International Journal of Women's Health and Reproduction Sciences最新文献

{"title":"Randomised Control Trial of 3 IU Intravenous Oxytocin Bolus With 7 IU Oxytocin Infusion Versus 10 IU Intramuscular Oxytocin in the Third Stage of Labour in the Prevention of Postpartum Hemorrhage","authors":"Aruna M Biradar, Rajasri G Yaliwal, S. Kori, Sangamesh S Mathapati, Shobha S Shiragur, S. Mudanur","doi":"10.15296/ijwhr.2021.32","DOIUrl":"https://doi.org/10.15296/ijwhr.2021.32","url":null,"abstract":"Objectives: Intravenous (IV) oxytocin during vaginal delivery has been rarely used since an intramuscular (IM) route or IV infusion have been preferred in this regard. The trial aimed to compare the low-dose IV bolus 3 IU of oxytocin, along with 7 IU oxytocin infusion with 10 IU oxytocin infusion in cesarean section. Materials and Methods: A parallel control randomized study was conducted on a total of 320 consenting term pregnant women based on the inclusion criteria. The participants were randomized into either 3 IU IV bolus and 7 IU infusion of oxytocin or 10 IU of IM oxytocin following vaginal delivery. The difference in pre- and post-delivery hemoglobin (Hb) levels, tone of the uterus, hemodynamic changes, adverse effects of the drug, and the need for additional uterotonics and blood transfusions were assessed based on the aim of the study. Results: Based on the results, more women with severe blood loss were found in the IM oxytocin group in comparison to the IV bolus with infusion group following vaginal delivery. In addition, more women had a drop in the Hb of 3 gm/dL in the IM oxytocin group compared to the IV bolus-infusion group (11% vs. 4%, odds ratio=0.768, P=0.469) although there was no statistical significance in this respect. The tone of the uterus was firmer in the IV bolus with infusion group at 3 and 5 minutes. Eventually, the difference in hemodynamic changes, side effects, and the need for additional uterotonics or blood transfusions was not significant. Conclusions: In general, an IV bolus of 3 IU with a 7 IU infusion of oxytocin is as safe as and more effective than the IM injection of 10 IU of oxytocin at the time of vaginal delivery for the prevention of postpartum hemorrhage.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72861698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Oocyte and Embryo Quality in Women With Polycystic Ovary Syndrome and the Control Group Candidate for In Vitro Fertilization and Intracytoplasmic Sperm Injection","authors":"Maliheh Afiat, N. Khadem, Elnaz Nayeri, Roya Jalali, S. Akhlaghi, Elaheh Akhgari, A. Attaranzadeh, F. Borzoee, Azadeh Khazaie, Behnaz Souizi","doi":"10.15296/ijwhr.2021.31","DOIUrl":"https://doi.org/10.15296/ijwhr.2021.31","url":null,"abstract":"Objectives: Polycystic ovary syndrome (PCOS) is the most common cause of female infertility. The aim of this study was to compare the oocyte and embryo quality between the PCOS women with the control group candidate for in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI). Materials and Methods: The present study was designed at the Infertility Research Center of Milad in the prospective cohort format and was carried out on 100 cases of infertile women with confirmed PCOS (case group) and the male factor (control group) as the first IVF cycle candidates. Both groups underwent the ovary stimulation cycle and ICSI under the standard antagonist protocol. The collected data were then processed and analyzed using the SPSS software, version 16. Results: The average age of study cases was 35±3, and oocyte necrosis was the underlying pathological factor in both groups (28% and 26% in the PCOS and control groups, respectively). In addition, most embryones belonged to either grade 1 or 2 or were 8-cell embryos. Furthermore, the highest number of transferred embryos among the patients was related to the 8-cell and grade 1. The occurrences of biochemical pregnancy in the PCOS and control groups were up to 31.91% and 22%, respectively, leading to 72.73% and 60% childbirth in cases of both groups. Finally, there were no significant differences observed with respect to the quality and the quantity of the embryones, the oocyte, the transferred embryo, the germinal vesicle oocytes, and the rate of pregnancy among the two groups (P>0.05). Conclusions: According to the results of the present study, no differences were found concerning the oocyte quality, embryo, and the pregnancy rate between PCOS cases and any other patients requiring ICSI. Therefore, such cases can similarly benefit from ICSI methods as well.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76166512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Relationship of Anthropometric Indices With Vitamin D, Zinc, and Fasting Blood Sugar Levels in Women With and Without Infection Following Abdominal Hysterectomy: A Case-Control Study","authors":"Sanaz Mousavi, Hamid Owaysee Osquee, Seyed Mehdi Haghdoost","doi":"10.15296/ijwhr.2021.36","DOIUrl":"https://doi.org/10.15296/ijwhr.2021.36","url":null,"abstract":"Objectives: It is necessary to prevent postoperative infection following abdominal hysterectomy. The present study aimed to assess the relationship of anthropometric indices with vitamin D, zinc (Zn), and fasting blood sugar (FBS) levels in women with and without infection following abdominal hysterectomy in order to determine the exact effects of these factors on infection. Materials and Methods: This case-control study was conducted in three teaching hospitals affiliated with Tabriz University of Medical Sciences in an 18-month period leading up to 2020. The participants consisted of 90 women who were candidates for abdominal hysterectomy. Anthropometric indices and vitamin D, Zn, and FBS levels were measured before the surgery. These factors were compared in the two groups of women with and without infection using the independent t-test and Pearson correlation coefficient, and P<0.05 was statistically significant. Results: No significant relationship was found between vitamin D, Zn, and FBS levels and anthropometric indices except for body mass index (BMI) that had a significant negative relationship with vitamin D blood levels (r = -0.20 and P = 0.043) while a significant positive relationship with FBS levels (r= +30 and P = 0.036) in infected patients. Therefore, patients with a higher BMI showed lower vitamin D whereas higher FBS levels in the group with infection. Conclusions: In general, vitamin D levels decreased and FBS levels increased by an increase in the BMI. These factors altogether increased the risk of postoperative infection following abdominal hysterectomy.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85006172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premature Restriction of Foramen Ovale in an Anemic Fetus From a Rhesus-negative Mother: A Case Report","authors":"H. Vafaei, N. Asadi, Ali Mohammad Shakibafard, M. Kasraeian, Neda Rahimirad, Shaghayegh Moradi Alamdarloo, Shohreh Roozmeh, K. Hessami","doi":"10.15296/ijwhr.2021.28","DOIUrl":"https://doi.org/10.15296/ijwhr.2021.28","url":null,"abstract":"Rhesus (Rh) negative women who are exposed to Rhpositive red blood cells (RBCs) (e.g., those who deliver a D-positive baby) are at the risk of developing anti-D antibodies against the Rh antigens present on the surface of RBCs. Memory response of maternal immune system in subsequent re-exposures makes Ig G antibody which is transferred across the placenta into the fetal circulation. Rh-positive fetuses from these mothers are at the risk of serious morbidity and mortality, and a group of disorders such as severe hemolytic anemia, hydrops fetalis, and intrauterine fetal demise if not treated. The fetal middle cerebral artery-peak systolic velocity (MCA-PSV) is a noninvasive tool for the diagnosis of fetal anemia. The sensitivity of MCA-PSV> 1.5 MoM (multiples of the median) is 100% for the prediction of moderate or severe anemia in the fetuses never transfused with a false positive rate of 12% (1). During intrauterine life, foramen ovale (FO) is the only pathway for the oxygenated maternal blood to enter from the right atrium of the heart to the left one and then being pumped into the upper part of fetus’s body (2). Premature closure or restriction of the FO is a rare and serious clinical condition that prevents this normal fetal blood circulation. It can be associated with fetal arrhythmia, right -side heart failure, pericardial effusion, tricuspid regurgitation (TR), non-immune hydrops fetalis, and intrauterine fetal death with unknown causes during the pregnancy (3,4). Premature restriction of FO is diagnosed based on the following criteria (5): • An FO diameter <3 mm with a Doppler velocity measured gradient >5 mm Hg or • FO diameter <2 mm with Doppler velocity >120 cm/s In this study, a case of premature restriction of FO was described in a fetus from the RH alloimmunizated mother who had severe intrauterine hemolytic anemia not detected antepartum by routine Doppler ultrasound examination of MCA-PSV-MoM..","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2019-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84043758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Short-term Foot Reflexology in Improving Constipation Symptoms During Pregnancy: A TwoArmed, Randomized Controlled Trial","authors":"Fahimeh Sehhatti, C. Hughes, M. Mirghafourvand, Zahra Anjoman Azari","doi":"10.15296/IJWHR.2020.49","DOIUrl":"https://doi.org/10.15296/IJWHR.2020.49","url":null,"abstract":"\u0000 Objectives: Reflexology is a popular type of complementary medicine in medical practices, especially in midwifery fields. Materials and Methods: This randomized controlled trial aimed to determine the effect of foot reflexology on idiopathic constipation symptoms, as well as anxiety and fetal activity during pregnancy. This study was conducted on seventy-four nulliparous women with constipation, referring to private and public health care centers in Tabriz-Iran, between 2017 and 2018. The participants were then randomly assigned to foot reflexology or control groups. The intervention group underwent 12 minutes of weekly foot reflexology treatment for 6 weeks. Constipation symptoms were measured at baseline and 6 times (weekly) after the intervention by the Constipation Assessment Scale (CAS). In addition, the State-Trait Anxiety Inventory (STAI) questionnaire was used to measure the participant’s anxiety at baseline and 6 weeks after the completion of the study. Finally, fetal movements were measured at baseline and 6 times (weekly) after the intervention using a kick chart. Results: Based on the results, 97% of women reported improvement in their CAS measures at the end of six weeks following reflexology. The mean scores of STAI at the end of the intervention were 38.5 and 42.2 (State anxiety), as well as 39.1 and 40.2 (Trait anxiety) in the reflexology and control groups, respectively. Statistically significant differences in fetal movements between the two groups were only observed in the fourth (P=0.001) and fifth weeks (P=0.007) after intervention sessions. The results further indicated that about 67% of mothers were satisfied with reflexology intervention for improvement in their constipation symptoms. Eventually, no harmful side events were reported among women. Conclusions: Short-term foot reflexology in this context may have potential healing benefits in improving constipation and anxiety symptoms during pregnancy. However, further investigation for antenatal reflexology is necessary.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82426532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can We Use Placental Growth Factor-Based Tests to Assess Women With Suspected Pre-eclampsia?","authors":"Nevin Sağsöz","doi":"10.15296/ijwhr.2019.71","DOIUrl":"https://doi.org/10.15296/ijwhr.2019.71","url":null,"abstract":"<jats:p>\u0000 </jats:p>","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89925562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Peer Education on Fear of Childbirth in Pregnant Women: A Randomized Clinical Trial","authors":"R. Rahmani, Fatemeh Yaghoobi Moghadam, Fatemeh Hadizadeh-Talasaz, M. Rahmani","doi":"10.15296/ijwhr.2020.33","DOIUrl":"https://doi.org/10.15296/ijwhr.2020.33","url":null,"abstract":"\u0000 Objectives: The fear of childbirth (FOC) is a common problem in women’s lives. Several interventions were carried out to reduce the fear of delivery during pregnancy. Despite these interventions, the increase in cesarean statistics indicates that routine interventions are not effective in controlling the FOC. Accordingly, the present study investigated the effect of peer education on the degree of FOC in pregnant women. Materials and Methods: This clinical trial was performed on 108 low-risk pregnant women aged 18-35 years old referring to community health centers of Gonabad University of Medical Sciences. The participants were randomly assigned to peer education, discussion, and control groups using block randomization (36 in each group). The peer education and discussion groups included four 2-hour sessions for 4 weeks and a training booklet. In peer education and discussion groups, the training was done by trained counterparts and a specialist, respectively. Finally, the data were analyzed using SPSS software through ANOVA and chi-square tests. Results: The results showed a significant difference between mean scores of the FOC in the 3 groups after the intervention (P=0.007). In addition, the Scheffe test showed a significant difference between peer education and the discussion groups (P=0.013). However, after 4 weeks of intervention, no significant difference was observed in the choice of delivery type in the 3 groups (P=0.122). Conclusions: In general, the interventional therapy program of peer education is effective in decreasing the FOC in pregnant women.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2019-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75207984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Investigation Into the Effects of Magnesium Sulfate on the Complications of Succinylcholine Administration in Nulliparous Women Undergoing Elective Cesarean Section: A Double-Blind Clinical Trial","authors":"Davoud Aghamohamadi, M. Khanbabayi Gol","doi":"10.15296/ijwhr.2019.86","DOIUrl":"https://doi.org/10.15296/ijwhr.2019.86","url":null,"abstract":"Objectives: Controlling the complications of anesthetics (e.g., succinylcholine) seems necessary since they are greater for nulliparous women who undergo elective cesarean section (C-section). The present study aimed to investigate the effects of magnesium sulfate on the complications of succinylcholine administration in nulliparous women undergoing elective C-section. Materials and Methods: This double-blind clinical trial was conducted on 60 nulliparous women during 2012-2013. The women were randomly assigned to A and B groups. Before inducing the rapid anesthesia with succinylcholine, patients in the intervention group received 30 mg/kg of magnesium sulfate within 10 minutes and then the hemodynamic status and the side effects of succinylcholine were recorded in a special form. Statistical tests were performed using repeated-measures ANOVA, chi-square test, and one-way ANOVA tests and the level of significance was determined to be P<0.05. Results: There was no significant difference between the two groups in terms of demographic data (P>0.059). However, the results indicated that there was a significant difference between the 2 groups regarding the myoglobin level (P=0.010). Contrarily, the results showed that most patients in the intervention (n=23) and control (n=15) groups experienced no or mild and severe fasciculation, respectively (P<0.001). Conclusions: In general, magnesium sulfate can greatly control and reduce the complications of succinylcholine administration, including fasciculation.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2019-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79629110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiotherapy and Pelvic Floor Muscle Exercises for the Prevention and Treatment of Pregnancy-Related Pelvic Floor Dysfunctions: A Systematic Review and Meta-analysis","authors":"Fahimeh Khorasani, F. Ghaderi, P. Sarbakhsh, P. Ahadi, E. Khorasani, F. Ansari, Nafiseh Vahed","doi":"10.15296/ijwhr.2020.20","DOIUrl":"https://doi.org/10.15296/ijwhr.2020.20","url":null,"abstract":"\u0000 Objectives: The present systematic review focused on the prevention or treatment of three main types of pelvic floor dysfunctions (PFDs) specifically pelvic organ prolapse (POP), urinary incontinence (UI), and fecal incontinence (FI) using physiotherapy and pelvic floor muscle exercises (PFMEs). With regard to the breadth of the problem, there is not much evidence grounded on the best management. The main purpose of this systematic review was to evaluate the effects of physiotherapy and PFMEs on the prevention and treatment of pregnancy-related PFDs; namely, POP, FI, and UI. Therefore, this review incorporated studies comparing the use of physiotherapy and PFMEs with every other existing interventions. Methods: This systematic review and meta-analysis was conducted on randomized-controlled-trial (RCT) articles and quasi-RCT designs through a search in the studies published with no time limits until December 2017 in the databases of PubMed (Medline), Web of Science, Scopus, Embase, Cochrane Library, and ProQuest. The meta-analysis was also applied for data synthesis. Moreover, heterogeneity was assessed using Cochran’s Q test and I2 index. Results: A total number of 26 RCTs were examined in this review in which the outcome variables were related to POP, UI, and FI prevalence; POP, UI, and FI severity, as well as pelvic floor muscle (PFM) strength and endurance. In most articles, UI prevalence or severity in intervention groups had significantly improved compared with those in controls. The number of studies examining POP and FI was also relatively low. In two studies, FI severity or prevalence in intervention groups had significantly enhanced in comparison with those in control groups; however, FI prevalence in two articles had been reported lower in intervention groups than that in control groups although no significant difference had been observed. There was also no significant improvement in intervention groups in two other studies in this respect. Besides, three articles had not reported traces of improvement in POP, as well as a significant difference between intervention and control groups. Nevertheless, two studies had found a significant improvement in POP in this regard. Based on meta-analysis results for the variable of PFM strength, Cochran’s Q test (P<0.001) and I2 index (90.02) indicated heterogeneity between studies; so, a random-effect meta-analysis was applied to estimate overall effect sizes. The overall mean differences following intervention between the study groups were also equal to 6.94, with a 95% CI (1.36 to 12.52). Conclusions: It was concluded that physiotherapy and PFMEs might have effects on pregnancy-related UI, but they had not consistently reduced FI severity or prevalence and failed to constantly improve POP.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2019-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80413908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Examination of the Therapeutic Deficiency of Oral Metronidazole Plus Prangos ferulacea Vaginal Cream Versus Oral Metronidazole Plus Placebo Vaginal Cream in Accelerating Trichomonas Vaginalis Infection Recovery: A Triple-Blind Clinical Trial","authors":"Asieh Azadpour Motlagh, M. Dolatian, F. Mojab, M. Nasiri, Behrouz Ezatpour, N. Sharifi, Narjes Feizollahi, Z. Mahmoodi","doi":"10.15296/ijwhr.2020.28","DOIUrl":"https://doi.org/10.15296/ijwhr.2020.28","url":null,"abstract":"\u0000 Objectives: Trichomonas infection is prevalent in the United States and a metronidazole oral tablet is the medication of choice for treating this infection. Based on various side-effects of oral or vaginal metronidazole and the increase in microbial resistance against chemical antibiotics, the use of herbal medicine with fewer side-effects seems to be essential. Laboratory experiments indicate the strong anti-microbial effects of Prangos ferulacea (PF) medicinal herb. However, no clinical trial has focused on its anti-microbial effects in humans. Thus, the present study aimed to determine the effects of PF vaginal cream on accelerating Trichomonas vaginalis infection (TVI) recovery. Materials and Methods: The present randomized clinical trial was conducted on 80 non-pregnant women visiting the healthcare centers affiliated with Lorestan University of Medical Sciences, Iran, in 2018. Trichomonas infection was diagnosed based on patient complaints, clinical observations, as well as wet mount and stained microscopic tests. The women were randomly divided into two groups of 40 each. One group received oral metronidazole plus PF vaginal cream while the other received oral metronidazole plus placebo vaginal cream for 7 days. Clinical observations, along with wet mount and stained microscopic tests were performed during 7 days following the treatment. Finally, data were analyzed using independent-samples t test, as well as chi-square, Fisher exact, Mann-Whitney U, and McNemar tests at the significance level of P<0.05. Results: Based on the results, the response to treatment with oral metronidazole plus PF vaginal cream was 92.50 based on patient complaints. More precisely, 86.25% was based on clinical criteria (i.e., strawberry cervix, foamy greenish-yellow vaginal discharge, pH ≥4.5, and positive amine test) and 85% was related to the microscopic criteria of wet mount (x40) and polymorphonuclear leukocytes (x100). In addition, the response to treatment with oral metronidazole and placebo vaginal cream was 91.25%, 83.12%, and 80% based on the patient complaint, clinical criteria, and microscopic criteria, respectively. Eventually, the analysis of the patient complaint, clinical criteria, and microscopic criteria in each group revealed a significant difference before and after the treatment (P<0.001) Conclusions: The results of this study showed that the PF herbal vaginal cream can be used for the treatment of TVI as an effective treatment along with oral metronidazole.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2019-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85871681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}