An Investigation Into the Effects of Magnesium Sulfate on the Complications of Succinylcholine Administration in Nulliparous Women Undergoing Elective Cesarean Section: A Double-Blind Clinical Trial

IF 0.8 Q4 REPRODUCTIVE BIOLOGY
Davoud Aghamohamadi, M. Khanbabayi Gol
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引用次数: 8

Abstract

Objectives: Controlling the complications of anesthetics (e.g., succinylcholine) seems necessary since they are greater for nulliparous women who undergo elective cesarean section (C-section). The present study aimed to investigate the effects of magnesium sulfate on the complications of succinylcholine administration in nulliparous women undergoing elective C-section. Materials and Methods: This double-blind clinical trial was conducted on 60 nulliparous women during 2012-2013. The women were randomly assigned to A and B groups. Before inducing the rapid anesthesia with succinylcholine, patients in the intervention group received 30 mg/kg of magnesium sulfate within 10 minutes and then the hemodynamic status and the side effects of succinylcholine were recorded in a special form. Statistical tests were performed using repeated-measures ANOVA, chi-square test, and one-way ANOVA tests and the level of significance was determined to be P<0.05. Results: There was no significant difference between the two groups in terms of demographic data (P>0.059). However, the results indicated that there was a significant difference between the 2 groups regarding the myoglobin level (P=0.010). Contrarily, the results showed that most patients in the intervention (n=23) and control (n=15) groups experienced no or mild and severe fasciculation, respectively (P<0.001). Conclusions: In general, magnesium sulfate can greatly control and reduce the complications of succinylcholine administration, including fasciculation.
硫酸镁对未产妇女择期剖宫产术后给药琥珀酰胆碱并发症影响的双盲临床研究
目的:控制麻醉药(如琥珀胆碱)的并发症似乎是必要的,因为它们对进行选择性剖宫产(c -剖宫产)的未产妇女更大。本研究旨在探讨硫酸镁对无产妇女择期剖腹产时琥珀胆碱给药并发症的影响。材料与方法:本双盲临床试验于2012-2013年对60例未生育妇女进行研究。这些女性被随机分为A组和B组。干预组患者在用琥珀胆碱诱导快速麻醉前,在10分钟内给予30 mg/kg硫酸镁,然后用专用表格记录琥珀胆碱的血流动力学状态和副作用。采用重复测量方差分析、卡方检验和单因素方差分析进行统计检验,显著性水平为P0.059)。然而,结果显示两组在肌红蛋白水平上有显著性差异(P=0.010)。结果显示,干预组(n=23)和对照组(n=15)中大多数患者无或轻度和重度肌束收缩(P<0.001)。结论:总的来说,硫酸镁能极大地控制和减少琥珀胆碱给药的并发症,包括肌束。
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来源期刊
CiteScore
1.60
自引率
14.30%
发文量
8
期刊介绍: All kind of knowledge contributing to the development of science by its content, value, level and originality will be covered by IJWHR. Problems of public health and their solutions are at the head of the windows opening us to the world. The "International Journal of Women''s Health and Reproduction Sciences” is a modern forum for scientific communication, covering all aspects women health and reproduction sciences, in basic and clinical sciences, mainly including: -Medical Education in Women Health and Reproduction Sciences -Cardiology in Women Health-Related Reproductive Problems -Sports Medicine in Women Health and Reproduction Sciences -Psychiatry in Women Health-Related Reproductive Problems -Antioxidant Therapy in Reproduction Medicine Sciences -Nutrition in Women Health and Reproduction Sciences -Defense Androgen and Estrogen -Fertility and Infertility -Urogynecology -Endometriosis -Endocrinology -Breast Cancer -Menopause -Puberty -Eroticism -Pregnancy -Preterm Birth -Vaginal Diseases -Sex-Based Biology -Surgical Procedures -Nursing in Pregnancy -Obstetrics/Gynecology -Polycystic Ovary Syndrome -Hyperandrogenism in Females -Menstrual Syndrome and Complications -Oncology of Female Reproductive Organs -Traditional Medicine in Women Reproductive Health -Ultrasound in Women Health Reproduction sciences -Stem Cell Research In Women Reproduction Sciences -Complementary Medicine in Women Reproductive Health -Female Sexual Dysfunction: Pathophysiology & Treatment
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