Invertebrate Neuroscience最新文献_第4页

Increase in serotonin precursor levels reinstates the context memory during reconsolidation 血清素前体水平的增加在重新巩固过程中恢复了上下文记忆

Invertebrate Neuroscience Pub Date : 2019-07-30 DOI: 10.1007/s10158-019-0227-9

A. Zuzina, A. Vinarskaya, P. Balaban

引用次数: 15

Assessment of the molluscicidal impact of extracted chlorophyllin on some biochemical parameters in the nervous tissue and histological changes in Biomphalaria alexandrina and Lymnaea natalensis snails 叶绿素提取物对绿僵螺和绿僵螺神经组织生化指标及组织学变化的影响

Invertebrate Neuroscience Pub Date : 2019-07-27 DOI: 10.1007/s10158-019-0230-1

A. Ibrahim, F. Bakry

引用次数: 17

Identification of putative amine biosynthetic enzymes in the nervous system of the crab, Cancer borealis. 北蟹神经系统推定胺类生物合成酶的鉴定。

Invertebrate Neuroscience Pub Date : 2019-07-01 DOI: 10.1007/s10158-019-0226-x

Andrew E Christie

{"title":"Identification of putative amine biosynthetic enzymes in the nervous system of the crab, Cancer borealis.","authors":"Andrew E Christie","doi":"10.1007/s10158-019-0226-x","DOIUrl":"https://doi.org/10.1007/s10158-019-0226-x","url":null,"abstract":"Amines function as neuromodulators throughout the animal kingdom. In decapod crustaceans, the amines serving neuromodulatory roles include dopamine, octopamine, serotonin and histamine. While much work has focused on examining the physiological effects of amines on decapod nervous systems, the identity of the native enzymes involved in their biosynthesis remains largely unknown. In an attempt to help fill this void, a transcriptome generated from multiple portions of the crab, Cancer borealis, nervous system, a species that has long served as a model species for investigating the neuromodulatory control of rhythmically active neural networks, was used to identify putative amine biosynthetic enzyme-encoding transcripts, and by proxy, proteins. Transcripts encoding full complements of the enzymes involved in the production of dopamine, octopamine, serotonin, and histamine were deduced from the C. borealis assembly, i.e., tryptophan-phenylalanine hydroxylase, tyrosine hydroxylase, DOPA decarboxylase, tyrosine decarboxylase, tyramine β-hydroxylase, tryptophan hydroxylase, and histidine decarboxylase. All proteins deduced from the C. borealis transcripts appear to be full-length sequences, with reciprocal BLAST and structural domain analyses supporting the protein family annotations ascribed to them. These data provide the first descriptions of the native amine biosynthetic enzymes of C. borealis, and as such, serve as a resource for initiating gene-based studies of aminergic control of physiology and behavior at the level of biosynthesis in this important biomedical model.","PeriodicalId":14430,"journal":{"name":"Invertebrate Neuroscience","volume":"19 2","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10158-019-0226-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37388144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Neural pathways in the pallial nerve and arm nerve cord revealed by neurobiotin backfilling in the cephalopod mollusk Octopus vulgaris. 头足类软体动物寻常章鱼神经生物素回填所揭示的苍白部神经和上臂神经索的神经通路。

Invertebrate Neuroscience Pub Date : 2019-05-10 DOI: 10.1007/s10158-019-0225-y

Pamela Imperadore, Maria Grazia Lepore, Giovanna Ponte, Hans-Joachim Pflüger, Graziano Fiorito

{"title":"Neural pathways in the pallial nerve and arm nerve cord revealed by neurobiotin backfilling in the cephalopod mollusk Octopus vulgaris.","authors":"Pamela Imperadore, Maria Grazia Lepore, Giovanna Ponte, Hans-Joachim Pflüger, Graziano Fiorito","doi":"10.1007/s10158-019-0225-y","DOIUrl":"https://doi.org/10.1007/s10158-019-0225-y","url":null,"abstract":"Here, we report the findings after application of neurobiotin tracing to pallial and stellar nerves in the mantle of the cephalopod mollusk Octopus vulgaris and to the axial nerve cord in its arm. Neurobiotin backfilling is a known technique in other molluscs, but it is applied to octopus for the first time to be best of our knowledge. Different neural tracing techniques have been carried out in cephalopods to study the intricate neural connectivity of their nervous system, but mapping the nervous connections in this taxon is still incomplete, mainly due to the absence of a reliable tracing method allowing whole-mount imaging. In our experiments, neurobiotin backfilling allowed: (1) imaging of large/thick samples (larger than 2 mm) through optical clearing; (2) additional application of immunohistochemistry on the backfilled tissues, allowing identification of neural structures by coupling of a specific antibody. This work opens a series of future studies aimed to the identification of the neural diagram and connectome of octopus nervous system.","PeriodicalId":14430,"journal":{"name":"Invertebrate Neuroscience","volume":"19 2","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2019-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10158-019-0225-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37226003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Lidocaine and carbamazepine inhibit while phenytoin and lamotrigine paradoxically enhance the insect neuromuscular transmission. 利多卡因和卡马西平抑制，而苯妥英和拉莫三嗪矛盾地增强昆虫神经肌肉传递。

Invertebrate Neuroscience Pub Date : 2019-02-08 DOI: 10.1007/s10158-019-0224-z

Irina M Fedorova, Denis B Tikhonov

{"title":"Lidocaine and carbamazepine inhibit while phenytoin and lamotrigine paradoxically enhance the insect neuromuscular transmission.","authors":"Irina M Fedorova, Denis B Tikhonov","doi":"10.1007/s10158-019-0224-z","DOIUrl":"https://doi.org/10.1007/s10158-019-0224-z","url":null,"abstract":"Primary mechanism of action of local anesthetics and various anticonvulsants is the voltage-gated sodium channel block. Many of these small molecules also have other targets in nervous system of vertebrates. However, little is known about their action on invertebrate nervous system. Nevertheless, insect-based models are suggested for high-throughput screening of antiepileptic drugs. In the present work, we characterized action of lidocaine, carbamazepine, lamotrigine, and phenytoin on the neuromuscular transition of Calliphora vicina fly larvae using conventional voltage-clamp approach. Carbamazepine and lidocaine caused inhibition of synaptic transmission, which has presynaptic origin. This action is in agreement with inhibition of voltage-gated sodium channels that reduces depolarization of nerve terminals and, thus, calcium entry. Surprisingly, phenytoin and lamotrigine produced a prominent increase in the evoked postsynaptic currents without any effect on frequency or amplitude of spontaneous miniature currents. Potassium channel blocker 4-aminopyridine affects synaptic transmission in similar way. Elevation of synaptic quantal content via increase in calcium concentration or via application of 1 mM 4-aminopyridine eliminates the enhancement effect or even turns it to modest inhibition. We propose that lamotrigine and phenytoin act as inhibitors of insect potassium channels that cause the membrane depolarization and thus facilitates calcium entry into the nerve terminal.","PeriodicalId":14430,"journal":{"name":"Invertebrate Neuroscience","volume":"19 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2019-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10158-019-0224-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36940477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Dysregulation of axogenesis in the antennal nervous system of the embryonic grasshopper Schistocerca gregaria. 胚胎蚱蜢触角神经系统的无轴发育失调。

Invertebrate Neuroscience Pub Date : 2019-01-17 DOI: 10.1007/s10158-019-0223-0

George Boyan, Erica Ehrhardt

引用次数: 2

A study of the role of vision in the foraging behaviour of the pyrrhocorid bug Antilochus conquebertii (Insecta; Hemiptera; Pyrrhocoridae). 视觉在拟南蝽觅食行为中的作用研究半翅类;红蝽科)。

Invertebrate Neuroscience Pub Date : 2019-01-02 DOI: 10.1007/s10158-018-0222-6

Monalisa Mishra, Ishita Chakraborty, Srirupa Basu

引用次数: 3

Na⁺/K⁺-pump and neurotransmitter membrane receptors. 钠离子/钾离子泵和神经递质膜受体。

Invertebrate Neuroscience Pub Date : 2018-11-28 DOI: 10.1007/s10158-018-0221-7

Arkady S Pivovarov, Fernando Calahorro, Robert J Walker

引用次数: 93

Yeast two-hybrid screening identifies MPZ-1 and PTP-1 as candidate scaffolding proteins of metabotropic glutamate receptors in Caenorhabditis elegans. 酵母双杂交筛选发现MPZ-1和PTP-1是秀丽隐杆线虫代谢性谷氨酸受体的候选支架蛋白。

Invertebrate Neuroscience Pub Date : 2018-11-11 DOI: 10.1007/s10158-018-0218-2

James Dillon, Lindy Holden-Dye, Vincent O'Connor

{"title":"Yeast two-hybrid screening identifies MPZ-1 and PTP-1 as candidate scaffolding proteins of metabotropic glutamate receptors in Caenorhabditis elegans.","authors":"James Dillon, Lindy Holden-Dye, Vincent O'Connor","doi":"10.1007/s10158-018-0218-2","DOIUrl":"https://doi.org/10.1007/s10158-018-0218-2","url":null,"abstract":"The metabotropic glutamate receptors (mGluRs) are a class of G-protein-coupled receptor that undergo extensive interactions with scaffolding proteins, and this is intrinsic to their function as an important group of neuromodulators at glutamatergic synapses. The Caenorhabditis elegans nervous system expresses three metabotropic glutamate receptors, MGL-1, MGL-2 and MGL-3. Relatively little is known about how the function and signalling of these receptors is organised in C. elegans. To identify proteins that scaffold the MGL-1 receptor, we have conducted a yeast two-hybrid screen. Three of the interacting proteins, MPZ-1, NRFL-1 and PTP-1, displayed motifs characteristic of mammalian mGluR scaffolding proteins. Using cellular co-expression criterion, we show mpz-1 and ptp-1 exhibited overlapping expression patterns with subsets of mgl-1 neurons. This included neurones in the pharyngeal nervous system that control the feeding organ of the worm. The mGluR agonist L-CCG-I inhibits the activity of this network in wild-type worms, in an MGL-1 and dose-dependent manner. We utilised L-CCG-I to identify if MGL-1 function was disrupted in mutants with deletions in the mpz-1 gene. The mpz-1 mutants displayed a largely wild-type response to L-CCG-I, suggesting MGL-1 signalling is not overtly disrupted consistent with a non-obligatory modulatory function in receptor scaffolding. The selectivity of the protein interactions and overlapping expression identified here warrant further investigation of the functional significance of scaffolding of metabotropic glutamate receptor function.","PeriodicalId":14430,"journal":{"name":"Invertebrate Neuroscience","volume":"18 4","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2018-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10158-018-0218-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36655354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rapid introduction to neurological biochemistry using Drosophila melanogaster. 用黑腹果蝇快速介绍神经生物化学。

Invertebrate Neuroscience Pub Date : 2018-11-08 DOI: 10.1007/s10158-018-0220-8

Setareh S Chong, Anthony J Wilkinson, Sangeeta Chawla

引用次数: 0