International Journal of PharmTech Research最新文献

{"title":"Approaches for Solubility enhancement of Floroqunilones(Second Generation) during Scale Up Procedures","authors":"S. Minocha, S. Pahwa","doi":"10.20902/IJPTR.2019.120306","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120306","url":null,"abstract":"","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"177 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77101194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Characteristics of Patients With Giant Cell Tumors in\u0000General Hospital of Haji Adam Malik Medan In 2013-2018","authors":"Agussalim salim, Nazar Moesbar, Andriandi","doi":"10.20902/ijptr.2019.120401","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120401","url":null,"abstract":"Objective-Giant Cell Tumors (GCT) in bone is a rare musculoskeletal tumor. The purpose of this study was to study the characteristics of patients with Giant Cell Tumors in RSUP. Haji Adam Malik for 2013- 2018. Materials and Methods-The type of research conducted is a retrospective descriptive research method. This research was conducted in RSUP. Adam Malik Haji Medan based on medical records of patients with Giant Cell Tumors during the period of January 2013 - December 2018. The collected medical and demographic data is tabulated and presented in the form of a frequency distribution chart or table and analyzed in full. Data analysis used in this study uses total sampling which is presented in the form of tables or diagrams.Results-During the period of the study taken from the medical record data of Medan Haji Adam Malik Hospital, 37 patients with Giant Cell Tumors were treated. Distribution of the number of sample subjects with diagnoses of giant cell tumors of male sex as many as 19 patients (51.3%) while female sex numbered 18 patients (48.6%). Based on the location of giant cell tumors obtained by distal radius of 3 patients (8.1%), femur as many as 9 patients (24.3%), fibula as many as 2 patients (5.4%), proximal tibia as many as 14 patients (37 , 9)%), then in categories other than long bones (digiti) as many as 5 patients (13.5%), patella as many as 2 patients (5.4%), and pedis as many as 2 patients (5.4%). Based on the actions taken, as many as 21 people (56.7%) carried out extensive excision, curettage + bone cement as many as 11 people (29.7%), amputation in 3 patients (8.1%), ORIF + bone grafts by 2 people (5.5%). In this study, of 37 patients with giant cell tumors with stage 1 no patients, stage 2 as many as 12 people (32.4%), stage 3 as many as 25 people (67.5%).Conclusion- Patients with tumor giant cells were found at productive age, there was not much difference in sex, the most campanacci stage was in stage 3, the most common sites were proximal to the tibia, the most extensive measures were also available, and metastases were not available to other organs.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81375782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Findings of Ultrasound (USG) Examination in\u0000Pediatric Patients with suspected Appendicitis with\u0000Intraoperative Findings","authors":"Hari Irawan, E. Fikri, E. R. Daulay","doi":"10.20902/ijptr.2019.120410","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120410","url":null,"abstract":"Background & Objectives: Unspecified lower abdominal pain might confuse clinicians in diagnosing pediatric appendicitis. Ultrasonography, as an initial affordable tool, has been learned its role in reducing unnecessary appendectomy. This study aimed to determine the accuracy of ultrasonography in pediatric acute appendicitis and its correlation to intraoperative findings, confirmed by histopathology results. The result would verify other study experience. Methods : The study was a diagnostic study which retrospectively review the children who underwent an ultrasound study for suspected appendicitis in pediatric surgery division of Haji Adam Malik Hospital and Universitas Sumatera Utara Hospital, Medan, North Sumatera between January 2014 until March 2019. We determined the accuracy along with sensitivity and specificity results of Ultrasonography (USG) using calculated formula. The comparation between ultrasonography results and intraoperative findings was analyzed using Chi Square test or its alternative. Results : Among the 32 patients, male and female were almost equal in 1:1 ratio, with mean age of 14.06 (±3.98) years old. Twenty-six patients were positively diagnosed as appendicitis using ultrasonography. Only two patients have no appendicitis based on intraoperative findings, confirmed by histopathology results. There is a statistically significant difference between ultrasonography findings and histopathology results (p=0,03). We obtained the accuracy of ultrasonography in predicting appendicitis was 87.5%, with 86.7% sensitivity and 100% specificity. Conclusion : Our results compare favorably with alternative studies, however indicate the potential for improvement in accuracy of image, with a future study incorporating new ways of categorizing ultrasound findings presently being undertaken.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78288624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory Activity Goblet Depletion and focal inflammatory Phaleria macrocarpha Leaves Ethanol Extract on Crypta Mouse after Dextran Sodium Sulphate Induction","authors":"R. Maharani, Kusmardi, B. Elya","doi":"10.20902/IJPTR.2019.120106","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120106","url":null,"abstract":"Colitis Ulcerative is a major public health problem throught the worldwide. Recently many studies have focused to finding antinflammatory based on the natural product. The study was aimed to investigative the inhibitory activity of Phaleria macrocarpa leaves extract on goblet cell in colitis ulcerative. Methods: In this study, Swiss mice were induced by 2% dextran sodium sulfate during a week. Phaleria macrocarpa leaves extract each dose of 100, 200, and 300 mg daily and aspirin 0.2 mg, administered orally. Histopathological examination of the colon tissue (hematoxylin-eosin staining) was done by counting the number of goblet cells a in five randomly selected fields visual. The results: Phaleria macrocarpa leaves extract significantly inhibit the depletion of the count of goblet cells (P 0.000) in colitis. Phaleria macrocarpa leaves extract significantly reduce the amount of focus of inflammation (P 0.000) in colitis. Conclusion: Our results indicated that may have inhibitory activity in colitis through inhibiting reduction in the number of goblet cell.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85477910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Components from Flowers of Sesbania grandiflora\u0000L.: Extraction and Optimization Studies","authors":"S. Sujithra","doi":"10.20902/ijptr.2019.120403","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120403","url":null,"abstract":"Plant based extracts are attractive sources of nutraceutical which have been shown to produce promising results in the treatment of curing many diseases and disorders. Sesbania grandiflora Linn is one such plant commonly known as Agathi belongs to the family, Fabaceae native to tropical region that has been used medicinally for centuries. The present study deals with bioactive components extraction from the flowers of Sesbania grandiflora using different solvents namely ethanol, methanol, petroleum ether, acetone, and n-hexane using soxhlet apparatus. Response surface methodology is applied to optimize the extraction process of bioactive components from Sesbania grandiflora flower. The effect of process parameters such as temperature (40 0C to 600C), time (8hr to 10hr) and the quantity of sample (10gm to 20gm) on extraction yield was studied. Among the five solvents used in the study, a maximum yield 9.95% was found when ethanol is used. Phytochemical constituents of the extract were analyzed using phytochemical screening methods. The extraction yield is optimized for different process variables using design of experiments.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89972416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased Blood Glucose and Histopathology Improvement\u0000in Hyperbaric Hyperoxic Conditions Alloxan-induced\u0000rats(Laboratory Experimental Study)","authors":"R. Budiarti","doi":"10.20902/ijptr.2019.120408","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120408","url":null,"abstract":"Background: Diabetes mellitus is still a problem in Indonesia, related to the number of organs involved. This disease has relatively high morbidity and mortality rates. Adjuvant therapy is needed considering the long-term therapy that must be consumed by patients. Objective: To explain the effect of hyperbaric oxygen in reducing blood glucose levels, and repairing histopathological damage to the pancreas and liver. Method : this study was an experimental laboratory study using whistar strain rats (Rattus Norvegicus) which were given a normal diet then induced alloxan to create a hyperglycemia condition. After that, 12 rats from the treatment group were given 3 x 30’ hyperbaric oxygen exposure for 6 days. Blood glucose levels, histopathological changes in the pancreas and liver was measured between the treatment group and the control group were not given hyperbaric oxygen exposure. Results: There was a significant difference (α< 0,05) in decreasing blood glucose and repairing histopathological damage in pancreatic and liver tissue between treated group and control group. Conclusion: hyperbaric oxygen treatment as much as 3 x 30'for days at 2.4 ATA O2 100% reduce blood glucose levels and repair histopathological damage to pancreatic tissue and liver of alloxan- induced white rats.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90295977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two- Year Survival Analysis and Factors influencing Survival of Acute Myocardial Infarction","authors":"Yasmine F. Siregar, S. Kasiman, Z. Safri, H. Hasan, Abdul H. Reynaldo, F. Habib","doi":"10.20902/ijptr.2019.120204","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120204","url":null,"abstract":"Background: Non-ST segment elevation myocardial infarction (NSTEMI) has less frequent complications, but has worse long-term prognosis than ST segment elevation myocardial infarction (STEMI). Mortality rates of NSTEMI were lower than STEMI but after 6 months both mortality were similar. The purpose of this study was to determine the 2-year survival in patients with acute myocardial infarction (AMI). Method: This cohort retrospective study included 264 AMI patients treated from January – December 2015 in H. Adam Malik Medan General Hospital. The study sample was divided based on the diagnosis of STEMI and NSTEMI. Data were obtained from medical records. All patients were contacted by phone to determine their condition 2 years after experiencing AMI. Multivariate analysis was performed to assess the factors that affect the survival. The 2-year survival of STEMI and NSTEMI was compared using the Kaplan Meier plot.Result: From 264 patients, there were 216 (81.8%) men with median age of 56 years. We found 147 STEMI patients and 117 NSTEMI patients. NSTEMI group tended to have history of coronary artery disease, higher blood pressure, less revascularization, longer hospitalization days and less number of post AMI complications. Survival and mortality rates in 2 years were 58% and 28%. Multivariate analysis showed higher blood pressure (OR 1.023, CI 95%, 1.003 – 1.044) dan PCI during hospitalization (OR 8.604, CI 95%, 2.264 – 32.702) showed better 2-year survival. There were no significant 2-year survival differences between the two groups (log rank 0.136). Better 2-year survival was found in patients with single vessel disease (log rank 0.001), patients who received revascularization (log rank 0.001) and patients who did not experience heart failure or cardiogenic shock during hospitalization (log rank 0.001). Conclusion: There was no difference in 2-year survival between STEMI and NSTEMI patients who were admitted to H. Adam Malik Medan General Hospital in 2015. The 2-year survival appeared better in patients with single vessel disease, received revascularization and did not experience heart failure or cardiogenic shock during hospitalization. Keyword: survival, mortality, STEMI, NSTEMI. Yasmine F. Siregar et al /International Journal of PharmTech Research, 2019,12(2): 119127. DOI: http://dx.doi.org/10.20902/IJPTR.2019.120204 International Journal of PharmTech Research CODEN (USA): IJPRIF, ISSN: 0974-4304, ISSN(Online): 2455-9563 Vol.12, No.02, pp 119-127, 2019 Yasmine F. Siregar et al /International Journal of PharmTech Research, 2019,12(2): 119-127. 120","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85280203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocompatibility Assessments of Surgical sutures: Intracutaneous Reactivity Test in New Zealand White Rabbits","authors":"Tangthong Jiraporn, Klinkhamhom Aekkarin, Likitsuntornwong Wanlop, Amted Nanthana","doi":"10.20902/IJPTR.2019.120208","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120208","url":null,"abstract":"","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86754712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrophotometric Determination of Vandetanib in Bulk by Area Under Curve and First Order Derivative Methods","authors":"B. Khandare, P. Dudhe, S. Upasani, M. Dhoke","doi":"10.20902/ijptr.2019.120202","DOIUrl":"https://doi.org/10.20902/ijptr.2019.120202","url":null,"abstract":"","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79898424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of Dry Dispersible Emulsion (DDE) to Enhance The Dissolution Rate of Curcumin","authors":"M. Jufri","doi":"10.20902/IJPTR.2019.120211","DOIUrl":"https://doi.org/10.20902/IJPTR.2019.120211","url":null,"abstract":"","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82058347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}