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International Journal of Peptide Research and Therapeutics最新文献

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Correction: Anti-Inflammatory Mechanism of Walnut Meal Peptide/ Ellagic Acid Nanoparticles on LPS-Stimulated RAW264.7 Cells by Inhibition of NFκB and MAPK Activation 更正:核桃粕肽/鞣花酸纳米颗粒通过抑制NFκB和MAPK活化对lps刺激的RAW264.7细胞的抗炎机制
4区 生物学
International Journal of Peptide Research and Therapeutics Pub Date : 2023-11-09 DOI: 10.1007/s10989-023-10579-2
Yuxi Ling, Yanxia Feng, Ziqi Li, Le Cheng, Xuan Zhang, Difeng Ren
{"title":"Correction: Anti-Inflammatory Mechanism of Walnut Meal Peptide/ Ellagic Acid Nanoparticles on LPS-Stimulated RAW264.7 Cells by Inhibition of NFκB and MAPK Activation","authors":"Yuxi Ling, Yanxia Feng, Ziqi Li, Le Cheng, Xuan Zhang, Difeng Ren","doi":"10.1007/s10989-023-10579-2","DOIUrl":"https://doi.org/10.1007/s10989-023-10579-2","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135241755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the Effects of Temporin-Rb, an Antimicrobial Peptide, on Cell Viability and Pro-inflammatory Gene Expression in A549 Cells 抗菌肽Temporin-Rb对A549细胞活力和促炎基因表达的影响
4区 生物学
International Journal of Peptide Research and Therapeutics Pub Date : 2023-11-09 DOI: 10.1007/s10989-023-10576-5
Niloufar Shakibapour, Ahmad Asoodeh, Yasamin Yousefi, Jamshidkhan Chamani
{"title":"Investigating the Effects of Temporin-Rb, an Antimicrobial Peptide, on Cell Viability and Pro-inflammatory Gene Expression in A549 Cells","authors":"Niloufar Shakibapour, Ahmad Asoodeh, Yasamin Yousefi, Jamshidkhan Chamani","doi":"10.1007/s10989-023-10576-5","DOIUrl":"https://doi.org/10.1007/s10989-023-10576-5","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135242633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial Mechanism of a Novel Peptide Dendrocin‑ZM1 Against Staphylococcus aureus by Increasing Membrane Permeability 新型肽Dendrocin‑ZM1通过增加膜通透性对金黄色葡萄球菌的抗菌机制
4区 生物学
International Journal of Peptide Research and Therapeutics Pub Date : 2023-11-08 DOI: 10.1007/s10989-023-10577-4
Sima Sadat Seyedjavadi, Mehdi Razzaghi-Abyaneh, Parmida Bagheri, Mehdi Goudarzi
{"title":"Antibacterial Mechanism of a Novel Peptide Dendrocin‑ZM1 Against Staphylococcus aureus by Increasing Membrane Permeability","authors":"Sima Sadat Seyedjavadi, Mehdi Razzaghi-Abyaneh, Parmida Bagheri, Mehdi Goudarzi","doi":"10.1007/s10989-023-10577-4","DOIUrl":"https://doi.org/10.1007/s10989-023-10577-4","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135391252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving the Antibacterial Activity of Tryptophan-Containing Peptide Nanostructures Through Self-Assembly 通过自组装提高含色氨酸肽纳米结构的抗菌活性
4区 生物学
International Journal of Peptide Research and Therapeutics Pub Date : 2023-11-06 DOI: 10.1007/s10989-023-10575-6
Lei Zhao, Zhaoyang Liu, Mingyang Ji
{"title":"Improving the Antibacterial Activity of Tryptophan-Containing Peptide Nanostructures Through Self-Assembly","authors":"Lei Zhao, Zhaoyang Liu, Mingyang Ji","doi":"10.1007/s10989-023-10575-6","DOIUrl":"https://doi.org/10.1007/s10989-023-10575-6","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BMAP-27 Peptide Reduces Proliferation and Increases Apoptosis in Primary and Metastatic Colon Cancer Cell Lines BMAP-27肽可减少原发性和转移性结肠癌细胞系的增殖并增加凋亡
4区 生物学
International Journal of Peptide Research and Therapeutics Pub Date : 2023-10-19 DOI: 10.1007/s10989-023-10572-9
Alakesh Das, Dikshita Deka, Nabajyoti Baildya, Antara Banerjee, Atil Bisgin, Suman Adhikari, Asim K. Duttaroy, Surajit Pathak
{"title":"BMAP-27 Peptide Reduces Proliferation and Increases Apoptosis in Primary and Metastatic Colon Cancer Cell Lines","authors":"Alakesh Das, Dikshita Deka, Nabajyoti Baildya, Antara Banerjee, Atil Bisgin, Suman Adhikari, Asim K. Duttaroy, Surajit Pathak","doi":"10.1007/s10989-023-10572-9","DOIUrl":"https://doi.org/10.1007/s10989-023-10572-9","url":null,"abstract":"Abstract BMAP-27 peptide is reported to possess apoptotic and anti-proliferative effects against cancer cells but the actual mechanism of action is yet to be investigated. In the current investigation, we aimed to study the role of the BMAP-27 peptide in reducing proliferation and increasing apoptosis in colon cancer cell lines. In this study, we used primary and metastatic colon cancer cell lines SW480 and SW620. Cell proliferation was measured using MTT and CCK-8 assays, and cellular damage was analyzed by lactate dehydrogenase assay. Apoptosis, cell cycle, and proliferation potentials were measured by the expression of CASPASE3, BAX, BCL-2, TP53, CDK-6, PCNA, WNT11, AXIN1 , and CTNNB1 genes. Additionally, in-silico studies were conducted to determine the binding affinities of BMAP-27 with adenomatous polyposis coli (APC) and β-catenin proteins, one of the primary regulators of colon cancer. BMAP-27 peptide reduced colon cancer cell proliferation, upregulated tumor suppressor genes CASPASE3, BAX, TP53, AXIN1 expression, and downregulated the expression of oncogenes BCL-2, CDK-6, PCNA, WNT11, CTNNB1 in both the cell lines, however, in the primary colon cancer cell line the changes are found to be more significant. The molecular dynamic simulation analysis revealed substantial binding affinity of the peptide to APC and β-catenin proteins. BMAP-27 peptide significantly inhibited the proliferation and induced apoptosis in the primary colon cancer cell line than in the metastatic colon cancer cell line. In-silico results suggest that BMAP-27 shows a strong binding affinity with APC and β-catenin proteins, highlighting its role in inhibiting colon cancer cell proliferation.","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135732571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-Inflammatory Mechanism of Walnut Meal Peptide/ Ellagic Acid Nanoparticles on LPS-Stimulated RAW264.7 Cells by Inhibition of NF-κB and MAPK Activation 核桃粕肽/鞣花酸纳米颗粒通过抑制NF-κB和MAPK活化对lps刺激的RAW264.7细胞的抗炎机制
4区 生物学
International Journal of Peptide Research and Therapeutics Pub Date : 2023-10-16 DOI: 10.1007/s10989-023-10571-w
Yuxi Ling, Yanxia Feng, Ziqi Li, Le Cheng, Xuan Zhang, Difeng Ren
{"title":"Anti-Inflammatory Mechanism of Walnut Meal Peptide/ Ellagic Acid Nanoparticles on LPS-Stimulated RAW264.7 Cells by Inhibition of NF-κB and MAPK Activation","authors":"Yuxi Ling, Yanxia Feng, Ziqi Li, Le Cheng, Xuan Zhang, Difeng Ren","doi":"10.1007/s10989-023-10571-w","DOIUrl":"https://doi.org/10.1007/s10989-023-10571-w","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136112880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dried Blood Spot Sampling in Protein and Peptide Bioanalysis: Optimism, Experience, and the Path Forward 干血点取样在蛋白质和多肽生物分析:乐观，经验，和前进的道路
4区 生物学
International Journal of Peptide Research and Therapeutics Pub Date : 2023-10-04 DOI: 10.1007/s10989-023-10570-x
Sneha Kaareddy, Pooja Dhakne, Megha Pillai, Niraj Rajput, Tarang Jadav, Rakesh K. Tekade, Pinaki Sengupta
{"title":"Dried Blood Spot Sampling in Protein and Peptide Bioanalysis: Optimism, Experience, and the Path Forward","authors":"Sneha Kaareddy, Pooja Dhakne, Megha Pillai, Niraj Rajput, Tarang Jadav, Rakesh K. Tekade, Pinaki Sengupta","doi":"10.1007/s10989-023-10570-x","DOIUrl":"https://doi.org/10.1007/s10989-023-10570-x","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135592590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vitro Biological Evaluation and Mechanism of Action of Peptoid Analogue Based on Cationic, Amphipathic Peptide A-12 基于阳离子两性肽A-12的类肽类似物的体外生物学评价及作用机制
4区 生物学
International Journal of Peptide Research and Therapeutics Pub Date : 2023-10-04 DOI: 10.1007/s10989-023-10566-7
Lalita Sharma, Gopal Singh Bisht
{"title":"In Vitro Biological Evaluation and Mechanism of Action of Peptoid Analogue Based on Cationic, Amphipathic Peptide A-12","authors":"Lalita Sharma, Gopal Singh Bisht","doi":"10.1007/s10989-023-10566-7","DOIUrl":"https://doi.org/10.1007/s10989-023-10566-7","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135592247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aspartame, a Synthetic Dipeptide Mediated Biochemical and Histopathological Alterations in Hepato-nephric Tissues of Mice and Pharmaceutical Intervention by Sesame Oil 合成二肽阿斯巴甜介导小鼠肝肾组织生化和病理改变及香油的药物干预
4区 生物学
International Journal of Peptide Research and Therapeutics Pub Date : 2023-10-03 DOI: 10.1007/s10989-023-10564-9
Chaman Ara, Memoona Arshad, Shaukat Ali, Hafiz Abdullah Shakir, Muhammad Summer, Muhammad Khan, Iram Liaqat, Madeeha Arshad
{"title":"Aspartame, a Synthetic Dipeptide Mediated Biochemical and Histopathological Alterations in Hepato-nephric Tissues of Mice and Pharmaceutical Intervention by Sesame Oil","authors":"Chaman Ara, Memoona Arshad, Shaukat Ali, Hafiz Abdullah Shakir, Muhammad Summer, Muhammad Khan, Iram Liaqat, Madeeha Arshad","doi":"10.1007/s10989-023-10564-9","DOIUrl":"https://doi.org/10.1007/s10989-023-10564-9","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135696550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Antimicrobial Property of Bacteriocin Capped Silver Nanoparticles Prepared from Cell Free Supernatant of Lactobacillus brevis Isolated from Marine Fishes 海洋鱼类短乳杆菌无细胞上清制备细菌素包覆银纳米颗粒的抗菌性能评价
4区 生物学
International Journal of Peptide Research and Therapeutics Pub Date : 2023-09-28 DOI: 10.1007/s10989-023-10569-4
Tamil Selvi Alagumuthu, Sugapriya Samidurai, Yasmin Khambhaty, Kanagaraj James
{"title":"Evaluation of Antimicrobial Property of Bacteriocin Capped Silver Nanoparticles Prepared from Cell Free Supernatant of Lactobacillus brevis Isolated from Marine Fishes","authors":"Tamil Selvi Alagumuthu, Sugapriya Samidurai, Yasmin Khambhaty, Kanagaraj James","doi":"10.1007/s10989-023-10569-4","DOIUrl":"https://doi.org/10.1007/s10989-023-10569-4","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135344107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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