International Journal of Women's Health and Reproduction Sciences最新文献

{"title":"Dual FSH and HCG Triggering Increases Clinical Pregnancy Rate in IUI for Unexplained Infertility: A Randomized Controlled Trial","authors":"Mahshid Alborzi, K. Pouya, Reza Asadi maman, A. Fattahi, Kobra Hamdi, Parvin Hakimi","doi":"10.15296/ijwhr.2024.6010","DOIUrl":"https://doi.org/10.15296/ijwhr.2024.6010","url":null,"abstract":"Objectives: Despite advancements in the assisted reproduction technology (ART), the proportion of unexplained infertility is 30% among infertile couples. This study aimed to explore the pregnancy proportions in women with primary unexplained infertility who were given follicle-stimulating hormone (FSH) along with the human chorionic gonadotropin (hCG) trigger compared with those who were only given the hCG trigger. Materials and Methods: In this randomized controlled trial, the women eligible for intrauterine insemination (IUI) were investigated between April 1, 2022 and April 1, 2023 at Al-Zahra referral academic center. To this end, a total of 130 women were primarily screened and then 50 ones were excluded from the study based on the pre-defined inclusion criteria. Therefore, the final study population consisted of 80 eligible women with primary unexplained infertility, who were randomly assigned to the intervention group (n=40) and control group (n=40). The patients in the intervention group received two ampules (75 IU) of FSH in addition to two ampoules (5000 IU) of hCG, while the patients in the control group only received hCG. Both groups underwent IUI 34-36 hours after the hCG triggering. The biochemical and clinical pregnancy rates were evaluated as primary outcomes. Results: No significant differences were observed between the baseline and clinical characteristics, including endometrial thickness and the number of follicles before intervention (P>0.05). However, the clinical pregnancy rate was higher in the dual FSH and hCG group (40.0%, 16/40) than that in the hCG group (20.0%, 8/40) (P=0.048). The chemical pregnancy rates were 32.5% (13/40) and 37.5% (15/40) for the hCG and dual FSH and hCG groups, respectively. No significant relationships were detected between the biochemical pregnancy and the number of gestational sacs (P>0.05). Conclusions: The dual administration of FSH and hCG for oocytes, compared with the injection of hCG alone, improved the clinical pregnancy. The biochemical pregnancy and live birth rates as well as the number of gestational sacs were not improved significantly.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140709426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Septolysis Surgery and Pregnancy Outcome in Resectoscope Versus Hysteroscopic Scissor","authors":"L. Hafizi, Seyedeh Azam Pourhoseini, Mona Jafari, Mina Bradaran, Golrokh Sherafati","doi":"10.15296/ijwhr.2024.6011","DOIUrl":"https://doi.org/10.15296/ijwhr.2024.6011","url":null,"abstract":"Objectives: This study aimed to evaluate the short-term and long-term outcomes of adopting two types of resectoscopes and hysteroscopic scissors metroplasty methods. Methods: In this prospective, comparative, and cohort study, participants who were candidates for septum resection were recruited during 2015-2018. The uterine septum was removed using hysteroscopic scissors or a resectoscope. The second-look hysteroscopy was performed in the follicular phase after two months. In the second-look hysteroscopy, surgery outcomes were evaluated, and the residual septa or adhesions were removed in case of incidence. The study followed participants for up to five years to observe pregnancy outcomes. This involved recording the duration from hysteroscopy to pregnancy and determining if these pregnancies led to live births. Results: A total of 119 female patients with a mean age of 30.20±6.14 years were enrolled in this study, out of who 62 cases (52.1%) were in the hysteroscopic scissors group, and 57 cases (47.9%) were in the resectoscope group. The 63 (52.9%) cases had primary infertility, and the prevalence of abortion was 46 (38.7%). During the second look, hysteroscopy adhesion was diagnosed in 18 cases (15.1%), and septum residue was seen in 49 cases (67.1%). The adhesion rate in the hysteroscopic scissors group was higher than that in the resectoscope group, but it was insignificant (P=0.223). At the second follow-up stage, only 85 patients out of 119 ones were available. The successful pregnancy rate was 46 out of 85 (54.1%). The mean age of the patients in the successful pregnancy group was significantly lower than that in the unsuccessful pregnancy group (P<0.001). Conclusion: There were no differences among resectoscope and hysteroscopic scissor methods’ outcomes in term of metroplasty associated with septate uterus (SU).","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140709298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Regulatory Effect of Eugenol on FSHR, LHCGR, and ER Expression during Follicular Development in Female Rats With Ovarian Torsion","authors":"Ramesh Baradaran Bagheri, Seyedeh Sara Salami, Linda Mohammadzadeh Boukani, A. Khaki","doi":"10.15296/ijwhr.2023.24","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.24","url":null,"abstract":"Objectives: This study aimed to investigate the role of Eugenol in regulating the expression of FSH receptor (FSHR), human luteinizing hormone choriogonadotropin receptor (LHCGR), and estrogen receptor (ER) during follicular development in female rat ovarian torsion. Materials and Methods: In this experimental study, 48 female rats were randomly assigned to 4 groups, including G1 (i.e., sham), G2 (i.e., ovarian torsion/detorsion group), G3 (i.e., ovarian torsion/detorsion group treated with 30 mg/kg of eugenol), G4 (i.e., healthy group treated with 30 mg/kg of eugenol). After covering a treatment period of ten days, the ovarian tissue was collected for the histological analysis, the measurement of ER, FSHR, and LHCGR expression, as well as the assessment of testosterone, LH, FSH, and estrogen levels in blood serum. Results: Histological evaluation revealed the damage to ovarian tissue, the reduced oocyte, and the granulosa cell diameter in the torsion/detorsion group. However, the treatment with eugenol mitigated this damage. Eugenol administration increased the levels of estrogen, LH, and FSH, but it decreased the testosterone levels in the treated group. Moreover, the expression of ER, FSHR, and LHCGR was upregulated in the treated groups. Administration of eugenol was associated with an enhanced fertility. Conclusions: It was concluded that eugenol administration may have been effective in protecting the ovarian tissue from the damage caused by torsion/detorsion. Furthermore, eugenol was found to have the potential to modulate hormonal profiles and regulate the expression of ER, FSHR, and LHCGR, thereby contributing to an increased fertility.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80781684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celebrating the First Impact Factor: A Turning Point for Our Journal","authors":"A. Khaki","doi":"10.15296/ijwhr.2023.17","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.17","url":null,"abstract":"","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73809925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental Endocan Expression in Woman With Preeclampsia and its Relation With Maternal and Fetal Outcomes: A Cross-section Study","authors":"Fadia J Alizzi, S. Kadhim","doi":"10.15296/ijwhr.2023.19","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.19","url":null,"abstract":"Objectives: This study aimed to determine placental endocan expression in women with preeclampsia (PE) and its relation to fetal and maternal outcomes. Materials and Methods: This cross-sectional study was carried out at the Obstetrics Department/Al-Yarmouk Teaching Hospital from January 2020 to October 2020. The study included 90 pregnant inpatient women with PE. The participants were divided into 3 groups including 30 patients with severe PE, 30 non-severe PE, and 30 normotensives. After delivery, placental endocan expression was determined immunohistochemically. Results: The study showed that endocan was expressed in 44 patients’ placenta, all of them were hypertensive vs. 46 negatives for endocan (P=0.001), this expression correlated with adverse maternal outcomes including HELLP (haemolysis, elevated liver enzymes, and low platelets count) syndrome (9.1%), Placental abruption (13.6%) and increase rate of CS (63.6%), as well as adverse fetal outcomes (P=0.001). included stillbirth (13.6%), birth weight <2500 g (68.2%), Apgar score in 1 min <7 (63.6%) and in 5 minutes <7 (31.8), admission to neonatal intensive care unit (NICU) (31.8%), and (68.2%) delivered preterm. Conclusions: This study showed a higher expression of endocan in the placenta of women with PE, and it had a positive correlation with adverse maternal and fetal outcomes.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79316626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Glycosylated Hemoglobin and Fasting Blood Sugar Replace Glucose Challenge Test in Screening for Gestational Diabetes?","authors":"S. Dehghan, Farima Mohammadianamiri, S. Yazdani, H. Musavi, Seyed Zahra Bouzari, Samira Mesbah, M. Bayani, Mohammad Abedi Samakoush, Z. Bouzari, E. Ebrahim","doi":"10.15296/ijwhr.2023.23","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.23","url":null,"abstract":"Objectives: The present study aimed to compare the diagnostic values of glycosylated hemoglobin (HbA1c) and fasting blood sugar (FBS) using the glucose challenge test (GCT) in screening for gestational diabetes. Materials and Methods: A total of 618 women at 24-28 weeks of pregnancy were selected, and their FBS and HbA1c were measured using the GCT. The obtained results were compared in terms of sensitivity, specificity, as well as positive and negative predictive values using the ROC curve. Results: At the cut-off point of 1.4, sensitivity was 69.74% and specificity was 69.05 for the FBS test; at the cut-off point of 6.6, sensitivity was 90.79% and specificity was 80.95% for the HbA1c test; the area under the ROC curve was 0.925 with a 95% confidence interval (0.979, 0.872). Conclusion: The diagnostic values of the HbA1c test and GCT were favorable in screening for gestational diabetes; the HbA1c test also showed a high diagnostic value in women with positive OGCT and GCT results.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85094707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Matrix Metalloproteinase–9 in the Pathogenesis of Preeclampsia","authors":"A. Mourad, Zina Abdulla, Maryam T. Abbas, Hayder Adnan Fawzi","doi":"10.15296/ijwhr.2023.20","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.20","url":null,"abstract":"Objectives: The goal of this research was to investigate whether metalloproteinases could be used as predictors of preeclampsia (PE) during pregnancy. Materials and Methods: This case-control study included 100 pregnant women which they further grouped into PE and control group (each composed of 50 women). Both groups were further subdivided according to their gestational age (GA), using the 37th week of gestation as a divider, as preterm and term infants. Results: In both preterm (P=0.001) and term infants (P=0.001), mean metalloproteinase-9 (MMP-9) was considerably lower in PE mothers compared to controls, with the difference being greater in preterm infants. In ROC analysis, MMP-9 showed excellent ability to predict PE in preterm infants (AUC = 0.980, cut-off ≤26.2) and good ability to predict PE in term infants (AUC 0.770, cut-off ≤ 34.4). Conclusions: The matrix MMP-9 is a non-specific predictor of PE for term and preterm pregnant women, with higher accuracy for preterm pregnant women.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85330572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruptured Ectopic Pregnancy at Tertiary Care Centre: A Cross-sectional Study","authors":"Shobha S Shiragur, Preeti Patil, Praveen Ganganahalli, M. Gudadinni, S. Bidri, Aruna M Biradar, Rajasri G Yaliwal","doi":"10.15296/ijwhr.2023.22","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.22","url":null,"abstract":"Objectives: Ectopic pregnancy (EP) is the leading cause of early pregnancy accounting for 10-15% of pregnancy-related deaths. It is life-threatening condition where the majority of them present late. This study aims to evaluate the incidence, risk factors, clinical features, diagnosis, and management of EP in the tertiary care center. Materials and Methods: This study conducted a retrospective analysis of electronic medical records from June 2015 to June 2020, focusing on participants in the age group of 18 to 45 years, to examine the occurrence of EP. The data were analysed with simple descriptive statistics and presented in frequency tables and charts of age group, parity, anemia grades, risk factors and presenting symptoms. Results: The incidence of EP in the current study was 0.38%. In the present study, 73.8% of women were of 20–30-year-old. In this study, 54.1% of women had a history of pelvic inflammatory disease (PID). Prior EP was seen in 19.7 % of cases. 16.4% of participants had a prior history of tubectomy and 19.7% had a previous history of infertility treatment, and 21.3% had a previous history of lower segment caesarean section (LSCS). In the present study, 65.5% of women presented with amenorrhea of 4-8 week, and 95% had abdominal pain. In the present study, common site was the right fallopian tube in 73.9% of cases. In this study, all cases need surgical management most common procedure carried out was salpingectomy. intensive care unit (ICU) admission was needed in 26.2% of cases, and no mortality was seen in our study. Conclusions: EP is a serious and potentially life-threatening condition. Early diagnosis and prompt management are crucial in reducing maternal mortality and morbidity rates.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89001281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\u0000 Clinical Integration of Patients’ Preferences in Treatment Decision Making Among Women With Infertility: A Cross-sectional Study","authors":"M. Alshrouf, Abdulrahman Karam, Muayad I. Azzam, N. Muhaidat","doi":"10.15296/ijwhr.2023.21","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.21","url":null,"abstract":"Objectives: This study aimed to evaluate infertile women’s treatment-seeking behavior and to determine the factors that impact the treatment method choices while assessing patients’ views regarding infertility management. Materials and Methods: This cross-sectional survey was distributed anonymously online and targeted infertile females seeking infertility treatment and included participants from all the 12 governorates in Jordan. An electronic questionnaire was designed, which was then distributed on several social media platforms during January 2021. This study included 429 participants seeking in vitro fertilization (IVF), and 52 were seeking intrauterine insemination (IUI) as a treatment modality. The study aimed to examine the aspects that influence infertile women’s treatment-seeking behavior and technique selection. Results: A total of 481 infertile females aged 21-50 years were included in the study. There was a statistically significant relationship between treatment modality and the number of children (P = 0.012), years of trying to conceive (P = 0.006), and causes of infertility (P = 0.017). Participants who wanted to use the IUI method had a significantly higher average number of children (IUI vs. IVF: 0.88 ± 1.11, 0.46 ± 0.96). Calculating the binary logistic regression to predict the selection of a treatment method based on prior trials of IVF and IUI indicated that the IVF prior trial is a significant predictor method of treatment selection (P < 0.001). Conclusions: The decisions regarding infertility treatment should be shared between the patient and the treating physician. Socioeconomic status, past gynecological, and infertility history should be evaluated to better understand the patient’s preference.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88831157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Affecting Postpartum Overt and Covert Urinary Retention After Vaginal Delivery","authors":"A. Ghanbarpour, S. Barat, Fatemeh Amirkhanloo, K. Hajian, Z. Bouzari","doi":"10.15296/ijwhr.2023.13","DOIUrl":"https://doi.org/10.15296/ijwhr.2023.13","url":null,"abstract":"Objectives: The aim of this study was to investigate the factors affecting postpartum urinary retention (PPUR) following vaginal delivery. Materials and Methods: This cross-sectional analytical study measured the post-void residual (PVR) urine volume by ultrasound, at most, 15 minutes after the first urination after delivery. Women with a PVR >150 mL without urinary symptoms were assigned to the postpartum covert urinary retention group. Data were analyzed with SPSS22. The chi-square and Mann-Whitney tests were used for quantitative and qualitative variables, respectively. Results: In this study, 1120 patients had a normal delivery at Ayatollahs Rouhani hospital from 21 January 2016 to 20 January 2017. Of this number, 306 (29.4%) and 734 (70.6%) cases with and without urinary retention were allocated to the case and control groups, respectively. Women with instrumental delivery had 30.19 times (P=0.003) higher odds of urinary retention. Instrumental delivery is one of the known risk factors of urinary retention. The linear effect of the total length of labor was also measured, and the results revealed that every one-minute increase in the total length of labor increases the odds of covert urinary retention by 1.008 times (P<0.001). Conclusions: The findings of the study showed that various factors are involved in the incidence of urinary retention. More precisely, instrumental delivery, birth weight, gestational age, and other factors can each be a risk factor for urinary retention.","PeriodicalId":14346,"journal":{"name":"International Journal of Women's Health and Reproduction Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75703972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}