International Journal of Pharmaceutical Quality Assurance最新文献_第9页

Validated HPTLC Analysis for Estimation of Quercetin in Seeds of Anethum graveolens 高效液相色谱法测定白花菊种子中槲皮素含量

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI: 10.25258/ijpqa.14.2.05

Sukeshini B. Lote, S. Agrawal, Shirin Ghune, Pravina Gurjar

{"title":"Validated HPTLC Analysis for Estimation of Quercetin in Seeds of Anethum graveolens","authors":"Sukeshini B. Lote, S. Agrawal, Shirin Ghune, Pravina Gurjar","doi":"10.25258/ijpqa.14.2.05","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.05","url":null,"abstract":"A high-performance thin layer chromatography (HPTLC) method for the quantification of quercetin was developed on methanolic extract of dill (Anethum graveolens) seeds and subsequently validated. A suitable mobile phase was used to establish the HPTLC method, ethyl acetate, toluene, methanol, chloroform, and formic acid (2:3:3:2). A densitometric analysis was done at 366 nm of wavelength. Quercetin has an Rf value of 0.55. In the dilution range of 100 to 800 ng per band, quercetin revealed a linear connection with r2= 0.9938 in the calibration’s linear regression analysis. By conducting replication analysis on 2 separate days and one day, accuracy was verified. The standard addition method was used to conduct recovery studies to validate accuracy. The quercetin recovery rate was 98.60% on average. Five replicates of each of the three standards were used to detect the system suitability parameter. With regard to both the peak area and the Rf value, the %RSD was observed to be under 2%. The mobile phase concentration was altered from Toluene: Ethyl acetate: Chloroform: Methanol (2:3:3:2) to (3:2:2:3) with few drops of formic acid. It was found to have a %RSD of peak area below 10%, the robustness of the method was assessed. The developed HPTLC method was discovered to be easy to use, precise, accurate, suitable, and robust for estimating quercetin from dill seed extract.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48651880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of HPLC Method for Estimation of Some Active Analytes in Combined Dosage form an Application to In-vitro Dissolution Studies 高效液相色谱法测定联合剂型中某些活性分析物的开发与验证——在体外溶出度研究中的应用

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI: 10.25258/ijpqa.14.2.16

Mayuri N. Deshmukh, Vaibhav Uplanchiwar, V. M. Thakare, Namrata S. Mane, S. Gaikwad, N. Dighade, Hina. Mehta, R. Bakal, Prashant R. Umate

引用次数: 0

Prevalence of Stress Among Health Professionals During COVID-19 Pandemic in The UAE: A Cross-sectional Study 阿联酋新冠肺炎大流行期间卫生专业人员压力的患病率：一项跨部门研究

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI: 10.25258/ijpqa.14.2.13

S. L. Budihal, S. A. Sharbatti

{"title":"Prevalence of Stress Among Health Professionals During COVID-19 Pandemic in The UAE: A Cross-sectional Study","authors":"S. L. Budihal, S. A. Sharbatti","doi":"10.25258/ijpqa.14.2.13","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.13","url":null,"abstract":"A cross-sectional study was conducted among full-time health professionals of both genders who agreed to participate and sign the consent form. A self-administered, standardized, work-related stress (WSQ) and perceived stress (PSS-10) questionnaire were used. In addition, information on socio-demography, general health, and work characteristics was obtained. Data was analyzed by SPSS version 27. The Chi-square test and logistic analysis were used. Results: The prevalence of moderate/high stress was 90%. The greatest prevalence of high stress was found among older compared to younger professionals [8.6 vs.7.5%, p=0.004], females compared to males [8.1 vs.7.8%, p=0.006], specialist/consultant compared to nurses and medical practitioners [9.7, 8, 2.6%; p=0.01]. Working > 48 hours/ week compared to ≤ 48 hours/week [8.6 vs. 6.3%, p=0.005], have chronic disease compared to No chronic disease [ 8.2 vs. 7.8%, p=0.04]. The percentage of stress in the following work domains: low influence at work; work interference with leisure time; items in “Indistinct Organization and Conflicts” and “Demands and commitments” were: 13, 70.3, 12.1 and 16.3%, respectively. Logistic analyses showed that gender and age significantly predict a high-stress level. Conclusion: The present study showed a high prevalence (90%) of moderate- to high-stress levels. Age and gender were significant predictors of high-stress levels among healthcare professionals. The most frequent work-related stress factor was work interference with leisure time (70.3%).","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46980043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Videodermoscopy Evaluation in Non-scarring Alopecia of Scalp 头皮无瘢痕性脱发的影像皮肤镜检查评价

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI: 10.25258/ijpqa.14.2.26

G. Rajauria, Sarita Jangra, Lokesh Barde, Kranti P. Musmade, Shaima Ka, B. Bhyan, C. Vani, V. S., R. S, H. Tare

{"title":"Videodermoscopy Evaluation in Non-scarring Alopecia of Scalp","authors":"G. Rajauria, Sarita Jangra, Lokesh Barde, Kranti P. Musmade, Shaima Ka, B. Bhyan, C. Vani, V. S., R. S, H. Tare","doi":"10.25258/ijpqa.14.2.26","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.26","url":null,"abstract":"Introduction: Hair is a versatile structure, and its importance has been linked to it in the beautification of human beings for ages. According to studies on the psychological impacts of androgenetic alopecia (AGA) in men, they are older, weaker, and less appealing. Hair loss in women gives significant stress and lowers self-confidence. Aim: To perform videodermoscopic findings in non-scarring alopecia of scalp versus control volunteers. Material and Methods: Total of 140 patients satisfied the study’s inclusion criteria after a general medical examination, scalp examination (including inspection of the hair shaft and root), and hair anchoring and fragility tests. We examined the lesions with a videodermoscopy, took images, and wrote up our findings. Results: The study found that patients averaged 26.85. Onset averaged 25.15 alopecia averaged 10.3 months. Our sample had 87.7% spotty AA. Conclusion: Videodermoscopy is an effective non-invasive tool of considerable potential in dermatological practice. It is becoming popular as a hair loss differential diagnosis tool.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49495987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Horse Chestnut Seed Extract: An Opportunity for Creating Evidencebased New Natural Products 七叶树籽提取物:创造基于证据的新天然产品的机会

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI: 10.25258/ijpqa.14.2.33

Poonam N. Chougule, M. Tayade, N. Chougule

{"title":"Horse Chestnut Seed Extract: An Opportunity for Creating Evidencebased New Natural Products","authors":"Poonam N. Chougule, M. Tayade, N. Chougule","doi":"10.25258/ijpqa.14.2.33","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.33","url":null,"abstract":"For centuries, herbal remedies have been used to prevent and treat disease. Horse chestnut seeds are an abundant source of phytoconstituents containing triterpenoid saponins, with thirty molecules isolated and characterized. Escin, which is a combination of acylated triterpene glycosides composed of α- and β-escin, is the major biologically active component of horse chestnut seed extract. Escin is the most researched veno-active compound with anti-inflammatory, anti-oedematous, and antioxidant properties. Due to their unique three pharmacological actions, escin is a well-established molecule for the management of venous diseases such as chronic venous insufficiency (CVI) and hemorrhoids. The available treatments for CVI have some disadvantages, including severe side effects, expensive surgical options, long duration of treatment, and limited accessibility to allopathic drugs. As a result, phytoconstituents and lifestyle changes can be seen as safe and effective therapy options for CVI management because they have no major side effects and can simultaneously function on several targets. This review article focuses on the chemical components of horse chestnut extract, particularly the phytoconstituents escin, and proanthocyanidins, which have been extensively studied in preclinical and clinical studies. The review article provides a comprehensive overview of their potential therapeutic benefits in managing symptoms of CVI and their regulatory status.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42268582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Evaluation of Extracts and Pharmacological Activity of Polyherbal Emulgel 多草药乳液提取物的植物化学评价及药理活性

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI: 10.25258/ijpqa.14.2.17

Jitendra Kandale, J. Sangshetti, P. Mahaparale, G. Dama, J. Bidkar

引用次数: 0

Formulation and Optimisation of Microspheres of Leaves extract of Lantana camara 32 Design Approach 大叶灯笼叶提取物微球的制备及优化

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI: 10.25258/ijpqa.14.2.04

Smita Mujbaile, D. Khobragade, Dharmenndra Mundhada

引用次数: 0

Investigation of the Effects of Chia-fortified Basisa on Diabetic Patients 中药加强型巴西沙对糖尿病患者疗效的研究

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI: 10.25258/ijpqa.14.2.18

Wedad M. A. Manjil, M. Ilowefah, H. B. Ismail, Hussein L. Algboory

{"title":"Investigation of the Effects of Chia-fortified Basisa on Diabetic Patients","authors":"Wedad M. A. Manjil, M. Ilowefah, H. B. Ismail, Hussein L. Algboory","doi":"10.25258/ijpqa.14.2.18","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.18","url":null,"abstract":"It suggested that phytochemicals found in cereals, legumes and chia possess several health effects. Consequently, this study aimed to investigate the influences of chia-fortified basisa on type II diabetes, total cholesterol and triglycerides. Urea, creatinine, blood pressure and body mass index were also determined. Basisa is a cereal-legumes food that were prepared using wheat, chickpea, lentils, fenugreek, turmeric and cumin in measured ratios. Chia powder was added to basisa by 5 and 10%. The participants were diabetic (type II) with cholesterol and triglycerides elevation. They were divided into three groups according to the chia powder (0, 5 and 10%) used. The study were conducted for 90 days. The results indicated that groups who had basisa with chia had significantly (p ˂ 0.01) low levels of HbA1c, cholesterol, LDL, triglycerides, BMI and blood pressure compared to the control groups after 90 days of the study. Urea and creatinine levels were increased; however, their levels were still in the normal range. It can be concluded chia powder enhanced the positive effects of basisa on chronic diseases and obesity.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43508211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of Hydroxypropyl Sesbania Galactamannan Seed Gum for Pharmaceutical Application 药用田菁半乳甘露聚糖羟丙基种子胶的合成与表征

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI: 10.25258/ijpqa.14.2.11

V. Chatap, G. Choudhari, Prashant Jain, M. Bhat

{"title":"Synthesis and Characterization of Hydroxypropyl Sesbania Galactamannan Seed Gum for Pharmaceutical Application","authors":"V. Chatap, G. Choudhari, Prashant Jain, M. Bhat","doi":"10.25258/ijpqa.14.2.11","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.11","url":null,"abstract":"The core focus of current research is chemical polysaccharide modification in pharmaceutical applications. The gum is made from the endosperm of Sesbania grandiflora Plant seeds that belongs to family Leguminosae. Both water-soluble and waterinsoluble gum were present in the Sesbania seed powder; the water-soluble gum was removed during purification, yielding a 30% purification yield. In order to increase the applications of partially hydroxypropyl Sesbania gum, the modifications indicated here entail adding hydroxypropyl groups to the molecule under a variety of different conditions. Among the factors that were looked at were the etherifying agent concentration, alkaline volume, and preparation medium parameters, including the reaction time and temperature. The degree of substitution (DS) was raised, which boosted the unaltered gum’s solubility, stability, and viscosity. Increases in an etherifying agent and alkali concentration, volume, reaction duration, and temperature increase DS from 0.4 to 0.7. The finished product was characterized using IR spectroscopy, differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, rheologic property, solubility, swelling index, and gel fraction analysis of batch F1 as an improved batch. The alternate method for developing drug-loaded nanoparticles for controlled release dosages form by suing hydroxypropyl Sesbania gum.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42391936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methacrylic Acid-Acrylamide based ZnO Hydrogel Nanocomposite Assisted Photocatalytic Decolorization of Methylene Blue Dye 甲基丙烯酸-丙烯酰胺基ZnO水凝胶纳米复合材料对亚甲基蓝染料的光催化脱色

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI: 10.25258/ijpqa.14.2.06

A. Alkaim, F. H. Abdulrazzak, Shaimaa M. Essa, Usama S. Altimari, Montather F. Ramadan, Aseel M. Aljeboree

{"title":"Methacrylic Acid-Acrylamide based ZnO Hydrogel Nanocomposite Assisted Photocatalytic Decolorization of Methylene Blue Dye","authors":"A. Alkaim, F. H. Abdulrazzak, Shaimaa M. Essa, Usama S. Altimari, Montather F. Ramadan, Aseel M. Aljeboree","doi":"10.25258/ijpqa.14.2.06","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.06","url":null,"abstract":"In this research, preparation of methacrylic acid-acrylamide based ZnO hydrogel nanocomposite (MAA-AM)/ZnO hydrogel nanocomposite by way of co-polymerization via used acrylate acid (AA) (or acrylate salt) (AA) or methacrylic acid (MAA)) and acrylamide (AM). Nanocomposites based on acrylate are characterized via being hydrophilic and able to retain water. Nanocomposite properties were studied using different techniques (FE-SEM, TEM, and EDX). The photocatalytic degradation of methylene blue MB dye under different conditions was studied using nanocomposite like time of irradiation, mass of catalyst (MAA- AM)/ZnO hydrogel nanocomposite, initial MB dye concentration onto photocatalytic degradation and reactivation were studied. The result increases the photocatalytic degradation with the rise weight of catalyst (MAA- AM)/ZnO hydrogel nanocomposite range (0.1–0.25 g). Too, a decrease in photocatalytic degradation was observed with an increase in MB. Observed that after reuse, ((MAA- AM)/ZnO) nanocomposite hydrogel appear photocatalytic efficiency from of the use 1 to 6 cycle 87.88 to 58.87%, showing that ((MAA- AM)/ZnO hydrogel nanocomposite surface appear good stability.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41432499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0