International Journal of Pharmaceutical Chemistry最新文献_第5页

Analytical studies on zero order and first order derivative and area under curve UV-spectrophotometric methods for estimation of pimavanserin tartrate in bulk and In-house tablet formulation 零阶导数、一阶导数及曲线下面积紫外分光光度法测定原料药和内服片中酒石酸匹马万色林含量的分析研究

International Journal of Pharmaceutical Chemistry Pub Date : 2020-01-15 DOI: 10.18231/j.ijpca.2019.022

Abdul Wahab, Mohammad Mojeeb Gulzar Khan, A. Shirkhedkar

{"title":"Analytical studies on zero order and first order derivative and area under curve UV-spectrophotometric methods for estimation of pimavanserin tartrate in bulk and In-house tablet formulation","authors":"Abdul Wahab, Mohammad Mojeeb Gulzar Khan, A. Shirkhedkar","doi":"10.18231/j.ijpca.2019.022","DOIUrl":"https://doi.org/10.18231/j.ijpca.2019.022","url":null,"abstract":"The proposed of work to establish simple, rapid, sensitive, economical and accurate UV spectrophotometric methods for the quantificationof Pimavanserin tartrate in bulk material and in-house tablet formulation. This study is designed to validate the developed methods as per ICH guidelines. Pimavanserin tartrate an atypical anti-psychotic drug also used for the treatment of Parkinson Disease. Four simple UV Spectroscopy methods developed and validated for the estimation of Pimavanserin tartrate, by using double beam spectrophotometer (UV-2450, Shimadzu, Japan). Maximum absorbance (?max) of pimavanserin tartrate was observed at 226 nm used methanol as a solvent. The calibration curve of concentration range 5-30 ?g/ml obeyed Beer lambert law. The % recovery was found to be in the range of 98-101%. Precision values observed less than 2 in the terms of % RSD that shows precise nature of developed methods. It was concluded that statistical analysis and the result amongst all four methods, AUC method is most simple, specific, accurate and precise. All four methods can be used as routine analysis of Pimavanserin tartrate in bulk and pharmaceutical formulations.\u0000\u0000Keywords: Area under curve, Derivative-spectrophotometry, Pimavanserin tartrate, UV Spectroscopy.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"38 1","pages":"120-126"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81752098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non peptidic small molecular inhibitors of the p53-MDM2 interaction p53-MDM2相互作用的非肽类小分子抑制剂

International Journal of Pharmaceutical Chemistry Pub Date : 2020-01-15 DOI: 10.18231/j.ijpca.2019.019

Chiragkumar J. Gohil, M. Noolvi

{"title":"Non peptidic small molecular inhibitors of the p53-MDM2 interaction","authors":"Chiragkumar J. Gohil, M. Noolvi","doi":"10.18231/j.ijpca.2019.019","DOIUrl":"https://doi.org/10.18231/j.ijpca.2019.019","url":null,"abstract":"Cancer is a tumorous disease, which involves the unwanted cell growth and cell division. The imbalance or inactivity of the apoptosis in the body is responsible for the occurrence of tumour and cancer. This apoptosis is regulated by the p53 protein, which is tumour suppressor protein. In the cancer cells, this p53 has been inhibited by the MDM2 protein. MDM2 interact with the p53 and make it inactive. This p53-MDM2 interaction is responsible for the cancer genesis. If we target this interaction, then we can initiate the apoptosis in the cancer cells by making the free p53 protein. There are many strategies to inhibit this p53-MDM2 interaction. Among them non-peptidic small molecule inhibitors are the convenient approach. Small molecule inhibitors have a three pocket binding, so they bind with p53 binding pocket (Trp 23, Leu 26 and Phe 19), present in the MDM2 protein. That is how it spares the p53 protein and makes it available in the cancer cells. Hence, small molecule inhibitors successfully inhibit the p53-MDM2 interaction and can initiate the apoptosis in the cancer cells, which are having the un-mutated p53 protein. They can’t inhibit this interaction in the cells which contains the mutated or deleted p53 protein. Hence, this limitation must be addressed. Many of the small molecular MDM2 inhibitors have been successfully entered into the clinical trials and they are performing well. The clinical data indicate that the small molecular MDM2 inhibitors are having very low toxicity to the normal cells. And they are non-genotoxic so they are near to nontoxic to the normal cells. But none of the any small molecule MDM2 inhibitor has been enters into the market yet. So till then, it has required advancement and research to make more selective and specific for the cancer cells over the normal cells. \u0000\u0000Keywords: Cancer, Apoptosis, p53 protein, MDM2 protein, p53-MDM2 interaction, Three pocket binding, Small molecule p53-MDM2 interaction inhibitors.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"27 1","pages":"104-109"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82585956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Advanced drug delivery systems: Nanotechnology of health design and its potential clinical Application 先进给药系统:健康设计的纳米技术及其潜在的临床应用

International Journal of Pharmaceutical Chemistry Pub Date : 2020-01-15 DOI: 10.18231/j.ijpca.2019.018

Mayurdhvajsinh R Sindha, J. Kher

引用次数: 3

X-ray crystal structure of N'-[(1E)-1-(2,4-dihydroxyphenyl)-ethylidene]pyridine-4-carbohydrazide N'-[(1E)-1-(2,4-二羟基苯基)-乙基]吡啶-4-碳肼的x射线晶体结构

International Journal of Pharmaceutical Chemistry Pub Date : 2019-03-27 DOI: 10.14805/JPHCHEM.2019.ART108

Venkatesan Jayaprakash, A. Timiri, Viswanathan Vijayan, B. N. Sinha, V. Devadasan

引用次数: 1

A mini review on thiadiazole compounds and their pharmacological interest 噻二唑类化合物及其药理研究进展综述

International Journal of Pharmaceutical Chemistry Pub Date : 2019-01-30 DOI: 10.18231/2394-2797.2018.0026

M. Asif, Abida

引用次数: 2

A short commentary on substituted Indoles, pyrazolones and imidazolinones 取代吲哚类、吡唑酮类和咪唑啉酮类的简要评述

International Journal of Pharmaceutical Chemistry Pub Date : 2019-01-30 DOI: 10.18231/2394-2797.2018.0029

M. Asif, Mrityujoy Acharya

{"title":"A short commentary on substituted Indoles, pyrazolones and imidazolinones","authors":"M. Asif, Mrityujoy Acharya","doi":"10.18231/2394-2797.2018.0029","DOIUrl":"https://doi.org/10.18231/2394-2797.2018.0029","url":null,"abstract":"Introduction German scientist Hugo Schiff discovered compounds which have azomethine group. Various azomethines were prepared for different of amines and aldehydes and used for diverse industrial applications. Schif’s bases were also used for their industrial applications such as metal chelating ability and analytical purpose for various metal ions testing. They were used as intermediates for the synthesis of various biological active heterocycles compounds like β-lactums and thiazolidinones. The mechanism of action of some antibiotics such as streptomycin, tetracycline, aspergillic acid and usinic acid were exhibited antibacterial effect due to their metal chelating activities. Metal chelating abilities of Schif’s bases, inspired several chemist to test the antibacterial and other biological activities of Schif’s bases. This was a distraction from research on diazo compounds, as diazo compounds were proved to be toxic and azomethines were believed as substitute to diazo compounds in search for novel molecules and resulted in synthesis of various Schif’s bases for testing their biological activities. Some amino acid-schiff bases 1, 2 were tested for their antibacterial activity against various gram positive and gram negative bacterial strains and some of the tested Schiff’s bases exhibited promising activity. A series of Schif’s bases 3 which have isatin nucleus and exhibited moderate pharmacological activities such as analgesic, antiinflammatory, and anti-pyretic activities. All the tested compounds.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"104 1","pages":"188-191"},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80466370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress degradation studies of hydrochlorothiazide and development of validated method by UV spectroscopy 氢氯噻嗪的应力降解研究及紫外光谱验证方法的建立

International Journal of Pharmaceutical Chemistry Pub Date : 2018-12-31 DOI: 10.14805/JPHCHEM.2018.ART105

D. Velmurugan

引用次数: 0

Docking studies of tetra substituted pyrazolone derivatives as potential antiviral agents 四取代吡唑酮衍生物作为潜在抗病毒药物的对接研究

International Journal of Pharmaceutical Chemistry Pub Date : 2018-12-20 DOI: 10.14805/JPHCHEM.2018.ART103

Jyothi Achuthanandhan, B. Lakshmanan

引用次数: 3

The Quantum Chemical Calculations of SomeTetrathiapentalene (TTP) Derivatives 某些四硫戊烯(TTP)衍生物的量子化学计算

International Journal of Pharmaceutical Chemistry Pub Date : 2018-05-13 DOI: 10.7439/IJPC.V8I2.4756

Tahar Abbaz, A. Bendjeddou, D. Villemin

引用次数: 0

Fluorescence spectroscopy and its applications: A Review 荧光光谱学及其应用综述

International Journal of Pharmaceutical Chemistry Pub Date : 2018-05-13 DOI: 10.7439/IJAPA.V8I1.4578

A. Bose, Irene Thomas, G. Kavitha, E. Abraham

引用次数: 22