Design and Development of Analytical Method for Deflazacort Estimation: A Robust HPLC Approach

Q3 Pharmacology, Toxicology and Pharmaceutics

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI:10.25258/ijpqa.14.2.21

S. Pund, Vaibhav V Changediya, V. Rajurkar

引用次数: 0

Abstract

The data show that the RP-HPLC method can accurately determine the amount of deflazacort (DEF) in compound. Validation of procedure followed ICH standards. The wavelength of estimation for deflazacort was 266 nm. Linearity was found to be 20 to 100 μg/mL for deflazacort. The %recovery for deflazacort was found to be 80 to 120%. Intraday precision of deflazacort was found to be 0.069 to 0.168% RSD. Interday precision found to be 0.0156 and 0.176% RSD .

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一种稳健的高效液相色谱法设计和开发去甲氧杂星的分析方法

数据表明，反相高效液相色谱法能准确地测定复方中的去甲硫醚（DEF）含量。程序验证遵循ICH标准。平替氮唑的估算波长为266 nm。研究发现，平缩唑的线性范围为20至100μg/mL。爆燃的回收率为80%至120%。研究发现，平替扎卡的日内精密度RSD为0.069至0.168%。日间精密度分别为0.0156和0.176%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Pharmaceutical Quality Assurance Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE is a quarterly international journal publishing the finest peer-reviewed research in the field of Pharmaceutical Quality Assurance and Pharmaceutical Analysis on the basis of its originality, importance, disciplinary interest, timeliness, accessibility, elegance, and surprising conclusions. IJPQA also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.