediated immune response. Vincristine (Vinc) and doxorubicin (Dox) are classical antitumor drugs, in which Dox serves a key role in chemotherapy against cHL and Vinc induces disruption of microtubule function that inhibits mitosis of cancer cells. Little is known about the roles of <i>A20/CYLD</i> in regulating macrophage function from cHL patients upon treatment with Vinc or Dox. This study, therefore, asked whether <i>A20/CYLD</i> expression affects function of macrophages in cHL cases.</p><p><strong>Materials and methods: </strong>Macrophages from cHL patients differentiated from bone marrow cells were exposed to Vinc or Dox. Gene expression levels were determined by real time-qPCR, cell maturation, apoptosis and phagocytosis by flow cytometry, and cytokine release by ELISA.</p><p><strong>Results: </strong>Dox induced maturation, apoptosis, and phagocytosis of macrophages in cHL cases. Moreover, the percentage of CD68⁺CD40⁺, but not CD68⁺CD86⁺ cells as well as levels of IL-1β were further enhanced when exposed to <i>A20</i> siRNA, whereas the absence of <i>CYLD</i> unaltered macrophage function in cHL patients. Importantly, the increased numbers of <i>A20</i>-sensitive CD68⁺CD40⁺ and Annexin V^-PI⁺ cells as well as enhanced levels of caspase 3 were abolished in the presence of mTOR inhibitor Everolimus.</p><p><strong>Conclusion: </strong>The present study indicates that Dox-induced macrophage maturation and apoptosis are dependent on <i>A20</i> expression through mTOR signaling. Moreover, inhibition of Dox-induced macrophage maturation in the patients with low A20 expression by Everolimus might represent a promising therapy for <i>A20</i>-sensitive cHL cases.</p>","PeriodicalId":14495,"journal":{"name":"Iranian Journal of Basic Medical Sciences","volume":"28 10","pages":"1354-1362"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of artificial intelligence (AI) in academic writing and publication: Iranian Journal of Basic Medical Sciences (IJBMS) policy.","authors":"Leila Arabi, Ali Roohbakhsh, Bizhan Malaekeh-Nikouei, Bibi Sedigheh Fazly Bazzaz","doi":"10.22038/ijbms.2025.25229","DOIUrl":"10.22038/ijbms.2025.25229","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to determine the effect of 8-week high-intensity interval training (HIIT) on oxidative stress and apoptosis in the hippocampus of male rats with type 2 diabetes (T2D). The study focused on examining the role of proliferator-activated receptor gamma co-activator 1α (PGC1α)/Kelch-like ECH-associated protein Keap1/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway.</p><p><strong>Materials and methods: </strong>Twenty-eight 8-week-old Wistar rats were randomly assigned to one of four groups (n=7): control (Con), type 2 diabetes (T2D), exercise (Ex), and exercise + type 2 diabetes (Ex+T2D). The Ex and Ex+T2D groups completed an 8-week exercise program consisting of 80-100% Vmax and 4-10 intervals. The homeostasis model assessment of insulin resistance (HOMA-IR) index was used to assess insulin resistance. The levels of Bcl2, BAX, musculoaponeurotic fibrosarcoma (Maf), Nrf2, Keap1, and PGC1α in the hippocampus were assessed using the western blot method. Additionally, the levels of antioxidant enzymes in the hippocampus were measured using ELISA.</p><p><strong>Results: </strong>The findings indicated that the T2D group had lower levels of antioxidant enzymes, Maf, Bcl2, PGC1α, and Nrf2, and higher levels of BAX and Keap1 in the hippocampus. Conversely, the HIIT group exhibited increased levels of antioxidant enzymes, Maf, Bcl2, Nrf2, and PGC1α, along with decreased levels of BAX and Keap1 in the hippocampus.</p><p><strong>Conclusion: </strong>The study demonstrated that 8-week HIIT was effective in reducing hippocampal apoptosis and oxidative stress induced by T2D by activating the PGC1α-Keap1-Nrf2 signaling pathway. The metabolic changes induced by exercise may lead to an increase in PGC1 expression, which is the primary stimulator of the Keap1-Nrf2 signaling pathway.</p>","PeriodicalId":14495,"journal":{"name":"Iranian Journal of Basic Medical Sciences","volume":"28 1","pages":"1-2"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pim3 up-regulation by YY1 contributes to diabetes-induced cardiac hypertrophy and heart failure.","authors":"Xiao-Ping Jin, Yi-Fei Ren, Li-Guo Wang, Hao Xie, Lu Huang, Juan Zhang, Zuo-Ying Hu","doi":"10.22038/ijbms.2024.78688.17016","DOIUrl":"10.22038/ijbms.2024.78688.17016","url":null,"abstract":"<p><strong>Objectives: </strong>The close relationship of proto-oncogenes to myocardial hypertrophy has long been recognized, and cardiac hypertrophy leads to heart failure (HF). However, whether proviral insertion of Moloney virus 3 kinase (Pim3), a proto-oncogene, contributes to cardiac hypertrophy in diabetes mellitus (DM) remains unknown. This study aims to investigate whether Pim3 is involved in DM-induced cardiac hypertrophy and HF and to elucidate its underlying mechanisms.</p><p><strong>Materials and methods: </strong>DM was induced in mice by intraperitoneal injection of streptozotocin. Cardiac function was evaluated by echocardiography, and cardiac hypertrophy was determined through histological analysis, quantitative real-time polymerase chain reaction, and western blotting. Silencing RNA transfection and lentivirus-mediated gene knockdown were performed both in vitro and in vivo. Transcriptional activity was analyzed using chromatin immunoprecipitation and luciferase reporter assay.</p><p><strong>Results: </strong>Compared with C57BL/6J mice, cardiac hypertrophy and dysfunction were observed in mice with DM. Pim3 mRNA and protein expression were significantly up-regulated in diabetic hearts and high glucose-cultured H9C2 cells. Yin Yang 1 (YY1), which translocated from the cytoplasm into the nucleus under hyperglycemia, bound to the Pim3 promoter and enhanced Pim3 transcriptional activity. Pim3 or YY1 knockdown profoundly reduced cell size and inhibited the mRNA and protein expression of cardiac hypertrophy markers, as well as markedly attenuating myocardial hypertrophy and cardiac dysfunction.</p><p><strong>Conclusion: </strong>Hyperglycemia induced nuclear translocation of YY1, leading to Pim3 up-regulation, eventually developing into cardiac hypertrophy and HF. Targeting YY1-Pim3 signaling may be a promising therapeutic avenue for DM-induced cardiac hypertrophy and HF.</p>","PeriodicalId":14495,"journal":{"name":"Iranian Journal of Basic Medical Sciences","volume":"28 2","pages":"245-253"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}