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International Journal of Pharmacology最新文献

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Non-Insulin Secretion Relative Hypoglycemic Effect of Neonatal Streptozotocin-induced Diabetic Rats by Gavage Feeding Antrodia cinnamomea (Agaricomycetes) 链状佐菌素诱导的新生糖尿病大鼠灌胃非胰岛素分泌相对降糖作用
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2022-11-15 DOI: 10.3923/ijp.2022.1605.1612
Bingzhen Ji, Chi-Wen Huang, Ying‐I Chen, W. Ho, Shu-Wei Chang, Shih-Liang Chang, Chin-Hsien Chang
{"title":"Non-Insulin Secretion Relative Hypoglycemic Effect of Neonatal Streptozotocin-induced Diabetic Rats by Gavage Feeding Antrodia cinnamomea (Agaricomycetes)","authors":"Bingzhen Ji, Chi-Wen Huang, Ying‐I Chen, W. Ho, Shu-Wei Chang, Shih-Liang Chang, Chin-Hsien Chang","doi":"10.3923/ijp.2022.1605.1612","DOIUrl":"https://doi.org/10.3923/ijp.2022.1605.1612","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44346687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Arabic Gum (Acacia senegal) on Paracetamol-Induced Chronic Nephrotoxicity in Albino Rats 阿拉伯胶对白化大鼠扑热息痛所致慢性肾毒性的影响
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2022-11-15 DOI: 10.3923/ijp.2022.1593.1604
Walla’a A Osman, Gomaa Mostafa-He, A. Osman, L. Rashed, Dina A Labib
{"title":"Effect of Arabic Gum (Acacia senegal) on Paracetamol-Induced Chronic Nephrotoxicity in Albino Rats","authors":"Walla’a A Osman, Gomaa Mostafa-He, A. Osman, L. Rashed, Dina A Labib","doi":"10.3923/ijp.2022.1593.1604","DOIUrl":"https://doi.org/10.3923/ijp.2022.1593.1604","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42894014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network Pharmacological Investigation of Sinomenine Action Against Synovitis 青藤碱抗滑膜炎作用的网络药理学研究
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2022-11-15 DOI: 10.3923/ijp.2022.1550.1559
Zhi Li, Jian-Yu Mao, Xiaodong Zhou, Zhen-dong Xu
{"title":"Network Pharmacological Investigation of Sinomenine Action Against Synovitis","authors":"Zhi Li, Jian-Yu Mao, Xiaodong Zhou, Zhen-dong Xu","doi":"10.3923/ijp.2022.1550.1559","DOIUrl":"https://doi.org/10.3923/ijp.2022.1550.1559","url":null,"abstract":"Background and Objective: Synovitis is characterized as the inflammation of the synovial membrane, which often occurs in osteoarthritis. The incidence of this medical condition may be related to age, immunological responses and other co-morbidities. Therefore, the objective of the study was to elucidate the anti-Synovitis potential of sinomenine. Materials and Methods: The associated targets about sinomenine and synovitis were investigated in Homo sapiens, which was then elucidated by the PPI network construction via STITCH database. Furthermore, Cytoscape and its plugin were used for gene ontology (GO) analysis. Results: The literature survey and the network revealed 25 potential target proteins to be associated with sinomenine, of which many proteins such as OPRD1, CHRM1 and DAMGO were found to be significantly related to the bioactive action of sinomenine in Homosapiens. Moreover,the GO terms which were associated with the functioning of sinomenine for its anti-Synovitis potential were found to befour, analyzed by the functional annotation gene clusters and abundance values of the target proteins. Conclusion: The results of the study demonstrate the anti-Synovitis potential of sinomenine, where its action is dependent upon the molecular mechanisms that exert its beneficial role against synovitis. The core mechanisms that may be related to its anti-synovitis action may be adenylate cyclase-activating G-protein coupled receptor signalling pathway, regulation of smooth muscle contraction, adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signalling pathway and positive regulation of nitric oxide metabolic process.","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46537358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ameliorating Effect of Propofol on Cisplatin-Induced Liver and Kidney Damage in Rats 异丙酚对顺铂所致大鼠肝肾损伤的改善作用
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2022-11-15 DOI: 10.3923/ijp.2022.1623.1635
O. Ozkul, B. Ozkul, M. Erdoğan, O. Erbaş
{"title":"Ameliorating Effect of Propofol on Cisplatin-Induced Liver and Kidney Damage in Rats","authors":"O. Ozkul, B. Ozkul, M. Erdoğan, O. Erbaş","doi":"10.3923/ijp.2022.1623.1635","DOIUrl":"https://doi.org/10.3923/ijp.2022.1623.1635","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49291535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-Diabetic Potential of Alstonia scholaris Bark Extract Against Streptozotocin-Induced Diabetes Mellitus 枸杞子树皮提取物对链脲佐菌素所致糖尿病的抗糖尿病作用
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2022-09-15 DOI: 10.3923/ijp.2022.1449.1455
Haleema Shahin, A. Shenoy, R. Sultana, Juveriya Farooq, Manodeep Chakrabort, A. Alamri, M. Alhomrani, W. Alsanie, S. Asdaq, Shahamah Jomah
{"title":"Anti-Diabetic Potential of Alstonia scholaris Bark Extract Against Streptozotocin-Induced Diabetes Mellitus","authors":"Haleema Shahin, A. Shenoy, R. Sultana, Juveriya Farooq, Manodeep Chakrabort, A. Alamri, M. Alhomrani, W. Alsanie, S. Asdaq, Shahamah Jomah","doi":"10.3923/ijp.2022.1449.1455","DOIUrl":"https://doi.org/10.3923/ijp.2022.1449.1455","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41617137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asiatic Acid Ameliorates Cognitive Impairment in Diabetic Rats 亚细亚酸改善糖尿病大鼠认知功能障碍
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2022-09-15 DOI: 10.3923/ijp.2022.1500.1508
L. Xianchu
{"title":"Asiatic Acid Ameliorates Cognitive Impairment in Diabetic Rats","authors":"L. Xianchu","doi":"10.3923/ijp.2022.1500.1508","DOIUrl":"https://doi.org/10.3923/ijp.2022.1500.1508","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42343326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticonvulsant and Proconvulsant Effects of Trazodone in Different Seizure Models 曲唑酮在不同癫痫模型中的抗惊厥和促惊厥作用
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2022-09-15 DOI: 10.3923/ijp.2022.1474.1481
Wenhao Luo, Wenli Liu, Yushan Huang, Xianqing Deng
{"title":"Anticonvulsant and Proconvulsant Effects of Trazodone in Different Seizure Models","authors":"Wenhao Luo, Wenli Liu, Yushan Huang, Xianqing Deng","doi":"10.3923/ijp.2022.1474.1481","DOIUrl":"https://doi.org/10.3923/ijp.2022.1474.1481","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45751237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antihypertensive Effect of the lyophilized Aqueous Extract of Lannea microcarpa in L-NAME-Induced Hypertensive Wistar Rats 小叶兰冻干水提物对l - name致高血压大鼠的降压作用
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2022-09-15 DOI: 10.3923/ijp.2022.1401.1411
Nintie San Ga Yasmina Va, L. Belemnaba, Mathieu Nitiema, Christian Windingoudi Rimwagna O, Tata Kadiatou Traoré, Souleymane Compaoré, S. Ouedraogo, N. Ouedraogo, S. Ouédraogo
{"title":"Antihypertensive Effect of the lyophilized Aqueous Extract of Lannea microcarpa in L-NAME-Induced Hypertensive Wistar Rats","authors":"Nintie San Ga Yasmina Va, L. Belemnaba, Mathieu Nitiema, Christian Windingoudi Rimwagna O, Tata Kadiatou Traoré, Souleymane Compaoré, S. Ouedraogo, N. Ouedraogo, S. Ouédraogo","doi":"10.3923/ijp.2022.1401.1411","DOIUrl":"https://doi.org/10.3923/ijp.2022.1401.1411","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43194783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of CYP2C9*2 and VKORC-1639G/A Polymorphisms on Warfarin Doses Requirements in Sudanese Patients CYP2C9*2和VKORC-1639G/A多态性对苏丹患者华法林剂量需求的影响
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2022-09-15 DOI: 10.3923/ijp.2022.1366.1373
A. Elsadig, Abdel Rahim M. Muddath, E. Elamin, Nasr Eldin MA Shrif, H. Waggiallah
{"title":"Effect of CYP2C9*2 and VKORC-1639G/A Polymorphisms on Warfarin Doses Requirements in Sudanese Patients","authors":"A. Elsadig, Abdel Rahim M. Muddath, E. Elamin, Nasr Eldin MA Shrif, H. Waggiallah","doi":"10.3923/ijp.2022.1366.1373","DOIUrl":"https://doi.org/10.3923/ijp.2022.1366.1373","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46705175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective Effect of Polyethylene Glycol (PEG) 3350 on a Cisplatin-Induced Rat Model of Neuropathy 聚乙二醇(PEG) 3350对顺铂诱导大鼠神经病变模型的保护作用
IF 0.6 4区 医学
International Journal of Pharmacology Pub Date : 2022-09-15 DOI: 10.3923/ijp.2022.1359.1365
Edip Gonullu, Gozde Dagistan, M. Erdoğan, O. Erbaş
{"title":"Protective Effect of Polyethylene Glycol (PEG) 3350 on a Cisplatin-Induced Rat Model of Neuropathy","authors":"Edip Gonullu, Gozde Dagistan, M. Erdoğan, O. Erbaş","doi":"10.3923/ijp.2022.1359.1365","DOIUrl":"https://doi.org/10.3923/ijp.2022.1359.1365","url":null,"abstract":"","PeriodicalId":14222,"journal":{"name":"International Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44578528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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