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Idiopathic intracranial hypertension pathogenesis: The jugular hypothesis. 特发性颅内高压发病机制:颈静脉假说
IF 1.7 4区 医学
Interventional Neuroradiology Pub Date : 2024-08-08 DOI: 10.1177/15910199241270660
Kyle M Fargen, Jackson P Midtlien, Connor R Margraf, Ferdinand K Hui
{"title":"Idiopathic intracranial hypertension pathogenesis: The jugular hypothesis.","authors":"Kyle M Fargen, Jackson P Midtlien, Connor R Margraf, Ferdinand K Hui","doi":"10.1177/15910199241270660","DOIUrl":"10.1177/15910199241270660","url":null,"abstract":"<p><p>In spite of expanding research, idiopathic intracranial hypertension (IIH) and its spectrum conditions remain challenging to treat. The failure to develop effective treatment strategies is largely due to poor agreement on a coherent disease pathogenesis model. Herein we provide a hypothesis of a unifying model centered around the internal jugular veins (IJV) to explain the development of IIH, which contends the following: (1) the IJV are prone to both physiological and pathological compression throughout their course, including compression near C1 and the styloid process, dynamic muscular/carotid compression from C3 to C6, and lymphatic compression; (2) severe dynamic IJV stenosis with developments of large cervical gradients is common in IIH-spectrum patients and significantly impacts intracranial venous and cerebrospinal fluid (CSF) pressures; (3) pre-existing IJV stenosis may be exacerbated by infectious/inflammatory etiologies that induce retromandibular cervical lymphatic hypertrophy; (4) extra-jugular venous collaterals dilate with chronic use but are insufficient resulting in impaired aggregate cerebral venous outflow; (5) poor IJV outflow initiates, or in conjunction with other factors, contributes to intracranial venous hypertension and congestion leading to higher CSF pressures and intracranial pressure (ICP); (6) glymphatic congestion occurs but is insufficient to compensate and this pathway becomes overwhelmed; and (7) elevated intracranial CSF pressures triggers extramural venous sinus stenosis in susceptible individuals that amplifies ICP elevation producing severe clinical manifestations. Future studies must focus on establishing norms for dynamic cerebral venous outflow and IJV physiology in the absence of disease so that we may better understand and define the diseased state.</p>","PeriodicalId":14380,"journal":{"name":"Interventional Neuroradiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing thrombectomy in medium vessel occlusion: Focus on vessel diameter. 优化中血管闭塞时的血栓切除术:关注血管直径。
IF 1.7 4区 医学
Interventional Neuroradiology Pub Date : 2024-08-08 DOI: 10.1177/15910199241272638
Yujiro Tanaka, Daisuke Watanabe, Yusuke Kanoko, Aya Inoue, Daichi Kato, Shota Igasaki, Akira Kikuta, Motoyori Ogasawara, Kodai Kanemaru, Hibiku Maruoka
{"title":"Optimizing thrombectomy in medium vessel occlusion: Focus on vessel diameter.","authors":"Yujiro Tanaka, Daisuke Watanabe, Yusuke Kanoko, Aya Inoue, Daichi Kato, Shota Igasaki, Akira Kikuta, Motoyori Ogasawara, Kodai Kanemaru, Hibiku Maruoka","doi":"10.1177/15910199241272638","DOIUrl":"10.1177/15910199241272638","url":null,"abstract":"<p><strong>Objectives: </strong>Mechanical thrombectomy for medium vessel occlusion (MeVO) is a challenging field with limited results. In this study, we aimed at evaluating the efficacy and safety of a procedural strategy beginning with occluded vessel diameter measurement and matched aspiration catheter selection.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed all sequentially treated patients by mechanical thrombectomy at two comprehensive stroke centers between May 2020 and April 2023, focusing on the occluded vessel diameter. We included patients who underwent thrombectomy for MeVO based on the matching strategy (a procedural approach involving vessel diameter assessment, matching aspiration catheter selection, and firm clot engagement with or without a stent retriever). We evaluated efficacy and safety using the modified Thrombolysis in the Cerebral Infarction Scale (mTICI) and intracranial hemorrhage (ICH) and procedure-related complications.</p><p><strong>Results: </strong>Seventy patients fulfilled the final inclusion criteria. The median occluded vessel diameter was 1.71 mm. We achieved mTICI 2b/2c/3 in 82.9% and mTICI 2c/3 in 51.4% of the cases and did not observe any symptomatic ICH. We detected asymptomatic subarachnoid hemorrhage (SAH) in 24.3% of the cases, that is, 5.6%, 20.0%, and 45.5% in the vessel diameter groups ≥2.0, 1.5-2.0, and ≤1.5 mm, respectively. The SAH incidence was significantly higher in narrower vessel groups. The occluded vessel diameter and the contact method with clots predicted clinical outcomes.</p><p><strong>Conclusions: </strong>Matching strategy-based thrombectomy yields acceptable efficiency and safety results. In narrower vessels, it is optimal to engage matched aspiration catheters and clots without the assistance of conventional stent retrievers.</p>","PeriodicalId":14380,"journal":{"name":"Interventional Neuroradiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Part 1: Pushing the boundaries of neurointerventional surgery: A historical review of the work of Dr Gerard Debrun. 第 1 部分:推动神经介入手术的发展:杰拉德-德布隆博士工作的历史回顾。
IF 1.7 4区 医学
Interventional Neuroradiology Pub Date : 2024-08-08 DOI: 10.1177/15910199241272519
Adrusht Madapoosi, Anthony Sanchez-Forteza, Tatiana Abou Mrad, Laura Stone McGuire, Peter Theiss, Mpuekela Tshibangu, Fady Charbel, Ali Alaraj
{"title":"Part 1: Pushing the boundaries of neurointerventional surgery: A historical review of the work of Dr Gerard Debrun.","authors":"Adrusht Madapoosi, Anthony Sanchez-Forteza, Tatiana Abou Mrad, Laura Stone McGuire, Peter Theiss, Mpuekela Tshibangu, Fady Charbel, Ali Alaraj","doi":"10.1177/15910199241272519","DOIUrl":"10.1177/15910199241272519","url":null,"abstract":"<p><p>French-American neurointerventionalist and pioneer, Dr Gerard Debrun, laid the groundwork for treatments which have become irreplaceable in neurointerventional surgery today. This article aims to outline the career of Dr Debrun while highlighting his accomplishments and contributions to the field of neurointerventional surgery. We selected relevant articles from PubMed authored or co-authored by Dr Debrun between 1941 and 2023. All included articles discuss the accomplishments and contributions of Dr Debrun. Dr Debrun began his career in France by investigating neurointerventional techniques, most notably the intravascular Detachable Balloon Catheter (DBC). His work was recognized by renowned neurosurgeon Dr Charles Drake, who recruited him to London, Ontario. Dr Debrun created the foundation for homemade manufacturing of DBCs, building on one of the largest series for use of DBCs in cerebrovascular disease. Dr Debrun spent time as faculty at Massachusetts General Hospital (MGH) and Johns Hopkins Hospital, before arriving at the University of Illinois Chicago (UIC) where he remained until his retirement. Dr Debrun's subsequent contributions included the calibrated-leak balloon catheter, pioneering of glue embolization, setting the foundation for preoperative AVM embolizations, and as an early adopter of the Guglielmi detachable coil (GDC), including mastering the balloon remodeling technique for wide neck aneurysms. Dr Debrun established the first integrated neurointerventional surgery program at UIC, establishing a well sought-after fellowship program. Dr Debrun lectured extensively and was a prolific writer on neurointerventional surgery throughout this career. His contributions established the foundation for several techniques which have since become standard practice in present-day neurointerventional surgery.</p>","PeriodicalId":14380,"journal":{"name":"Interventional Neuroradiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robotic spinal angiography: A single-center experience. 机器人脊柱血管造影术:单中心经验。
IF 1.7 4区 医学
Interventional Neuroradiology Pub Date : 2024-08-08 DOI: 10.1177/15910199241272515
Oleg Shekhtman, Georgios S Sioutas, Mert Marcel Dagli, Irina-Mihaela Matache, Bryan A Pukenas, Brian T Jankowitz, Jan-Karl Burkhardt, Visish M Srinivasan
{"title":"Robotic spinal angiography: A single-center experience.","authors":"Oleg Shekhtman, Georgios S Sioutas, Mert Marcel Dagli, Irina-Mihaela Matache, Bryan A Pukenas, Brian T Jankowitz, Jan-Karl Burkhardt, Visish M Srinivasan","doi":"10.1177/15910199241272515","DOIUrl":"10.1177/15910199241272515","url":null,"abstract":"<p><strong>Background and objectives: </strong>Robotic neurointervention enhances procedural precision, reduces radiation risk, and improves care access. Originally for interventional cardiology, the CorPath GRX platform has been used in neurointerventions. Recent studies highlight robotic cerebral angiography benefits, but information on spinal angiography is limited. While a new generation of robotic solutions is on the horizon, this series evaluates our experience with the CorPath GRX in spinal angiographic procedures, addressing a key gap in neurointerventional research.</p><p><strong>Methods: </strong>In this single-center retrospective case series, we analyzed 11 patients who underwent robotic-assisted diagnostic procedures with the CorPath GRX system from February 2022 to March 2023 at our institution. A descriptive synthesis was performed on the demographic, baseline, surgical, and postoperative data collected.</p><p><strong>Results: </strong>The average age of the 11 patients was 54 ± 20.34 years, with six (54.55%) female. The mean body mass index was 29.58 ± 7.86, and 7 (63.64%) were non-smokers. Of the 11 procedures using the CorPath GRX system, four (36.36%) were partially converted to manual technique. General anesthesia was used in nine cases (81.82%), and right-side femoral access in ten (90.91%) patients. Mean fluoroscopy time was 24.81 ± 10.19 min, contrast dose 174.09 ± 57.31 mL, dose area product 472.23 ± 437.57 Gy·cm², and air kerma 2438.84 ± 2107.06 mGy. No robot-related complications and minimal procedure-related complications were reported.</p><p><strong>Conclusion: </strong>The CorPath GRX system, a robotic-assisted platform, has proven reliable and safe in spinal angiography, evidenced by its enhanced procedural accuracy and reduced radiation exposure for operators.</p>","PeriodicalId":14380,"journal":{"name":"Interventional Neuroradiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endovascular approaches for the treatment of dural carotid-cavernous fistulas: A systematic review. 治疗硬脑膜颈动脉海绵瘘的血管内方法:系统综述。
IF 1.7 4区 医学
Interventional Neuroradiology Pub Date : 2024-08-08 DOI: 10.1177/15910199241272595
Edward S Harake, Edwin Nieblas-Bedolla, Zachary Wilseck, Neeraj Chaudhary, Rocco A Armonda, Aditya S Pandey, Ehsan Dowlati
{"title":"Endovascular approaches for the treatment of dural carotid-cavernous fistulas: A systematic review.","authors":"Edward S Harake, Edwin Nieblas-Bedolla, Zachary Wilseck, Neeraj Chaudhary, Rocco A Armonda, Aditya S Pandey, Ehsan Dowlati","doi":"10.1177/15910199241272595","DOIUrl":"10.1177/15910199241272595","url":null,"abstract":"<p><strong>Introduction: </strong>Dural carotid-cavernous fistulas (dCCFs), also known as indirect carotid-cavernous fistulas, represent abnormal connections between the arterial and venous systems within the cavernous sinus that are typically treated via endovascular approach. We aim to investigate the clinical characteristics of patients with dCCFs based on the endovascular treatment approach and assess angiographic and clinical outcomes.</p><p><strong>Methods: </strong>A systematic review of the literature was performed. Data including number of patients, demographics, presenting clinical symptoms, etiology of fistula, Barrow classification, and embolization material were collected and evaluated. Outcome measures collected included degree of fistula occlusion, postoperative symptoms, complications, and mean follow-up time.</p><p><strong>Results: </strong>A total of 52 studies were included examining four primary endovascular approaches for treating dCCFs: transarterial, transfemoral-transvenous (transpetrosal or other), transorbital (percutaneous or via cutdown), and direct transfacial access. Overall data was collected from 736 patients with 817 dCCFs. Transarterial approaches exhibit lower dCCF occlusion rates (75.6%) compared to transvenous techniques via the inferior petrosal sinus (88.1%). The transorbital approach via direct puncture or surgical cutdown offers a more direct path to the cavernous sinus, although with greater complications including risk of orbital hematoma. The direct transfacial vein approach, though limited, shows up to 100% occlusion rates and minimal complications.</p><p><strong>Conclusion: </strong>We provide a comprehensive review of four main endovascular approaches for dCCFs. In summary, available endovascular treatment options for dCCFs have expanded and provide effective solutions with generally favorable outcomes. While the choice of approach depends on individual patient factors and technique availability, traditional transvenous procedures have emerged as the first-line endovascular treatment. There is growing, favorable literature on direct transorbital and transfacial approaches; however, more studies directly comparing these general transvenous options are necessary to refine treatment strategies.</p>","PeriodicalId":14380,"journal":{"name":"Interventional Neuroradiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of digital subtraction angiography in acute cervical spinal cord ischemia. 数字减影血管造影术在急性颈脊髓缺血中的作用。
IF 1.7 4区 医学
Interventional Neuroradiology Pub Date : 2024-08-07 DOI: 10.1177/15910199241272610
Osama Intikhab, Brian Cristiano, Ali Tehrani, Steven Zeiler, Ryan J Felling, Philippe Gailloud
{"title":"Role of digital subtraction angiography in acute cervical spinal cord ischemia.","authors":"Osama Intikhab, Brian Cristiano, Ali Tehrani, Steven Zeiler, Ryan J Felling, Philippe Gailloud","doi":"10.1177/15910199241272610","DOIUrl":"10.1177/15910199241272610","url":null,"abstract":"<p><p>Ascertaining the etiology of cervical spinal cord dysfunction presents a challenge to clinicians, as the list of differential diagnoses is extensive. Although compressive and inflammatory disorders are common and should be considered immediately, vascular causes are similarly important and acute. The overlap of clinical, magnetic resonance imaging, and cerebrospinal fluid features among the causes of myelopathies may lead to erroneous diagnoses. Such errors may be compounded if routine vascular imaging does not reveal the underlying vasculopathy. We present here three cases in which computed tomography angiography and magnetic resonance angiogram could not clarify the nature of an acute myelopathy, whereas digital subtraction angiography established the diagnosis of spinal cord ischemia.</p>","PeriodicalId":14380,"journal":{"name":"Interventional Neuroradiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Degree of subarachnoid hemorrhage affects clinical outcome after mechanical thrombectomy for M2 occlusion. 蛛网膜下腔出血程度影响 M2 闭塞机械取栓术的临床疗效。
IF 1.7 4区 医学
Interventional Neuroradiology Pub Date : 2024-08-07 DOI: 10.1177/15910199241270706
Fumiaki Oka, Takuma Nishimoto, Naomasa Mori, Akiko Kawano, Hideyuki Ishihara
{"title":"Degree of subarachnoid hemorrhage affects clinical outcome after mechanical thrombectomy for M2 occlusion.","authors":"Fumiaki Oka, Takuma Nishimoto, Naomasa Mori, Akiko Kawano, Hideyuki Ishihara","doi":"10.1177/15910199241270706","DOIUrl":"10.1177/15910199241270706","url":null,"abstract":"<p><strong>Purpose: </strong>The prognostic relevance of post-mechanical thrombectomy (MT) subarachnoid hemorrhage (SAH) remains controversial. This study aimed to investigate whether the thickness of the SAH clot affects clinical outcomes following MT for M2 occlusion.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on a prospective database of patients who underwent MT for isolated M2 occlusion. Patients were categorized into three groups based on the presence and thickness of SAH. Clinical and angiographical characteristics and outcomes were compared.</p><p><strong>Results: </strong>Of the 36 patients included, SAH was observed in 15 (42%). When comparing patients with no SAH (grade 0) or thin SAH (grade 1) (N = 28) with those who had thick SAH (grade 2) (N = 8), patients with Grade 2 SAH required a higher number of passes and had a more severe angulation at M2. Patients with SAH Grade 2 had significantly worse NIHSS scores at 24 h (median, 4 vs. 14), but only one patient was identified as having a symptomatic intracranial hemorrhage. Patients with SAH Grade 2 were found to have a lower rate of favorable outcome (modified Rankin scale 0-2) (23% vs. 75%, P = 0.0026) and higher mortality (25% vs. 0%, P = 0.0499) at 90 days.</p><p><strong>Conclusion: </strong>The study found that thick SAH prevents clinical recovery after MT for M2 occlusion, even in cases of successful recanalization, and is associated with an unfavorable outcome. Thick SAH after MT is also linked to an increase in the number of passes and severe angulation at the M2 segment.</p>","PeriodicalId":14380,"journal":{"name":"Interventional Neuroradiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Part 2: The development and advancement of the detachable balloon catheter; a historical and technical review. 第 2 部分:可分离球囊导管的发展和进步;历史和技术回顾。
IF 1.7 4区 医学
Interventional Neuroradiology Pub Date : 2024-08-07 DOI: 10.1177/15910199241272531
Adrusht Madapoosi, Anthony Sanchez-Forteza, Tatiana Abou Mrad, Laura Stone McGuire, Peter Theiss, Mpuekela Tshibangu, Fady Charbel, Ali Alaraj
{"title":"Part 2: The development and advancement of the detachable balloon catheter; a historical and technical review.","authors":"Adrusht Madapoosi, Anthony Sanchez-Forteza, Tatiana Abou Mrad, Laura Stone McGuire, Peter Theiss, Mpuekela Tshibangu, Fady Charbel, Ali Alaraj","doi":"10.1177/15910199241272531","DOIUrl":"10.1177/15910199241272531","url":null,"abstract":"<p><p>The detachable balloon catheter (DBC) was a revolutionary technique for the treatment of cerebrovascular pathologies. It was used to treat carotid cavernous fistulas (CCFs), vertebro-jugular fistulas, arteriovenous malformations (AVMs), and aneurysms. The DBC became the foundation for neurointerventional techniques, leading to the development of coil embolization and bioactives. Our team selected relevant articles from PubMed published between 1974 and 2023. Articles were excluded if they did not discuss the use or development of the detachable balloon catheter or subsequent technologies. The DBC was used to occlude vessels, either temporarily or permanently. Dr Gerard Debrun implemented findings from Dr Fedor Serbinenko's research to develop an intravascular detachable balloon technique. He developed many variations using type I and type II balloon catheters that differed in size, length, and material, allowing for the personalization of treatment based on the lesion. This revolutionary thinking showed that every pathology has a different shape and anatomy that require a unique approach. The DBC would offer the first alternative to the conventional practice of carotid occlusion in CCF treatment at the time. The DBC would later be used in aneurysm occlusion and the embolization of AVMs, with additional benefit in traumatic vascular sacrifice. Although the DBC has largely been replaced, it is still useful in a small subset of patients, and has financial incentive as it is more affordable than coils. This technique was a monumental stride in the history of neurointervention and helped propel the specialty to the current era of patient-specific interventions.</p>","PeriodicalId":14380,"journal":{"name":"Interventional Neuroradiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigator-initiated clinical trial of stabilizer device: A novel intracranial exchange guidewire for neuroendovascular treatments. 由研究者发起的稳定器临床试验:用于神经内血管治疗的新型颅内交换导丝。
IF 1.7 4区 医学
Interventional Neuroradiology Pub Date : 2024-08-07 DOI: 10.1177/15910199241262851
Chiaki Sakai, Nobuyuki Sakai, Catherine Peterson, Tsuyoshi Ohta, Hidenori Oishi, Toshiyuki Fujinaka, Yuji Matsumaru, Akira Ishii, Hirotoshi Imamura, Shinichi Yoshimura, Takashi Izumi, Tetsu Satow, Yasushi Ito, Kenji Sugiu, Shigeru Miyachi, Teruyuki Hirano, Tatsuo Kagimura, Naoki Kaneko, Satoshi Tateshima
{"title":"Investigator-initiated clinical trial of stabilizer device: A novel intracranial exchange guidewire for neuroendovascular treatments.","authors":"Chiaki Sakai, Nobuyuki Sakai, Catherine Peterson, Tsuyoshi Ohta, Hidenori Oishi, Toshiyuki Fujinaka, Yuji Matsumaru, Akira Ishii, Hirotoshi Imamura, Shinichi Yoshimura, Takashi Izumi, Tetsu Satow, Yasushi Ito, Kenji Sugiu, Shigeru Miyachi, Teruyuki Hirano, Tatsuo Kagimura, Naoki Kaneko, Satoshi Tateshima","doi":"10.1177/15910199241262851","DOIUrl":"10.1177/15910199241262851","url":null,"abstract":"<p><strong>Background: </strong>Neuroendovascular procedures, especially those involving significant vessel tortuosity, giant intracranial aneurysms, or distally located lesions, frequently necessitate exchange methods. However, exchange maneuvers pose a risk of inadvertent vessel injury. To address these challenges, a Stabilizer device was developed and evaluated for its efficacy and safety. This clinical trial aimed to assess the efficacy and safety of the Stabilizer device in facilitating the navigation of neuroendovascular devices to target lesions in cases where the exchange technique was necessary.</p><p><strong>Methods: </strong>This was a single-arm, prospective, open-label, multicenter clinical trial performed at nine different sites. It focused on investigating the use of the Stabilizer device for treating intracranial aneurysms and atherosclerosis.</p><p><strong>Results: </strong>A total of 31 patients were enrolled across nine centers in Japan from July 21, 2022, to March 10, 2023. The study enrolled 24 (77.4%) patients with intracranial aneurysms and seven (22.6%) patients with intracranial artery stenosis. Majority of the target lesions were in the middle cerebral artery territory (83.9%). The Stabilizer device was used to exchange for 0.027-inch catheters, intermediate catheters, PTA balloons, and Wingspan stent system. The Stabilizer device demonstrated 100% technical success rate. While three complications related to the treatment were noted, there were no complications related to the device, including any vascular damage.</p><p><strong>Conclusions: </strong>This is the first multicenter clinical trial that investigated and demonstrated technical efficacy as well as overall safety profile of the Stabilizer device in neuroendovascular procedures where the use of an exchange method was necessary.</p>","PeriodicalId":14380,"journal":{"name":"Interventional Neuroradiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technical video: Onyx-18 embolization of spinal epidural arteriovenous Fistula using the scepter-Mini balloon catheter. 技术视频:使用 scepter-Mini 球囊导管对脊柱硬膜外动静脉瘘进行 Onyx-18 栓塞治疗。
IF 1.7 4区 医学
Interventional Neuroradiology Pub Date : 2024-08-01 Epub Date: 2022-11-10 DOI: 10.1177/15910199221138633
Krishna Amuluru, Andrew Denardo, John Scott, Troy Payner, Charles Kulwin, Daniel H Sahlein
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