International Journal Of Medical Science And Clinical Invention最新文献_第7页

Physical Fitness of Young Japanese Adults Evaluated by Old and New Diagnostic Criteria for Sarcopenia 日本年轻人肌肉减少症新旧诊断标准评价的身体健康状况

International Journal Of Medical Science And Clinical Invention Pub Date : 2022-05-29 DOI: 10.18535/ijmsci/v9i05.06

T. Yasuda

{"title":"Physical Fitness of Young Japanese Adults Evaluated by Old and New Diagnostic Criteria for Sarcopenia","authors":"T. Yasuda","doi":"10.18535/ijmsci/v9i05.06","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i05.06","url":null,"abstract":"The purpose of this study was to compare the fitness levels of healthy young Japanese adults based on the “old” and “new” sarcopenia versions of the European Working Group on Sarcopenia in the Older People (EWGSOP1 and EWGSOP2) and the Asian Working Group for Sarcopenia (AWGS 2014 and AWGS 2019) criteria. Sixty-nine Japanese young adults were evaluated using the diagnostic criteria and classification of sarcopenia (muscle strength, physical ability, and muscle mass). For both sexes, the percentage classified as “robust” on the sarcopenia diagnostic criteria was lower in “old” than in “new” classification. The “sarcopenia” category comprised 2% of females only, but none of them had “severe sarcopenia”. The proportion of participants with “presarcopenia” (old classification) was 19-38%, and that with “possible sarcopenia” (new classification) was 2% for females only. A higher proportion of healthy young adults were classified as “robust” in “new” compared to “old” because \"presarcopenia\" was eliminated in “new”. Moreover, since the proportion of low muscle mass exists in one-fifth of males and one-third of females, it would be difficult to use the new criteria to promote muscle mass gains and prevent from a young age to care for the future.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79510646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myocarditis Associated With COVID-19 Infection and Mrna Vaccination: A Review Article 与COVID-19感染和Mrna接种相关的心肌炎:一篇综述文章

International Journal Of Medical Science And Clinical Invention Pub Date : 2022-05-27 DOI: 10.18535/ijmsci/v9i05.05

Arshan Khan, Mohammad K. Balaw, H. Sattar, Yash Garg, Freny Sebastian, C. Agyingi, Hardik A. Fichadiya, Muhammad Haseeb

{"title":"Myocarditis Associated With COVID-19 Infection and Mrna Vaccination: A Review Article","authors":"Arshan Khan, Mohammad K. Balaw, H. Sattar, Yash Garg, Freny Sebastian, C. Agyingi, Hardik A. Fichadiya, Muhammad Haseeb","doi":"10.18535/ijmsci/v9i05.05","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i05.05","url":null,"abstract":"Coronavirus disease 2019 (Covid-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Initially, COVID-19 was considered a respiratory illness, but later on, it was found out that this disease can affect many organ systems. Cardiovascular manifestations of this disease include myocarditis, heart failure, myocardial infarction, and thromboembolism. Myocarditis related to COVID-19 is thought to be due to the direct viral injury and host immune response. The cases of myocarditis after the COVID-19 mRNA vaccine have been reported in the literature as well. COVID-19 myocarditis can present as chest pain, shortness of breath, acute heart failure, arrhythmia, and possibly death. The initial workup should include an electrocardiogram (ECG) and troponins if myocarditis is suspected.\u0000Further screening should be done if troponins are elevated, or the patient has ECG changes concerning myocardial damage. Noninvasive imaging that helps to diagnose COVID-19 myocarditis includes echocardiograms, computerized tomographic (CT) with contrast, and cardiac magnetic resonance imaging (CMR). An endomyocardial biopsy (EMB) can be performed if the diagnosis remains unclear. Initial treatment of COVID-19 myocarditis is mainly supportive, and intravenous immunoglobulin (IVIG) and corticosteroid may be effective, particularly in fulminant myocarditis. If the patient develops life-threatening arrhythmias or shock, advanced mechanical support is required. Early intervention is a critical factor in decreasing morbidity and mortality. Further research is needed to determine the efficacy of different treatment modalities, including IVIG and corticosteroids, in patients with COVID-19 myocarditis.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85272187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Bronchial Stent for High Ciliary Function in Respiratory Tract 用于呼吸道高纤毛功能支气管支架的研制

International Journal Of Medical Science And Clinical Invention Pub Date : 2022-05-25 DOI: 10.18535/ijmsci/v9i05.04

Kothwala Deveshkumar Mahendralal, Minocha Dr. Pramod Kumar, Dave Arpit Pradipkumar

引用次数: 0

A Favorable Outcome With CPX-351 Liposome (Vyxeos) in the Management of A Sporadic Monosomy 7 Myelodysplastic Syndrome Related Acute Myeloid Leukemia CPX-351脂质体(Vyxeos)治疗散发性单体7骨髓增生异常综合征相关急性髓系白血病的有利结果

International Journal Of Medical Science And Clinical Invention Pub Date : 2022-05-22 DOI: 10.18535/ijmsci/v9i05.03

M. Z. Mohamed Jiffry, Jonathan Vargas, M. Ahmed-khan, Teena Thomas, Jeltsina Sosa

{"title":"A Favorable Outcome With CPX-351 Liposome (Vyxeos) in the Management of A Sporadic Monosomy 7 Myelodysplastic Syndrome Related Acute Myeloid Leukemia","authors":"M. Z. Mohamed Jiffry, Jonathan Vargas, M. Ahmed-khan, Teena Thomas, Jeltsina Sosa","doi":"10.18535/ijmsci/v9i05.03","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i05.03","url":null,"abstract":"Introduction: Although Acute Myeloid Leukemia (AML) has been associated with several environmental factors, in some patients the evolution to AML is preceded by myelodysplastic syndrome (MDS). We report a case of 63-year-old male who was diagnosed with sporadic monosomy 7 MDS/AML who achieved good response to treatment with CPX-351 (Vyxeos) induction chemotherapy.\u0000Case information: A 63-year-old male initially presented to the ED for further evaluation of pancytopenia that was discovered incidentally during a routine office visit. Further evaluation revealed his blast count was elevated with presence of Auer rods, myelocytes and basophilia. He was admitted for further work-up of pancytopenia with suspicion being for MDS/AML and bone marrow biopsy for flow cytometric evaluation of the bone marrow was strongly suggestive of acute myeloid leukemia, with morphology suggesting a predisposing MDS. Subsequent molecular cytogenetic [FISH] report confirmed -7/7q abnormality in 80% of nuclei with loss of 1 copy of chromosome 7. The following week, patient was initiated on CPX–351 [Vyxeos; daunorubicin and cytarabine liposome for injection]. Bone marrow biopsy following induction chemotherapy showed 11 to 12% of CD34 positive myeloid blasts with abnormal myeloid maturation, representing notable improvement with greater than 50% reduction in his blast count.\u0000Conclusion: Sporadic monosomy 7 MDS/AML that arises without evidence of germline genetic predisposition and in the absence of other predisposing medical conditions or treatments is an uncommon subset of AML. Vyxeos induction chemotherapy may be an excellent option in the management of sporadic monosomy 7 MDS/AML.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"34 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91542468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Qsar Studies of Benzimidazole Nucleus As Anti-Infective Agents 苯并咪唑核抗感染药物的设计与Qsar研究

International Journal Of Medical Science And Clinical Invention Pub Date : 2022-05-15 DOI: 10.18535/ijmsci/v9i04.05

Sakharam Sirvi, D. Joshi, Raghvendra Singh Bhadauria

{"title":"Design and Qsar Studies of Benzimidazole Nucleus As Anti-Infective Agents","authors":"Sakharam Sirvi, D. Joshi, Raghvendra Singh Bhadauria","doi":"10.18535/ijmsci/v9i04.05","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i04.05","url":null,"abstract":" \u0000The objective of current study is to design, synthesize the benzimidazoles derivative and evaluate it for anti-malarialactivity by the recently developed Computer Aided Drug Designing techniques with development of new pharmacological active compounds However, a promising approach is needed to use these agents as templates for designing new derivatives with improved properties. The Aim of this project was thus to investigate the potential of the lead compound for future antimalrial drugs. . In order to accomplish this aim a range of synthetic derivatives of Benzimidazoles were prepared and biologically evaluated for Antimalarial activity. 2D Structure of all the designed compounds were draw with the help of chem Draw ultra-version 8.0.3 and exported to window of Chem 3D ultra version 8.0.3 Energy of all the 3D structures were minimized through MOPAC up to RMS gradient 0.001 and saved in MDL Mol file (.Mol) format. )]. In order to examine the predictive power of the QSAR models, the dataset was divided into training set consisting of 32 molecules and test set consisting of 8 compounds in such a way that the utilizing the diversity method in such a way that the structural diversity and a wide range of biological activity in the data set were added. The IC50 values were transformed to pIC50 in order to give numerically larger data values.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83307283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Process Validation of Sevelamer Hydrochloride Film Coated Tablet 盐酸舍维拉默薄膜包衣片的工艺验证

International Journal Of Medical Science And Clinical Invention Pub Date : 2022-05-14 DOI: 10.18535/ijmsci/v9i04.06

Aditya Thakur, D. Joshi, R. Bhadauria

引用次数: 0

Analysis the Alert Village to Reduce Maternal Mortality Rate in Jember Regency 警备村降低琼县孕产妇死亡率的分析

International Journal Of Medical Science And Clinical Invention Pub Date : 2022-05-13 DOI: 10.18535/ijmsci/v9i05.02

Estik Ikka Indah Purwati, Ristya Widi Endah Yani

引用次数: 0

Phytochemical Screening of Barleria Prionitis L Leaves Using Hydrotropic Solvents 利用亲水溶剂对朊芽孢杆菌叶片进行植物化学筛选

International Journal Of Medical Science And Clinical Invention Pub Date : 2022-05-10 DOI: 10.18535/ijmsci/v9i04.04

Rakesh P. Singh, D. Joshi, R. Bhadauria

{"title":"Phytochemical Screening of Barleria Prionitis L Leaves Using Hydrotropic Solvents","authors":"Rakesh P. Singh, D. Joshi, R. Bhadauria","doi":"10.18535/ijmsci/v9i04.04","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i04.04","url":null,"abstract":"Hydrotropic agents are stated as ionic organic salts which help to increase or decrease the solubility of solute in a given solvent via ‘salt in’ or ‘salt out’ effects, respectively. Salts which show ‘salt in’ of non-electrolytes are called “hydrotropic salts” and the phenomenon is known as “hydrotropism. There are about 45,000 plant species in India, with concentrated hotspots in the region of Eastern Himalayas. Entire plants of Barleriaprionitis L. collected from Shrinathji Institute of pharmacy, Nathdwara and the plant was authenticated by Dr. R.L. Bhardwaj. The leaves of Barleria Prionitis L plant was characterized by its morphological features like colour, shape, size and surface characteristics has been studies. The plant materials (1 kg) were initially defatted with petroleum ether and then extracted with blends RP-1 to RP-6 using a Soxhlet apparatus. The yield of the plant extracts measured about 20 g each after evaporating the solvent using water bath. As per result of HPTLC, we found that the hydrotropic blends solution aur ecoferindly and cost effective method for the extraction purpose. All the phytoconstitutents which was earlier reported in previous literature by the use of organic solvents which were also present for the use of hydrotropic solvents.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79142913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioanalytical method Development and Validation for Estimation of Olanzapine in K3edta Human Plasma by Liquid Chromatography–Tandem Mass Spectrometry and Application to a Pharmacokinetic Study 液相色谱-串联质谱法测定K3edta人血浆中奥氮平的生物分析方法的建立与验证及其在药代动力学研究中的应用

International Journal Of Medical Science And Clinical Invention Pub Date : 2022-05-10 DOI: 10.18535/ijmsci/v9i04.03

Jitendra Malviya, D. Joshi, R. Bhadauria

引用次数: 0

Naturoestheticotherapy, Based on E-Coaching with Food Cosmetic Remedy Prepared from Medicinal Plants and Essential Oils Mixtures, Alone or in Combination of Conventional Medicines to Treat Covid-19 Patients and Symptoms. 基于电子指导的自然美容疗法，使用由药用植物和精油混合物制成的食品美容疗法，单独或与常规药物联合治疗Covid-19患者和症状。

International Journal Of Medical Science And Clinical Invention Pub Date : 2022-05-08 DOI: 10.18535/ijmsci/v9i05.01

Rafatro Herintsoa, Andrianomentsoa Bezanahary Hanitrinivony, Randriamavo Solo Hasiniaina Norovololona Angèle, Ramanampamaharana Rija Herindrainy

{"title":"Naturoestheticotherapy, Based on E-Coaching with Food Cosmetic Remedy Prepared from Medicinal Plants and Essential Oils Mixtures, Alone or in Combination of Conventional Medicines to Treat Covid-19 Patients and Symptoms.","authors":"Rafatro Herintsoa, Andrianomentsoa Bezanahary Hanitrinivony, Randriamavo Solo Hasiniaina Norovololona Angèle, Ramanampamaharana Rija Herindrainy","doi":"10.18535/ijmsci/v9i05.01","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i05.01","url":null,"abstract":"Introduction: This is the first study to evaluate the family (30) members (98) practice combining specific lifestyle with the use of medicinal plants based on EOM and conventional medicines.\u0000Clinical observation procedures: A considered multi-centric, controlled and single-blind, phase two clinical trial was realized to patients consulted and received in the Antananarivo Naturoestheticotherapy e-Coaching cabinet of Gasy Products Services and those from Covid-19 Treatment Centers, respectively, during twenty-two months: from May 1st, 2020 to March 1st, 2022. Patients were recommended to follow a specific alimentation and behavior lifestyle. Food Cosmetic Remedy, based on medicinal plant and essential oil mixtures with patient’s optional conventional medicines were given to those presenting Covid-19 principal symptom, such as breath shortness accompanied other indicated symptoms or confirmed medical diagnoses/tests.\u0000Outcomes and conclusion: Inhalation of EOM were immediately stopped breath shortness, combining medicinal plants based on essential oil and conventional medicines was psychologically help and physically reinforce the organism to improve Covid-19 symptoms. Food Cosmetic Remedy (combination of medicinal plant and essential oil mixtures) was quickly recovered patients from principal symptoms and reduced time care and long-Covid-19 period. No patient death was registered during the studied observation period.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82306374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0