International Journal of Radiation Oncology Biology Physics最新文献

{"title":"Neurocognitive and resting-state functional MRI changes in patients with diffuse gliomas after chemoradiotherapy.","authors":"Zhihua Liu, Timothy J Mitchell, Chongliang Luo, Ki Yun Park, Joshua S Shimony, Robert Fucetola, Eric C Leuthardt, Stephanie M Perkins, Abraham Z Snyder, Tong Zhu, Jiayi Huang","doi":"10.1016/j.ijrobp.2025.03.017","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2025.03.017","url":null,"abstract":"<p><strong>Background: </strong>This prospective observational study employed resting-state functional MRI (rs-fMRI) to investigate network-level disturbances associated with neurocognitive function (NCF) changes in patients with gliomas following partial-brain radiation therapy (RT).</p><p><strong>Methods: </strong>Adult post-operative patients with either IDH-wildtype or IDH-mutant gliomas underwent computerized NCF testing and rs-fMRI at baseline and 6 months post-RT. rs-fMRI data were assessed using seed-based functional connectivity (FC). NCF changes were quantified by the percent change in age-normalized composite scores from baseline (ΔNCF_comp). Connectivity-regression analysis assessed the association between network FC changes and NCF changes, using a split-sample approach with a 26-patient training set and a 6-patient validation set, iterated 200 times. Permutation tests evaluated the significance of network selection.</p><p><strong>Results: </strong>Between September 2020 and December 2023, 43 patients were enrolled, with 32 completing both baseline and follow-up evaluations. The mean ΔNCF_comp was 2.9% (SD: 13.7%), with 38% experiencing a decline. Patients with IDH-mutant glioma had similar NCF changes compared to those with IDH-wildtype glioma. Intra-hemispheric FC was similar between ipsilateral and contralateral hemispheres for 91% patients at baseline, and 69% had similar intra-hemispheric FC change post-treatment. FC changes accounted for a moderate fraction of variance in NCF changes (mean R²: 0.301, SD: 0.249), with intra-network FC of the Parietal Memory Network (PMN-PMN, p=0.001) and inter-network FC between the PMN and the Visual Network (PMN-VN, p=0.002) as the most significant factors. Similar findings were obtained by sensitivity analyses using only the FC data from the hemisphere contralateral to the tumor.</p><p><strong>Conclusions: </strong>Post-RT rs-fMRI changes significantly reflected NCF decline, highlighting rs-fMRI as a promising imaging biomarker for neurocognitive decline after RT.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minibeam radiotherapy valley dose determines tolerance to acute and late effects in the mouse oral cavity.","authors":"Darwin A Garcia, Jennifer M Fazzari, Ruslan Hlushchuk, Oleksiy-Zakhar Khoma, Katrina K Bakken, Danielle M Burgenske, Scott C Lester, Robert W Mutter, Fabrice Lucien, Nicholas B Remmes, Jann N Sarkaria, Sean S Park, Valentin G Djonov, Michael P Grams","doi":"10.1016/j.ijrobp.2025.03.016","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2025.03.016","url":null,"abstract":"<p><strong>Purpose: </strong>Minibeam radiotherapy (MBRT) is an innovative strategy to improve normal tissue sparing by delivering alternating, submillimeter-wide regions of high \"peak\" and low \"valley\" doses. The purpose of this work is to characterize both acute and late MBRT-induced normal tissue toxicities and determine the dosimetric parameters that dictate toxicity.</p><p><strong>Methods and materials: </strong>Mice were stratified by weight and randomized to receive a single dose of conventional radiotherapy (uniform open field) or MBRT (0.5 mm-wide minibeams spaced 1.1 mm center-to-center) to the oral cavity. The conventional RT groups (n=4 per group) received 16 or 20 Gy, while the MBRT groups (n=5 per group) received peak:valley doses of 48:8, 72:12, 96:8, 96:16 or 152:8 Gy. Acute toxicity (≤3 weeks) was evaluated using changes in weight and mucosal histology. Late effects on bone and dentition were evaluated using microscopic computed tomography (microCT).</p><p><strong>Results: </strong>Animals irradiated with 16 Gy (n=1), 20 Gy (n=4), and 96:16 Gy (n=5) reached acute toxicity endpoint (≥20% weight loss) between 9-11 days post-radiation and exhibited histological changes indicative of mucositis. No animals in the other MBRT groups reached acute toxicity endpoint. While 96:8 Gy induced marked mucosal damage in peak regions, the spared tissue in the valley regions enabled restoration of mucosal integrity within two weeks post-MBRT. MicroCT of surviving mice 12 months post-radiation revealed an alternating pattern of decreased bone volume consistent with the MBRT pattern. The upper incisors of most animals were shortened or completely missing. The mice receiving 16 Gy and 48:8 Gy exhibited the most and least dental damage, respectively.</p><p><strong>Conclusion: </strong>This preliminary work emphasizes that normal tissue sparing by MBRT, as determined by the valley dose, significantly ameliorates dose-limiting toxicities and enables escalation to MBRT peak doses up to an order of magnitude greater than conventional RT doses.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of intra-fractional anatomical variations during liver MRgART under abdominal compression using optical flow calculation.","authors":"Takanori Adachi, Nobutaka Mukumoto, Haruo Inokuchi, Nobunari Hamaura, Mutsumi Yamagishi, Mai Sakagami, Naoki Mukumoto, Kenji Hayashi, Ryo Ogino, Mitsuhiro Nakamura, Keiko Shibuya","doi":"10.1016/j.ijrobp.2025.03.014","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2025.03.014","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the intra-fractional anatomical variations during liver magnetic resonance-guided adaptive radiotherapy (MRgART) under abdominal compression (AC) using optical flow calculations.</p><p><strong>Methods: </strong>This study included 27 consecutive patients who underwent liver MRgART under AC. Overall, 387,566 slices from 145 single-slice cine MR series obtained from 29 different treatment plans were analyzed in the coronal and sagittal planes through tumor centers. After defining the square regions as 12 pixels centered on the isocenter for the tumor and 8 pixels between the inspiratory and expiratory phases, excluding the lung/liver boundary for the diaphragm, the vectors were calculated using Farnebäck optical flow. The intra-fractional superior-inferior (SI) motion range and the root-mean-square error (RMSE) between the position of the tumor and the diaphragm in the coronal (SI_coronal and RMSE_coronal) and sagittal planes (SI_sagittal and RMSE_sagittal) were classified according to the Couinaud-based tumor regions (segment I+IV, II+III, V+VIII, and VI+VII). Statistical significance was determined using the Wilcoxon signed-rank test with Holm-Bonferroni corrections (p < 0.05).</p><p><strong>Results: </strong>The median SI_coronal and SI_sagittal motion ranges of the tumor were 6.1 mm (range, 1.5-18.0 mm) and 8.1 mm (range, 1.0-21.0 mm), respectively (p < 0.05). When classified according to tumor location, segment VI+VII showed the largest difference, with the median SI_coronal and SI_sagittal motion ranges of 6.5 mm (range, 2.3-17.7 mm) and 10.6 mm (range, 4.8-21.0 mm), respectively (p < 0.05). The median RMSE_coronal and RMSE_sagittal values were the largest in segment VI+VII, showing significant differences of 2.6 mm and 2.2 mm, respectively (p < 0.05). These differences were due to the sliding motion of dorsally located tumors.</p><p><strong>Conclusions: </strong>Optical flow analysis underestimated the SI motion range in the coronal plane compared with that in the sagittal plane during liver MRgART under AC. Tumor motion should be monitored in the sagittal plane, considering sliding motion of the liver, with individualized margins according to tumor location.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An International Lymphoma Radiation Oncology Group study of radiotherapy for bilateral indolent orbital adnexal lymphomas.","authors":"Krystel Tran, Dongryul Oh, Richard Tsang, Chang-Ok Suh, Hong-In Yoon, Hwa Kyung Byun, Senzo Taguchi, Jill Gunther, Bouthaina Dabaja, Chelsea Pinnix, John Plastaras, Christopher Wright, Brandon S Imber, Joachim Yahalom, Khaled Elsayad, Hans Eich, Andrea Ng, Rachel Rabinovitch, Michael Binkley, Richard Hoppe, Jessica Brady, George Mikhaeel, Xinyue Wang, Shunan Qi, Mario Levis, Umberto Ricardi, Maggie Harris, Tim Illidge, Michael MacManus, Mathias Bressel, Andrew Wirth","doi":"10.1016/j.ijrobp.2025.03.011","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2025.03.011","url":null,"abstract":"<p><strong>Purpose/objectives: </strong>Radiotherapy (RT) is curative for the majority of patients with primary indolent orbital adnexal lymphoma (IOAL). Some reports suggest inferior outcomes for bilateral IOAL, leading to uncertainty regarding optimal management for this presentation. This multicentre, retrospective study evaluated long-term outcomes of bilateral IOAL patients treated with radiotherapy alone.</p><p><strong>Materials/methods: </strong>One hundred and eighty-four patients with synchronous (defined as ≤90 days between orbit diagnoses), or metachronous bilateral IOAL, and no prior lymphoma history, received radiotherapy to both orbits. Overall (OS), failure-free survival (FFS), freedom from local (FFLF) and distant (FFDF) failure and toxicity were evaluated. The study met local institutional review board requirements.</p><p><strong>Results: </strong>A total of 184 patients were treated for IOAL from 16 centres. The median age at first orbit diagnosis was 51 years (15-91 years) with 170 (92%) of patients having MZL. Disease location included the conjunctiva in 265 (72%) of orbits. The RT dose (per orbit) was 4 Gy for 40 (11%), 20-26 Gy for 217 (59%), 27-30.6 Gy for 87 (24%), >30.6 Gy for 24 (6.5%). Radiotherapy volume was whole orbit for 162 (44%), conjunctiva only for 177 (48%) and other partial orbit for 29 (8%). The median follow-up was 5.7 years. Ten-year OS and FFS were 99% (95% CI: 95-100) and 72% (95% CI: 62-79), respectively. Ten-year FFLF and FFDF were 87% (95% CI: 80-92) and 81% (95% CI: 72-88), respectively. Ten-year FFS was 85% (95% CI: 75-91) and 50% (95% CI: 32-65) for patients with conjunctival-only disease versus any non-conjunctival disease, respectively. Late toxicities included dry eye in 42% of patients (grade 1 in 86%) and cataract in 27%.</p><p><strong>Conclusions: </strong>In this large, multicentre experience, patients with bilateral IOAL treated with radiotherapy alone had outcomes comparable to historical series of unilateral disease. These results support the treatment of bilateral IOAL as a localised process with curative intent radiotherapy.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply to Saraei and Hosseini","authors":"Daichi Torizuka MD, PhD,&nbsp;Megumi Uto MD, PhD,&nbsp;Katsutsugu Umeda MD, PhD,&nbsp;Tatsuya Kamitori MD,&nbsp;Atsushi Iwai MD,&nbsp;Satoshi Saida MD, PhD,&nbsp;Itaru Kato MD, PhD,&nbsp;Yohei Mineharu MD, PhD,&nbsp;Yoshiki Arakawa MD, PhD,&nbsp;Junko Takita MD, PhD,&nbsp;Takashi Mizowaki MD, PhD","doi":"10.1016/j.ijrobp.2024.12.024","DOIUrl":"10.1016/j.ijrobp.2024.12.024","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 5","pages":"Pages 1395-1396"},"PeriodicalIF":6.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oligometastatic Head and Neck Squamous Cell Carcinoma: Is SABR the Solution?","authors":"Sean M McBride MD, MPH","doi":"10.1016/j.ijrobp.2024.11.075","DOIUrl":"10.1016/j.ijrobp.2024.11.075","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 5","pages":"Pages 1207-1208"},"PeriodicalIF":6.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Regard to Macchia et al","authors":"Ezgi Gurlek MD,&nbsp;Sezin Yuce Sari MD,&nbsp;Melis Gultekin MD,&nbsp;Mustafa Cengiz MD,&nbsp;Ferah Yıldız MD","doi":"10.1016/j.ijrobp.2024.12.032","DOIUrl":"10.1016/j.ijrobp.2024.12.032","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 5","pages":"Page 1401"},"PeriodicalIF":6.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Over Tradition: Transforming Prostate Cancer Treatment with Stereotactic Radiation Therapy","authors":"Priyamvada Maitre MD ,&nbsp;Nicholas G. Zaorsky MD, MS ,&nbsp;Robert T. Dess MD ,&nbsp;Bridget F. Koontz MD ,&nbsp;Alison Tree MD(Res) ,&nbsp;Thomas Zilli MD","doi":"10.1016/j.ijrobp.2024.12.013","DOIUrl":"10.1016/j.ijrobp.2024.12.013","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 5","pages":"Pages 1093-1097"},"PeriodicalIF":6.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Regard to Poulsen et al.","authors":"Emanuele Scifoni PhD,&nbsp;Marie-Catherine Vozenin PhD,&nbsp;Francesco Giuseppe Cordoni PhD,&nbsp;Martina Christina PhD,&nbsp;Joao Seco PhD","doi":"10.1016/j.ijrobp.2024.12.033","DOIUrl":"10.1016/j.ijrobp.2024.12.033","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 5","pages":"Pages 1397-1399"},"PeriodicalIF":6.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contouring with FLAIR: Targeting Peritumoral Edema (and Beyond) in Glioblastoma","authors":"Jerome M. Karp MD, PhD ,&nbsp;Tim J. Kruser MD","doi":"10.1016/j.ijrobp.2024.11.073","DOIUrl":"10.1016/j.ijrobp.2024.11.073","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 5","pages":"Pages 1182-1184"},"PeriodicalIF":6.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}