1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)最新文献_第9页

ECG monitoring through environmental electrodes 通过环境电极进行心电监测

1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451) Pub Date : 2000-10-12 DOI: 10.1109/MMB.2000.893859

G. Andreoni, A. Pedotti, M. Di Rienzo

引用次数: 7

Formation of monodispersed microspheres from microfabricated channel array 微制造通道阵列形成单分散微球

1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451) Pub Date : 2000-10-12 DOI: 10.1109/MMB.2000.893788

S. Sugiura, M. Nakajima, M. Seki

{"title":"Formation of monodispersed microspheres from microfabricated channel array","authors":"S. Sugiura, M. Nakajima, M. Seki","doi":"10.1109/MMB.2000.893788","DOIUrl":"https://doi.org/10.1109/MMB.2000.893788","url":null,"abstract":"Microspheres (MS), such as emulsion droplets, multiple emulsions, microparticles, microcapsules, and liposomes have been utilized in various industries. The authors proposed a novel microfabricated device for making super-monodispersed emulsion droplets from microchannel (MC) array. The average diameter and the coefficient of variation of the prepared emulsion were 21.3 /spl mu/m and 4.1%. Using this emulsification technique, the authors prepared the monodispersed solid lipid MS. High melting point edible oils such as hydrogenated fish oil and tripalmitin were used for solid lipid MS. Monodispersed emulsion droplets composed of high melting point edible oil were prepared from MC at 70/spl deg/C. The prepared emulsion was recovered from the module and cooled down at room temperature, and then the solid lipid MS suspension was obtained. The prepared microspheres had the diameters of approximately 21.7 /spl mu/m and the coefficient of variation less than 3.6%. Effects of different surfactants, pressure difference on MC emulsification and a diameter distribution of prepared droplets were studied.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134084874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Fabrication and test of implantable thin-film electrodes for stimulation and recording of biological signals 用于刺激和记录生物信号的可植入薄膜电极的制造和试验

1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451) Pub Date : 2000-10-12 DOI: 10.1109/MMB.2000.893860

S. Metz, F. Oppliger, R. Holzer, B. Buisson, D. Bertrand, P. Renaud

{"title":"Fabrication and test of implantable thin-film electrodes for stimulation and recording of biological signals","authors":"S. Metz, F. Oppliger, R. Holzer, B. Buisson, D. Bertrand, P. Renaud","doi":"10.1109/MMB.2000.893860","DOIUrl":"https://doi.org/10.1109/MMB.2000.893860","url":null,"abstract":"The fabrication, characterization and application of polyimide-based flexible microelectrodes for recording from and stimulation of biological tissue are described. The planar electrodes consist of a polyimide-platinum-polyimide sandwich structure with a total thickness of 10 to 40 /spl mu/m fabricated on Pyrex or silicon wafers. Several designs with mono-polar or multi-polar probe-type electrodes have been realized. Two different fabrication technologies using photosensitive (PS-PI) and non-photosensitive polyimide (NPS-PI) have been developed. For the photostructurable polyimide a three-mash process was realized, whereas for the non-photosensitive polyimide a simpler two-mask process using dry etching techniques was used. A sacrificial layer of aluminum served for detachment of the structures by anodic metal dissolution. This is a particularly biocompatible release procedure as the microelectrodes are detached from the fabrication substrate in a sodium salt solution. Obtained microelectrodes were characterized by impedance spectroscopy and were used to record multi-channel EMG signals from free-walking insects.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132465031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Laser microfabricated polymer surfaces: effect of microtopography on cell growth 激光微加工聚合物表面:微形貌对细胞生长的影响

1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451) Pub Date : 2000-10-12 DOI: 10.1109/MMB.2000.893843

A. Duncan, F. Weisbuch, F. Rouais, S. Lazarez, C. Baquey

{"title":"Laser microfabricated polymer surfaces: effect of microtopography on cell growth","authors":"A. Duncan, F. Weisbuch, F. Rouais, S. Lazarez, C. Baquey","doi":"10.1109/MMB.2000.893843","DOIUrl":"https://doi.org/10.1109/MMB.2000.893843","url":null,"abstract":"The relatively recent introduction of microelectronics technology into the area of biological sciences has drastically revolutionized the field. New foreseeable applications include miniaturized, multiparametric biosensors for high performance multianalyte assays or DNA sequencing, biocomputers, and substrates for controlled cell growth (i.e. tissue engineering). The objectives of this work were to investigate new methods combining microphotolithographical techniques with high energy KrF excimer laser beam technology to create surfaces with well defined 3-D microdomains in order to delineate critical microscopic topographical surface features that are relevant in governing material-cell interaction. Another obvious application of this study pertains to the fabrication of cell-based biosensors. Reproducible submicron features could also be obtained using this method. Subsequently, model osteoblast-like cells plated onto the laser modified surfaces showed preferential cell deposition on surfaces presenting \"smooth\" microtopographical transitions. This system may provide an interesting model for further insights into correlations between 3-D surface microtopography and cell response with new applications in the field of biosensor, biomaterial and pharmaceutical engineering sciences (e.g. new cell based biosensors, controlled synthesis of immobilized cell derived active ingredients).","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123793271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Intravascular micro active catheter for minimal invasive surgery 微创手术血管内微活动导管

1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451) Pub Date : 2000-10-12 DOI: 10.1109/MMB.2000.893781

J. Chang, S. Chung, Yongku Lee, Junha Park, Seung-Ki Lee, Sangsik Yang, Shin-Yong Moon, Dong-Chul Han

{"title":"Intravascular micro active catheter for minimal invasive surgery","authors":"J. Chang, S. Chung, Yongku Lee, Junha Park, Seung-Ki Lee, Sangsik Yang, Shin-Yong Moon, Dong-Chul Han","doi":"10.1109/MMB.2000.893781","DOIUrl":"https://doi.org/10.1109/MMB.2000.893781","url":null,"abstract":"The authors have developed an intravascular micro active catheter system for microsurgery in human vascular systems, such as cerebrovascular and coronary arteries. Also this system can be applied to laparoscopical treatment. It consists of the micro active bending catheter and some functional catheters. The former is a tube-like catheter which has an outer-diameter of 3.0 mm, an inner-diameter of 2.0 mm and a length of 1000 mm. It's inner hole is a pathway for the functional catheters, such as conventional guide wire, balloon catheter, conventional suction tube, micro ultrasound probe catheter, fiber optics (angioscope), angioplatic devices and drug injection lines. This active bending catheter is actuated with three SMA (shape-memory-alloy) zigzag type springs-SMA wires are connected with plastic and brass connection links. This actuator can be bent to any direction with the PWM controlled electric current. The authors also developed a micro drug infusion catheter and a micro ultrasound probe catheter fitted to the inner hole of active bending catheter. All of these systems were evaluated with the human mock circulation system. They can be introduced through 90/spl deg/, 120/spl deg/, 180/spl deg/ crooked branches to the brachiocephalic artery, common carotid artery, subelavian artery and so on in the mock circulation system. Also, the authors tested this endoscope system in vivo by performing laparoscopical surgery on a pig. They could easily induce the catheter to the point they wanted in the pig ovary.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"189 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123846988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Simultaneous measurement of blood flow distribution and oxygen tension by photo-excitation in organ microcirculation 光激发法同时测量器官微循环血流分布和氧张力

1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451) Pub Date : 2000-10-12 DOI: 10.1109/MMB.2000.893747

K. Tsukada, K. Hase, E. Sekizuka, C. Oshio, H. Minemitani

{"title":"Simultaneous measurement of blood flow distribution and oxygen tension by photo-excitation in organ microcirculation","authors":"K. Tsukada, K. Hase, E. Sekizuka, C. Oshio, H. Minemitani","doi":"10.1109/MMB.2000.893747","DOIUrl":"https://doi.org/10.1109/MMB.2000.893747","url":null,"abstract":"The microcirculatory system plays a very important role in delivering oxygen and materials to tissues and organs. In this study, the authors set up a new system with two light sources to measure blood flow velocity, vessel diameter, and pO/sub 2/ simultaneously in organ microcirculation. Pd-meso-tetra(4-carboxyphenyl)-porphyrin was employed as an oxygen-sensitive probe, and was excited with the second harmonic of a Nd:YAG pulse laser (wavelength: 532 nm) at 1 Hz. The phosphorescence lifetime was obtained from the emission decay curve and pO/sub 2/ was calculated from the Stern-Volmer equation. At the same time, blood flow in organ microvessels was visualized by perfusing red blood cells labeled with fluorescent isothiocyanate. Blood flow velocity and vessel diameter were quantified by processing images with a personal computer. Through measurements on rats in vivo, the changes in blood flow velocity and pO/sub 2/ in organ microvessels were quantified during asphyxia and hemorrhagic shock. The results demonstrate that the system can measure blood now and oxygen delivery in the microcirculatory system. In the future, the authors will use this system to analyze pathologic physiology, such as blood flow change in diabetes mellitus.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124842529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multichannel neural cuff electrodes with integrated multiplexer circuit 集成多路复用电路的多通道神经袖电极

1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451) Pub Date : 2000-10-12 DOI: 10.1109/MMB.2000.893861

M. Schuettler, K. Koch, T. Stieglitz, O. Scholz, W. Haberer, R. Keller, J. Meyer

引用次数: 19

Screening of sleep-disordered breathing through the recording of mandibular movements 通过记录下颌运动来筛选睡眠呼吸障碍

1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451) Pub Date : 2000-10-12 DOI: 10.1109/MMB.2000.893854

Bemard Beckers, R. Poirrier, Jacques Destink

引用次数: 6

Single-unit and polygraphic recordings in the awake, anaesthetic-free and head-restrained rat 清醒、不麻醉和头部受限大鼠的单单元和多测记录

1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451) Pub Date : 2000-10-12 DOI: 10.1109/MMB.2000.893782

N. Rentéro, N. Urbain, F. Soulière, L. Lobo, B. Astier, A. Abergel, G. Chouvet, B. Renaud

{"title":"Single-unit and polygraphic recordings in the awake, anaesthetic-free and head-restrained rat","authors":"N. Rentéro, N. Urbain, F. Soulière, L. Lobo, B. Astier, A. Abergel, G. Chouvet, B. Renaud","doi":"10.1109/MMB.2000.893782","DOIUrl":"https://doi.org/10.1109/MMB.2000.893782","url":null,"abstract":"In vivo investigation of the central nervous system is subject to interference with anaesthetic agents. Their influence on neural activity during electrophysiological recordings can be bypassed using a pre-implanted animal model, developed in the authors' laboratory. In this model, the preimplantation on the skull of a light device for further stereotaxic frame attachment allows, after a contention habituation period, classical electrophysiological approaches in the central nervous system of anaesthetic free-rats, The use of this model is compatible with repetitive single unit recordings. These experiments may be associated with other electrophysiological or physiological recordings such as electroencephalogram and electromyogram (EEG, EMG) or systemic/local pharmacological challenges (iontophoresis, pneumatic ejection). This technique allowed the authors to record simultaneously cortical activity and firing activity of basal ganglia neurones involved in movement disorders such as Parkinson's disease. The authors describe time-locked changes in firing pattern of subthalamic nucleus cells and cortical activity during vigilance state transitions in the normal rat.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121188913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Development of a non-invasive measurement system for the pressure of esophageal varices 一种无创食管静脉曲张压力测量系统的研制

1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451) Pub Date : 2000-10-12 DOI: 10.1109/MMB.2000.893755

Zhongming Ma, Lui Siew Kwok, Yap Chin Guan

引用次数: 0