{"title":"The minimum achievable timing resolution with high-aspect-ratio scintillation detectors for time-of-flight PET","authors":"J. Cates, R. Vinke, C. Levin","doi":"10.1109/NSSMIC.2014.7430913","DOIUrl":"https://doi.org/10.1109/NSSMIC.2014.7430913","url":null,"abstract":"Clinically translatable scintillation detectors employ relatively long crystals (20-30 mm) for increased system sensitivity in whole-body PET. In these high-aspect ratio (HAR) crystals (long and narrow), the degradation in timing performance due to variance in the optical path length of scintillation light is non-negligible. In this work, an accurate, analytical probability density function (p.d.f.) for photon transit time was incorporated into a calculation of the Cramr-Rao Lower Bound (CRLB) on timing resolution to investigate the minimum achievable timing resolution for crystals with HAR geometries. The analytical p.d.f. was compared against light transport simulations and direct measurement of photon arrival time statistics using time-correlated single photon counting techniques (TCSPC), demonstrating consistency between the observed and theoretical distributions (χ2 p-value > 0.95). A coincidence timing resolution for two 3×3×20 mm3 LYSO:Ce scintillators coupled to MPPCs was measured to be 162 ps FWHM, approaching the statistically calculated limit of 152 ps within 6.5%. Parametric studies, where crystal and photosensor properties were varied, revealed that the increased optical transport spread in HAR crystals does not preclude an achievable coincidence timing resolution of 100 ps FWHM. The CRLB for various HAR scintillation detectors is presented, and instrumentation performance improvements necessary for achieving 100 ps FWHM coincidence timing resolution with HAR scintillators are discussed.","PeriodicalId":144711,"journal":{"name":"2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124967523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A simple semi-empirical model for positron annihilation non-collinearity based on quadHIDAC measurements","authors":"Don Vernekoh, K. Schafers, J. Wessels","doi":"10.1109/NSSMIC.2014.7430831","DOIUrl":"https://doi.org/10.1109/NSSMIC.2014.7430831","url":null,"abstract":"Positron annihilation non-collinearity is one physical factor that constraints the achievable spatial resolution in PET. The quadHIDAC is a high resolution small animal PET scanner with a unique detection principle, relying on multi-wire proportional chamber detectors. In a comparison of simulation and measurement of a 22Na point source, slight discrepancies are observed, which are addressed to an inappropriateness of the used non-collinearity model. Hence, a new simple model for non-collinearity is developed and adjusted to the observed data. It will be presented that the exclusive properties of the quadHIDAC, i.e., high 3D spatial resolution for single photon interactions measured on large radial offsets, offer a perfect environment to separate positron range and detector resolution influences from the measurements and simulations. This allows the investigation of the pure spatial resolution degradation induced by the annihilation non-collinearity of positron emitting sources. Furthermore, simulations, including the proposed non-collinearity implementation, for a possible improved HIDAC setup on an illustrative zebrafish emission model are performed, where associated reconstructed images for the different setups are compared.","PeriodicalId":144711,"journal":{"name":"2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129640345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The simulation of a multi energy bone mineral densitometry method","authors":"Ruizhe Li, Liang Li, Zhiqiang Chen, Li Zhang","doi":"10.1109/NSSMIC.2014.7430918","DOIUrl":"https://doi.org/10.1109/NSSMIC.2014.7430918","url":null,"abstract":"The developing of photon counting detectors makes it is feasible to obtain multi energy information from one X-ray source. Based on the photon counting system, this paper proposes a simulation of multi energy BMD method, which can lead to the promotion of current BMD accuracy as well as providing multi information of human tissue. In our simulation, we generalize the conic surface equation fitting method used in DEXA. In order to adapt to the multi energy condition, the conic surface equation is extended. A model of human forearm cross profile composed by five types of tissue (adipose, muscle, bone, blood and contrast agent) is used in attenuation. To imitate the photon counting system, the attenuation data from 20 keV to 120 keV is separated into five energy segments. As a comparison, dual energy information is also collected in this system. Our goal is to compare the accuracy between multi energy system and dual energy one, as well as to verify the density measurement of other tissue.","PeriodicalId":144711,"journal":{"name":"2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129923800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Madden, P. Bloser, J. Legere, M. McConnell, J. Ryan
{"title":"Enhanced data analysis for an imaging neutron/gamma-ray spectrometer","authors":"A. Madden, P. Bloser, J. Legere, M. McConnell, J. Ryan","doi":"10.1109/NSSMIC.2014.7431110","DOIUrl":"https://doi.org/10.1109/NSSMIC.2014.7431110","url":null,"abstract":"The ability to detect the presence of radioactive sources and Special Nuclear Materials (SNM) is of extreme importance for homeland security efforts. Today, we face terrorist threats in the form of explosive nuclear devices and Radiation Dispersal Devices (RDDs). The ability to remotely locate and identify the materials used to create these devices is imperative in the interdiction of terrorist threats. The Neutron SPECTrometer (NSPECT) developed by Michigan Aerospace Corporation and the University of New Hampshire is a dual-species instrument that detects both neutrons and gamma rays emitted from SNM, and gamma rays emitted from radioactive material. NSPECT provides spectroscopic information on the radioactive and fissile sources present while simultaneously imaging the sources within the instrumental field of view for enhanced detection capabilities. Creation and application of a detailed instrument response function through numerical simulations, analytical descriptions, and real NSPECT data provides the most detailed information on the detected neutrons and gamma rays, thereby allowing for the most sensitive and reliable detection of nuclear and radioactive threats.","PeriodicalId":144711,"journal":{"name":"2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130653523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design of a high speed online maximum likelihood positioning algorithm using FPGA","authors":"Xinyi Cheng, Yong Xiao, Yonggang Wang, Deng Li","doi":"10.1109/NSSMIC.2014.7430954","DOIUrl":"https://doi.org/10.1109/NSSMIC.2014.7430954","url":null,"abstract":"We present a high speed implementation of maximum-likelihood estimator using FPGA as positioning method for monolithic scintillation crystal based PET detector. Instead of using channel distribution parameters to recalculate the fitting curves, we suggest using real possibility distribution function for channels of all possible positions, which largely reduces the requirement of computation resources (e.g. on-chip DSP). With optimization of subordinate regions of these distributions, the whole storage requirement are trimmed to no more than one-fourth as before without loss of performance compared to an off-line implementation. The simplified hardware structure makes a tight pipelined structure possible that the event processing rate can be 25M events per second with the main clock at 200M Hz.","PeriodicalId":144711,"journal":{"name":"2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","volume":"42 5-7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123374483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Machine learning based parametric image estimation for Analyzer-based phase contrast imaging","authors":"Oriol Caudevilla, J. Brankov","doi":"10.1109/NSSMIC.2014.7430958","DOIUrl":"https://doi.org/10.1109/NSSMIC.2014.7430958","url":null,"abstract":"An X-ray beam passing through biological tissue is deflected (i.e., refracted) by a small angle typically <;10 μrad. Analyzer-based phase contrast imaging (ABI) systems are capable of measuring this tinny refraction by sampling the intensity of the beam at different propagation directions. An Analyzer crystal is the key element for this task as it acts as a narrow angular filter. Since refraction effects are highly dependent of the radiation wavelength, X-ray beam must be quasi-monochromatic. Therefore the amount of photons that reach the object and detector is much lower then that in traditional radiography. Using a reasonable exposure time, noisy reconstructions of refraction images are obtained. In this manuscript, we present a machine learning parametric image estimation approach to obtain accurate refraction images from noisy raw data.","PeriodicalId":144711,"journal":{"name":"2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116252812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Madden, Sufeng Niu, S. Narayanan, A. Sandy, J. Weizeorick, P. Denes, J. Joseph, Victoria Moeller-Chan, D. Doering, P. McVittie
{"title":"Real-time MPI-based software for processing of XPCS data","authors":"T. Madden, Sufeng Niu, S. Narayanan, A. Sandy, J. Weizeorick, P. Denes, J. Joseph, Victoria Moeller-Chan, D. Doering, P. McVittie","doi":"10.1109/NSSMIC.2014.7431129","DOIUrl":"https://doi.org/10.1109/NSSMIC.2014.7431129","url":null,"abstract":"We describe a software library, called MPIFCCD, based on the Message Passing Interface (MPI) for real-time parallel computing on data continuously streamed from the Frame Store Fast Charge-Coupled Device (FSFCCD) Detector located at the Advanced Photon Source (APS) at Argonne National Laboratory. The FSFCCD is used to collect data for X-ray Photon Correlation Spectroscopy (XPCS) experiments at Sector 8-ID at APS. MPIFCCD is integrated into another software package called CINController, developed at APS and Lawrence Berkeley National Laboratory to serve as a QT-based user interface for control and data collection from the FSFCCD. Real-time calculations performed by MPIFCCD include dark image integration and subtraction, noise image integration, image descrambling, and lower-level discrimination. MPIFCCD allows for continuous real-time data collection of FSFCCD data at image rates of 100 frames- per-second (fps) for 1 mega-pixel images and 1000fps for 10 kilo-pixel images. In the future, more complex computations will be implemented in real time with MPIFCCD.","PeriodicalId":144711,"journal":{"name":"2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116516082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Castoldi, C. Guazzoni, T. Parsani, F. Riccio, L. Carraresi, F. Taccetti, L. Acosta, I. Martel, J. Dueñas
{"title":"Characterization of a NTD Double-Sided Silicon Strip Detector using a pulsed ion beam","authors":"A. Castoldi, C. Guazzoni, T. Parsani, F. Riccio, L. Carraresi, F. Taccetti, L. Acosta, I. Martel, J. Dueñas","doi":"10.1109/NSSMIC.2014.7431094","DOIUrl":"https://doi.org/10.1109/NSSMIC.2014.7431094","url":null,"abstract":"A highly segmented Double-Sided Silicon Strip Detector has been characterized using mono-energetic pulsed beams of protons (1 and 3 MeV) and carbon (13 MeV). The detector was manufactured from a Neutron Transmutation Doped (NTD) silicon wafer yielding a bulk resistivity of 2.3 kOhm cm. In this work we show the interstrip effects caused by the beam striking only one strip and the beam on both the strip and the interstrip gap. The pre-amplified output waveforms of the strips on both detector sides have been digitized at 100 MS/s. Charge sharing, induced signal and charge loss have been investigated for different incident positions between adjacent strips, for beam entering from the junction side and the ohmic side, and as a function of the depletion voltage.","PeriodicalId":144711,"journal":{"name":"2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114833122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of electromagnetic calorimeter using GSO and LYSO crystals for the J-PARC muon-to-electron conversion search experiment","authors":"K. Oishi","doi":"10.1109/NSSMIC.2014.7431243","DOIUrl":"https://doi.org/10.1109/NSSMIC.2014.7431243","url":null,"abstract":"An electromagnetic calorimeter (ECAL) using an inorganic scintillating crystal has recently been developed for the COMET experiment at J-PARC in Japan, which searches for muon-to-electron conversion of a charged lepton flavor violating process. The ECAL is required to have an energy resolution better than 5% at 105 MeV, position resolution shorter than 1 cm, and time response faster than 100 ns which can be operated in a vacuum and a magnetic field of 1 T. A prototype ECAL was developed with the candidate crystals of GSO (Gd2SiO5) and LYSO (Lu2-xYxSiO5). A beam test was carried out using an electron beam of 65 - 145 MeV/c at the Research Center for Electron Photon Science at Tohoku University in Japan. The results were as follows: Both the crystals have good linearity. GSO (LYSO) has energy resolution of 5.50 ± 0.02(stat) ± 0.04(syst) % (4.91 ± 0.01(stat) ± 0.07(syst) %), and position resolution of 8.1 mm (7.9 mm) at 105 MeV/c. The energy and position resolution depend on the beam incident position on the ECAL.","PeriodicalId":144711,"journal":{"name":"2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","volume":"202 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124531261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fang Meng, M. Koschan, Yuntao Wu, C. Melcher, P. Cohen
{"title":"Relationship between Ca2+ concentration and the properties of codoped GGAG:Ce scintillators","authors":"Fang Meng, M. Koschan, Yuntao Wu, C. Melcher, P. Cohen","doi":"10.1109/NSSMIC.2014.7431229","DOIUrl":"https://doi.org/10.1109/NSSMIC.2014.7431229","url":null,"abstract":"Codoping is a method of current interest for modifying the properties of scintillators. The study reported here explores the effect of codoping on cerium doped Gd3Ga3Al2O12 (GGAG:Ce) crystals with various concentrations of Ca. These single crystals were grown via the Czochralski technique with Ce concentrations fixed at 0.2 at% and Ca concentrations ranging from 0.1 at% to 0.4 at% in the initial melt. The relationship between dopant concentration and light yield and scintillation decay times was determined.","PeriodicalId":144711,"journal":{"name":"2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127681481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}