International Journal of Sciences: Basic and Applied Research最新文献_第7页

Bafetinib inhibits ishikawa cells growth through modulating p16 expression 巴非替尼通过调节p16表达抑制石川细胞生长

International Journal of Sciences: Basic and Applied Research Pub Date : 2017-06-27 DOI: 10.14419/IJBAS.V6I3.7860

M. Althubiti

{"title":"Bafetinib inhibits ishikawa cells growth through modulating p16 expression","authors":"M. Althubiti","doi":"10.14419/IJBAS.V6I3.7860","DOIUrl":"https://doi.org/10.14419/IJBAS.V6I3.7860","url":null,"abstract":"Bafetinib is a tyrosine kinase inhibitor of Lyn- BCR/ABL that has been used experimentally for leukemia therapy. From our previous experimental work with bafetinib, it showed an anti-proliferative effect on Ishikawa cell line at concentration of 200nM. This observation was supported by colonogenic assay, the number of colonies formed by Ishikawa cells was 6 folds in the control comparing to bafetinib treated cells. Cells counting also support this finding, Ishikawa treated cells were unable to continue growing after 2 days of the drug addition comparing to the control cells that continued dividing. This underscores the role of bafetinib as anti-neoplastic agent on Ishikawa cells. To understand its mechanism of action, cyclin-dependent kinase inhibitors p16INK4a and p21 WAF1 that have major role in cell cycle arrest were measured. No difference was noticed in p21 levels between the treated and control cells; however, increasing in p16 expression was observed in treated Ishikawa cells. This underlines the role of bafetinib in inhibiting Ishikawa cells through modulating p16 expression. This suggests that bafetinib could be used as a therapy in case of endometrial cancer. But, further work should be conducted to examine the effect of bafetinib on other endometrial cancer cells and on mice before testing its effect on endometrial cancer patients.","PeriodicalId":14296,"journal":{"name":"International Journal of Sciences: Basic and Applied Research","volume":"57 1","pages":"42-44"},"PeriodicalIF":0.0,"publicationDate":"2017-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77650663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of nylon garment to improve its proper-ties 对尼龙服装进行处理以改善其性能

International Journal of Sciences: Basic and Applied Research Pub Date : 2017-06-13 DOI: 10.14419/IJBAS.V6I3.7627

Ghada Abdulla Lotfy Elkholy

引用次数: 0

Financial Management Practices of Investors:An Insight from Monthly Budgetary Allocation 投资者的财务管理实践:来自月度预算分配的洞察

International Journal of Sciences: Basic and Applied Research Pub Date : 2017-06-01 DOI: 10.21904/weken/2017/v2/i1/117917

V. Pendse, Riddhi Panchal

引用次数: 0

A Strategy Engagement in Marketing: A Reviews of the Literature 市场营销中的战略参与:文献综述

International Journal of Sciences: Basic and Applied Research Pub Date : 2017-05-16 DOI: 10.31227/osf.io/kw9uz

S. Sarkum

引用次数: 3

4Hz mechanical vibration relieves pain through Na+/K+-ATPase α3 isoform-dependent brain tissue dehydration 4Hz机械振动通过Na+/K+- atp酶α3亚型依赖的脑组织脱水来缓解疼痛

International Journal of Sciences: Basic and Applied Research Pub Date : 2017-05-14 DOI: 10.14419/ijbas.v6i2.7365

G. Musheghyan, A. Minasyan, G. Arajyan, S. Ayrapetyan

{"title":"4Hz mechanical vibration relieves pain through Na+/K+-ATPase α3 isoform-dependent brain tissue dehydration","authors":"G. Musheghyan, A. Minasyan, G. Arajyan, S. Ayrapetyan","doi":"10.14419/ijbas.v6i2.7365","DOIUrl":"https://doi.org/10.14419/ijbas.v6i2.7365","url":null,"abstract":"In this work the effect of 4Hz 30dB horizontal mechanical vibration (MV) on thermal pain threshold, hydration and [ 3 H]-ouabain binding in brain and heart muscle tissues of rats was studied. It was revealed that 4Hz MV treatment for 10 minutes increased pain threshold, which was accompanied by brain and heart muscle tissue dehydration. In vitro state, hydration of brain and heart muscle tissues of sham animals was increased, while in 4Hz MV-treated animals the increase of brain tissue hydration was more pronounced and heart muscle tissues were dehydrated. The fact that 4Hz MV treatment also impacted heart muscle tissue hydration indicates that 4Hz MV effect on brain and heart muscle tissues is realized through a common messenger circulating in blood. The incubation of brain and heart muscle tissues in PS containing 10 -4 M and 10 -9 M ouabain led to tissue hydration in sham and 4Hz MV-treated animals. However, tissues of 4Hz MV-treated animals were less hydrated, and this hydration was accompanied by the decrease and increase of membrane receptors’ affinity at 10 -4 M and 10 -9 M ouabain concentrations, respectively. Based on the obtained data, it is suggested that pain-relieving effect of 4Hz MV is due to α 3 isoform-dependent brain tissue dehydration.","PeriodicalId":14296,"journal":{"name":"International Journal of Sciences: Basic and Applied Research","volume":"119 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2017-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77950774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Use of plant-derived products to control household and structural arthropod pests 使用植物衍生产品控制家庭和结构节肢动物害虫

International Journal of Sciences: Basic and Applied Research Pub Date : 2017-05-12 DOI: 10.14419/IJBAS.V6I2.7483

R. Gahukar

引用次数: 1

Temporal sleep patterns between healthy and depressed individuals 健康和抑郁个体的睡眠模式

International Journal of Sciences: Basic and Applied Research Pub Date : 2017-05-08 DOI: 10.14419/IJBAS.V6I2.7490

Mohammad A. Alotaibi, M. Halaki, C. Chow

{"title":"Temporal sleep patterns between healthy and depressed individuals","authors":"Mohammad A. Alotaibi, M. Halaki, C. Chow","doi":"10.14419/IJBAS.V6I2.7490","DOIUrl":"https://doi.org/10.14419/IJBAS.V6I2.7490","url":null,"abstract":"Background: Individuals with depression differ in their sleep patterns from healthy subjects. However, there are no studies that compare the temporal sleep patterns between healthy and depressed people or explore the relations between depressive symptomatology and physical activity levels. This study is an attempt to address this gap. Method: Participants recruited were 20 healthy and 20 depressed individuals. Data related to sleep-wake patterns, and activity levels were collected over four weeks using actigraph device (Actiwatch 2) and depressive symptoms were collected using the Depression Anxiety and Stress Scale (DASS) and Quick Inventory of Depressive Symptoms (QIDS) questionnaire. The data for the two groups were compared using t-tests. Correlation analyses were employed to test for associations between depressive symptoms, activity level and sleep patterns for each group. Result: The depressed group had significantly higher scores for depression, longer total sleep time, and lower level of activity compared to the healthy group. Sleep onset latency (SOL) was significantly correlated with the anxiety subscale of DASS, the depression score as measured by QIDS, and the activity level in the depressed group. The positive association between activity level and SOL was anomalous, and did not reflect the expected pattern seen in healthy individuals. Conclusion: The depressed group was confirmed to have significantly higher levels of depression, stress and anxiety, and lower level of physical activity. Increased anxiety and depression predicted delayed sleep onset. Depressive symptoms may have masked the expected relation between physical activity and SOL seen in healthy individuals.","PeriodicalId":14296,"journal":{"name":"International Journal of Sciences: Basic and Applied Research","volume":"79 1","pages":"17-21"},"PeriodicalIF":0.0,"publicationDate":"2017-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79306459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Laser Pulses and Energy on the Structural Properties of ZnO Thin Film Prepared using PLA Technique 激光脉冲和能量对聚乳酸法制备ZnO薄膜结构性能的影响

International Journal of Sciences: Basic and Applied Research Pub Date : 2017-04-04 DOI: 10.20944/preprints201704.0017.v1

Alaa Jabbar Ghazaia, Wisam J. Azizb, Nedaa Taha Yassenab

引用次数: 5

Adsorptive removal of catechol and resorcinol by orange flavedo (citrus sinensis): mechanisms based on the flavedo com-ponents d-limonene, carotenoids, ascorbates, flavonoids and hydroxycinnamic acids 柑桔黄酮吸附去除儿茶酚和间苯二酚:基于黄酮成分d-柠檬烯、类胡萝卜素、抗坏血酸、类黄酮和羟基肉桂酸的机理

International Journal of Sciences: Basic and Applied Research Pub Date : 2017-02-22 DOI: 10.14419/IJBAS.V6I1.6647

K. Théophile, Doungmo Giscard, Ngouoko Kouonang Jimmy Julio, Tchieno Melataguia Francis Merlin, Ketcha MBadkam Joseph

{"title":"Adsorptive removal of catechol and resorcinol by orange flavedo (citrus sinensis): mechanisms based on the flavedo com-ponents d-limonene, carotenoids, ascorbates, flavonoids and hydroxycinnamic acids","authors":"K. Théophile, Doungmo Giscard, Ngouoko Kouonang Jimmy Julio, Tchieno Melataguia Francis Merlin, Ketcha MBadkam Joseph","doi":"10.14419/IJBAS.V6I1.6647","DOIUrl":"https://doi.org/10.14419/IJBAS.V6I1.6647","url":null,"abstract":"Orange flavedo and its adsorption behavior towards catechol (Ctc) and resorcinol (Res) were studied. Adsorption experiments were conducted in batch mode at room temperature. X-ray diffraction (XRD), Scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), Brunauer−Emmett−Teller (BET) and Fourier transform infrared (FTIR) data were used to characterize the biosorbent. The Effects of various parameters including equilibrium pH, sorbent dosage, initial adsorbate concentration and contact time were investigated. The optimum contact time and pH for the removal of Ctc and Res were 35 min and pH 2 respectively. The adsorption isotherms fitted well with Freundlich model, the adsorption of Ctc and Res being multilayer and the surface of orange flavedo heterogeneous; the pseudo-second order kinetic model better reflects the adsorption phenomena. An adsorption mechanism based on the molecules grafted to the surface of the orange flavedo is proposed in this study. 0.2 gram of the biosorbent was sufficient to completely eliminate 2.2 milligrams of resorcinol and catechol from solution. Therefore, non-modified orange flavedo is a promising candidate, as a low-cost biosorbent, for the removal of Ctc and Res from aqueous solution.","PeriodicalId":14296,"journal":{"name":"International Journal of Sciences: Basic and Applied Research","volume":"118 1","pages":"7-16"},"PeriodicalIF":0.0,"publicationDate":"2017-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80251548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Impact of different fertilizers on some phytochemical constituents and biological activities of Beta vulgaris L. leaves 不同肥料对甜菜叶片部分化学成分及生物活性的影响

International Journal of Sciences: Basic and Applied Research Pub Date : 2017-01-30 DOI: 10.14419/IJBAS.V6I1.7228

G. Farouk, H. Mostafa

{"title":"Impact of different fertilizers on some phytochemical constituents and biological activities of Beta vulgaris L. leaves","authors":"G. Farouk, H. Mostafa","doi":"10.14419/IJBAS.V6I1.7228","DOIUrl":"https://doi.org/10.14419/IJBAS.V6I1.7228","url":null,"abstract":"Red beet leaves are used in some countries in salads, while others consider them as leftover. Our goal is to conduct field experiment, for two seasons, to evaluate the effect of various combinations of (organic, chemical and bio-/yeast) fertilizers and different harvest dates on some leaves growth parameters, biocostituents and biological activities. The applied fertilizers significantly increased most of the growth parameters compared to control and highest values were produced by 100%chemical fertilizer (2), followed by treatments of 75%biofertilizer (4) and 75%yeast (8). Highest chlorophyll (a&b) and carotenoids contents were recorded by treatments 2, 4 and 8, particularly those of the second stage. Most of the studied fertilizers significantly increased betanin and polyphenolic contents compared to control and highest values were attained by treatments 4 and 8. Maximum values of betanin and polyphenols were reached in the first and third stages, respectively. Additionally, highest antioxidant activity was afforded by leaves of treatments 4 and 8, whereas leaves of treatment 4 provided a broader antimicrobial activity than control. Moreover, the highest cytotoxic activity was exerted by leaves of treatment 4. Finally, it is recommended to harvest beet leaves at the appropriate stage to obtain high growth values and reasonable percentages of bioactive metabolites.","PeriodicalId":14296,"journal":{"name":"International Journal of Sciences: Basic and Applied Research","volume":"1 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82713595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2