A short commentary on substituted Indoles, pyrazolones and imidazolinones

Introduction German scientist Hugo Schiff discovered compounds which have azomethine group. Various azomethines were prepared for different of amines and aldehydes and used for diverse industrial applications. Schif’s bases were also used for their industrial applications such as metal chelating ability and analytical purpose for various metal ions testing. They were used as intermediates for the synthesis of various biological active heterocycles compounds like β-lactums and thiazolidinones. The mechanism of action of some antibiotics such as streptomycin, tetracycline, aspergillic acid and usinic acid were exhibited antibacterial effect due to their metal chelating activities. Metal chelating abilities of Schif’s bases, inspired several chemist to test the antibacterial and other biological activities of Schif’s bases. This was a distraction from research on diazo compounds, as diazo compounds were proved to be toxic and azomethines were believed as substitute to diazo compounds in search for novel molecules and resulted in synthesis of various Schif’s bases for testing their biological activities. Some amino acid-schiff bases 1, 2 were tested for their antibacterial activity against various gram positive and gram negative bacterial strains and some of the tested Schiff’s bases exhibited promising activity. A series of Schif’s bases 3 which have isatin nucleus and exhibited moderate pharmacological activities such as analgesic, antiinflammatory, and anti-pyretic activities. All the tested compounds.