İstanbul Journal of Pharmacy最新文献

{"title":"Evaluation of the association of SNP in carboxylesterase enzyme (CES1) with pharmacokinetic and adverse effects of capecitabine in breast and colorectal cancer patients","authors":"Merve Yuksel, D. Ozturk, E. Oztas, G. Özhan, Aylin Turker, T. Korkmaz, A. Okyar, Z. Kara","doi":"10.26650/istanbuljpharm.2019.19018","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.19018","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.19018 Capecitabine is an oral prodrug and converted to 5-fluorouracil using three-step enzymatic pathways which include carboxylesterase (CES).  Interindividual differences in the activities of drug-metabolizing enzymes may affect efficacy and toxicity. The aim of this study is to evaluate the association of Single nucleotide polymorphisms (SNP) in CES1 with the pharmacokinetic and adverse effects of capecitabine. Plasma samples were obtained from 7 breast and colorectal cancer patients who were treated with capecitabine-based chemotherapy (1000-1250 mg/m2) at 0.5, 1, 2, 3 and 4 hours following drug administration on their first day of the first cycle. The plasma concentrations of the capecitabine were determined by using a high-pressure liquid chromatography-UV detector. SNP (rs8192950) was genotyped using the reverse transcription-polymerase chain reaction. Patients were found to have heterozygote (57%), wild (29%), and mutant (14%) distributions of genotypes (p=0.909). The mean plasma area under the curve (AUC0-4h) was 4.60±2.25 µg.h/mL, and maximum plasma concentration (Cmax) was 3.19±2.5 µg/mL. There were no statistically significant differences between genotypes and AUC values (p=0.2236) and the most frequently observed side effects were diarrhea (p=0.1028), asthenia (p=0.6456), anemia (p=0.6456), emesis (p=0.3499). This is the first study evaluating an association of genetic variation in CES1 (rs8192950) with pharmacokinetic and adverse effects of capecitabine. Therefore, additional study in larger groups of patients is required to support our study.  Cite this article as : Kurtan Yuksel M, Ozturk D, Oztas E, Ozhan G, Altanlar Turker A, Korkmaz T, Okyar A, Pala Kara Z (2019). Evaluation of the association of SNP in carboxylesterase enzyme (CES1) with pharmacokinetic and adverse effects of capecitabine in breast and colorectal cancer patients. Istanbul J Pharm 49 (2): 64-69.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82892436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between botanical source and the biologically active compounds of propolis","authors":"Ö. G. Çelemli, M. Atakay, K. Sorkun","doi":"10.26650/istanbuljpharm.2019.435408","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.435408","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.435408 In this research, five propolis samples collected from Turkey were investigated to observe the correlation between botanical sources and chemical contents of the samples and in this way emphasize the influence of botanical sources of propolis on its chemical characterization. As a first step, to determine the botanical sources of the samples, microscopic analysis was performed. According to the microscopic analysis results; two samples that were collected from Rize (P1 and P2), were characterized as most probably being chesnut propolis; while one sample collected from Tekirdag (P3) was evaluated as being a mixed type, in the other Tekirdag sample (P4), the pollens belonging to the taxa of the Brassicaceae family were found as dominant. The sample collected from Sivas (P5); was also recognized as  mixed type. The second step of the research was the chemical analyses of the propolis samples. According to the results; the balsamic contents of the propolis samples ranged between 59.97 and 83.31%, total phenolic contents were ranged between 27.56±0.05 and 171.93±0.28 mgGAE/g. The minimum flavone and flavonol content of 0.28±0.01% was found in the P1 sample described as chesnut propolis and colected from Rize. The maximum value 5.1±0.07% was found in the P4 sample as was total phenolic content. Flavanones and Dihydroflavonols contents varied between 6.58±0.009-12.94±0.007%. According to the GC-MS results the investigated samples contained compounds belonging to the various groups. With regard to the Excel correllation,  the balsamic content showed a negative correlation with total phenolic content, flavone and flavonol content, flavanones and dihydroflavonols content. Cite this article as : Gencay Celemli O, Atakay M, Sorkun K (2019). The correlation between botanical source and the biologically active compounds of propolis. Istanbul J Pharm 49 (2): 81-87.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88201086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines","authors":"Çağla Begüm Apaydın, Z. Cesur","doi":"10.26650/ISTANBULJPHARM.2019.19002","DOIUrl":"https://doi.org/10.26650/ISTANBULJPHARM.2019.19002","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.19002 This report is about an unexpected formation of N,N’-bis(substituted phenoxyacetyl) hydrazine derivatives. The reaction between N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide with sulfanyl acids to obtain 4-thiazolidinones s,  gave an unexpected product, N,N’-bis(phenoxyacetyl)hydrazine, with high purity instead of the expected cyclocondensation product.  When repeating the reaction with p-toluenesulfonic acid under the same conditions, the reaction resulted in the same compound. This indicates that two molecules of N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide were involved in the reaction. The reaction can be applied as a different and new procedure for the synthesis of several N,N’-bis(substituted phenoxyacetyl)hydrazine derivatives.  Cite this article as: Apaydin CB, Cesur Z (2019). A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines. Istanbul J Pharm 49 (2): 61-63.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73464092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deontological violations of community pharmacies in Turkey","authors":"B. Kiran, Elif Gizem Karaca","doi":"10.26650/ISTANBULJPHARM.2019.18009","DOIUrl":"https://doi.org/10.26650/ISTANBULJPHARM.2019.18009","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.18009 Deontological violations are important in terms of reputation of public health, pharmacy profession, and protection of public finance. The aim of this study is to determine types and prevalence of deontological crimes reflected in records of High Honor Court (HHC) in Turkish Pharmacists’ Association (TPA), to develop proposals on corrective and preventive occupational policies. Crime types in disciplinary files were classified according to classification method of deontological crimes in 3-groups, and results were evaluated by frequency and percentage distributions. In the study, 32 deontological crime types and 112 criminal cases were detected. Accordingly, it was found that deontological crimes due to competition are in the first rank with 51 cases, TPA, Drug-Pharmacy Legislation violations in the second with 50 cases and Social Security Institution protocol provisions violations in the last rank with 11 cases, and in all types of crime, “collusion” is in the first rank (30.4%).It is thought that “collusion” crime being in the first rank increasing its share from 18.6% to 30.4% in all crimes despite increasing punishments. Persistence of crime despite punitive sanctions aggravated by recent regulations suggests that it is not possible to solve only by punitive sanctions, and it must be get to the bottom of the problem. Cite this article as : Kiran B, Karaca EG (2019). Deontological violations of community pharmacies in Turkey. Istanbul J Pharm 49 (1): 20-24.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84958641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative and quantitative phytochemical analysis and in-vitro biological activity of Rheum ribes L. different parts","authors":"T. Taşkın, Gizem Bulut","doi":"10.26650/ISTANBULJPHARM.2019.18012","DOIUrl":"https://doi.org/10.26650/ISTANBULJPHARM.2019.18012","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.18012 The methanol extracts from different parts of Rheum ribes were subjected to qualitative and quantitative phytochemical and in vitro biological activity (antioxidant, anti-urease, anticholinesterase). Qualitative phytochemical tests were performed using standard analysis methods and these studies revealed the presence of phenolics and tannins. Following this, a quantitative determination of total phenolics and tannins contents was carried out. The antioxidant activity of the extracts were assayed using DPPH, FRAP, TEAC/ABTS and CUPRAC techniques. In addition, the anti-urease and anticholinesterase activity of the extracts were examined using indophenol and Ellman methods, respectively. In this study, it was determined that the macerated flowers extract contained higher total phenolic and tannins contents than the other extracts. According to the results obtained from the antioxidant experiment, the macerated extract of flowers showed the strongest ABTS.+ scavenging and ferric reducing antioxidant power activity. The macerated leaves and Soxhlet radix extracts exhibited the strongest DPPH. scavenging and cupric reducing antioxidant activity, respectively. The young shoots extracts obtained using the Soxhlet methods showed the highest anticholinesterase activity. All extracts obtained from different parts of the plant were found to have very low anti-urease activity when compared to the  anti-urease activity of standard compound. Therefore, methanol extracts from plant’s flowers, leaves and young shoots can be used as a natural antioxidant and anticholinesterase agent respectively, for the pharmaceutical and food industry in the future. Cite this article as : Taskin T, Bulut G (2019). Qualitative and quantitative phytochemical analysis and in-vitro biological activity of Rheum ribes L. different parts. Istanbul J Pharm 49 (1): 7-13.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85916165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plants used in traditional treatment against diarrhea in Turkey","authors":"Seçil Karahüseyi̇n, A. Sarı","doi":"10.26650/ISTANBULJPHARM.2019.404211","DOIUrl":"https://doi.org/10.26650/ISTANBULJPHARM.2019.404211","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.404211 Turkey is one of the richest countries in the world in terms of flora with its extraordinary plant diversity. Its flora consists of about 10,000 vascular plants and approximately one third of them (34.4 %) are endemic to the country. In recent years, the use of ethnobotanical information obtained from medicinal plant research has gained attention all around the world. For this reason, numerous ethnobotanical studies have recently been published and much has been written about medicinal plants in our country. This study deals with 133 taxa used in traditional treatments against diarrhea in Turkey and it aims to give information about scientific and local names of these taxa, families, used parts and usage in diarrhea. Cite this article as : Karahuseyin S, Sari A (2019). Plants used in traditional treatment against diarrhea in Turkey. Istanbul J Pharm 49(1): 33-44.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73179461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real time monitoring of cytotoxicity of Callistemon citrinus against Colo-205 cell line","authors":"A. Dokumacı, P. O. Fayemi, M. Yerer","doi":"10.26650/ISTANBULJPHARM.2019.418892","DOIUrl":"https://doi.org/10.26650/ISTANBULJPHARM.2019.418892","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.418892 Callistemon citrinus is a member of Myrtaceae family that thrives under different ecological conditions. The leaves, flowers, stem backs and roots of the plant contain various phytochemicals that are useful in   folk medicine for different remedies such as antimicrobial, anti-nociceptive, fungicide and anti-inflammatory purposes. In this study, we investigated the cytotoxic effect of Callistemon citrinus leaf and flower methanolic extracts against human Colo-205 Cell Line using real time cell analyzer device for monitoring in time-dependent manner. To determine the mechanism of cytotoxicity of the extracts, Western blotting assay was used for measuring evocation of Akt pathway. Extracts were found to exert cytotoxic effect at a dose dependent manner. IC50 values of leaves and flowers extract were 6.49 µg/mL and 5.22 µg/mL, respectively. At the early stages of the experiment, Akt pathway was triggered at high extract concentrations. Although, high extract concentrations showed proliferative effect at early stages, this effect reversed after 5 and 8 h resulting in low cell viability. Findings from this study therefore showed that extracts of leaf and flower from Callistemon citrinus demonstrated cytotoxic effect against Colo-205 but seems not to be related Akt signaling pathway. Cite this article as : Dokumaci AH, Fayemi PO, Aycan Yerer B. (2019). Real time monitoring of cytotoxicity of Callistemon citrinus against Colo-205 cell line. Istanbul J Pharm 49 (1): 25-32.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"168 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82728380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PPARγ Pro12Ala and C161T polymorphisms, but not PPARα L162V, are associated with osteoporosis risk in Turkish postmenopausal women","authors":"Özlem Kurt Şirin, H. Aydogan, M. Uyar, A. Can","doi":"10.26650/ISTANBULJPHARM.2019.18005","DOIUrl":"https://doi.org/10.26650/ISTANBULJPHARM.2019.18005","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.18005 Stimulation of peroxisome proliferator-activated receptors (PPARs) causes mesenchymal stem cells of the human bone marrow differentiate into adipocytes instead of osteoblasts leading to a decreased number of osteoblasts and a decrease in bone mineral density (BMD). Thus, PPARs may have impacts on bone metabolism. 224 postmenopausal women (171 osteoporotic and osteopenic, 53 healthy control) were included in this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and agarose gel electrophoresis techniques were performed to detect PPARα L162V and PPARγ Pro12Ala/C161T polymorphisms. The distribution of PPARγ Pro12Ala genotype and allele frequencies was not statistically different in control and patient (osteopenic+osteoporotic) groups (p>0.05). However, in the patient group, subjects with “Pro12Pro” genotype had lower lumbar spine (L1-L4) BMD values than those with “Ala” allele (p 0.05). We suggested that PPARγ Pro12Ala and C161T gene variants might be contributing factors in the development of osteoporosis.  Cite this article as : Kurt Şirin O, Yilmaz Aydogan H, Uyar M, Can A (2019). PPARγ Pro12Ala and C161T polymorphisms, but not PPARα L162V, are associated with osteoporosis risk in Turkish postmenopausal women. Istanbul J Pharm 49 (1): 14-19.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80338642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of pharmacists in the management of autism spectrum disorder: A survey to determine the knowledge and perception of the parents","authors":"Zeliha Pala Kara, B. Cakir, Deniz Kaleli Durman, B. Uydeş Doğan","doi":"10.26650/istanbuljpharm.2019.19042","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.19042","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.19042 Background and aims : Autism spectrum disorder (ASD) is one of the neuropsychiatric disorders of childhood and has many causes including genetic, neurobiological, environmental as well as other risk factors that can trigger the disorder. The aim of this survey is to determine the knowledge of the families about ASD, the most prescribed medications, their side effects and the alternative therapies used besides to the pharmacological treatment. Methods : This study was survey-based and conducted among parents of children with ASD (N=50). Results : Risperidone, aripiprazole, and valproate were the most prescripted drugs (64%) and weight gain (n=14), increased aggressive behavior (n=11) and drowsiness/sedation (n=11) were reported as the main side effects. Besides to pharmacological therapy, most of ASD children have used complementary and alternative medicine like gluten and casein-free diet (n =23) or the sugar diet (n=15) as well as omega-3 (n=43), multivitamins (n=40), heavy metal chelation agents (n=27), vitamin B12 (n=18), zinc (n=17) vitamin D (n=9), and probiotics (n= 7). Conclusion : It is revealed that pharmacists should be able to inform the parents about the general characteristics of ASD, to inform the parents about new treatment approaches and providing rational use of prescribed drugs in children with autism. You may cite this article as : Pala Kara Z, Cakir B, Kaleli Durman D, Uydes Dogan S (2019). The role of pharmacists in the management of autism spectrum disorder: A survey to determine the knowledge and perception of the parents. Istanbul J Pharm 10.26650/IstanbulJPharm.2019.19042.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"255 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73362201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Assessment of in Vitro Cardiotoxic Potentials for Synthetic Cannabinoid, AM-2201","authors":"Esra Nişikli, M. Akar, G. Ozhan","doi":"10.26650/istanbuljpharm.2019.19004","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.19004","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.19004 Synthetic cannabinoid abuse becomes more common in recent years, although knowledge about the risk of the relatively new synthetic cannabinoid molecules is not adequate. Data is mainly limited with new analytical methods and case reports related to their clinical effects. The studies are generally related to the cardiac effects of first defined molecules rather than every molecule in the group. The cardiac clinical effects of synthetic cannabinoid abuse and underlying mechanisms are not certain. Therefore, we aimed to investigate AM-2201, one of synthetic cannabinoids, because knowledge for AM-2201 is less than the others in this group. The cardiotoxicity and underlying mechanisms of AM-2201 were assessed on cardiac cell culture. The half-maximal inhibition concentration (IC50) values were 101.49 and 63.33 M by WST-1 and LDH assays. AM-2201 was not induced either the total antioxidant capacity (TAC) or reactive oxygen species (ROS) levels. As to the measurements Annexin V-FITC and acridine orange dye, AM-2201 did not induce apoptosis and the primary cell death was necrosis. According to our results, further studies such as mechanism on cell death and cancer pathways should be investigated. You may cite this article as : Nisikli E, Celiksoz Akar M, Ozhan G (2019). The Assessment of in Vitro Cardiotoxic Potentials for Synthetic Cannabinoid, AM-2201. Istanbul J Pharm 10.26650/IstanbulJPharm.2019.19004.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"50 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91050662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}