International Journal of Pharmacology最新文献

{"title":"ACE/ACE2 Steady State: A Novel Mechanism of Rosmarinic Acid in Alcohol-Associated Gastric Ulcer","authors":"T. Luo, X Zhang, Zhi-qiang null Zheng, Tao null Zeng, F Y Li, Li-hong null Wan, Zhi-hui null Yi, Li Zhu","doi":"10.31083/ijp47086","DOIUrl":"https://doi.org/10.31083/ijp47086","url":null,"abstract":"Background: The local inhibition of the gastric renin angiotensin system (RAS) has emerged as a pivotal therapeutic target in treating gastric ulcers. Rosmarinic acid (RA), a medically significant herb belonging to the category of water-soluble polyphenolic compounds, exhibits notable antiulcer properties. Our previous research has demonstrated that the anti-ferroptosis effect of RA in lipopolysaccharide (LPS)-induced septic acute respiratory distress syndrome (ARDS) depends on the RAS. Therefore, this study aimed to assess the underlying mechanism through which RA mitigates ethanol-induced gastric ulcers in mice. Methods: Gastric tissue samples were collected from patients with gastric ulcers to perform RNA sequencing (RNA-seq) and bioinformatics analyses. Moreover, the gastric ulcer mouse model was induced through a single gavage of absolute ethanol at a dose of 0.1 mL/10 g. Before induction, mice were orally administered RA at doses of 4 and 20 mg/kg, or esomeprazole 3.03 mg/kg (as a reference drug), for a duration of 5 days. The anti-gastric ulcer effects were assessed through histopathological evaluations and Western blot analysis. Results: The RNA-seq data and bioinformatic insights revealed that the angiotensin-converting enzyme (ACE)/angiotensin (Ang) 2 converting enzyme (ACE2) balance may constitute a novel mechanism in alcohol-related gastric ulcer, which RA modulates. A total of six overlapping targets related to both RA and gastric ulcers were identified. Among them, matrix metalloproteinase-1 (MMP1), matrix metalloproteinase-3 (MMP3), and A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, type 4 (ADAMTS4) presented low binding energy with RA and formed a protein-protein interaction (PPI) network with ACE and ACE2. In vivo experiments further substantiated that RA conferred gastric protection by restoring the ACE/ACE2 balance and upregulating GPX4 expression. Conclusions: RA might be a potential gastroprotective agent by suppressing RAS-related ferroptosis in the gastric tissues.","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"21 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Characterization of Coated and Uncoated Liposomes as Insulin Carriers","authors":"Dinorah Vargas-Est, María J. Bernad-Ber, Sara del Carmen Caballero-, Sheila I. Peñ, Jessica Contreras-, Ramiro Gonz&aacut, Alejandra Romero-Mon, Jesus Gracia-Mor, Francisco Sánchez Bartez, María I. Gracia-Mor","doi":"10.3923/ijp.2023.466.484","DOIUrl":"https://doi.org/10.3923/ijp.2023.466.484","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"237 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135352778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effects of Ibudilast Against Cisplatin-Induced Hepatotoxicity and Nephrotoxicity Mediated by Prostacyclin Enhancement","authors":"Özlem Özkul, B. Özkul, M. Erdoğan, O. Erbaş","doi":"10.3923/ijp.2023.447.454","DOIUrl":"https://doi.org/10.3923/ijp.2023.447.454","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44920830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin and Resveratrol Suppress Oxidative Stress/Hypoxia Axis Associated with the Amelioration of Thioacetamide-Induced Liver Injury","authors":"M. Alzahrani, H. Ebrahim, Aida Sanad Alqarni, F. Al-Hashem","doi":"10.3923/ijp.2023.439.446","DOIUrl":"https://doi.org/10.3923/ijp.2023.439.446","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46597329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autophagy Anticancer Properties of Rosmarinus officinalis L. Essential Oils on The SH-SY5Y Neuroblastoma Cell Line in vitro","authors":"A. Al-dbass, Sohair Aly Hassan, R. Bhat, A. I. A. Khayyat, A. El-Ansary","doi":"10.3923/ijp.2023.881.892","DOIUrl":"https://doi.org/10.3923/ijp.2023.881.892","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"25 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139339521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Cinnamon Extract on Ovarian Torsion Detorsion Damage in Rats","authors":"Eda Bingul, Elif Hizal, B. Suleyman, R. Mammadov, S. Bulut, D. Altuner, Tugba Bal Tastan, Tugba Erkmen Dogru, H. Suleyman","doi":"10.3923/ijp.2023.842.851","DOIUrl":"https://doi.org/10.3923/ijp.2023.842.851","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"59 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139339555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aesculus hippocastanum Alleviates Diabetic Neuropathy by Reducing MMP-9 and MMP-10 Levels","authors":"Edip Gonullu, Gozde Dagistan, Yakup Ozsezer, M. Erdoğan, O. Erbaş","doi":"10.3923/ijp.2023.862.871","DOIUrl":"https://doi.org/10.3923/ijp.2023.862.871","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"34 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139339680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Anti-Tyrosinase Activity of Pyrus communis Leaves Extract and Cosmetic Formulation","authors":"Jing Wang, Imtiaz Gull, S. Kousar, Rimsha Shahzad","doi":"10.3923/ijp.2023.834.841","DOIUrl":"https://doi.org/10.3923/ijp.2023.834.841","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"21 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139352248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombocytopenia Induced in Mice by Intraperitoneal Administration of Gold and Iron Oxide Nanoparticles","authors":"Hassan Almarshad, Abozer Y. Elderdery, Fawaz Alenazy, Khaled Shalaby, Ismail Hamad, Omnia Hendawy","doi":"10.3923/ijp.2023.801.809","DOIUrl":"https://doi.org/10.3923/ijp.2023.801.809","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"22 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139352264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulation of MicroRNA-146a Increases the Sensitivity of Cisplatin-Resistant Lung Cancer Cells to Chemotherapy Through the Toll-Like Receptor-Signaling Pathway","authors":"M. Kandeel, M. A. Morsy, Hany Mohamed Abd El-Lat, Mohamed Marzok, Hossam S. El-Beltagi, K. Venugopala","doi":"10.3923/ijp.2023.749.757","DOIUrl":"https://doi.org/10.3923/ijp.2023.749.757","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":"5 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139352459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}