International Journal of Pharmaceutical Quality Assurance最新文献

{"title":"Exploring the Potential of Eclipta alba: A Promising Approach for Hair Treatment Management through 5-Alpha Reductase Inhibition","authors":"Arpan Chakraborty, A. Bhattacharjee, B. Mondal, Manas Chakraborty, G. Mukhopadhyay, Maitrish Ghosh, A. Majumder","doi":"10.25258/ijpqa.14.2.07","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.07","url":null,"abstract":"A class of medications known as 5 alpha reductase (5α-reductase or 5αR) inhibitors is used to treat male pattern hair loss and benign prostatic hyperplasia. This study shows that Eclipta alba has 5αR inhibitory action that is helpful in the treatment of androgenic diseases. For 5αR enzyme inhibition evaluation, E. alba was extracted using methanol and petroleum ether. Further phytochemical screening can be done. Phytosterols test negatively found in methanol extract during phytochemical screening but positive in petroleum ether extract of E. alba. HPTLC data of different extracts was performed based on the phytochemical screening found. According to the HPTLC analysis, petroleum ether extract of E. alba contained 0.11% of β-sitosterol, while the methanolic extract had a higher concentration of 4.75%. The inhibitory activity of these plant extracts against 5αR was examined in comparison to the commonly used 5αR inhibitor, finasteride. IC50 measurements for petroleum ether extract of E. alba and β-sitosterol (a chemical biomarker derived from the plant material) were established as 150.76 ± 4.56 and 77.09 ± 3.07 μg/mL, correspondingly. These results indicate their potential as compelling contenders worthy of deeper exploration regarding their anti-androgenic properties. The notable abundance of β-sitosterol in the petroleum ether extract of E. alba enhances its potential for significant biological activity, particularly in terms of inhibiting the 5αR enzyme.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48906499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing of Nursing Intervention on Knowledge, Perceived Stigma and Health related Outcomes among Patients with Hepatitis B Virus","authors":"Nabila E. Sabola, Shereen A. Hussien, Azziza Kamel, Marwa A. Elsalamony, M. Shahin, L. A. Ali, Samia A. Loulah","doi":"10.25258/ijpqa.14.2.22","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.22","url":null,"abstract":"Background: Despite significant advances in the therapy components for hepatitis B virus (HBV) prevention and treatment, HBV-related stigma is seen as a major barrier to HBV management. The HBV-related health stigma has a direct negative impact on the process of healthcare delivery and medical decision-making. The study aimed to evaluate the effect of implementing the nursing intervention on knowledge, perceived stigma and Health-related outcomes among patients with hepatitis B Virus. Subjects and method: A quasi-experimental (pre -posttest) study research design was used. Study setting: The present study was carried out at Menoufia University Hospital (in-patient medical department) and well as in the out-patient medical department after patients discharge and followed up. Sampling. A purposive sample of 50 adult patients who were diagnosed with HBV virus. Results: The total mean knowledge score was significantly improved post-intervention than pre-intervention among studied HBV patients. The mean of hepatitis B stigma level reduced post-intervention. There were statistically significant improvements among studied patients’ related to some of abdominal, activity, and systemic symptoms post-intervention. There was a significant improvement for serum total bilirubin and serum ALT among studied patients post-intervention. There was a reverse correlation between hepatitis B knowledge and hepatitis B stigma post-intervention. Conclusion: Implementing a nursing intervention significantly enhances patient knowledge, lowers perceived stigma level and improves health-related outcomes. Recommendation: Establish periodic public awareness campaigns emphasizing hepatitis B virus transmission methods to discover new cases and control infection.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44393044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Significance of Benincasa hispida","authors":"Aryan Aggarwal, L. Sharma, Dhananjay Sharma, S. Dhobale, Nitin Deshmukh, Lokesh Barde, H. Tare","doi":"10.25258/ijpqa.14.2.28","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.28","url":null,"abstract":"Ash gourd is sometimes known as wax gourd, and it’s scientific name is “Benincasa hispida,” also known as B. cerifera, and it is from the family- Cucurbitaece. B. hispida is said to be originated from Japan and Java, but it was widely cultivated in warm climates. It is one of the most well-known crops, farmed largely due to its fruits, and is known for its nutritional and therapeutic benefits, particularly in Asia. It’s a famous vegetable crop that was used both for nutrition and medicine. Volatile oils, flavonoids, saccharides, glycosides, vitamin, proteins, ß-sitosterin, minerals, carotenes, and uronic acid are among the major constituents of B. hispida fruits, according to phytochemical analysis. According to pharmacological studies, the pharmacological activities of this plant included central nervous effects (muscle relaxant, anxiolytic, antidepressant, in the Alzheimer’s disease treatment and to reduce opiates withdrawal symptoms), antioxidant tanalgesic, antiasthmatic, diuretic, antiinflammatory, hypolipidemic, antidiabetic, nephroprotective, and antimicrobial. B. hispida’s chemical constituents and pharmacological effects were highlighted in this review. This paper discusses the cultivation, nutritional and chemical content, as well as the medical and therapeutic properties of this versatile fruit as one of the potential sources of bioactives for functional foods, among other topics.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45636958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Development of Analytical Method for Deflazacort Estimation: A Robust HPLC Approach","authors":"S. Pund, Vaibhav V Changediya, V. Rajurkar","doi":"10.25258/ijpqa.14.2.21","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.21","url":null,"abstract":"The data show that the RP-HPLC method can accurately determine the amount of deflazacort (DEF) in compound. Validation of procedure followed ICH standards. The wavelength of estimation for deflazacort was 266 nm. Linearity was found to be 20 to 100 μg/mL for deflazacort. The %recovery for deflazacort was found to be 80 to 120%. Intraday precision of deflazacort was found to be 0.069 to 0.168% RSD. Interday precision found to be 0.0156 and 0.176% RSD .","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49639604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the Power of AI in Pharmacokinetics and Pharmacodynamics: A Comprehensive Review","authors":"V. Pawar, A. Patil, F. Tamboli, D. Gaikwad, D. Mali, A. Shinde","doi":"10.25258/ijpqa.14.2.31","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.31","url":null,"abstract":"Personalized medicine, medication discovery, and development might all benefit greatly from AI’s incorporation into pharmacokinetics and pharmacodynamics. Target identification, therapeutic effectiveness prediction, drug design optimization, obstacles, and future possibilities are all explored in this survey of AI applications in these areas. An overview of pharmacokinetics and pharmacodynamics is presented first, stressing the significance of knowing how drugs are absorbed, distributed, metabolized, and excreted and the correlation between drug concentration and pharmacological effect. The article then looks into the function of AI in target identification, exploring how machine learning algorithms and data integration may be used to discover new drug targets and enhance the design of existing ones. Classification and regression methods are also investigated for their potential use in the prediction of therapeutic efficacy using AI. Patient data, molecular interaction data, and clinical response data are just a few examples of the types of data that may be used to fuel the creation of predictive models that might assist in dosage and efficacy optimization. Metrics and procedures for validating these models are addressed to evaluate their efficacy. Additionally, de novo drug design, virtual screening, and structure-based drug design are all discussed in relation to the use of AI in optimizing drug development. The paper provides examples of how AI has been applied successfully in different settings, demonstrating its potential to hasten the drug discovery process and enhance treatment outcomes. We examine data availability, interpretability, and ethical implications as challenges and limits of AI in pharmacokinetics and pharmacodynamics. To guarantee these technologies’ proper and ethical use, we also discuss the regulatory elements and rules for applying AI in drug research. Possibilities and prospects for the use of AI in pharmacokinetics and pharmacodynamics are discussed as a conclusion to the review. It stresses the significance of regulatory standards and clinical translation, as well as the incorporation of multiomics data, deep learning methods, real-time monitoring, explainable artificial intelligence, collaborative networks, and more.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45857348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosynthesis of Silver Nanoparticles using Annona squamosa L Seed and Leaves Extract: Evaluation of the Anti-inflammatory, Antifungal, and Antibacterial Potency","authors":"Yogesh S Kolekar, F. Tamboli, D. Gaikwad, S. Memon, S. Gulavani, K. Alaskar, D. Mali, V. Pawar","doi":"10.25258/ijpqa.14.2.23","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.23","url":null,"abstract":"Creating efficient therapeutic techniques against multi-drug resistant pathogens is crucial in the age of rising bacterial resistance and infectious disease outbreaks. In this case, Annona squamosa seed and leaf extract were used to create silver nanoparticles, which were then assessed using various characterization techniques, including UV-vis scanning electron microscopy, X-ray powder diffraction, particle size, and Fourier-transform infrared spectroscopy. The synthesized AgNPs were tested for their ability to combat a variety of gram-positive and gram-negative bacteria as well as their ability to control free radicals and inflammation brought on by skin damage caused by microbial infection. AgNPs from seeds have a greater effect than those from leaves, so they were used to create several batches of gel formulation utilizing different gelling agents such as HPMC, chitosan, and Carbopol. Gel was also evaluated for its physical characteristics, including color, clarity, pH, viscosity, spreadability, and extrudability. It also underwent a centrifugation test and a drug release test. Since the F6 batch outperformed the other batches in the evaluation test, it was chosen to evaluate the antibacterial and antifungal activity.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44559136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Nutritional Needs of Mothers and Babies: A Review","authors":"S. Joshi, L. Sharma, Lokesh Barde, Manoj Tare, Dwarkadas Baheti, G. Dama, H. Tare","doi":"10.25258/ijpqa.14.2.30","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.30","url":null,"abstract":"The aim is to assess the importance of measuring healthy habits by pregnant women, that enhance different factors of mother and fetus health. We evaluate the change and variations in dietary recommendations. A female went through a lot of physical and mental changes in different stages of pregnancy and there are some common symptoms such as vomiting, fatigue, nausea, frequent urination, dizziness, etc. Certain hormonal changes are there to balance the body’s fatigue, tiredness, and hormones, few dietary recommendations are mentioned and it has been concluded that diet plays an important role during pregnancy, and meeting all the nutrition needs is an essential factor in planning the diet. Many diseases/deficiencies are there such as goiter, iodine deficiency, folate deficiency, gestational diabetes mellitus, gestational weight gain, Neural tube defects, and much more. A detailed view is mentioned below in the following paper: On average, pregnancy lasts 40 to 42 weeks (Nine months). On average, weight gain for a pregnant woman is 12 to 14 kg, thus weight gain can lower the risk of complications during labor and also lower the risk of LBW (low birth weight). Low GWG increases the risk of having an LBW infant. The average weight of the baby should be 2.5–3 kg. A baby having this much body weight should be considered a healthy infant. We provide up-to-date advice for achieving optimal nutrition before conception, throughout breastfeeding, in the first two years of life, and for preschoolers, with an eye on long-term health benefits. These guidelines are intended to aid in the primary prevention of obesity and the non-communicable diseases it is linked to among economically privileged groups, such as European women and children. Medical professionals should be incentivized and educated to promote and advise patients on preconception nutrition, which includes enhancing adolescent nutrition and health. Women who are physically active, eat healthily, don’t smoke, don’t drink excessively, and have a good body mass index (BMI) have a higher chance of having a safe pregnancy. Women of childbearing age should have their consumption and status of specific micronutrients closely monitored, especially folate. Women at risk for insufficient dietary intake of certain micronutrients may benefit from taking dietary supplements containing iron, vitamin D, vitamin B12, iodine, and maybe others. Smoke and alcohol should be strictly eliminated from the diet. Yes, diet plays an important role during pregnancy but staying physically active is equally important for the mother and the baby to promote general health and well-being. Exercise and stretching can reduce the risk of excessive maternal weight gain or gestational weight gain(Obesity). A long walk can greatly help a pregnant woman after lunch or in the morning.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44923838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of HPLC And HPTLC for Simultaneous Analysis of E and Z Guggulsterone, A-11–KBA And 11–KBA from Herbal Formulation","authors":"S. Ahmad, Aakanksha Dashpute, M. Patil, Manish Bhise, Lokesh Barde, Kranti P. Musmade, H. Tare","doi":"10.25258/ijpqa.14.2.25","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.25","url":null,"abstract":"RP-HPLC and HPTLC are two easy, sensitive, efficient, and accurate procedures that allow for simultaneous estimates of Z and E guggulsterone, A-11-KBA, and 11-KBA. For the HPLC method, we recommend the use of a symmetry C18 column. Using a solvent gradient based on solvent A (orthophosphoric acid) and solvent B (methanol), the effluent was monitored at 250 nm with a 1.0 mL/min flow rate. The peaks of 11-KBA and A-11-KBA were eluted at 5.8 and 6.3 minutes, while those of Z and E-guggulsterone were at 4.8 and 5.3 minutes. For the HPTLC method of separation, a silica gel layer was applied on an aluminum plate prewashed in methanol using a Camag Linomat V applicator fitted with a 100 μL syringe. The linear expansion was carried out using a solvent mixture of n-hexane, chloroform, ethyl acetate, and methanol (v/v/v: 10:3:3:1, respectively). Camag T.L.C. scanner III (V 1.4.3.6336), operating in reflectance-absorbance mode at 254 nm and controlled by win CATS software, was used to carry out the densitometric scanning. The R.F. resolutions for 11-KBA, A-11-KBA, E-guggulsterone, and Z-guggulsterone in the selected mobile phase were 0.68, 0.61, 0.39, and 0.28, respectively. The linearity, accuracy, and precision of the techniques were all confirmed. The proposed methods were successful in estimating E- and Z-guggulsterone as well as 11-KBA and A-11-KBA.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41644381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QbD Approach for Analysis of Tirzepatide in its Bulk and Marketed Formulation by Stability Indicating RP-HPLC","authors":"V. Goud, P. Sirisha, R. N, Ramreddy Godela, B.durga Prasad","doi":"10.25258/ijpqa.14.2.27","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.27","url":null,"abstract":"The core intentions of the stated work has been to create and validate a simple, sensitive, specific, precise and cost-effective RP-HPLC method with good performance for the investigation of tirzepatide in API powder and its marketed formulation. HPLC system (WATERS) equipped with DAD detection system was used to develop the current system. The procedure conditions of BDS C18 (150 x 4.6 mm,5 m), 0.01N KH2PO4: Acetonitrile in the ratio of 41:59 (% v/v), a flow of 0.9 mL/min, and a temperature of 31°C were successfully optimized by central composite design of QbD experiments. The optimized wavelength selected was 250 nm. RT of tirzepatide was observed to be 2.841 minutes with good system suitability. The ICH Q2(R1) standards functioned as a validation for the planned action strategy. Linearity was observed for 5 to 30 μg/mL concentration series of tirzepatide with R2 of 0.999. The %RSD results of both precisions were found in the range of 0.40 to 0.41.% recovery of Tirzepatide in spiked samples was assessed to be 99.89%. The LoD and LoQ of tirzepatide were calculated to be 0.05 and 0.14 μg/mL, respectively. The results assured that the established procedure was simple, sensitive, specific, accurate and costeffective. Exploration of tirzepatide under a diversity of FD conditions represents the stability representing the quality of the established HPLC procedure. Hence, the anticipated process has significant credit in the pharmaceutical segment.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41995419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation, Optimization, Compatibility Study of Captopril Proniosome, and In-vitro, In-vivo Evaluation of Release Study","authors":"Vaibhav L. Narwade, N. Singh","doi":"10.25258/ijpqa.14.2.14","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.14","url":null,"abstract":"Coagulation compartment isolation technology has also developed transdermal proteosome arrays using various non-ionic surfactants. Span-60 proteasomes have reduced HLB values, longer chains alkyl, and high transition temperatures, resulting in higher capture efficiency (84.14 ± 4.76). The addition of cholesterol LDL and lecithin also increased bilayer stiffness. The size of the vesicles decreases with his Tween method and multiplies with wingspan and consciousness. Low polydispersity index and high zeta capacity were observed in the arrangement of proteasomes. TEM studies confirm perfectly round niosomes. Infrared studies have confirmed that the vesicular form has no drug interactions and no drug is trapped. Proniosomes demonstrated slower release kinetics than controls. Captopril in 40% PEG. Additionally, the defined emission charge of span changes compared to Tween, which can be attributed to the lipophilicity of span and captopril. The release profile was observed for the Higuchi version, suggesting that drug introduction is diffusion controlled. The transdermal flux of captopril was highest for the span 60 system in isolated and closed rat skin.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42284787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}