International Journal of Pharmacological Research最新文献_第8页

Comparison Of Effect Of Addition Of Fluvoxamine Or Risperidone To Clozapine In Chronic Partially Responsive Schizophrenic Patients On Clinical Response, QTc interval And Lipid profile 氟伏沙明与利培酮联合氯氮平治疗慢性部分反应性精神分裂症患者临床疗效、QTc间期及血脂的比较

International Journal of Pharmacological Research Pub Date : 2016-07-30 DOI: 10.7439/IJPR.V6I7.3347

Sunil M. Mahakalkar, D. Patil, P. Waradkar, Chetan S. Urade, C. Bajait

{"title":"Comparison Of Effect Of Addition Of Fluvoxamine Or Risperidone To Clozapine In Chronic Partially Responsive Schizophrenic Patients On Clinical Response, QTc interval And Lipid profile","authors":"Sunil M. Mahakalkar, D. Patil, P. Waradkar, Chetan S. Urade, C. Bajait","doi":"10.7439/IJPR.V6I7.3347","DOIUrl":"https://doi.org/10.7439/IJPR.V6I7.3347","url":null,"abstract":"Objective To study & compare the augmentation effect of addition of fluvoxamine or risperidone in chronic partially responsive schizophrenic patients receiving clozapine on clinical and laboratory parameters. Methods - A prospective, randomized, parallel, open label 12 weeks study. The schizophrenic patients, aged 20-60 years, who followed the DSM-IV diagnostic criteria and receiving clozapine therapy, showing partial response to the treatment were recruited and the study was carried out from January 2007 to June 2008. Subjects were randomized into two groups: Group A (n=28): fluvoxamine (25-50mg/day) was added to clozapine (25-200mg/day) & Group B (n=27): risperidone (1-5mg/day) was added to clozapine therapy. The effect of drugs was assessed by PANSS, BPRS scale and ECG and lipid profile were done at 6 and 12 weeks. Result - There was significant decrease in PANSS and BPRS score in both groups. Fluvoxamine + clozapine significantly reduced PANSS score as compared to risperidone + clozapine compared to baseline and between 6 and 12 weeks. Risperidone +clozapine prolonged QTc interval (at 12 weeks) and elevated serum TG, VLDL, HDL significantly at 6 and 12 weeks. Conclusion Although addition of fluvoxamine and risperidone to clozapine are effective in management of chronic partially responsive schizophrenia on clozapine, fluvoxamine is more effective as well as safer compared to Risperidone when compared for 6 and 12 weeks in these patients.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"49 1","pages":"231-237"},"PeriodicalIF":0.0,"publicationDate":"2016-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82244174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nature of Prescribing and incidence of medication prescription errors in general practice 处方的性质和在一般实践中药物处方错误的发生率

International Journal of Pharmacological Research Pub Date : 2016-07-30 DOI: 10.7439/IJPR.V6I7.3156

Mital Hanumant Volvoikar

{"title":"Nature of Prescribing and incidence of medication prescription errors in general practice","authors":"Mital Hanumant Volvoikar","doi":"10.7439/IJPR.V6I7.3156","DOIUrl":"https://doi.org/10.7439/IJPR.V6I7.3156","url":null,"abstract":"Introduction: Medication use involves a complex process that is subject to errors at many points in health care settings. According to the stage of the medication use cycle in which they occur, medication errors can be broadly divided into four levels prescription or prescribing, transcription, dispensing and administration errors. Prescription errors that constitute the bulk of medication errors are common in government as well as private setting. Materials and methods: Our study was aimed to analyse the prescription errors in general practice. The prescriptions were photographed after the consent of the patient and returned back to them. Almost all the prescriptions contained brand names which were then converted into their respective generic names and analysed for errors. Results: A total of 1015 prescriptions were analysed during a 15 month period. Out of these, 415 (40.88%) prescriptions had errors. A few prescriptions had more than one type of prescribing error. The total number of errors thus amounted to 577. Most of the errors were related to prescription of CNS drugs followed by chemotherapeutic drugs. Our study reveals that combination errors are the commonest followed by indication, dosing and kinetic types of prescription errors. Discussion: Medication errors are common in general practice and in hospitals and can result in harm to patients. We analysed the prescription errors into 4 categories- indication, dosing, kinetic and combination errors. The study revealed a maximum of combination errors thus confirming our assertion that doctors do not give proper thought when they prescribe FDCs.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"28 1","pages":"238-243"},"PeriodicalIF":0.0,"publicationDate":"2016-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80268398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The biochemical effect of probiotic and /or mesenchymal stem cells on LPS-induced kidney disorder 益生菌和/或间充质干细胞对lps诱导的肾脏疾病的生化作用

International Journal of Pharmacological Research Pub Date : 2016-07-30 DOI: 10.7439/IJPR.V6I7.3445

A. M. Badawi

{"title":"The biochemical effect of probiotic and /or mesenchymal stem cells on LPS-induced kidney disorder","authors":"A. M. Badawi","doi":"10.7439/IJPR.V6I7.3445","DOIUrl":"https://doi.org/10.7439/IJPR.V6I7.3445","url":null,"abstract":"The current study aimed to evaluate the beneficial effect of kefir probiotic and /or Mesenchymal stem cells (MSCs) on acute kidney injury (AKI) induced by lipopolysaccharide (LPS) challenge, and to investigate could kefir potentiate the therapeutic action of MSCs. Sixty female albino rats were used in this study and divided into 6 groups (10 rats each): control group; LPS-challenged group; LPS + MSCs group; LPS + kefir group; kefir +LPS +kefir (prophylactic) group and kefir + LPS + MSCs + kefir (prophylactic-MSCs) group. Samples were collected at two point's time. Renal function, serum IL-10, TNF-α, renal MDA, GSH contents, SOD and PON-I were assayed. The mRNA expression of NF-κB, iNOS and caspase-3 were monitored in kidney tissue. Our results revealed that LPS significantly increased renal function tests, TNF-α in association with dramatic decrease of creatinine clearance and serum IL-10 levels. Oxidative stress was proved in LPS group by increasing MDA level, reduction in GSH content, SOD and PON-1 activities in kidney. The mRNA expression of NF-κB, iNOS and caspase-3 were significantly up-regulated in AKI. Administration of kefir or MSCs alone significantly attenuated LPS-induced AKI. The pre and co-treatment of kefir with MSCs potentiate their therapeutic action. Conclusion: A combination of kefir probiotic and MSCs may be of interest for clinical use.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"114 1","pages":"244-255"},"PeriodicalIF":0.0,"publicationDate":"2016-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73042201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

An update on the management of immune thrombocytopenic purpura and emerging treatment options: A review and case report 关于免疫性血小板减少性紫癜的管理和新出现的治疗方案的最新进展:综述和病例报告

International Journal of Pharmacological Research Pub Date : 2016-07-30 DOI: 10.7439/IJPR.V6I7.3416

R. Krishnan, P. MohammedFaisalK, S. MerlinT, Cijo Oommen

引用次数: 2

Erythropoietin Biosimilar Products and Immunogenicity: A Pharmacovigilance Study 促红细胞生成素生物类似物和免疫原性:一项药物警戒研究

International Journal of Pharmacological Research Pub Date : 2016-06-30 DOI: 10.7439/IJPR.V6I6.3311

Y. Bustanji

引用次数: 0

Acute toxicity evaluation of aminomethylnaphthoquinone (AMNQ 1) in BALB/c mice 氨基甲基萘醌(amnq1)对BALB/c小鼠急性毒性评价

International Journal of Pharmacological Research Pub Date : 2016-06-30 DOI: 10.7439/IJPR.V6I6.3326

Valéria Garrido, Caroline Barros, M. Tonelli, G. Teixeira, Patrícia Ocampo, G. Bezerra, Viveca A Giongo, I. Paixão

{"title":"Acute toxicity evaluation of aminomethylnaphthoquinone (AMNQ 1) in BALB/c mice","authors":"Valéria Garrido, Caroline Barros, M. Tonelli, G. Teixeira, Patrícia Ocampo, G. Bezerra, Viveca A Giongo, I. Paixão","doi":"10.7439/IJPR.V6I6.3326","DOIUrl":"https://doi.org/10.7439/IJPR.V6I6.3326","url":null,"abstract":"We report the first preclinical tests showing that aminomethylnaphthoquinone - 3-[N-(n-butyl) amino-2,4-diclorobenzyl]-2-hydroxy-1,4-naphthoquinone (AMNQ 1) has low cytotoxicity and anti-HSV-1 activity in vitro in Vero cells. The aim of this study was to evaluate the acute toxicity of AMNQ 1 in BALB/c mice. We used BALB/c female mice to evaluate the median lethal dose (LD50) of AMNQ 1 with 2000 mg/kg body weight and other three concentrations using 550, 175 and 55 mg/kg. We compared this to acyclovir (ACV-50 mg/kg) and 10% dimethyl sulfoxide (10% DMSO) over a 14-day period. The BALB/c mice received a single oral dose by gavage. There were no deaths in either group and no change in the murine clinical signs. The hematological and biochemical analyses showed some changes that returned to reference levels without impairment of hemostasis. The AMNQ 1 treatment did not induce untoward changes in organs as shown by histological studies. The in vivo results showed that AMNQ 1 has low toxicity. In conclusion, AMNQ 1 is safe and can be potentially used as an anti-HSV-1 agent in future studies.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"24 1","pages":"217-223"},"PeriodicalIF":0.0,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74832211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A review: Cataract, a common ocular complication in Diabetes 综述:白内障是糖尿病常见的眼部并发症

International Journal of Pharmacological Research Pub Date : 2016-06-30 DOI: 10.7439/IJPR.V6I6.3286

Mital Bhadania

引用次数: 6

Metronomic Chemotherapy: Low Dose Less Toxicity Anticancer Strategy 节拍化疗:低剂量低毒抗癌策略

International Journal of Pharmacological Research Pub Date : 2016-06-30 DOI: 10.7439/IJPR.V6I6.3196

A. Khadka, Neha Akhoon

引用次数: 0

A Study on in vitro antiviral activities of lyophilized extracts of Glycyrrhiza glabra on Hepatitis B Virus 甘草冻干提取物对乙型肝炎病毒体外抗病毒活性的研究

International Journal of Pharmacological Research Pub Date : 2016-06-30 DOI: 10.7439/IJPR.V6I6.3309

S. Vani, S. Rajarajan

引用次数: 1

Study on self-medication practice among consumers in parts of East Bengaluru 东班加罗尔部分地区消费者自我药疗实践研究

International Journal of Pharmacological Research Pub Date : 2016-06-02 DOI: 10.7439/IJPR.V6I6.3284

M. Silvan

{"title":"Study on self-medication practice among consumers in parts of East Bengaluru","authors":"M. Silvan","doi":"10.7439/IJPR.V6I6.3284","DOIUrl":"https://doi.org/10.7439/IJPR.V6I6.3284","url":null,"abstract":"Background: Self medication is defined as the use of medication by a patient on his own initiative or on the advice of a pharmacist or a lay person instead of seeking advice a medical practitioner. Objectives: To assess the self medication practices for allopathic drugs in East Bengaluru and also identify the association between self-medication practice and socio demographic characteristics in the study population. Methodology: A community based cross sectional study was conducted in East Bengaluru area over the period of 6 months using pre tested semi structured questionnaire. Result: The data on practice of self medication were collected from 427 study participants. A significant correlation was observed for younger age group, while a moderate correlation for education, economic status of the survey respondents. Fever, pain and cough (20.60%), pain (17.09%), and fever & pain (16.85%) were the most common illnesses where self-medication is being used. Pain killers (68.85%) and antipyretic drug (50.58%) were the most commonly used self medicating drugs. Telling the symptoms to pharmacist (89.69%) was the commonest method adopted to procure drugs by the users. The major reason for practicing self medication was lack of time to visit doctor (32.31). Conclusion : Self-medication is an important health issue in this area. Health education of the public and regulation of pharmacies may help in limiting the self-medication practices.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"10 1","pages":"210-216"},"PeriodicalIF":0.0,"publicationDate":"2016-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79672656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0