International Journal of Toxicology最新文献_第7页

Safety Assessment of Soy-Derived Ingredients as Used in Cosmetics. 化妆品中使用的大豆成分安全评估。

IF 2.2 4区医学

International Journal of Toxicology Pub Date : 2024-02-11 DOI: 10.1177/10915818241231249

Priya Cherian, Wilma F Bergfeld, Donald V Belsito, Curtis D Klaassen, Daniel C Liebler, James G Marks, Lisa A Peterson, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice Fiume, Bart Heldreth

引用次数: 0

Safety Assessment of Ginkgo biloba-Derived Ingredients as Used in Cosmetics. 化妆品用银杏叶衍生成分的安全性评估。

IF 2.2 4区医学

International Journal of Toxicology Pub Date : 2024-02-01 Epub Date: 2023-11-06 DOI: 10.1177/10915818231210792

Christina L Burnett, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice Fiume, Bart Heldreth

{"title":"Safety Assessment of Ginkgo biloba-Derived Ingredients as Used in Cosmetics.","authors":"Christina L Burnett, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice Fiume, Bart Heldreth","doi":"10.1177/10915818231210792","DOIUrl":"10.1177/10915818231210792","url":null,"abstract":"The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 10 Ginkgo biloba-derived ingredients, which are most frequently reported to function in cosmetics as skin conditioning agents or antioxidants. The Panel reviewed the available data to determine the safety of these ingredients. Because final product formulations may contain multiple botanicals, each containing the same constituents of concern, formulators are advised to be aware of these constituents and to avoid reaching levels that may be hazardous to consumers. The Panel was concerned about the presence of ginkgolic acid in cosmetics. Industry should use good manufacturing practices to limit impurities. The Panel concluded that 5 Ginkgo biloba leaf-derived ingredients are safe in the present practices of use and concentration described in this safety assessment when formulated to be non-sensitizing; data are insufficient to determine the safety of the remaining 5 ingredients under the intended conditions of use in cosmetic formulations.","PeriodicalId":14432,"journal":{"name":"International Journal of Toxicology","volume":" ","pages":"64S-81S"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71481529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety Assessment of Adenosine as Used in Cosmetics. 化妆品中使用的腺苷安全性评估。

IF 2.2 4区医学

International Journal of Toxicology Pub Date : 2024-02-01 Epub Date: 2023-12-25 DOI: 10.1177/10915818231221790

Priya Cherian, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice Fiume, Bart Heldreth

引用次数: 0

Safety Assessment of Butyrospermum parkii (Shea)-Derived Ingredients as Used in Cosmetics. 化妆品中使用的乳木果提取成分的安全性评估。

IF 2.2 4区医学

International Journal of Toxicology Pub Date : 2024-02-01 Epub Date: 2024-01-02 DOI: 10.1177/10915818231224230

Christina L Burnett, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice Fiume, Bart Heldreth

引用次数: 0

Safety Assessment of Trialkyl Trimellitates as Used in Cosmetics. 化妆品中使用的三烷基三甲酸酯的安全评估。

IF 2.2 4区医学

International Journal of Toxicology Pub Date : 2024-02-01 Epub Date: 2023-12-30 DOI: 10.1177/10915818231224248

Monice M Fiume, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Lillian J Gill, Bart Heldreth

引用次数: 0

Safety Assessment of Hops as Used in Cosmetics. 化妆品中使用啤酒花的安全性评估。

IF 2.2 4区医学

International Journal of Toxicology Pub Date : 2024-02-01 Epub Date: 2023-12-21 DOI: 10.1177/10915818231221796

Lillian Becker, Ivan Boyer, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice Fiume, Bart Heldreth

{"title":"Safety Assessment of Hops as Used in Cosmetics.","authors":"Lillian Becker, Ivan Boyer, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice Fiume, Bart Heldreth","doi":"10.1177/10915818231221796","DOIUrl":"10.1177/10915818231221796","url":null,"abstract":"The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Humulus Lupulus (Hops) Extract (reported functions include antimicrobial agent and hair conditioning agent) and Humulus Lupulus (Hops) Oil (reported function is fragrance). The Panel reviewed the relevant data related to these ingredients. Because final product formulations may contain multiple botanicals, each containing the same constituents of concern, formulators are advised to be aware of these constituents and to avoid reaching levels that may be hazardous to consumers. For these ingredients, the Panel was concerned about the presence of 8-prenylnaringenin, β-myrcene, and quercetin in cosmetics, which could result in estrogenic effects, dermal irritation, and genotoxicity, respectively. Industry should use current good manufacturing practices to limit impurities and constituents of concern. The Panel concluded that Humulus Lupulus (Hops) Extract and Humulus Lupulus (Hops) Oil are safe in cosmetics in the present practices of use and concentration when formulated to be non-sensitizing.","PeriodicalId":14432,"journal":{"name":"International Journal of Toxicology","volume":" ","pages":"5S-29S"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138829720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety Assessment of Alkyl Sultaines as Used in Cosmetics. 化妆品中使用的烷基舒他宁的安全性评估。

IF 2.2 4区医学

International Journal of Toxicology Pub Date : 2024-02-01 Epub Date: 2023-12-21 DOI: 10.1177/10915818231221791

Christina L Burnett, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice Fiume, Bart Heldreth

引用次数: 0

Book Review: Hayes’ Principles and Methods of Toxicology 7th Edition 书评：海斯的《毒理学原理与方法》第 7 版

IF 2.2 4区医学

International Journal of Toxicology Pub Date : 2024-01-03 DOI: 10.1177/10915818231224870

Elliot B. Gordon

引用次数: 0

The Nonclinical Assessment of Trans-1,3,3,3-tetrafluoropropene (HFO-1234ze (E)), a Near Zero Global Warming Potential Propellant for Use in Metered Dose Inhalation Products. 反-1,3,3,3-四氟丙烯（HFO-1234ze（E））的非临床评估，这是一种用于计量剂量吸入产品的近零全球变暖潜能推进剂。

IF 2.2 4区医学

International Journal of Toxicology Pub Date : 2024-01-01 Epub Date: 2023-10-20 DOI: 10.1177/10915818231206025

Paul S Giffen, Joanne D Kilgour, Matthew Jacobsen, Karen Thacker, Ann A Holmberg

{"title":"The Nonclinical Assessment of Trans-1,3,3,3-tetrafluoropropene (HFO-1234ze (E)), a Near Zero Global Warming Potential Propellant for Use in Metered Dose Inhalation Products.","authors":"Paul S Giffen, Joanne D Kilgour, Matthew Jacobsen, Karen Thacker, Ann A Holmberg","doi":"10.1177/10915818231206025","DOIUrl":"10.1177/10915818231206025","url":null,"abstract":"HFO-1234ze (E) is proposed as a near zero global warming propellant for use in metered dose inhaled (MDI) products. This paper describes the non-clinical safety assessment in mice, rats, and dogs and supplements previously reported data (genetic toxicology, short-term toxicology, and reproductive toxicology). In all species, HFO-1234ze (E) was only detectable in blood for a short period after dosing with no evidence of accumulation. HFO-1234ze (E) was without any toxicological effects at very high doses in subchronic (13-week mouse) and chronic (39-week dog) studies. Chronic (26-week) administration to rats at very high doses was associated with an exacerbation of rodent progressive cardiomyopathy, a well-documented background finding in rodents. In a 2-generation study, extremely high doses were associated with the early euthanasia of some lactating female rats. This finding was considered to be significantly influenced by a state of negative energy balance, reflecting the specific vulnerability of rats during lactation. These findings are considered to not pose a risk to humans with typical MDI use given they occurred at doses which far exceed those expected in patients. Overall, the nonclinical safety data for HFO-1234ze (E) support its further development as an MDI propellant.","PeriodicalId":14432,"journal":{"name":"International Journal of Toxicology","volume":" ","pages":"4-18"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10851632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49677418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preclinical Safety Evaluation of the Human-Identical Milk Oligosaccharide Lacto-N-Triose II. 人乳低聚糖乳糖-N-三糖的临床前安全性评价II。

IF 2.2 4区医学

International Journal of Toxicology Pub Date : 2024-01-01 Epub Date: 2023-09-28 DOI: 10.1177/10915818231203515

Xu Fang, Wei Zhu, Huiying Zhao, Wencheng Yin, Xiao Song, Fengxin Liu

{"title":"Preclinical Safety Evaluation of the Human-Identical Milk Oligosaccharide Lacto-N-Triose II.","authors":"Xu Fang, Wei Zhu, Huiying Zhao, Wencheng Yin, Xiao Song, Fengxin Liu","doi":"10.1177/10915818231203515","DOIUrl":"10.1177/10915818231203515","url":null,"abstract":"Lacto-N-triose II (LNT II), an essential human milk oligosaccharide and precursor to lacto-N-tetraose (LNT) and lacto-N-neotetraose (LNnT), was evaluated for safety. Genotoxicity was assessed through in vitro tests including Bacterial Reverse Mutation Test and mammalian cell micronucleus test, and a subchronic oral gavage toxicity study was conducted on juvenile Sprague-Dawley rats. In this study, LNT II was administered at dose levels of 0, 1,500, 2,500, or 5,000 mg/kg body weight (bw)/day for 90 days, followed by a 4-week treatment-free recovery period. LNT II was non-genotoxic in the in vitro assays. No compound-related effects were observed across all dosage levels based on various measures, including clinical observations, body weight gain, feed consumption, clinical pathology, organ weights, and histopathology. Consequently, the highest dosage of 5,000 mg/kg bw/day was established as the no-observed-adverse-effect-level (NOAEL). These results suggest the safe use of LNT II in young children formula and as a food ingredient, within the limits found naturally in human breast milk.","PeriodicalId":14432,"journal":{"name":"International Journal of Toxicology","volume":" ","pages":"27-45"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41096770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0