International Journal of Psychiatry in Clinical Practice最新文献

{"title":"Comparing the efficacy of aripiprazole as an add-on to valproate with other second-generation antipsychotics in acute mania symptoms in manic patients in Iran.","authors":"Zeinab Sadat Ayatollahi,&nbsp;Mehran Shayganfard,&nbsp;Hamidreza Jamilian,&nbsp;Anita Alaghmand","doi":"10.1080/13651501.2022.2030758","DOIUrl":"https://doi.org/10.1080/13651501.2022.2030758","url":null,"abstract":"<p><strong>Background: </strong>Given the great importance of treating patients with bipolar disorder, the aim of this study was to compare the efficacy of aripiprazole with other second-generation antipsychotics in relieving acute symptoms of mania.</p><p><strong>Materials and methods: </strong>In this study, 50 patients with bipolar I disorder, manic episode, were divided into two groups receiving aripiprazole (<i>n</i> = 25) and other second-generation antipsychotics (risperidone, olanzapine, and quetiapine) (<i>n</i> = 25) for 6 weeks. The disease severity was evaluated and compared according to YMRS and CGI criteria.</p><p><strong>Results: </strong>The mean severity of mania according to YMRS and CGI, at week 0 in comparison with weeks 2, 4 and 6 in both groups was significantly different (<i>p</i> < 0.0001) and the treatment with Aripiprazole at week 2 (<i>p</i> < 0.0001) and 4 (<i>p</i> = 0.0002) was significantly better than the other second-generation antipsychotics. The two groups also showed an overall improvement in CGI-based results at weeks 4 and 6 (<i>p</i> = 0.002). In addition, the efficacy index for aripiprazole at weeks 4 (<i>p</i> = 0.011) and 6 (<i>p</i> < 0.0001) as well as disease improvement in the second (<i>p</i> < 0.0001) and fourth (<i>p</i> = 0.026) weeks after treatment were better than the other second-generation antipsychotics.</p><p><strong>Conclusions: </strong>Aripiprazole and other second-generation antipsychotics, 2 weeks after initiation of treatment, significantly reduced mania severity in patients with bipolar disorder, however, aripiprazole seems to be more efficient and faster for controlling mania in patients with bipolar disorder.KEY POINTSAripiprazole and other second-generation antipsychotics, 2 weeks after initiation of treatment, significantly reduced mania severity in patients with bipolar disorder.Comparison between the two drugs, aripiprazole showed a more beneficial role in the second and fourth weeks than second-generation antipsychotics.Due to the fact that the possible mechanisms involved in the role of aripiprazole have not been considered compared to other antipsychotics in patients with bipolar disorder, there is a need for more extensive studies in this field.</p>","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":"26 4","pages":"363-369"},"PeriodicalIF":3.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10374474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparable reliability and acceptability of telepsychiatry and face-to-face psychiatric assessments in the emergency room setting.","authors":"Moises Bistre,&nbsp;Alzbeta Juven-Wetzler,&nbsp;Daniel Argo,&nbsp;Igor Barash,&nbsp;Gregory Katz,&nbsp;Ronen Teplitz,&nbsp;Muhamad-Musa Said,&nbsp;Yoav Kohn,&nbsp;Omer Linkovski,&nbsp;Renana Eitan","doi":"10.1080/13651501.2021.1979586","DOIUrl":"https://doi.org/10.1080/13651501.2021.1979586","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to compare the reliability and acceptability of psychiatric interviews using telepsychiatry and face-to-face modalities in the emergency room setting.</p><p><strong>Methods: </strong>In this prospective observational feasibility study, psychiatric patients (<i>n</i> = 38) who presented in emergency rooms between April and June 2020, went through face-to-face and videoconference telepsychiatry interviews in a non-randomised varying order. Interviewers and a senior psychiatry resident who observed both interviews determined diagnosis, recommended disposition and indication for involuntary admission. Patients and psychiatrists completed acceptability post-assessment surveys.</p><p><strong>Results: </strong>Agreement between raters on recommended disposition and indication for involuntary admission as measured by Cohen's kappa was 'strong' to 'almost perfect' (0.84/0.81, 0.95/0.87 and 0.89/0.94 for face-to-face vs. telepsychiatry, observer vs. face-to-face and observer vs. telepsychiatry, respectively). Partial agreement between the raters on diagnosis was 'strong' (Cohen's kappa of 0.81, 0.85 and 0.85 for face-to-face vs. telepsychiatry, observer vs. face-to-face and observer vs. telepsychiatry, respectively).Psychiatrists' and patients' satisfaction rates, and psychiatrists' perceived certainty rates, were comparably high in both face-to-face and telepsychiatry groups.</p><p><strong>Conclusions: </strong>Telepsychiatry is a reliable and acceptable alternative to face-to-face psychiatric assessments in the emergency room setting. Implementing telepsychiatry may improve the quality and accessibility of mental health services.Key pointsTelepsychiatry and face-to-face psychiatric assessments in the emergency room setting have comparable reliability.Patients and providers report a comparable high level of satisfaction with telepsychiatry and face-to-face modalities in the emergency room setting.Providers report a comparable level of perceived certainty in their clinical decisions based on telepsychiatry and face-to-face psychiatric assessments in the emergency room setting.</p>","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":"26 3","pages":"228-233"},"PeriodicalIF":3.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39473278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of antineuronal antibodies and 8-OHdG in mothers of children with autism spectrum disorder: a case-control study.","authors":"Şermin Bilgen Ulgar,&nbsp;Hamza Ayaydın,&nbsp;Hakim Çelik,&nbsp;İsmail Koyuncu,&nbsp;Adnan Kirmit","doi":"10.1080/13651501.2021.1993925","DOIUrl":"https://doi.org/10.1080/13651501.2021.1993925","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of our study was to investigated the anti-Yo, anti-Hu, anti-Ri, anti-amphiphysin antibody levels and 8-OHdG in mothers of children with autism.</p><p><strong>Methods: </strong>This study included 60 participants, 33 of whom were healthy mothers of 3-12-year-old children diagnosed with autism spectrum disorder (ASD) and the 27 others who constituted the control group, were healthy mothers with age-matched healthy children. Two groups were examined for plasma anti-Yo, anti-Hu, anti-amphiphysin and anti-Ri antibodies and, 8-OHdG levels. The participants were asked to accomplish a sociodemographic data form. The severity of ASD symptoms was evaluated according to the Childhood Autism Rating Scale (CARS).</p><p><strong>Results: </strong>Anti-amphiphysin antibody levels and anti-Ri antibody positivity were significantly higher in the case group (<i>p</i> = 0.001; <i>p</i> = 0.027, respectively). The two groups did not significantly differ in terms of anti-Yo and anti-Hu antibody levels and in terms of 8-OHdG levels (<i>p</i> = 0.065; <i>p</i> = 0.099; <i>p</i> = 0.490, respectively). The two groups did not significantly differ in terms of sociodemographic data (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>According to the our study, maternal antineuronal antibodies, such as anti-amphiphysin and anti-Ri, may contribute to the risk of childhood autism. Studies with larger samples are needed.KEY POINTSMaternal factors associated with autism should be investigated in order to create early diagnosis and treatment opportunities for autism.Based on the importance of immunological and cerebellar pathologies in autism aetiology, we aimed to investigate antineuronal antibodies in mothers of children with autism.Maternal antineuronal antibodies, such as anti-amphiphysin and anti-Ri, may contribute to the risk of childhood autism.High anti-amphiphysin antibody levels in mothers of children with autism may also occur against the amphiphysin in the structure of the SrGAP3 gene, which is associated with autism.</p>","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":"26 3","pages":"244-250"},"PeriodicalIF":3.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39554194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health care utilisation in treatment-resistant depression: a Swedish population-based cohort study.","authors":"Philip Brenner,&nbsp;Adam Nygren,&nbsp;David Hägg,&nbsp;Mikael Tiger,&nbsp;Marguerite O'Hara,&nbsp;Lena Brandt,&nbsp;Johan Reutfors","doi":"10.1080/13651501.2021.2003405","DOIUrl":"https://doi.org/10.1080/13651501.2021.2003405","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the health care utilisation (HCU) among patients with treatment-resistant depression (TRD) compared to patients with depression not meeting TRD criteria.</p><p><strong>Methods: </strong>Nationwide Swedish registers were used to identify patients 18-69 years old with incident depression and antidepressant treatment. Patients were followed prospectively and defined as having TRD at start of the third distinct consecutive treatment episode. Each of the 16,329 identified TRD patients were matched with five comparators with depression not meeting criteria for TRD. Main outcome measure was total number of inpatient days and outpatient visits, and secondary outcome was HCU in connection with a main diagnosis of depression or suicide attempt.</p><p><strong>Results: </strong>TRD patients had a significantly higher risk of all-cause inpatient care than comparators (first year adjusted risk ratio [aRR] 3.03 [95%CI 3.01-3.05], years 1-3 aRR 2.15 [2.13-2.16]). This was more pronounced when the main diagnosis was depression (first year aRR 4.41 [4.36-4.45]), and after suicide attempt (first year aRR 4.43 [4.26-4.60]). Outpatient visits were also markedly more frequent for patients with TRD (first year aRR 2.05 [2.03-2.07]). Higher HCU among TRD patients persisted throughout follow-up.</p><p><strong>Conclusions: </strong>Patients with TRD may have a twofold to fourfold higher HCU than other patients with depression.KEYPOINTSThis register-based prospective study investigated health care utilisation (HCU) among patients with treatment-resistant depression (TRD) compared to other patients with depression.Patients with TRD had a two to fourfold higher HCU regarding all measured outcomes, including inpatient hospital days and outpatient visits.The elevated HCU persisted for more than three years, although decreasing gradually. This should correspond to increased costs and individual burden for patients with TRD.</p>","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":"26 3","pages":"251-258"},"PeriodicalIF":3.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39682277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial 3.","authors":"Siegfried Kasper","doi":"10.1080/13651501.2022.2128578","DOIUrl":"https://doi.org/10.1080/13651501.2022.2128578","url":null,"abstract":"It is my great pleasure to welcome you to the third issue of the International Journal of Psychiatry in Clinical Practice in 2022. In this issue’s highlight, Volz et al. review available literature in order to aid in the operationalisation and epidemiology of subsyndromal generalised anxiety disorder. The result of this meticulous systematic review reveal that subsyndromal anxiety disorder poses a notable burden of disease to a large number of individuals. Additionally, authors propose a unified definition of subthreshold GAD. Polat et al. assessed the validity and reliability of the Turkish version of the self-evaluation of negative symptoms scale (SNS). Authors successfully indicate adequate internal consistency and a confirmatory five-factor structure akin to the original SNS. Bistre et al. examined comparable reliability and acceptability of telepsychiatry and face-to-face psychiatric assessments in the emergency room setting. In their prospective observational feasibility study, researchers illustrate that telepsychiatry is a well-grounded option to traditional face-to-face assessments. This finding is particularly interesting, as the rising trend of online treatment may allow for more remote psychiatric practices. In a meta-analysis, Khraisat et al. explored the pooled prevalence of mental disorders among COVID-19 survivors. Results indicate that not only were psychological sequelae evident amongst mentioned patient group, but spanned a variety of disorders and symptoms such as anxiety, depression, psychological distress, and sleep disorders. In a case-control study, Ulgar and colleagues evaluated antineuronal antibodies and 8-OHdG in mothers of children with autism spectrum disorder. Findings suggest that anti-amphiphysin and anti-RI antibody positivity appear to be significantly lower in the control as compared to the case group. Specifically, these results elucidate the role of antineuronal antibodies as potential risk-factors for childhood autism. Brenner and colleagues investigated the health care utilisation (HCU) in treatment-resistant depression (TRD) in a Swedish population-based cohort study. Patients suffering from treatment-resistant depression were matched with patients that do not fulfil the criteria for TRD. Not only did increased HCU occur significantly more often among patients with TRD (2 – 4 higher), but findings persisted longer for the TRD group than the nonTRD group. In an attempt to research the effects of electroconvulsive therapy (ECT) non nitrosative stress and oxidative DNA damage parameters in patients with a depressive episode, Karaya gmurlu et al. found that while ECT can decrease non nitrosative stress, it might increase oxidative DNA damage in individuals with depression. Plunkett and colleagues bridge the gap in research by quantitively evaluating dignity, coercion and involuntary psychiatric care in a study of involuntary and voluntary psychiatry inpatients in Dublin, Ireland. As previously not found in qua","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":"26 3","pages":"219-220"},"PeriodicalIF":3.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33497121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of lockdown on emergency room admissions for psychiatric evaluation: an observational study from 4 centres in Italy.","authors":"Massimiliano Beghi,&nbsp;Silvia Ferrari,&nbsp;Riccardo Brandolini,&nbsp;Ilaria Casolaro,&nbsp;Matteo Balestrieri,&nbsp;Chiara Colli,&nbsp;Carlo Fraticelli,&nbsp;Rosaria Di Lorenzo,&nbsp;Giovanni De Paoli,&nbsp;Alessandra Nicotra,&nbsp;Livia Pischiutta,&nbsp;Enrico Tedeschini,&nbsp;Giulio Castelpietra","doi":"10.1080/13651501.2021.1980588","DOIUrl":"https://doi.org/10.1080/13651501.2021.1980588","url":null,"abstract":"<p><p><b>Objectives:</b> An observation of the Emergency Room (ER) admissions during the lockdown.<b>Methods:</b> We monitored admissions to the ER requiring psychiatric evaluation during the 2020 lockdown (March 9^th-May 3^rd, 2020) compared to the same period of 2019, in four sites of Northern Italy (ASST Lariana, AUSL Modena, ASU Friuli Centrale and AUSL Romagna). Number of admissions, baseline demographic and clinical variables were extracted from the clinical databases.<b>Results:</b> A 20.0% reduction of psychiatric referrals was observed across the sites (24.2% in ASST Lariana, 30.5% in AUSL Modena, 12.0% in ASU Friuli Centrale and 14.5% in AUSL Romagna). This reduction peaked at 41.5% in the first month of the lockdown. Being homeless as well as with a dual diagnosis (OR 1,67, CI: 1.02-2.74), while living in a residential facility and admission for a depressive episode Being homeless (OR 2.50, CI: 1.36-4.61) and having a dual diagnosis (OR 1,67, CI: 1.02-2.74) were significantly associated with an increase in ER admission, while living in a residential facility (OR 0.48, CI: 0.31-0.74), having a depressive episode (OR 0.36, CI: 0.18-0.73) and a diagnosis of anxiety disorder (OR 0.60, CI: 0.36-0.99) were significantly associated with a decrease.<b>Conclusions:</b> During lockdown, a decrease in psychiatric referrals was observed.</p>","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":"26 3","pages":"316-320"},"PeriodicalIF":3.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39496852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotic symptoms prior or concomitant to diagnosis of multiple sclerosis: a systematic review of case reports and case series.","authors":"Michel Sabe,&nbsp;Othman Sentissi","doi":"10.1080/13651501.2021.1973506","DOIUrl":"https://doi.org/10.1080/13651501.2021.1973506","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to examine the clinical features of psychotic symptoms preceding or concomitant to multiple sclerosis (MS) diagnosis.</p><p><strong>Method: </strong>From the 1st to 10th of January 2020 a systematic review was conducted through an electronic search of different databases. Results were limited to English, French, German, Italian and Spanish language articles.</p><p><strong>Results: </strong>We identified 599 titles, and included 32 cases from case-report and case series. One case report from our department was added. The mean age of first psychiatric symptoms was 25.8 ± 10.2 years, the mean age of MS diagnosis was 31.2 ± 10.7 years and the mean delay until MS diagnosis was 2.7 ± 3 years. Most reported symptoms were delusions (81%), auditory hallucinations (59%) and visual hallucinations (50%). Upon the MS diagnosis, immunosuppressive therapy was significantly more effective for psychotic symptoms than antipsychotics (OR = 9.0; 95%CI: 2.15-37; <i>p</i> = 0.002). Diffuse periventricular lesions were found in 95.6% of cases, with mostly temporal or frontal predominant lesions. In cases affected by predominant temporal lesions, 83% of cases presented visual hallucinations (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Poor response or resistance to antipsychotics treatment should alert clinicians on the need to consider a differential diagnosis. Considering the impact of delay in MS diagnosis further research regarding this subject is warranted.KEY POINTSInsight into the occurrence of psychotic symptoms in multiple sclerosis (MS) is mainly limited to case reports and case series.Delay in MS management between initial psychotic symptoms and the MS diagnosis is 2.73 ± 3 years and 0.8 ± 1.2 years for patients presenting a first episode of psychosis.The resistance and poor response to antipsychotics found in most cases (75%) were associated with an excellent improvement (95%) of both psychiatric and neurologic symptoms with corticosteroids.Prospective studies are needed to investigate the spectrum of psychosis in MS.</p>","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":"26 3","pages":"287-293"},"PeriodicalIF":3.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39388499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subsyndromal generalised anxiety disorder: operationalisation and epidemiology - a systematic literature survey.","authors":"Hans-Peter Volz,&nbsp;Julia Saliger,&nbsp;Siegfried Kasper,&nbsp;Hans-Jürgen Möller,&nbsp;Erich Seifritz","doi":"10.1080/13651501.2021.1941120","DOIUrl":"https://doi.org/10.1080/13651501.2021.1941120","url":null,"abstract":"<p><p>The diagnosis of anxiety disorders, like other psychiatric disorders also, is operationalised since the introduction of diagnostic manuals. The diagnostic criteria of Generalised Anxiety Disorder (GAD) have been tightened in the last decades. This leads to the exclusion of patients with a high level of anxiety, but not fulfilling certain of the GAD-criteria, from effective treatment. Such so-called subsyndromal, subthreshold or subclinical GAD-states, however, often exhibit a comparable burden of disease like the full syndromal disorder and often tend to develop into the full syndromal disorder. The purpose of this review is - beside systematically reporting the papers found in respective data bases from 2013 onwards - to summarise the relevant data regarding definitions, epidemiology and consequences of subsyndromal anxiety states in order to give a comprehensive review.</p>","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":"26 3","pages":"277-286"},"PeriodicalIF":3.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13651501.2021.1941120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39226267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: Bright light treatment of non-seasonal depression for 28 adolescents.","authors":"","doi":"10.1080/13651501.2021.1934081","DOIUrl":"https://doi.org/10.1080/13651501.2021.1934081","url":null,"abstract":"Helmut Niederhofer & Kai von Klitzing (2012) Bright light treatment as mono therapy of non -seasonal depression for 28 adolescents, International Journal of Psychiatry in Clinical Practice, 16:3, 233-237, DOI: 10.3109/13651501.2011.625123. Since publication, concerns have been raised that this is a redundant publication. Upon investigation, it was discovered that the article is near identical and reports the same results to a previously published article:","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":"26 3","pages":"327"},"PeriodicalIF":3.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13651501.2021.1934081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39237533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced ability to discriminate colours - an under-recognised feature of depressive disorders? A pilot study.","authors":"Eberhard A Deisenhammer,&nbsp;Anna Strasser,&nbsp;Georg Kemmler","doi":"10.1080/13651501.2021.1993263","DOIUrl":"https://doi.org/10.1080/13651501.2021.1993263","url":null,"abstract":"<p><p><b>Background:</b> Although in clinical practice an impairment of sensory perception is frequently reported by depressed patients no mention of these symptoms is made in DSM-5, ICD-10 or ICD-11. Previous studies on colour perception have largely relied on patient self-reports and few have studied colour discrimination.<b>Methods:</b> The ability to discriminate small colour differences was assessed in 30 patients currently experiencing a moderate to severe depressive episode (ICD-10: F32.1-2, F33.1-2 or F31.3-4) and 32 healthy controls using the colour buttons of the Farnsworth Munsell 100-Hue test. Data were analysed by standard tests for comparing two groups (t-test, Mann-Whitney U-test, Chi-square test) and by ordinal regression and generalised estimating equation models.<b>Results:</b> Depressed patients failed significantly earlier (i.e., at larger differences between adjacent buttons) to discriminate between colours. This finding was retained after adjustment for potential confounders. There was no significant association with age, gender or depression score.<b>Conclusions:</b> We found a reduction in the ability to discriminate colours in depressed patients. This finding underlines the importance of sensory deficits as part of the symptomatology of depression. Sensory impairments should be taken into account in clinical care of patients with depression and should be included in diagnostic manuals. Further studies in larger samples including intra-individual comparisons between the depressed and the remitted state of patients are needed.Key pointsIn clinical practice, an impairment of sensory perception is frequently reported by depressed patients.However, no mention of these symptoms is made in the commonly used diagnostic manuals.In this pilot study, depressed patients and controls differed significantly in terms of the ability to discriminate colours with patients performing worse than their healthy counterparts.Sensory impairments should be taken into account in clinical care of patients with depression and should be included in diagnostic manuals.</p>","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":"26 3","pages":"321-326"},"PeriodicalIF":3.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39552548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}