钠离子/钾离子泵和神经递质膜受体。

Q4 Neuroscience

Invertebrate Neuroscience Pub Date : 2018-11-28 DOI:10.1007/s10158-018-0221-7

Arkady S Pivovarov, Fernando Calahorro, Robert J Walker

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引用次数: 93

摘要

Na+/K+泵是一种位于细胞外质膜的电致跨膜atp酶。Na+/K+- atp酶将3个钠离子泵出细胞，同时将2个钾离子泵入细胞。两个阳离子都逆其浓度梯度运动。这种酶的致电性质意味着它在稳定细胞静息膜电位、调节细胞体积和细胞信号转导方面具有慢性作用。本文将主要讨论Na+/K+泵在神经元中的作用，重点介绍其在调节神经递质受体中的作用。大多数关于神经递质受体调节的文献都是指哺乳动物神经系统的情况，但在大多数(如果不是全部的话)无脊椎动物神经系统中，这种情况可能是相似的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Na+/K+-pump and neurotransmitter membrane receptors.

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Na⁺/K⁺-pump and neurotransmitter membrane receptors.

Na⁺/K⁺-pump is an electrogenic transmembrane ATPase located in the outer plasma membrane of cells. The Na⁺/K⁺-ATPase pumps 3 sodium ions out of cells while pumping 2 potassium ions into cells. Both cations move against their concentration gradients. This enzyme's electrogenic nature means that it has a chronic role in stabilizing the resting membrane potential of the cell, in regulating the cell volume and in the signal transduction of the cell. This review will mainly consider the role of the Na⁺/K⁺-pump in neurons, with an emphasis on its role in modulating neurotransmitter receptor. Most of the literature on the modulation of neurotransmitter receptors refers to the situation in the mammalian nervous system, but the position is likely to be similar in most, if not all, invertebrate nervous systems.

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来源期刊

Invertebrate Neuroscience NEUROSCIENCES-

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Invertebrate Neurosciences publishes peer-reviewed original articles, reviews and technical reports describing recent advances in the field of invertebrate neuroscience. The journal reports on research that exploits the simplicity and experimental tractability of the invertebrate preparations to underpin fundamental advances in neuroscience. Articles published in Invertebrate Neurosciences serve to highlight properties of signalling in the invertebrate nervous system that may be exploited in the field of antiparisitics, molluscicides and insecticides. Aspects of particular interest include: Functional analysis of the invertebrate nervous system; Molecular neuropharmacology and toxicology; Neurogenetics and genomics; Functional anatomy; Neurodevelopment; Neuronal networks; Molecular and cellular mechanisms of behavior and behavioural plasticity.