International Journal of Research in Medical Sciences最新文献_第4页

Hepatitis B virus total core antibody status in unvaccinated general population in a community of Bangladesh 孟加拉国一个社区未接种疫苗普通人群的乙型肝炎病毒总核心抗体状况

International Journal of Research in Medical Sciences Pub Date : 2024-04-10 DOI: 10.18203/2320-6012.ijrms20240941

Mostak U. Ahmed, Sumona Tanu, Maisha T. Mithila, M. J. Alam, Madhusudan Saha, Sadia R. Chowdhury, S. A. Safwath, M. K. Chowdhury, M. O. Rahman, M. M. Rahman

{"title":"Hepatitis B virus total core antibody status in unvaccinated general population in a community of Bangladesh","authors":"Mostak U. Ahmed, Sumona Tanu, Maisha T. Mithila, M. J. Alam, Madhusudan Saha, Sadia R. Chowdhury, S. A. Safwath, M. K. Chowdhury, M. O. Rahman, M. M. Rahman","doi":"10.18203/2320-6012.ijrms20240941","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20240941","url":null,"abstract":"Background: Hepatitis B virus (HBV) infection poses a significant health challenge in Bangladesh, with the hepatitis B core antibody (anti-HBc) being a crucial marker due to its lifelong presence in the bloodstream. This study aimed to evaluate the prevalence of anti-HBc (total) positivity among unvaccinated adults in Northeastern Bangladesh.\u0000Methods: This cross-sectional observational study was conducted in the Sobhanighat area of Sylhet, Bangladesh, in collaboration with the department of gastroenterology, Sylhet MAG Osmani Medical College, from November 2022 to August 2023. A total of 216 participants were selected using consecutive sampling. HBsAg, anti-HBs, and anti-HBc (total) were tested for all subjects, and data were collected using a pre-formed questionnaire and analyzed using statistical package for the social sciences (SPSS) version 24.\u0000Results: Among the participants, 16 (7.4%) tested positive for anti-HBc (total), while HBsAg was positive in 6 (2.77%) individuals. Anti-HBs was detectable in 23 (10.6%) participants, with 3 (1.38%) showing isolated anti-HBc positivity. Notably, 20% of HBsAg-positive cases exhibited heterotypic anti-HBs. Moreover, 56.25% of respondents with anti-HBc (total) positivity had detectable anti-HBs (p<0.001). Gender did not show significant associations with HBsAg, anti-HBc (total), anti-HBs, or isolated anti-HBc (p>0.05).\u0000Conclusions: The study underscores a notable prevalence of anti-HBc (total) positivity among unvaccinated individuals in Bangladesh, indicative of past HBV exposure. It underscores the necessity for enhanced vaccination coverage and robust infection control measures to mitigate HBV transmission in this demographic.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"17 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140720247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A clinical study on reconstruction of traumatic auricular defects 重建外伤性耳廓缺损的临床研究

International Journal of Research in Medical Sciences Pub Date : 2024-04-10 DOI: 10.18203/2320-6012.ijrms20240942

A. R. C. Mohan, Jyostna Poldas, Jada Mabu, Vaibhav Thobbi

{"title":"A clinical study on reconstruction of traumatic auricular defects","authors":"A. R. C. Mohan, Jyostna Poldas, Jada Mabu, Vaibhav Thobbi","doi":"10.18203/2320-6012.ijrms20240942","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20240942","url":null,"abstract":"The auricle or external ear is an important aesthetic subunit of the face. The intricate anatomy due to multiple convolutions along with the thin integument poses a challenge to the reconstructive surgeon. The prominent position of the ear on either side of the face and over a bony prominence makes it more prone for injury. The objective of the study is to describe various traumatic auricular defects and their subsequent reconstructive methods. A retrospective analysis of 15 patients with traumatic auricular defects was carried out over a period of 2 years between the time period of January 2022 and December 2023. Various reconstructive methods such as Primary closure, use of chondral grafts and chondrocutaneous flaps, local flaps were employed depending on the size of the defect and according to the reconstructive ladder. Out of 15 patients, 12 were male and 3 were female, with traumatic ear defects secondary to road traffic accidents (12) and human bite (3). The site of the defect was upper 1/3d (8), upper+middle 1/3rd (3), lower+middle third (2), middle third (1) and lower 1/3rd (1) of the auricle. They were managed by debridement and primary closure in 5 cases, post auricular flap in 5 cases, preauricular flap in 2 cases, peninsular conchal island flap+postauricular flap in 1 case, and bilobed flap in 1 case. All the flaps settled well. 4 patients needed secondary procedures in the form of flap division and contour corrections. This study employed a variety of reconstruction methods of the auricle as per the reconstructive ladder. Some of the patients required secondary procedures. All patients in this study had a satisfactory end aesthetic outcome with no major complications.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140717391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of stent-related symptoms, passive ureter dilatation and stone clearance rate using 4.5 French versus 6 French double J stenting of unfavourable ureter: a prospective randomized controlled trial in a tertiary care centre 在一家三级医疗中心进行的前瞻性随机对照试验：采用 4.5 法郎与 6 法郎双 J 支架置入不利输尿管，与支架相关的症状、被动输尿管扩张和结石清除率的比较

International Journal of Research in Medical Sciences Pub Date : 2024-04-06 DOI: 10.18203/2320-6012.ijrms20240938

Manu K. Nagabhairava, Tarun Javali, M. T., Sandeep Puvvada, Amit Patil, R. D.

{"title":"Comparison of stent-related symptoms, passive ureter dilatation and stone clearance rate using 4.5 French versus 6 French double J stenting of unfavourable ureter: a prospective randomized controlled trial in a tertiary care centre","authors":"Manu K. Nagabhairava, Tarun Javali, M. T., Sandeep Puvvada, Amit Patil, R. D.","doi":"10.18203/2320-6012.ijrms20240938","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20240938","url":null,"abstract":"Background: Retrograde intrarenal surgery (RIRS) is the standard of care for renal stones of less than 1.5 cm and less than 1000 Hounsfield units (HU). Most virgin ureters do not allow the flexible ureteroscope in the first setting. Placement of a D-J stent in the ureter dilates the ureter. Therefore, our study aimed to compare stone clearance rates and symptom complex of passive ureteral dilation following 4.5 French/Fr versus 6 French/Fr double J (DJ) stent placement.\u0000Methods: After obtaining ethics approval and written informed consent, 100 patients satisfying the inclusion and exclusion criteria were included and data recorded. patients were randomized into group A (4.5 Fr) and group B (6 Fr). Stent was placed. After 4 weeks, symptoms were assessed by the ureteral stent symptom questionnaire (USSQ). Following retrograde intrarenal surgery (RIRS) successful passage of ureteric access sheath (UAS) and stone clearance rates were assessed.\u0000Results: The surgical success rate, stone clearance rate was similar in the two groups (p value: more than 0.05). The USSQ score was significantly lower in group A (p value: 0.001).\u0000Conclusions: Stent of smaller diameter (4.5 Fr) is associated with less patient discomfort with similar surgical completion rates and stone clearance.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"22 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140734504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of factors related to treatment failure and recurrence of superficial dermatophytosis 浅部皮癣治疗失败和复发的相关因素评估

International Journal of Research in Medical Sciences Pub Date : 2024-04-06 DOI: 10.18203/2320-6012.ijrms20240936

Evana Ibrahim, Rafiqul Mowla, Abu S. M. O. Faroque, Sabrina Shahrin, Umme Kulsum

{"title":"Assessment of factors related to treatment failure and recurrence of superficial dermatophytosis","authors":"Evana Ibrahim, Rafiqul Mowla, Abu S. M. O. Faroque, Sabrina Shahrin, Umme Kulsum","doi":"10.18203/2320-6012.ijrms20240936","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20240936","url":null,"abstract":"Background: Superficial dermatophytosis, commonly known as ringworm, is a fungal infection of the skin, hair, or nails caused by dermatophytes, primarily belonging to the genera Trichophyton, Microsporum, and Epidermophyton. Despite being a superficial infection, the rising incidence of treatment failure and recurrence has become a matter of concern in recent years.\u0000Methods: This prospective observational study, conducted at the department of dermatology and venereology of Chittagong Medical College Hospital, aimed to investigate the epidemiological factors associated with treatment failure and recurrent cases of superficial dermatophytosis. The study spanned from March 2022 to February 2023, involving 249 participants diagnosed with Tinea corporis, Tinea cruris, Tinea facies, or Tinea pedis. Factors such as excessive sweating, use of warm water, clothing habits, sharing practices, and topical corticosteroid application were analyzed.\u0000Results: The most common age group affected was 21-30 years, with a male preponderance (1.6:1). Excessive sweating, wearing water-soaked garments, and sharing towels were prevalent among participants. After 4 weeks of treatment, 81.5% achieved complete cure, but 52.7% of these cases experienced a recurrence within the subsequent 4 weeks. Multivariate analysis identified sharing towels, family history of dermatophytosis, and past topical steroid use as significant risk factors for treatment failure/recurrence.\u0000Conclusions: The study emphasizes the importance of linen (sharing towels) in the transmission of dermatophytosis and highlights the increased risk associated with a family history of the condition. Additionally, the injudicious use of topical steroids emerged as a significant factor contributing to treatment failure and recurrence.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"29 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140734638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of tamsulosin hydrochloride versus tamsulosin hydrochloride and deflazacort in relieving postoperative urinary retention in patients undergoing transurethral resection of prostate: a prospective randomized controlled trial in a tertiary care centre 盐酸坦索罗辛与盐酸坦索罗辛和德氟沙星在缓解经尿道前列腺切除术患者术后尿潴留方面的比较：在一家三级医疗中心进行的前瞻性随机对照试验

International Journal of Research in Medical Sciences Pub Date : 2024-04-06 DOI: 10.18203/2320-6012.ijrms20240937

Manu K. Nagabhairava, Sandeep Puvvada, M. T., Mani C. Reddy, Tarun Javali, R. D.

{"title":"Comparison of tamsulosin hydrochloride versus tamsulosin hydrochloride and deflazacort in relieving postoperative urinary retention in patients undergoing transurethral resection of prostate: a prospective randomized controlled trial in a tertiary care centre","authors":"Manu K. Nagabhairava, Sandeep Puvvada, M. T., Mani C. Reddy, Tarun Javali, R. D.","doi":"10.18203/2320-6012.ijrms20240937","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20240937","url":null,"abstract":"Background: Benign prostatic hyperplasia (BPH) is common amongst the elderly. Even after transurethral resection of prostate (TURP), retention of urine may persist in some leading to significant morbidity adversely affecting the quality of life. The role of alpha blockers in this situation as a combination is unclear. The present study was conducted to evaluate and compare the efficacy of tamsulosin versus tamsulosin and deflazacort in relieving the postoperative retention of urine following TURP.\u0000Methods: After obtaining ethics approval and written informed consent, 72 patients satisfying the eligibility criteria were included. After TURP, patients with urinary retention following catheter removal were randomized into group A (tamsulosin hydrochloride) and group B (tamsulosin hydrochloride and deflazocort). baseline international prostate symptom score (IPSS) score was done to assess quality of life and findings of radiological investigations were noted. Thereafter, medical therapy was done as per assigned group and postoperative findings were documented and analyzed.\u0000Results: Both the groups were similar in terms of demographic characteristics and baseline characteristics. The relief of symptoms was significantly more in group B along with lower IPSS score and residual volume.\u0000Conclusions: We recommend addition of deflazacort to tamsulosin hydrochloride as medical therapy for the management of postoperative retention of urine (POUR), especially following TURP.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"17 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140735593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of intracranial atherosclerosis disease in stroke cases in Indonesia utilizing cerebral digital subtraction angiography 印度尼西亚利用脑数字减影血管造影术观察中风病例颅内动脉粥样硬化疾病的特征

International Journal of Research in Medical Sciences Pub Date : 2024-03-29 DOI: 10.18203/2320-6012.ijrms20240826

F. S. Usman, M. Kastilong, David Susanto, M. Dafif, Gomgom Henrico Sirait

{"title":"Characteristics of intracranial atherosclerosis disease in stroke cases in Indonesia utilizing cerebral digital subtraction angiography","authors":"F. S. Usman, M. Kastilong, David Susanto, M. Dafif, Gomgom Henrico Sirait","doi":"10.18203/2320-6012.ijrms20240826","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20240826","url":null,"abstract":"Background: Intracranial atherosclerosis disease is a cause of ischemic stroke. Risk factors of ICAD included age, gender, race/ethnicity, hypertension, diabetes mellitus, and dyslipidaemia. This study aimed to describe the profile of ICAD in first-ever stroke and its association of recurrent stroke.\u0000Methods: The was a prospective cohort study conducted at a private hospital in Indonesia between January 2021 and June 2022. Inclusion criteria included patients with first-ever stroke and intracranial stenosis confirmed through digital subtraction angiography. The incidence of recurrent stroke was observed at six-month follow-up.\u0000Results: Of 40 subjects, 25 (62.5%) were females and most ages ranged from 20 to 40 years old. The prevalent site of intracranial stenosis were internal carotid artery in 19 (23.2%) and anterior cerebral artery in 19 (23.2%) subjects. Following six-month follow-up, there was only a patient with recurrent stroke.\u0000Conclusions: In first-ever stroke in Indonesia, ICAD was predominantly described in younger men within 41-60 years old. Stroke recurrence was observed in a patient who was old and had multiple comorbid. Further studies using a larger area and longer duration of follow-up may be considered to provide a more generalized description of ICAD in Indonesia.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"96 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140365977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study to evaluate the immediate effect of proprioceptive neuromuscular facilitation verses active dynamic stretching during warm-up on 20-meter sprint in amateur soccer players 评估本体感觉神经肌肉促进与热身时主动动态拉伸对业余足球运动员 20 米短跑的直接影响的研究

International Journal of Research in Medical Sciences Pub Date : 2024-03-29 DOI: 10.18203/2320-6012.ijrms20240840

Carol D. Dsouza, Neeraj Kumar

{"title":"A study to evaluate the immediate effect of proprioceptive neuromuscular facilitation verses active dynamic stretching during warm-up on 20-meter sprint in amateur soccer players","authors":"Carol D. Dsouza, Neeraj Kumar","doi":"10.18203/2320-6012.ijrms20240840","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20240840","url":null,"abstract":"Background: Soccer is a highly popular sport and is played worldwide. It is an explosive sport and has a high incidence of injuries. In soccer, sprinting dominates the majority of the game, and it imposes a demand on players to have strong, flexible, and dynamic lower limbs. Amateur soccer players don’t usually practice warm-ups before their matches; hence, an appropriate warm-up protocol is required that can be incorporated into the training routine of players to avoid injuries and improve performance. The current study aims to evaluate and compare the immediate effect of PNF stretching versus active dynamic stretching during warm-up on 20-meter sprint performance in amateur soccer players.\u0000Methods: According to the inclusion criteria, 80 amateur soccer players participated in this cross-sectional study design. They were randomly distributed into 2 groups: A) PNF stretching (N = 40) and B) active dynamic stretching (N = 40). Participants in both groups performed the 20-meter sprint test initially, followed by their respective warm-up intervention, after which the 20-meter sprint test was repeated and new readings were recorded.\u0000Results: Both Group A and Group B showed improved performance; however, Group B was significantly better. (p value<0.05).\u0000Conclusions: This study therefore concludes that both PNF and active dynamic stretching can be used as a warm-up protocol. However, according to the inter-group comparison, active dynamic stretching shows a noteworthy improvement in 20-m sprint performance in amateur soccer players.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"88 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140366365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benefits of core strengthening exercise in osteoarthritis knee patients: a narrative review 膝关节骨性关节炎患者进行核心强化训练的益处：叙述性综述

International Journal of Research in Medical Sciences Pub Date : 2024-03-29 DOI: 10.18203/2320-6012.ijrms20240868

Aavrati Rastogi, Roop B. Kalia, Pradeep K. Meena

{"title":"Benefits of core strengthening exercise in osteoarthritis knee patients: a narrative review","authors":"Aavrati Rastogi, Roop B. Kalia, Pradeep K. Meena","doi":"10.18203/2320-6012.ijrms20240868","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20240868","url":null,"abstract":"Osteoarthritis is a degenerative joint disease results from breakdown of cartilage that covers the ends of bones in joint. Breakdown causes bones to rub each other leading to pain, stiffness, swelling, loss of function in joint and can be accompanied by synovitis with or without joint fluid effusion. Muscle atrophy may develop if patient was inactive and did not perform exercises, which will affect functionality and stability of joint including activities of daily life. The aim of the study was to evaluate current literature and provide comprehensive overview of benefits of core muscle strengthening exercise in managing OA. The objective of this study was to discuss effectiveness of core muscle strengthening exercise in reducing pain, improving physical function, and enhancing quality of life in individuals with osteoarthritis knee. A systematic search was conducted to identify all relevant studies related to core muscle strengthening, database such as Pubmed, Cochrane library, Scopus had been used. Studies demonstrating clinical importance of core strengthening in treatment of osteoarthritis knee are limited. By performing randomized controlled trials with a big sample size, new researchers should produce more unique findings.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"69 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140366413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual finding during laparoscopic cholecystectomy: liver choristoma in the gallbladder wall 腹腔镜胆囊切除术中的异常发现：胆囊壁上的肝胆管瘤

International Journal of Research in Medical Sciences Pub Date : 2024-03-29 DOI: 10.18203/2320-6012.ijrms20240852

Miguel Ángel Echeverry-Gutiérrez, Karla Paola Muñoz Mata, Jose Manuel Zavala-Perez, Saul Ernesto Reyes-Gonzalez, Marco Antonio Trejo-Gonzalez

引用次数: 0

Detection of colistin susceptibility in extended spectrum β lactamases positive Klebsiella pneumoniae and Escherichia coli clinical isolates by broth disc elution method 肉汤圆盘洗脱法检测广谱β内酰胺酶阳性肺炎克雷伯菌和大肠埃希菌临床分离物对可乐定的敏感性

International Journal of Research in Medical Sciences Pub Date : 2024-03-29 DOI: 10.18203/2320-6012.ijrms20240844

Aiswarya Sivadas, Anakha Sajeev, H. Kumar K. S., Shinu Krishnan

{"title":"Detection of colistin susceptibility in extended spectrum β lactamases positive Klebsiella pneumoniae and Escherichia coli clinical isolates by broth disc elution method","authors":"Aiswarya Sivadas, Anakha Sajeev, H. Kumar K. S., Shinu Krishnan","doi":"10.18203/2320-6012.ijrms20240844","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20240844","url":null,"abstract":"Background: Antibiotic resistance is one of the greatest threats in human health. Extended spectrum β lactamases mediated resistance is prevalent worldwide, Klebsiella pneumoniae and Escherichia coli leap out as this significant ESBL producers conferring resistance to the expanded spectrum cephalosporins. Colistin is being administered as last line therapy for patients that have failed to respond to other available antibiotics that are active against Gram-negative bacteria.\u0000Methods: The present study was conducted at school of medical education Kottayam, Kerala from January 2023 to November 2023.During the period of study 150 isolates of K. pneumoniae and 136 isolates of E. coli were collected from various diagnostic microbiology laboratories in Kerala. The colistin susceptibility pattern of ESBL producing isolates was detected by broth disc elution method recommended by CLSI.\u0000Results: In this study prevalence of multi-drug resistant is 6% and 9.6% and Extensively-drug resistant is 62% and 63.9% for K. pneumoniae and E. coli respectively. ESBL production was detected as 72% in K. pneumoniae and 79% in E. coli. The colistin susceptibility pattern of ESBL producing K. pneumoniae and E. coli was detected as 76.9% and 87.9% respectively\u0000Conclusions: Our result demonstrated that the recent use of colistin as last resort treatment for extensively drug resistant gram-negative bacilli, it is essential to know the prevalence of susceptibility pattern to this antibiotic.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"19 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140367420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0