Yuxuan Xue, Yichen Wang, Xinyu Liu, Yin-Lau Lee, Jiawei Zhang, W. Yeung, Ning Xi
{"title":"Dual-Arm Nanorobotic System for Measuring Embryo with Minimum Disturbances","authors":"Yuxuan Xue, Yichen Wang, Xinyu Liu, Yin-Lau Lee, Jiawei Zhang, W. Yeung, Ning Xi","doi":"10.1109/NEMS57332.2023.10190875","DOIUrl":"https://doi.org/10.1109/NEMS57332.2023.10190875","url":null,"abstract":"The understanding of the embryo behavior, especially the early-stage development was hampered by the lack of proper diagnostic tools for clinical assessment before embryo implantation. Mechanical properties are label free biomarkers for the cells/embryo differentiation, as the atomic force microscopy (AFM) based experiment could simultaneously derive the surface morphological and mechanical information without damage to the cells. However, for the measurement of floating embryo, the lack of the constraint from the substrate will induce fluctuation and movement in lateral direction, causing failure in accurate measurement. Traditionally, researchers rely on the physical or chemical bounds to constrict the floating objects which may alter the objects’ properties and decrease the measurable region. Thus, it’s significant to implement the micromanipulator-based robot with AFM system to accomplish multiple tasks in the manipulation and measurement of single embryo. The system established in the current study could precisely manipulate and sense the living floating embryo without any extra treatment.","PeriodicalId":142575,"journal":{"name":"2023 IEEE 18th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124591606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detection of Different Structural Proteins Using Solid-state Nanopores","authors":"Lichun Zou, Peifu Bian, Haiyan Wang, Jingjie Sha","doi":"10.1109/NEMS57332.2023.10190955","DOIUrl":"https://doi.org/10.1109/NEMS57332.2023.10190955","url":null,"abstract":"As a crucial biomolecule of life, protein has diverse three-dimensional structural and functional properties, typically with various $alpha$-helix and $beta$-fold ratios. Its structure in living organisms provides important information for the study of normal or pathological physiological processes. And the nanopore technology, as a novel single-molecule sensor, has been used extensively in protein molecular detection and structural identification, because of its advantages such as label-free and easy operation. Here, we use solid-state nanopores to detect two kinds of structural proteins. The results show that since different proteins cause different blocking current signals when passing through solid-state nanopores, so we confirmed that solid-state nanopores enable protein characterization and the $beta$-fold-rich proteins have more structural possibilities.","PeriodicalId":142575,"journal":{"name":"2023 IEEE 18th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115665489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Frequency Avoid-Crossing Effect Induced by the Hybrid Modal Coupling in a Disk MEMS Resonator Gyroscope","authors":"Kuo Lu, Kai Wu, Qingsong Li, Xuezhong Wu, D. Xiao","doi":"10.1109/NEMS57332.2023.10190897","DOIUrl":"https://doi.org/10.1109/NEMS57332.2023.10190897","url":null,"abstract":"This paper reports the frequency avoid-crossing effect induced by the hybrid modal coupling in a disk resonator gyroscope. In the case of stiffness mismatch, the orthogonal response signals of hybrid modes can be simultaneously detected due to the existence of stiffness axis deflection angle. With the changing bias voltage, the hybrid modal coupling between the same-order eigenmodes can be described theoretically and experimentally. When two hybrid modal frequencies are gradually approximated, the frequency avoid-crossing effect appears under the influence of the stiffness axis declination. It demonstrates that the avoid-crossing region is determined by the stiffness axis declination, which reflects the hybrid modal coupling strength and provides guidelines for the tunable hybrid couplings.","PeriodicalId":142575,"journal":{"name":"2023 IEEE 18th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115571943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhiwei Wen, Xiyu Gu, Yao Cai, T. Luo, Xin-Yi Tong, Wenjuan Liu, Yuanhang Qu, Yan Liu, Chengliang Sun
{"title":"A Tunable Dual-mode Lamb Wave Resonator with Floating Electrodes","authors":"Zhiwei Wen, Xiyu Gu, Yao Cai, T. Luo, Xin-Yi Tong, Wenjuan Liu, Yuanhang Qu, Yan Liu, Chengliang Sun","doi":"10.1109/NEMS57332.2023.10190885","DOIUrl":"https://doi.org/10.1109/NEMS57332.2023.10190885","url":null,"abstract":"In this paper, we present a tunable dual-mode Lamb wave resonator (LWR) based on Aluminum nitride thin films. The dual-mode LWR consists of floating electrodes positioned between interdigital electrodes (IDTs), which results in two resonant peaks, operating at 1.69GHz and 1.757 GHz when the height (H) of floating electrodes is $0.05 mu mathrm{m}$ and the width W is $0.7 mu mathrm{m}$, respectively. The resonant frequency and impedance ratio of the two peaks are tuned by the size of the floating electrodes. When the H is from $0.05 mu mathrm{m}$ to 0.25 $mu mathrm{m}$ and the W is $0.7 mu mathrm{m}$, the distance between the two peaks $(Delta f)$ is adjusted from 67MHz to 455MHz. Furthermore, as W increases, the impedance ratio of the first peak is amplified while the second peak is attenuated. The coupling strength of the two peaks is close to that of conventional single-peak resonators. The tunable LWR with optimized floating electrodes shows great potential in fabricating high-frequency dual-passband filters.","PeriodicalId":142575,"journal":{"name":"2023 IEEE 18th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127053645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dongyang Chen, Lican Zheng, Jincheng Wang, Yu Xie, Wei Zhou, Tao Luo
{"title":"Simulation of A Bidirectional Microfluidic Pump Actuated by Ultrasound Based on Microcantilever Arrays","authors":"Dongyang Chen, Lican Zheng, Jincheng Wang, Yu Xie, Wei Zhou, Tao Luo","doi":"10.1109/NEMS57332.2023.10190972","DOIUrl":"https://doi.org/10.1109/NEMS57332.2023.10190972","url":null,"abstract":"In this work, we propose a novel design of a microfluidic pump that can pump flow bidirectionally by changing the frequency of the external remote ultrasound. Finite element analysis (FEA) is used to analyze the feasibility of our design. The bidirectional microfluidic pumping fundamentally relies on the utilization of microcantilevers with different dimensions for achieving distinct resonance frequencies. In this way, ultrasound with different frequencies can be used to induce bidirectional acoustic streaming flow in the microchannel by selective actuation of two microcantilever arrays. The simulation presented in this work shows that the direction of pumping flow can be changed by changing the frequency of the ultrasound, which lays a strong foundation for us to develop an fully implantable bidirectional micropump for applications such as implantable drug delivery and biopsy.","PeriodicalId":142575,"journal":{"name":"2023 IEEE 18th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133126183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chia-Chin Hsieh, Wang-Jiun Lee, Kuan-Chun Yeh, N. Huang
{"title":"The anodic aluminum oxide (AAO) template fabricated Localized Surface Plasmon Resonance (LSPR) sensor for the plasmonic coupling effect study","authors":"Chia-Chin Hsieh, Wang-Jiun Lee, Kuan-Chun Yeh, N. Huang","doi":"10.1109/NEMS57332.2023.10190902","DOIUrl":"https://doi.org/10.1109/NEMS57332.2023.10190902","url":null,"abstract":"The localized surface plasmon resonance (LSPR) sensing has drawn significant attention in biosensing fields due to its label-free, dynamic, sensitive, and ease-of-operation sensing capability. In our study, we utilized an anodic aluminum oxide (AAO) template to fabricate a large-area LSPR sensor with adjustable nanostructure parameters such as period and diameter. By using different nanostructure patterns, we investigated the plasmonic coupling effect and optimized the nanostructure geometry. Our research demonstrates the real-time and multipoint detection of pathogen DNA sequences. Based on the above features, we believe that this platform has the potential for point-of-care (POC) biosensing applications.","PeriodicalId":142575,"journal":{"name":"2023 IEEE 18th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134335274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Novel Method for Packaging Microfluidic Thread-based Analytical Devices by Encapsulating Threads into Thermal Contraction Tubes","authors":"Zejingqiu Chen, Muyang Zhang, Haonan Li, Weijin Guo","doi":"10.1109/NEMS57332.2023.10190958","DOIUrl":"https://doi.org/10.1109/NEMS57332.2023.10190958","url":null,"abstract":"Cotton threads have been popular for the fabrication of microfluidic thread-based analytical devices (μTADs) for point-of-care diagnostics. In this work, we introduced a new method for packaging μTADs by encapsulating cotton threads into thermal contraction tubes. After placing the cotton threads into thermal contraction tubes, a hot air gun is used to heat the contraction tube and make it shrink to encapsulate the cotton threads tightly. The thermal contraction tube can serve as a rigid backing of the cotton threads, and make it easier to handle them during experiments. We investigate the influence of this package method by conducting capillary filling experiments in cotton threads packaged by this method. We find that after the cotton threads are encapsulated into thermal contraction tubes, the volume capacity of water absorption and average capillary flow velocity change. Furthermore, by changing the length of thermal contraction tubes, we investigate the influence of partial encapsulation on the average capillary flow velocities in cotton threads. The results of this work can provide some guidance for design of μTADs.","PeriodicalId":142575,"journal":{"name":"2023 IEEE 18th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114800719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Junlin Lu, W. Nie, Yun Cao, Xiaoyu Kong, He Wang, Jionglu Wang
{"title":"Loitering Missile Environment Information analysis and application in Fuze S&A","authors":"Junlin Lu, W. Nie, Yun Cao, Xiaoyu Kong, He Wang, Jionglu Wang","doi":"10.1109/NEMS57332.2023.10190848","DOIUrl":"https://doi.org/10.1109/NEMS57332.2023.10190848","url":null,"abstract":"As a new kind of ammunition on the battlefield in recent years, airborne loitering missile is widely used to carry out various combat tasks and has attracted extensive attention from all countries in the world. Based on the campaign mode of the airborne loitering missile, there is no strong inertial force during its launching and flight, so the fuze S&A cannot rely on the strong inertial force. In this paper, identification and processing methods are designed for the weak environment information, which includes aerodynamic and attitude information. In the launching stage, the variations of missile’s aerodynamic and attitude angle are large and frequent. In contrast, the variations are slight and stable in the straight-level flight stage. Based on MEMS sensors and the missile guidance and controlling system, the difference of the weak environment information between the two adjacent stages can be obtained. Based on this difference, the loitering missile can distinguish whether it is in the straight-level flight stage, and it can be used as the typical feature for the missile fuze S&A arming. Due to the MEMS sensors and processing circiuts, the volume of fuze S&A will be smaller and the safety distance between the launching aircraft will also be extended by this method.","PeriodicalId":142575,"journal":{"name":"2023 IEEE 18th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125304696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anis Amirah Alim, Roharsyafinaz Roslan, Sh. Nadzirah, M. Nassir, Weihong Zhang, A. Ismail, Dee Chang Fu, Mohd Ambri Mohammed, J. Yunas, M. R. Buyong, A. A. Hamzah
{"title":"Carbon nanotubes grown on sputtered copper islands using atmospheric pressure chemical vapor deposition for biosensor applications","authors":"Anis Amirah Alim, Roharsyafinaz Roslan, Sh. Nadzirah, M. Nassir, Weihong Zhang, A. Ismail, Dee Chang Fu, Mohd Ambri Mohammed, J. Yunas, M. R. Buyong, A. A. Hamzah","doi":"10.1109/NEMS57332.2023.10190858","DOIUrl":"https://doi.org/10.1109/NEMS57332.2023.10190858","url":null,"abstract":"As-deposited copper on silicon wafer by sputtering and subsequent thermal annealing at atmospheric pressure enables the formation of copper islands. Dewetting of copper catalyst by annealing promotes the growth of self-assembly carbon nanotubes (CNT) on the copper islands. A few nanometers sputtered copper thin film was annealed with the presence of argan gas in vacuum-less chamber under 1000$^{circ}C$ to promote the dewetting process of copper thin film. $40 cm^{3}$/min of methane gas was supplied inside the chamber to grow the CNT. Due to this fabrication simplicity with the potential for mass production, dewetting technique was chosen compared to other preparation of catalyst nanoparticles method. Atomic Force Microscopy (AFM) and Field Emission Scanning Electron (FESEM) were done to study the morphology of the sample. Raman analysis was done to identify the quality of CNT with the presence of D,G, G’ and D peaks. The current obtained in the measurement was 55.3 $mu A$ in DC mode. Thus, CNT has garnered much attention as one of the most potential building blocks for high sensitivity and rapid detection sensing system.","PeriodicalId":142575,"journal":{"name":"2023 IEEE 18th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"334 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123334536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multifunctional lipopolymeric nanosystem for photothermal assisted cancer therapy","authors":"Monika Pebam, A. Rengan","doi":"10.1109/NEMS57332.2023.10190857","DOIUrl":"https://doi.org/10.1109/NEMS57332.2023.10190857","url":null,"abstract":"PTT has shown promising target cancer therapy and has been able to achieve high cancer cell death rates while rescuing normal tissue. In this article, IR-775 a less explored hydrophobic photosensitizer was used in combination with polyphenols for the treatment of cancer. The nanosystem consists of HSPC, PLA, IR-775 dye and the polyphenols constituents from Terminalia chebula. The lipopolymeric nanosystem HP pIR NPs (HSPC-PLA-polyphenols extract-IR775) exhibit size range of (142.6 ± 2nm). HP pIR NPs have shown excellent intracellular uptake when studied against A549 and zebrafish. Both the PDT/PTT trigger ROS production and enhance the cancer cell death inhibiting the growth of the remnant cell.","PeriodicalId":142575,"journal":{"name":"2023 IEEE 18th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125178814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}