Formulation and Optimisation of Microspheres of Leaves extract of Lantana camara 32 Design Approach

Q3 Pharmacology, Toxicology and Pharmaceutics

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI:10.25258/ijpqa.14.2.04

Smita Mujbaile, D. Khobragade, Dharmenndra Mundhada

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引用次数: 0

Abstract

The leaf extracts of plant Lantana camara shows significant antithrombin and thrombolytic activity. Modified release form of extract will show better therapeutics efficiency. In this work the extracts of plant L. camara-loaded polycaprolactone microspheres were prepared using the double emulsion method. 32 design approaches were used for the optimization of polycaprolactone and PVP concentration for response entrapment efficiency (Y1) and drug release (Y2). The microspheres of L. camara were analyzed for EE, FTIR, DSC, XRD and drug release. The entrapment efficiency of L. camara microspheres was in ranges of 62.25 to 84.04%. The particle size of optimized batch of microspheres was 789.6 (d. nm) with PDI 0.838. It shows pH dependant swelling with no interaction between drug and polymer was observed in DSC studies. The % drug release of all thirteen batches was in ranges of 87.91 to 99.04% for 12 hours duration. From the study we conclude the prepared L. camara loaded polycaprolactone microspheres show sustained release action for 12 hours.

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大叶灯笼叶提取物微球的制备及优化

植物山楂叶提取物具有显著的抗凝血酶和溶栓活性。改良的提取物释放形式将显示出更好的治疗效果。本研究采用双乳法制备了植物L. camara-聚己内酯提取物微球。采用32种设计方法对聚己内酯和PVP浓度的响应包封效率(Y1)和药物释放率(Y2)进行优化。采用EE、FTIR、DSC、XRD和药物释放分析等方法对其微球进行分析。柠条微球的捕集率为62.25% ~ 84.04%。优化后的微球粒径为789.6 (d. nm)， PDI为0.838。DSC研究显示，pH依赖性肿胀与药物和聚合物之间没有相互作用。13批药物在12小时内的释放率在87.91 ~ 99.04%之间。实验结果表明，制备的蓖麻载聚己内酯微球具有12小时的缓释作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Pharmaceutical Quality Assurance Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE is a quarterly international journal publishing the finest peer-reviewed research in the field of Pharmaceutical Quality Assurance and Pharmaceutical Analysis on the basis of its originality, importance, disciplinary interest, timeliness, accessibility, elegance, and surprising conclusions. IJPQA also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.