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International Journal of Pharmacology最新文献

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Investigating the Herb-Drug Interaction Between Danhong Injection and Dapagliflozin in Rats 丹红注射液与达格列净在大鼠体内的相互作用
4区 医学
International Journal of Pharmacology Pub Date : 2024-11-15 DOI: 10.3923/ijp.2024.1457.1465
Yuxian Lin, Huijun Shang, Jinhui Wang, Fengdong Zhao, Xinxin Yang, Zhennan Li, Yuanying Zhu, Qinghua Wen, Hui Xu, Yingcong Yu
{"title":"Investigating the Herb-Drug Interaction Between Danhong Injection and Dapagliflozin in Rats","authors":"Yuxian Lin, Huijun Shang, Jinhui Wang, Fengdong Zhao, Xinxin Yang, Zhennan Li, Yuanying Zhu, Qinghua Wen, Hui Xu, Yingcong Yu","doi":"10.3923/ijp.2024.1457.1465","DOIUrl":"https://doi.org/10.3923/ijp.2024.1457.1465","url":null,"abstract":"Background and Objective: Danhong injection (DHI) and Dapagliflozin (DAPA) cured diabetes and coronary heart disease and metabolized via the liver. The study observed the possible interaction of DHI and DAPA in vivo. Materials and Methods: The rats were divided into six groups: DAPA alone and co-administered with low/high-dose DHI for 7 days and DHI alone and co-administered with low/high-dose DAPA. The blood samples were collected at different times. The plasma concentrations of DAPA and salvianolic acid B (SAB), an ingredient in DHI, were analyzed. The rat liver microsomes (RLMs) investigate the UGT1A9 activity and protein concentration in the metabolism of DAPA and DHI. Results: The major PKs of DAPA, including AUC(0-t), CLz/F, Vz/F and Tmax, were significantly influenced by co-administration DHI. Conversely, the primary PKs of SAB, including AUC(0-t), AUC(0-4), Tmax, CLz/F, Vz/F and Cmax, were remarkable differences between DHI alone and co-administration DAPA. In the RLMs, low-dose DHI was a significant inhibitor of DAPA in UGT1A9 activity. There were no apparent changes in the protein concentration with RLMs in groups. Conclusion: The findings elucidated that there were partial differences in PK properties of DHI and SAB among groups, with a slight influence on the UGT1A9 activity. Increasing the amount of DHI resulted in a weakening of the effect of DAPA. The SAB changes may be induced by compounds of DHI with CYP-related and self-metabolism.","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"20 8","pages":"1457-1465"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://storage.imrpress.com/imr/journal/IJP/article/522711/1752884912304.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Design, Synthesis and Biological Evaluation of Biphenyl-1,2,3-Triazole Hybrid Analogues as PD-1/PD-L1 Inhibitors 联苯-1,2,3-三唑杂化PD-1/PD-L1抑制剂的设计、合成及生物学评价
4区 医学
International Journal of Pharmacology Pub Date : 2024-01-15 DOI: 10.3923/ijp.2024.106.114
Shijia Zhou, Suresh Narva, Mengda Wu, Ming Wang, Feng Zhang, Chenfeng Shen, Annoor Awadasseid, Wen Zhang
{"title":"Design, Synthesis and Biological Evaluation of Biphenyl-1,2,3-Triazole Hybrid Analogues as PD-1/PD-L1 Inhibitors","authors":"Shijia Zhou, Suresh Narva, Mengda Wu, Ming Wang, Feng Zhang, Chenfeng Shen, Annoor Awadasseid, Wen Zhang","doi":"10.3923/ijp.2024.106.114","DOIUrl":"https://doi.org/10.3923/ijp.2024.106.114","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"20 1","pages":"106-114"},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and Characterization of Coated and Uncoated Liposomes as Insulin Carriers 包被与未包被脂质体作为胰岛素载体的设计与表征
4区 医学
International Journal of Pharmacology Pub Date : 2023-09-15 DOI: 10.3923/ijp.2023.466.484
Dinorah Vargas-Est, María J. Bernad-Ber, Sara del Carmen Caballero-, Sheila I. Peñ, Jessica Contreras-, Ramiro Gonz&aacut, Alejandra Romero-Mon, Jesus Gracia-Mor, Francisco Sánchez Bartez, María I. Gracia-Mor
{"title":"Design and Characterization of Coated and Uncoated Liposomes as Insulin Carriers","authors":"Dinorah Vargas-Est, María J. Bernad-Ber, Sara del Carmen Caballero-, Sheila I. Peñ, Jessica Contreras-, Ramiro Gonz&aacut, Alejandra Romero-Mon, Jesus Gracia-Mor, Francisco Sánchez Bartez, María I. Gracia-Mor","doi":"10.3923/ijp.2023.466.484","DOIUrl":"https://doi.org/10.3923/ijp.2023.466.484","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"237 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135352778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective Effects of Ibudilast Against Cisplatin-Induced Hepatotoxicity and Nephrotoxicity Mediated by Prostacyclin Enhancement 异丁司特对顺铂肝毒性和前列环素增强介导的肾毒性的保护作用
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2023-09-15 DOI: 10.3923/ijp.2023.447.454
Özlem Özkul, B. Özkul, M. Erdoğan, O. Erbaş
{"title":"Protective Effects of Ibudilast Against Cisplatin-Induced Hepatotoxicity and Nephrotoxicity Mediated by Prostacyclin Enhancement","authors":"Özlem Özkul, B. Özkul, M. Erdoğan, O. Erbaş","doi":"10.3923/ijp.2023.447.454","DOIUrl":"https://doi.org/10.3923/ijp.2023.447.454","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44920830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metformin and Resveratrol Suppress Oxidative Stress/Hypoxia Axis Associated with the Amelioration of Thioacetamide-Induced Liver Injury 二甲双胍和白藜芦醇抑制氧化应激/缺氧轴与改善硫代乙酰胺诱导的肝损伤有关
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2023-09-15 DOI: 10.3923/ijp.2023.439.446
M. Alzahrani, H. Ebrahim, Aida Sanad Alqarni, F. Al-Hashem
{"title":"Metformin and Resveratrol Suppress Oxidative Stress/Hypoxia Axis Associated with the Amelioration of Thioacetamide-Induced Liver Injury","authors":"M. Alzahrani, H. Ebrahim, Aida Sanad Alqarni, F. Al-Hashem","doi":"10.3923/ijp.2023.439.446","DOIUrl":"https://doi.org/10.3923/ijp.2023.439.446","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46597329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy Anticancer Properties of Rosmarinus officinalis L. Essential Oils on The SH-SY5Y Neuroblastoma Cell Line in vitro 迷迭香精油对 SH-SY5Y 神经母细胞瘤细胞株的体外自噬抗癌特性
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2023-09-15 DOI: 10.3923/ijp.2023.881.892
A. Al-dbass, Sohair Aly Hassan, R. Bhat, A. I. A. Khayyat, A. El-Ansary
{"title":"Autophagy Anticancer Properties of Rosmarinus officinalis L. Essential Oils on The SH-SY5Y Neuroblastoma Cell Line in vitro","authors":"A. Al-dbass, Sohair Aly Hassan, R. Bhat, A. I. A. Khayyat, A. El-Ansary","doi":"10.3923/ijp.2023.881.892","DOIUrl":"https://doi.org/10.3923/ijp.2023.881.892","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"25 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139339521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Cinnamon Extract on Ovarian Torsion Detorsion Damage in Rats 肉桂提取物对大鼠卵巢扭转脱落损伤的影响
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2023-09-15 DOI: 10.3923/ijp.2023.842.851
Eda Bingul, Elif Hizal, B. Suleyman, R. Mammadov, S. Bulut, D. Altuner, Tugba Bal Tastan, Tugba Erkmen Dogru, H. Suleyman
{"title":"Effect of Cinnamon Extract on Ovarian Torsion Detorsion Damage in Rats","authors":"Eda Bingul, Elif Hizal, B. Suleyman, R. Mammadov, S. Bulut, D. Altuner, Tugba Bal Tastan, Tugba Erkmen Dogru, H. Suleyman","doi":"10.3923/ijp.2023.842.851","DOIUrl":"https://doi.org/10.3923/ijp.2023.842.851","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"59 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139339555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aesculus hippocastanum Alleviates Diabetic Neuropathy by Reducing MMP-9 and MMP-10 Levels 通过降低 MMP-9 和 MMP-10 水平缓解糖尿病神经病变
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2023-09-15 DOI: 10.3923/ijp.2023.862.871
Edip Gonullu, Gozde Dagistan, Yakup Ozsezer, M. Erdoğan, O. Erbaş
{"title":"Aesculus hippocastanum Alleviates Diabetic Neuropathy by Reducing MMP-9 and MMP-10 Levels","authors":"Edip Gonullu, Gozde Dagistan, Yakup Ozsezer, M. Erdoğan, O. Erbaş","doi":"10.3923/ijp.2023.862.871","DOIUrl":"https://doi.org/10.3923/ijp.2023.862.871","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"34 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139339680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Anti-Tyrosinase Activity of Pyrus communis Leaves Extract and Cosmetic Formulation 评估黄柏叶提取物和化妆品配方的抗酪氨酸酶活性
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2023-08-01 DOI: 10.3923/ijp.2023.834.841
Jing Wang, Imtiaz Gull, S. Kousar, Rimsha Shahzad
{"title":"Evaluation of Anti-Tyrosinase Activity of Pyrus communis Leaves Extract and Cosmetic Formulation","authors":"Jing Wang, Imtiaz Gull, S. Kousar, Rimsha Shahzad","doi":"10.3923/ijp.2023.834.841","DOIUrl":"https://doi.org/10.3923/ijp.2023.834.841","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"21 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139352248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thrombocytopenia Induced in Mice by Intraperitoneal Administration of Gold and Iron Oxide Nanoparticles 腹腔注射纳米金和氧化铁诱导小鼠血小板减少症
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2023-08-01 DOI: 10.3923/ijp.2023.801.809
Hassan Almarshad, Abozer Y. Elderdery, Fawaz Alenazy, Khaled Shalaby, Ismail Hamad, Omnia Hendawy
{"title":"Thrombocytopenia Induced in Mice by Intraperitoneal Administration of Gold and Iron Oxide Nanoparticles","authors":"Hassan Almarshad, Abozer Y. Elderdery, Fawaz Alenazy, Khaled Shalaby, Ismail Hamad, Omnia Hendawy","doi":"10.3923/ijp.2023.801.809","DOIUrl":"https://doi.org/10.3923/ijp.2023.801.809","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"22 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139352264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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