Ramesh Baradaran Bagheri, Seyedeh Sara Salami, Linda Mohammadzadeh Boukani, A. Khaki
{"title":"The Regulatory Effect of Eugenol on FSHR, LHCGR, and ER Expression during Follicular Development in Female Rats With Ovarian Torsion","authors":"Ramesh Baradaran Bagheri, Seyedeh Sara Salami, Linda Mohammadzadeh Boukani, A. Khaki","doi":"10.15296/ijwhr.2023.24","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.24","url":null,"abstract":"Objectives: This study aimed to investigate the role of Eugenol in regulating the expression of FSH receptor (FSHR), human luteinizing hormone choriogonadotropin receptor (LHCGR), and estrogen receptor (ER) during follicular development in female rat ovarian torsion. Materials and Methods: In this experimental study, 48 female rats were randomly assigned to 4 groups, including G1 (i.e., sham), G2 (i.e., ovarian torsion/detorsion group), G3 (i.e., ovarian torsion/detorsion group treated with 30 mg/kg of eugenol), G4 (i.e., healthy group treated with 30 mg/kg of eugenol). After covering a treatment period of ten days, the ovarian tissue was collected for the histological analysis, the measurement of ER, FSHR, and LHCGR expression, as well as the assessment of testosterone, LH, FSH, and estrogen levels in blood serum. Results: Histological evaluation revealed the damage to ovarian tissue, the reduced oocyte, and the granulosa cell diameter in the torsion/detorsion group. However, the treatment with eugenol mitigated this damage. Eugenol administration increased the levels of estrogen, LH, and FSH, but it decreased the testosterone levels in the treated group. Moreover, the expression of ER, FSHR, and LHCGR was upregulated in the treated groups. Administration of eugenol was associated with an enhanced fertility. Conclusions: It was concluded that eugenol administration may have been effective in protecting the ovarian tissue from the damage caused by torsion/detorsion. Furthermore, eugenol was found to have the potential to modulate hormonal profiles and regulate the expression of ER, FSHR, and LHCGR, thereby contributing to an increased fertility.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":"59 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80781684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Celebrating the First Impact Factor: A Turning Point for Our Journal","authors":"A. Khaki","doi":"10.15296/ijwhr.2023.17","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.17","url":null,"abstract":"","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73809925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Placental Endocan Expression in Woman With Preeclampsia and its Relation With Maternal and Fetal Outcomes: A Cross-section Study","authors":"Fadia J Alizzi, S. Kadhim","doi":"10.15296/ijwhr.2023.19","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.19","url":null,"abstract":"Objectives: This study aimed to determine placental endocan expression in women with preeclampsia (PE) and its relation to fetal and maternal outcomes. Materials and Methods: This cross-sectional study was carried out at the Obstetrics Department/Al-Yarmouk Teaching Hospital from January 2020 to October 2020. The study included 90 pregnant inpatient women with PE. The participants were divided into 3 groups including 30 patients with severe PE, 30 non-severe PE, and 30 normotensives. After delivery, placental endocan expression was determined immunohistochemically. Results: The study showed that endocan was expressed in 44 patients’ placenta, all of them were hypertensive vs. 46 negatives for endocan (P=0.001), this expression correlated with adverse maternal outcomes including HELLP (haemolysis, elevated liver enzymes, and low platelets count) syndrome (9.1%), Placental abruption (13.6%) and increase rate of CS (63.6%), as well as adverse fetal outcomes (P=0.001). included stillbirth (13.6%), birth weight <2500 g (68.2%), Apgar score in 1 min <7 (63.6%) and in 5 minutes <7 (31.8), admission to neonatal intensive care unit (NICU) (31.8%), and (68.2%) delivered preterm. Conclusions: This study showed a higher expression of endocan in the placenta of women with PE, and it had a positive correlation with adverse maternal and fetal outcomes.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":"38 4 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79316626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Dehghan, Farima Mohammadianamiri, S. Yazdani, H. Musavi, Seyed Zahra Bouzari, Samira Mesbah, M. Bayani, Mohammad Abedi Samakoush, Z. Bouzari, E. Ebrahim
{"title":"Can Glycosylated Hemoglobin and Fasting Blood Sugar Replace Glucose Challenge Test in Screening for Gestational Diabetes?","authors":"S. Dehghan, Farima Mohammadianamiri, S. Yazdani, H. Musavi, Seyed Zahra Bouzari, Samira Mesbah, M. Bayani, Mohammad Abedi Samakoush, Z. Bouzari, E. Ebrahim","doi":"10.15296/ijwhr.2023.23","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.23","url":null,"abstract":"Objectives: The present study aimed to compare the diagnostic values of glycosylated hemoglobin (HbA1c) and fasting blood sugar (FBS) using the glucose challenge test (GCT) in screening for gestational diabetes. Materials and Methods: A total of 618 women at 24-28 weeks of pregnancy were selected, and their FBS and HbA1c were measured using the GCT. The obtained results were compared in terms of sensitivity, specificity, as well as positive and negative predictive values using the ROC curve. Results: At the cut-off point of 1.4, sensitivity was 69.74% and specificity was 69.05 for the FBS test; at the cut-off point of 6.6, sensitivity was 90.79% and specificity was 80.95% for the HbA1c test; the area under the ROC curve was 0.925 with a 95% confidence interval (0.979, 0.872). Conclusion: The diagnostic values of the HbA1c test and GCT were favorable in screening for gestational diabetes; the HbA1c test also showed a high diagnostic value in women with positive OGCT and GCT results.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":"68 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85094707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Mourad, Zina Abdulla, Maryam T. Abbas, Hayder Adnan Fawzi
{"title":"Role of Matrix Metalloproteinase–9 in the Pathogenesis of Preeclampsia","authors":"A. Mourad, Zina Abdulla, Maryam T. Abbas, Hayder Adnan Fawzi","doi":"10.15296/ijwhr.2023.20","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.20","url":null,"abstract":"Objectives: The goal of this research was to investigate whether metalloproteinases could be used as predictors of preeclampsia (PE) during pregnancy. Materials and Methods: This case-control study included 100 pregnant women which they further grouped into PE and control group (each composed of 50 women). Both groups were further subdivided according to their gestational age (GA), using the 37th week of gestation as a divider, as preterm and term infants. Results: In both preterm (P=0.001) and term infants (P=0.001), mean metalloproteinase-9 (MMP-9) was considerably lower in PE mothers compared to controls, with the difference being greater in preterm infants. In ROC analysis, MMP-9 showed excellent ability to predict PE in preterm infants (AUC = 0.980, cut-off ≤26.2) and good ability to predict PE in term infants (AUC 0.770, cut-off ≤ 34.4). Conclusions: The matrix MMP-9 is a non-specific predictor of PE for term and preterm pregnant women, with higher accuracy for preterm pregnant women.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":"109 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85330572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shobha S Shiragur, Preeti Patil, Praveen Ganganahalli, M. Gudadinni, S. Bidri, Aruna M Biradar, Rajasri G Yaliwal
{"title":"Ruptured Ectopic Pregnancy at Tertiary Care Centre: A Cross-sectional Study","authors":"Shobha S Shiragur, Preeti Patil, Praveen Ganganahalli, M. Gudadinni, S. Bidri, Aruna M Biradar, Rajasri G Yaliwal","doi":"10.15296/ijwhr.2023.22","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.22","url":null,"abstract":"Objectives: Ectopic pregnancy (EP) is the leading cause of early pregnancy accounting for 10-15% of pregnancy-related deaths. It is life-threatening condition where the majority of them present late. This study aims to evaluate the incidence, risk factors, clinical features, diagnosis, and management of EP in the tertiary care center. Materials and Methods: This study conducted a retrospective analysis of electronic medical records from June 2015 to June 2020, focusing on participants in the age group of 18 to 45 years, to examine the occurrence of EP. The data were analysed with simple descriptive statistics and presented in frequency tables and charts of age group, parity, anemia grades, risk factors and presenting symptoms. Results: The incidence of EP in the current study was 0.38%. In the present study, 73.8% of women were of 20–30-year-old. In this study, 54.1% of women had a history of pelvic inflammatory disease (PID). Prior EP was seen in 19.7 % of cases. 16.4% of participants had a prior history of tubectomy and 19.7% had a previous history of infertility treatment, and 21.3% had a previous history of lower segment caesarean section (LSCS). In the present study, 65.5% of women presented with amenorrhea of 4-8 week, and 95% had abdominal pain. In the present study, common site was the right fallopian tube in 73.9% of cases. In this study, all cases need surgical management most common procedure carried out was salpingectomy. intensive care unit (ICU) admission was needed in 26.2% of cases, and no mortality was seen in our study. Conclusions: EP is a serious and potentially life-threatening condition. Early diagnosis and prompt management are crucial in reducing maternal mortality and morbidity rates.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":"96 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89001281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}