International Wound Journal最新文献

{"title":"The infected diabetic foot: Bacteraemia and endocarditis complicating moderate and severe foot infections","authors":"Mario C. Reyes,&nbsp;Arthur N. Tarricone,&nbsp;Mathew J. Sideman,&nbsp;Michael C. Siah,&nbsp;Bijan Najafi,&nbsp;Edgar J. G. Peters,&nbsp;Lawrence A. Lavery","doi":"10.1111/iwj.70102","DOIUrl":"https://doi.org/10.1111/iwj.70102","url":null,"abstract":"<p>To identify the incidence of blood stream infections (BSIs) and endocarditis in patients with diabetic foot infections (DFIs), risk factors and clinical outcomes. A post hoc analysis of 280 patients using pooled patient level data from three RTCs. Blood cultures were drawn at time of admission for DFI. Deep intraoperative cultures were obtained from infected foot wounds. Data from the 12-month follow-up were used to determine clinical outcomes. 77.1% (<i>N</i> = 216) had blood cultures of which 15.7% (<i>n</i> = 34) had BSI. One patient (3.3%) had endocarditis. Risk factors for BSI included Charcot Neuroarthropathy history (20.6% vs. 7.1%, <i>p</i> = 0.03), low systolic blood pressure (128.3 ± 21.0 vs. 140.8 ± 22.2 <i>p</i> = 0.003), low diastolic blood pressure (71.6 ± 9.4 vs. 79.3 ± 11.5 <i>p</i> &lt;0.001), leucocytosis &gt;12 000 (55.9% vs. 29.1%, <i>p</i> = 0.002) and elevated C-reactive protein (CRP) (26.8 ± 31.2 vs. 12.0 ± 19.6, <i>p</i> &lt;0.001). During the index hospitalization, BSI patients had longer median hospitalizations (14.0, 11.3–18.0 vs. 12.0, 9.0–16.0, <i>p</i> = 0.04). At 12-months, BSI patients were more likely to be admitted to the hospital (all cause hospital admissions 35.3% vs. 18.6%, <i>p</i> = 0.03). There was no difference in re-infection (20.6% vs. 32.9%, <i>p</i> = 0.21), foot-specific hospitalizations (17.6% vs. 22.5%, <i>p</i> = 0.65), wounds healing (64.7% vs. 67.5%, <i>p</i> = 0.88), time to heal (221.0, 74.0–365 vs. 109.5, 46.8–365, <i>p</i> = 0.16) or antibiotic duration (46.0, 39.3–76.5 vs. 45.0, 22.3–67.0, <i>p</i> = 0.09). The most common BSI pathogens were <i>Staphylococcus aureus</i> (79.4%) and <i>Streptococcus</i> spp. (50.0%) species. BSI is common in DFIs. Patients have longer hospitalizations and were more likely to be hospitalized after their initial discharge.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for surgical site infections after orthopaedic surgery: A meta-analysis and systematic review","authors":"Huan Liu,&nbsp;Hao Xing,&nbsp;Ge Zhang,&nbsp;An Wei,&nbsp;Zhengqi Chang","doi":"10.1111/iwj.70068","DOIUrl":"https://doi.org/10.1111/iwj.70068","url":null,"abstract":"<p>The objective of this meta-analysis was to investigate the occurrence and determinants of surgical site infections (SSIs) in individuals following orthopaedic surgical procedures. A systematic exploration of articles concerning factors predisposing individuals to SSIs after orthopaedic surgery was conducted across multiple databases, including PubMed, Embase, Cochrane Library and Web of Science, up to March 20, 2024. The Stata 15.0 software was employed to estimate combined odds ratios (ORs) utilizing either a random-effects model or a fixed-effects model based on the degree of heterogeneity among the included studies. Egger's test was used to assess publication bias. Among the 1248 records retrieved, 45 articles were deemed eligible after screening for studies incorporating multivariate analyses of risk factors associated with SSIs. These comprised four case–control studies and 41 cohort studies, collectively involving 1 572 160 patients, among whom 43 971 cases of SSIs were reported postoperatively. Meta-analysis outcomes indicated significant associations between SSIs and the following factors: low Albumin levels (&lt;35 g/L; OR = 2.29, 95% confidence interval [CI]: 1.45–3.62, <i>p</i> = 0.0001), ASA score &gt;2 (OR = 2.32, 95% CI: 1.86–2.89, <i>p</i> = 0.0001), elevated body mass index (BMI) (&gt;24 kg/m²) (OR = 2.15, 95% CI: 1.60–2.90, <i>p</i> = 0.0001), diabetes (OR = 2.25, 95% CI: 1.66–3.05, <i>p</i> = 0.0001), prolonged surgical duration (&gt;60 min) (OR = 2.06, 95% CI: 1.52–2.80, <i>p</i> = 0.001), undergoing multiple surgeries/procedures (OR = 2.38, 95% CI: 1.29–4.41, <i>p</i> = 0.006), presence of an open fracture (OR = 3.35, 95% CI: 2.51–4.46, <i>p</i> = 0.001), current smoking (OR = 2.87, 95% CI: 1.88–4.37, <i>p</i> = 0.0001), higher wound class (&gt;2; OR = 3.59, 95% CI: 1.68–7.66, <i>p</i> = 0.001) and utilization of implants (OR = 1.89, 95% CI: 1.15–3.11, <i>p</i> = 0.0012). The present study identified a number of risk factors for the development of SSIs following orthopaedic surgery. It is therefore recommended that clinicians closely monitor these indicators in order to prevent the development of postoperative SSIs. Furthermore, our interpretation of diabetes mellitus was not adequate. It is therefore recommended that future studies refine the effect of diabetes mellitus on SSIs in different situations.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Skin Wound Healing Through Chemically Modified Messenger RNA Encoding Epidermal Growth Factor (EGF)","authors":"Haiyang Hu,&nbsp;Qianglong Sheng,&nbsp;Fan Yang,&nbsp;Xinyi Wu,&nbsp;Youlai Zhang,&nbsp;Shuling Wu,&nbsp;Yihu Liu,&nbsp;Ningyan Hu,&nbsp;Chenhong Fu,&nbsp;Jialin Leong,&nbsp;Rufei Deng,&nbsp;Zhenyu Jiang,&nbsp;Jiaxin Chen,&nbsp;Zhenxing Wang,&nbsp;Chunyuan Chen,&nbsp;Fei Chen,&nbsp;Yixuan Luo,&nbsp;Yuanlin Zeng,&nbsp;Yin Yu,&nbsp;Hui Xie,&nbsp;Gang Wang,&nbsp;Lijin Zou","doi":"10.1111/iwj.70143","DOIUrl":"https://doi.org/10.1111/iwj.70143","url":null,"abstract":"<p>Efficient wound healing remains a formidable medical challenge in clinical practice, due to the prevalence of skin defects arising from diverse etiological factors. It is indisputable that epidermal growth factor (EGF) plays a pivotal role in wound repair. However, its clinical application through recombinant proteins encounters challenges, including a short half-life in vivo and high production costs. Addressing these limitations, recent advancements in chemically modified mRNA (cmRNA) technologies offer a promising alternative. This study explores the utilisation of cmRNA in a biocompatible citrate-saline formulation to encode EGF for therapeutic purposes, capitalising on the advantages of cmRNA's inherent stability and the formulation's compatibility with biological systems. CmRNA demonstrated high transfection efficiency in human immortalised keratinocyte (HaCaT) and normal human dermal fibroblasts (NHDF) cells (93.97% ± 1.25% and 90.37% ± 0.97%, respectively), resulting in efficient production of biologically active EGF protein. In vitro, EGF cmRNA significantly promoted HaCaT and NHDF cell cycle, proliferation and migration. In vivo, in vivo imaging system (IVIS) imaging of murine skin confirmed localised and sustained expression of Luciferase cmRNA, with signals detectable up to 11 days post-injection. Immunohistochemistry revealed protein expression in both epidermal and dermal layers as early as 1 h post-injection, peaking at 48 h, further corroborated by enzyme-linked immunosorbent assay (ELISA). In a full-thickness skin defect mouse model, EGF cmRNA significantly accelerated wound healing, with superior re-epithelialisation observed compared to controls by Day 6. Mitogen-activated protein kinase (MEK)/Extracellular signal-regulated kinase (ERK) and Ki67 mRNA expression levels were markedly increased, both in vitro and in vivo. By Day 14, histological and immunohistochemical analyses revealed that EGF cmRNA outperformed recombinant human EGF (rhEGF), as indicated by enhanced formation of hair follicles and cutaneous glands, better-organised collagen fibres, and a reduced collagen Type I/III ratio. No adverse effects were observed in major organs, confirming cmRNA's biosafety. These results highlight the therapeutic potential of EGF-encoding cmRNA as an effective and safe alternative for enhancing wound healing.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secretome from prolonged high-density human Wharton's jelly stem cell culture accelerates wound healing in both in vitro and in vivo models","authors":"Jiah Shin Chin,&nbsp;Mandy Li Ling Tan,&nbsp;Priscilla Lay Keng Lim,&nbsp;Bhavya Sharma,&nbsp;Aimin Yeo,&nbsp;Yi Bing Aw,&nbsp;Yi Zhen Ng,&nbsp;Carine Bonnard,&nbsp;David L. Becker,&nbsp;Pamela Mok","doi":"10.1111/iwj.70033","DOIUrl":"https://doi.org/10.1111/iwj.70033","url":null,"abstract":"<p>The complex of biofactors secreted by mesenchymal stem cells, termed the secretome, can promote wound healing. Studies using this secretome often utilise material collected from short term and sub-confluent lab-scale cultures. Secretome was derived from prolonged culture of high-density industrial scale human Wharton's jelly stem cells and its effects on wound healing was assessed. In vitro cell proliferation and scratch closure assays showed that secretome treatment dose-dependently increased cell proliferation and promoted scratch closure. Subsequently, using biopsy punch, circular wounds were created on three-dimensional de-epidermised dermis human skin equivalent (in vitro) where secretome-treated wounds showed accelerated wound closure, and enhanced epithelial proliferation and differentiation were observed and quantified. In an in vivo rat acute wound model, secretome applied to the back of test animals greatly enhanced wound healing by promoting re-epithelialisation, vascularisation and granulation maturation. In conclusion, secretome derived from prolonged culture of high-density industrial scale two-dimensional human Wharton's jelly stem cells possesses potent wound healing properties. This could greatly lower the cost of production and facilitate development of highly efficacious secretome-based wound healing products.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dialysis foot- the impact of presenting estimated glomerular filtration rate on clinical outcomes in patients hospitalized with diabetic foot infections","authors":"Arthur Tarricone,&nbsp;Tyler L. Coye,&nbsp;Allen Gee,&nbsp;Bijan Najafi,&nbsp;Michael C. Siah,&nbsp;Lawrence A. Lavery","doi":"10.1111/iwj.70122","DOIUrl":"https://doi.org/10.1111/iwj.70122","url":null,"abstract":"<p>To evaluate the association between presenting estimated glomerular filtration rate (eGFR) and clinical outcomes in patients hospitalized with diabetic foot infections. This retrospective cohort study included 344 patients with moderate to severe diabetic foot infections. Patients were categorized into three groups based on presenting estimated eGFR: eGFR ≥60 (eGFR &gt;60 mL/min), eGFR 30–60 (eGFR 30–60 mL/min) and eGFR &lt;30 (eGFR &lt;30 mL/min). Outcomes assessed included wound healing, time to heal, re-infection, amputation, mortality and re-hospitalization for infection. Compared with patients with eGFR &lt;30, patients with eGFR ≥60 had significantly lower rates of retinopathy, peripheral arterial disease and use of beta blockers or calcium channel blockers. Glycated haemoglobin levels were inversely related to eGFR, decreasing as eGFR severity increased. Haemoglobin levels were significantly lower, and inflammatory markers (ESR and CRP) were significantly higher in patients with eGFR &lt;30. There were no significant differences among eGFR groups in rates of wound healing, time to heal, re-infection or amputation. However, mortality increased with decreasing eGFR (1.9% in eGFR ≥60 vs. 3.2% in eGFR 30–60 vs. 8.1% in eGFR &lt;30; <i>p</i> = 0.04). Similarly, re-hospitalization for infection at a different site also increased with decreasing eGFR (20.5% in eGFR ≥60 vs. 28.1% in eGFR 30–60 vs. 48.4% in eGFR &lt;30; <i>p</i> &lt; 0.01). In diabetic foot infections, presenting eGFR severity did not affect rates of wound healing, time to heal, re-infection or amputation. However, decreasing eGFR was associated with increased mortality and re-hospitalization for infection at a different site. In this study, presenting eGFR was not a predictive value for wound healing or time until healing, however was associated with rehospitalization and overall mortality this diabetic foot population.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of diabetic foot ulcers at a Tertiary Care Foot Centre in Pakistan","authors":"Zahid Miyan,&nbsp;Arwa Hatim,&nbsp;Saniya Khakwani,&nbsp;Khalid Abdul Basit","doi":"10.1111/iwj.70084","DOIUrl":"https://doi.org/10.1111/iwj.70084","url":null,"abstract":"<p>To determine the frequency of osteomyelitis in diabetic foot ulcers (DFUs) and its outcomes in association with lower extremity amputation (LEA). This prospective cohort study was conducted at the Baqai Institute of Diabetology and Endocrinology, Pakistan. Patients with DFUs below the malleoli were included from 1st January to 31st December 2020. Data were extracted using the Health Management System. Osteomyelitis was diagnosed and managed through standardised methods. The primary endpoint was wound healing, with or without amputation, over a 1-year follow-up period. Amongst 1901 patients with DFUs, 1478 (77.8%) had infected DFUs and 594 (40.2%) had diabetic foot osteomyelitis (DFO). The final analysis included 300 patients, divided into ‘no amputation’ (137, 45.6%), ‘minor amputation’ (134, 44.6%) and ‘major amputation’ (29, 9.6%) groups. Osteomyelitis distribution significantly influenced amputation patterns, particularly in the forefoot, which was involved in 73.7% of ‘no amputation’, 97.7% of ‘minor amputation’ and 58.6% of ‘major amputation’ cases. The 1st toe, 1st metatarsophalangeal joint and 5th toe were major contributors to forefoot amputations. This study signifies that DFO is quite prevalent in DFUs with forefoot osteomyelitis being the most common site. Moreover, the majority of DFO cases, require LEA including both minor and major amputations. These findings highlight the imperative for clinicians to adopt an early, multidisciplinary approach in the management of DFUs and hence DFO, aiming to prevent the onset of DFO and subsequent amputations.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the Impact of Negative Pressure Wound Therapy on Healing in Patients Post Excision of Pilonidal Sinus? A Systematic Review and Meta-Analysis","authors":"Liliana Patricia Ferreira Morais,&nbsp;Zena Elizabeth Helen Moore,&nbsp;Declan Patton,&nbsp;Tom O' Connor,&nbsp;Hannah Jane Elizabeth Wilson","doi":"10.1111/iwj.70194","DOIUrl":"https://doi.org/10.1111/iwj.70194","url":null,"abstract":"<p>This systematic review aimed to determine the impact of negative pressure wound therapy on healing in patients with pilonidal sinus following surgical excision. Using systematic review methodology, we included original research studies written in English. The search was conducted using CINAHL Plus, Ovid, PubMed, EBSCO Host and Cochrane databases. Quality appraisal was undertaken using the Cochrane Collaboration tool for assessing risk of bias and the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Data were analysed using meta-analysis where appropriate; otherwise, the data are presented narratively. Ten studies were included with a mean sample size of 61 (SD: 33). Three studies were randomised control trials, four were retrospective studies, two were prospective cohort studies and one was pre-post study. Studies showed reduction in healing time, recurrence rates and postoperative pain, as well as higher patients' satisfaction with the use negative pressure wound therapy, however, the certainty of the evidence was very low. The evidence for the intervention is uncertain thus, it is unclear whether NPWT makes any difference when compared to any other dressings, on time to healing, recurrence, pain or patient's experience. Further high-quality research with larger sample sizes is recommended to clearly explore the impact of NPWT on PS healing, recurrence, pain and patient's satisfaction.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactive Oxygen Species and Antioxidants in Wound Healing: Mechanisms and Therapeutic Potential","authors":"Kelechi Ukaegbu,&nbsp;Edward Allen,&nbsp;Kathy K. H. Svoboda","doi":"10.1111/iwj.70330","DOIUrl":"https://doi.org/10.1111/iwj.70330","url":null,"abstract":"<p>Wound healing is a complex biological process encompassing haemostasis, inflammation, proliferation and matrix remodelling. Reactive oxygen species (ROS) play a pivotal role in regulating key events such as antimicrobial defence, platelet activation and angiogenesis. However, excessive ROS levels can induce oxidative stress (OS), disrupting the healing cascade and contributing to chronic wounds, inflammation and impaired tissue repair. Systemic conditions like diabetes, obesity, smoking and ageing further exacerbate OS, highlighting its clinical significance in wound management. Antioxidants (AOx), both endogenous and exogenous, have demonstrated therapeutic potential in mitigating OS, promoting wound closure and enhancing cellular recovery. Compounds like Vitamin E, curcumin, ferulic acid and resveratrol improve AOx enzyme activity, reduce oxidative damage and accelerate wound healing in multiple studies. Emerging evidence supports targeting oxidative pathways as a viable strategy to improve outcomes in chronic and systemic OS-related conditions. This review explores the dual role of ROS in wound healing, the impact of OS in systemic diseases, and the therapeutic potential of AOx in fostering optimal healing outcomes, advocating for robust clinical trials to establish standardised interventions.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70330","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational Interventions to Improve Knowledge Among Nurses in the Prevention of Skin Tears in Hospitalised Adults and Older Adults: A Scoping Review","authors":"Heidi Hevia Campos,&nbsp;Cinthia Viana Bandeira da Silva,&nbsp;Juliana Takahashi,&nbsp;Marilia Mastrocolla de Almeida Cardoso,&nbsp;Lily Ríos Mazzachiodi,&nbsp;Kevin Woo,&nbsp;Vera Lucia Conceição de Gouveia Santos","doi":"10.1111/iwj.70240","DOIUrl":"https://doi.org/10.1111/iwj.70240","url":null,"abstract":"<p>To map and synthesise the current literature on educational interventions provided by nurses to nursing professionals to prevent skin tears in adults and older adults. A scoping review based on JBI methodology. Medline, SCOPUS, CINAHL, Web of Science, Science Direct, LILACS, Cochrane Library, ERIC, EMBASE, BVS and J_STAGE were searched from June to November 2022. Grey literature and unpublished studies were included. Studies in English, Spanish or Portuguese were considered, with no year limits. Searches were managed in Endnote and Rayyan. Two independent reviewers screened titles, abstracts and full texts using Population, Concept and Context criteria. Discrepancies were resolved by a third reviewer. Data extraction employed a structured spreadsheet. Of 694 articles retrieved, four met the inclusion criteria, primarily prospective quasi-experimental studies. Two educational modalities were noted: face-to-face classes utilising PowerPoint presentations and online training accessible 24/7 via institutional websites. Key outcomes included improved knowledge levels and reduced skin tear incidence. Nurse-led educational interventions may enhance nursing knowledge and decrease skin tear incidence. Further research is necessary to identify optimal educational approaches and technologies, assess their feasibility and evaluate their direct impact on clinical practice and skin tear prevention and incidence.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinical Audit of Surgical Site Infection Surveillance in a Maxillo-Facial and Oral Surgery Unit in an Academic Hospital Complex in South Africa","authors":"Emmy Ngoakoana Nokaneng,&nbsp;Samantha L. Holloway","doi":"10.1111/iwj.70196","DOIUrl":"https://doi.org/10.1111/iwj.70196","url":null,"abstract":"<p>The clinical outcomes and financial impact of surgical site infection within South Africa is not well known due to the lack of an established national surveillance programme. The aim of this project was to undertake a baseline clinical audit of surgical site infection prevention in a Maxillo-facial and Oral Surgery unit using the National Institute for Health and Care Excellence clinical guideline (NG125) as the benchmark standard. The primary objective was to establish a baseline incidence of surgical site infection. This was a prospective and observational clinical audit undertaken at the MFOS unit in a University Hospital in South Africa. Thirty-seven participants who had surgical procedures were recruited and monitored telephonically post-discharge for a period of 30 days. The composite compliance rate to the process indicators was 39.86% (95% Confidence Interval 37.25–42.46). The incidence rate of surgical site infection was 14.81% (<i>n</i> = 8). The resection of head and neck malignancy contributed majority of the SSI cases (50%, <i>n</i> = 4). Five organ/space SSI cases were detected with a mortality rate of 25% (<i>n</i> = 2). The higher surgical site infection rates may be associated with the lapses in the infection control practices. For example, the lack of an aseptic technique <span>lack</span> or structured approach to wound management. The main recommendation was the development of evidence-based surgical site infection preventative strategies that are applicable to the Maxillo-facial and Oral Surgery procedures to reduce surgical site infection.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}