International Journal of Radiation Biology最新文献

{"title":"Effects of radiation on respiratory disease mortality: analysis of the national registry for radiation workers in United Kingdom.","authors":"Wei Zhang,&nbsp;Richard G E Haylock,&nbsp;Michael Gillies,&nbsp;Nezahat Hunter,&nbsp;Erica Zhang","doi":"10.1080/09553002.2023.2187474","DOIUrl":"10.1080/09553002.2023.2187474","url":null,"abstract":"<p><strong>Purpose: </strong>While some evidence of an effect of radiation exposure on respiratory disease at low dose levels has now emerged, there is heterogeneity in the risks between different studies and countries. In this paper, we aim to show the effect of radiation on three different sub-types of respiratory disease mortality through the analysis of the NRRW cohort in UK.</p><p><strong>Materials and methods: </strong>The NRRW cohort consisted of 174,541 radiation workers. Doses to the surface of the body were monitored using individual film badges. Most of the doses are associated with X-rays and gamma rays and to a less extent of beta and neutron particles. The overall mean 10-year lagged lifetime external dose was 23.2 mSv. Some workers were potentially exposed to alpha particles. However, doses from internal emitters were not available for the NRRW cohort. 25% of male workers and 17% of female workers were identified as being monitored for internal exposure. The Poisson regression methods for grouped survival data with a stratified baseline hazard function were used to describe the dependence of the risk on cumulative external radiation dose. The disease was analyzed by the following subgroups: Pneumonia (1066 cases including 17 cases of influenza), COPD and allied disease (1517 cases) and other remaining respiratory diseases (479 cases).</p><p><strong>Results: </strong>There was very little radiation effect on pneumonia mortality, but evidence of a reduction in mortality risk for COPD and allied disease (ERR/Sv= -0.56, 95%CI: -0.94, -0.06; <i>p</i> = .02) and an increase in risk for other respiratory disease mortality (ERR/Sv = 2.30, 95%CI: 0.67, 4.62; <i>p</i> = .01) with increasing cumulative external dose were observed. The effects of radiation were more prominent amongst workers monitored for internal exposure. The reduction in mortality risk of COPD and allied disease per cumulative external dose was statistically significant for the radiation workers monitored for internal exposure (ERR/Sv= -0.59, 95%CI: -0.99, -0.05; <i>p</i> = .017) but not significant among the workers who were not monitored (ERR/Sv= -0.43, 95%CI: -1.20, 0.74; <i>p</i> = .42). A statistically significant increased risk was observed for other respiratory diseases among monitored radiation workers (ERR/Sv = 2.46, 95%CI: 0.69, 5.08; <i>p</i> = .019), but not among unmonitored workers (ERR/Sv = 1.70, 95%CI: -0.82, 5.65; <i>p</i> = .25).</p><p><strong>Conclusion: </strong>The effects of radiation exposure can be different depending on the type of respiratory disease. No effect was seen in pneumonia; a reduction in mortality risk of COPD, and increased mortality risk of other respiratory diseases were observed with cumulative external radiation dose. More studies are needed to verify these findings.</p>","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9112251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"9th international symposium on physical, molecular, cellular, and medical aspects of Auger processes: preface.","authors":"Katherine A Vallis,&nbsp;Roger F Martin,&nbsp;Nadia Falzone","doi":"10.1080/09553002.2022.2074755","DOIUrl":"https://doi.org/10.1080/09553002.2022.2074755","url":null,"abstract":"The 9th International Symposium on Physical, Molecular, Cellular, and Medical Aspects of Auger Processes took place from 22nd to 24th August 2019. This is a quadrennial event that has traditionally been held as a ‘satellite’ meeting of the International Congress for Radiation Research. Removal of an inner orbital electron through the photoelectric effect, electron capture, or internal conversion leads to a vacancy which is then filled by a cascade of electron transitions from the outer shells. These transitions are accompanied by the emission of low energy ‘Auger’ electrons or characteristic X-rays. Auger electrons have low energy (<25 keV), have a short track length and are densely ionizing. As a result, the absorbed radiation dose they deposit in biological material is extremely high but restricted to a nanoscale volume (a few nm) around the decay site. These qualities mean that Auger electron emitting radionuclides are suited to the ultra-precise delivery of radiation to individual cells, organelles or even to specific molecular targets, and so hold promise as oncologic therapeutic agents. The 9th Auger Symposium opened with a plenary presentation by Roger Howell, Rutgers University, who gave a comprehensive exposition of the advances in the use of Auger electrons in science and medicine during the period 2015–2019. The rest of the programme was organized into five scientific sessions focused on the availability and characteristics of ‘new’ Auger electron emitting radionuclides, physics, radiobiology, dosimetry and novel applications. Each session was headed by presentations by leaders in the field followed by selected papers from among submitted abstracts. Some of the research presented at the meeting has now been published as a collection of papers, together with a review article by Roger Howell summarizing his Keynote talk, in this ‘Special Auger Issue’ of the International Journal of Radiation Biology. The current series of Auger Symposia was inaugurated in 1987, when a group of radiation biologists and nuclear physicists met at the modest venue of the Oxfordshire village of Charney Bassett. It felt apt then that the 9th Symposium, which attracted 60 scientists from 13 countries, returned to Oxfordshire, although this time convening in the stunning Sultan Nazrin Shah Center located in the grounds of Worcester College, Oxford University. The scientific sessions were punctuated by opportunities for attendees to network and to enjoy some late summer sunshine and the tranquility of the College gardens and orchards. We would like to thank the other members of the organizing committee (Ana Denis-Bacelar, Bart Cornelissen, Samantha Terry and Akinari Yokoya) for their contributions, Anne-Marie Honeyman-Tafa for administrative assistance and Theragostics and the Gray Laboratory Cancer Research Trust for their sponsorship of the meeting. Auger electrons were independently identified by the physicists Lise Meitner and Pierre Auger; with Pierre Auger’","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9150444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity scoring systems for radiation-induced GI injury - prioritization for use of GI-ARS medical countermeasures.","authors":"Doreswamy Kenchegowda,&nbsp;David L Bolduc,&nbsp;Lalitha Kurada,&nbsp;William F Blakely","doi":"10.1080/09553002.2023.2210669","DOIUrl":"https://doi.org/10.1080/09553002.2023.2210669","url":null,"abstract":"<p><strong>Purpose: </strong>Severity scoring systems for ionizing radiation-induced gastrointestinal injury have been used in animal radiation models, human studies involving the use of radiation therapy, and human radiation accidents. Various radiation exposure scenarios (i.e. total body irradiation, total abdominal irradiation, etc.) have been used to investigate ionizing radiation-induced gastrointestinal injury. These radiation-induced gastrointestinal severity scoring systems are based on clinical signs and symptoms and gastrointestinal-specific biomarkers (i.e. citrulline, etc.). In addition, the time course for radiation-induced changes in blood citrulline levels were compared across various animal (i.e. mice, minipigs, Rhesus Macaque, etc.) and human model systems.</p><p><strong>Conclusions: </strong>A worksheet tool was developed to prioritize individuals with severe life-threatening gastrointestinal acute radiation syndrome, based on the design of the Exposure and Symptom Tool addressing hematopoietic acute radiation syndrome, to rescue individuals from potential gastrointestinal acute radiation syndrome injury. This tool provides a triage diagnostic approach to assist first responders to assess individuals suspected of showing gastrointestinal acute radiation syndrome severity to guide medical management, hence enhancing medical readiness for managing radiological casualties.</p>","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9783469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transgenerational changes in <i>Daphnia magna</i> under radio frequency radiation in the juvenile and puberty period.","authors":"Elena I Sarapultseva,&nbsp;Darya V Uskalova,&nbsp;Ksenya V Ustenko,&nbsp;Viktor N Tikhonov,&nbsp;Igor A Ivanov,&nbsp;Alexander V Tikhonov","doi":"10.1080/09553002.2022.2087928","DOIUrl":"https://doi.org/10.1080/09553002.2022.2087928","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the results of direct and transgenerational effects of radio frequency electromagnetic fields (RF-EMF) on the model organism of crustaceans <i>Daphnia magna</i>.</p><p><strong>Materials and methods: </strong><i>D. magna</i> were chronically exposed at 900 GHz EMF with an energy flux density (EFD) of about 1 mW/cm² in the juvenile and pubertal periods of their ontogenesis. The cytotoxicity of exposure as well as survival, fertility and teratogenic effect of directly exposed daphnids and their progeny across three generations were analyzed.</p><p><strong>Results and conclusions: </strong>The results of our study show that exposure of RF-EMF at juvenile period can significantly affect the fertility and size of irradiated daphnids and their offspring of the first generation. The decrease in fertility may be associated with a cytotoxic effect on the cells of irradiated animals. The reduction in the size of the terminal spine and the body of individuals is an indicator of the negative impact of radiation on the protective strategy of the crustacean population. The reproductive process is restored by the second generation. The results of our study provide further insights into the possible mechanisms underlying the in vivo effects of RF-EMF.</p>","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9797001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of gamma irradiation on morphology and protein differential in M1V1 population of <i>Vanilla planifolia</i> Andrews.","authors":"Rohayu Ma'Arup,&nbsp;Nur Syazwani Ali,&nbsp;Fisal Ahmad,&nbsp;Zaiton Ahmad,&nbsp;Mohamad Feisal Mohamed Norawi,&nbsp;Homaa Faezah Moinuddin","doi":"10.1080/09553002.2022.2087932","DOIUrl":"https://doi.org/10.1080/09553002.2022.2087932","url":null,"abstract":"<p><strong>Purpose: </strong>Lower doses (1-10 Krad) of gamma-rays (<i>γ</i>) are frequently used in obtaining useful mutants in diverse plant species, whereas no report on gamma (<i>γ</i>) irradiation being used to develop new varieties of vanilla from vanilla cuttings. This study assessed the potential of lower doses of gamma-rays for vanilla mutation breeding.</p><p><strong>Materials and methods: </strong>We compared the morphological differences between vanilla plants irradiated at different lower doses of gamma radiation (10, 30, 40, and 50 Gy). We quantified protein and compared variation from the extracted protein of vanilla shoots regenerated between treatments.</p><p><strong>Results and conclusions: </strong>After 44 weeks, the results showed that the growth of M1V1 (mutation 1 in vegetative cycle 1) plants at 0 Gy (control) is highest compared with other doses of gamma radiation in terms of plant height and the number of shoots. However, the highest measurement for root length is at 10 Gy. The slowest growth rate was obtained from 40 to 50 Gy. Based on the unique band of protein that appears on the SDS-PAGE gel, 10 Gy has three unique bands at loci 0.105 RF, two bands lie at loci between 0.164 RF and 0.234 RF. While 30 Gy is absent two unique bands at loci 0.234 RF compared to 0 Gy. Thus, the dose of gamma rays at 10 Gy gave the highest number of protein fragments, which detected polymorphisms between the control (0 Gy) and the plants treated. To our knowledge, this is the first report of the protein variation in M1V1 of irradiated vanilla plants.</p>","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9797002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic DNA damage induced by co-exposure to DNA damaging agents and pulsed magnetic field.","authors":"Beatriz López-Díaz,&nbsp;Silvia Mercado-Sáenz,&nbsp;Antonio M Burgos-Molina,&nbsp;Alejandro González-Vidal,&nbsp;Francisco Sendra-Portero,&nbsp;Miguel J Ruiz-Gómez","doi":"10.1080/09553002.2022.2121873","DOIUrl":"https://doi.org/10.1080/09553002.2022.2121873","url":null,"abstract":"<p><strong>Purpose: </strong>Many articles describe the effects of extremely low-frequency magnetic fields (MFs) on DNA damage induction. However, the mechanism of MF interaction with living matter is not yet known with certainty. Some works suggest that MF could induce an increase in the efficacy of reactive oxygen species (ROS) production. This work investigates whether pulsed MF exposure produces alterations in genomic DNA damage induced by co-exposure to DNA damaging agents (bleomycin and methyl methanesulfonate (MMS)).</p><p><strong>Materials and methods: </strong>Genomic DNA, prepared from <i>S. cerevisiae</i> cultures, was exposed to pulsed MF (1.5 mT peak, 25 Hz) and MMS (0-1%) (15-60 min), and to MF and bleomycin (0-0.6 IU/mL) (24-72 h). The damage induced to DNA was evaluated by electrophoresis and image analysis.</p><p><strong>Results: </strong>Pulsed MF induced an increment in the level of DNA damage produced by MMS and bleomycin in all groups at the exposure conditions assayed.</p><p><strong>Conclusions: </strong>Pulsed MF could modulate the cytotoxic action of MMS and bleomycin. The observed effect could be the result of a multifactorial process influenced by the type of agent that damages DNA, the dose, and the duration of the exposure to the pulsed MF.</p>","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9797007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Candidate biomarkers and persistent transcriptional responses after low and high dose ionizing radiation at high dose rate.","authors":"Zhenqiu Liu, John Cologne, Sally A Amundson, Asao Noda","doi":"10.1080/09553002.2023.2241897","DOIUrl":"10.1080/09553002.2023.2241897","url":null,"abstract":"<p><strong>Purpose: </strong>Development of an integrated time and dose model to explore the dynamics of gene expression alterations and identify biomarkers for biodosimetry following low- and high-dose irradiations at high dose rate.</p><p><strong>Material and methods: </strong>We utilized multiple transcriptome datasets (GSE8917, GSE43151, and GSE23515) from Gene Expression Omnibus (GEO) for identifying candidate biological dosimeters. A linear mixed-effects model with random intercept was used to explore the dose-time dynamics of transcriptional responses and to functionally characterize the time- and dose-dependent changes in gene expression.</p><p><strong>Results: </strong>We identified genes that are correlated with dose and time and discovered two clusters of genes that are either positively or negatively correlated with both dose and time based on the parameters of the model. Genes in these two clusters may have persistent transcriptional alterations. Twelve potential transcriptional markers for dosimetry-ARHGEF3, BAX, BBC3, CCDC109B, DCP1B, DDB2, F11R, GADD45A, GSS, PLK3, TNFRSF10B, and XPC were identified. Of these genes, BAX, GSS, and TNFRSF10B are positively associated with both dose and time course, have a persistent transcriptional response, and might be better biological dosimeters.</p><p><strong>Conclusions: </strong>With the proposed approach, we may identify candidate biomarkers that change monotonically in relation to dose, have a persistent transcriptional response, and are reliable over a wide dose range.</p>","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10845127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9953611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/09553002.2022.2147347","DOIUrl":"10.1080/09553002.2022.2147347","url":null,"abstract":"","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9850924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The delayed effects of acute radiation exposure (DEARE): characteristics, mechanisms, animal models, and promising medical countermeasures.","authors":"Tong Wu, Christie M Orschell","doi":"10.1080/09553002.2023.2187479","DOIUrl":"10.1080/09553002.2023.2187479","url":null,"abstract":"<p><strong>Purpose: </strong>Terrorist use of nuclear weapons and radiation accidents put the human population at risk for exposure to life-threatening levels of radiation. Victims of lethal radiation exposure face potentially lethal acute injury, while survivors of the acute phase are plagued with chronic debilitating multi-organ injuries for years after exposure. Developing effective medical countermeasures (MCM) for the treatment of radiation exposure is an urgent need that relies heavily on studies conducted in reliable and well-characterized animal models according to the FDA Animal Rule. Although relevant animal models have been developed in several species and four MCM for treatment of the acute radiation syndrome are now FDA-approved, animal models for the delayed effects of acute radiation exposure (DEARE) have only recently been developed, and there are no licensed MCM for DEARE. Herein, we provide a review of the DEARE including key characteristics of the DEARE gleaned from human data as well as animal, mechanisms common to multi-organ DEARE, small and large animal models used to study the DEARE, and promising new or repurposed MCM under development for alleviation of the DEARE.</p><p><strong>Conclusions: </strong>Intensification of research efforts and support focused on better understanding of mechanisms and natural history of DEARE are urgently needed. Such knowledge provides the necessary first steps toward the design and development of MCM that effectively alleviate the life-debilitating consequences of the DEARE for the benefit of humankind worldwide.</p>","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9766477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of <i>acrocarpus fraxinifolius</i> extract against hepatic fibrosis induced by Gamma irradiation and carbon tetrachloride in albino rats.","authors":"Omama E El-Shawi,&nbsp;Heba A S El-Nashar,&nbsp;Sahar S Abd El-Rahman,&nbsp;Omayma A Eldahshan,&nbsp;Abdel Nasser B Singab","doi":"10.1080/09553002.2022.2087926","DOIUrl":"https://doi.org/10.1080/09553002.2022.2087926","url":null,"abstract":"<p><strong>Purpose: </strong>Liver fibrosis is considered as one of the ultimate outcomes of chronic liver disorders, characterized by outrageous cell proliferation and abnormal deposition of extracellular matrix, resulting in sever pathological distortions in the architecture and performance of liver tissues. The present study aimed to investigate the protective properties of aqueous methanol extract of <i>Acrocarpus fraxinifolius</i> leaves (AFL) against liver fibrosis induced by dual toxicity of γ-irradiation and carbon tetrachloride (CCl₄) in rats.</p><p><strong>Methods: </strong>The animals were exposed to 2 Gy irradiation once/week concurrently with intraperitoneal administration of CCl₄ (0.2 mL/100 g body weight) for seven weeks. Afterwards, liver toxicity and fibrosis were assessed biochemically at cellular and molecular as well as histopathological levels.</p><p><strong>Results: </strong>The livers of intoxicated rats showed distinct structural and functional changes, compared with the normal rats. The administration of AFL (500 mg/kg, <i>p.o</i>) significantly ameliorated the histopathological manifestations of fibrotic liver evidenced by mitigated steatosis progression, necrosis, fibrotic septa, apoptotic bodies, and immunochistochemical studies of alpha-smooth muscle actin. Also, AFL increased the final body weight, total protein, albumin levels and albumin/globulin ratio. While, the absolute liver weight, liver enzymes, total cholesterol and triglycerides were reduced. A significant modulation was observed in hydroxyproline, transforming growth factor-<i>β</i> and collagen-1expression. Furthermore, AFL exerted a direct effect on liver fibrosis by promoting extracellular matrix degradation via overexpression of the tissue inhibitor metalloproteinase-1, coupled with decease of metalloproteinase-9 activity.</p><p><strong>Conclusions: </strong>Our findings suggested that AFL effectively improved the architecture of fibrotic liver and modified the biochemical markers of liver fibrosis.</p>","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9294677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}