International journal of MS care最新文献

{"title":"The Prevalence of Comorbidities and Their Association With Disability Progression in Individuals With Multiple Sclerosis: A Study From Brazil.","authors":"Marco Aurélio Gralha de Caneda, Camila Batista Oliveira Silva, Maria Cecília Aragon de Vecino","doi":"10.7224/1537-2073.2023-103","DOIUrl":"10.7224/1537-2073.2023-103","url":null,"abstract":"<p><strong>Background: </strong>Comorbidities negatively impact the course of multiple sclerosis (MS). Identifying them is essential, as they represent potentially modifiable prognostic factors that can adversely influence the disease course. However, comorbidity prevalence remains underexplored in certain populations, including in individuals in Brazil.</p><p><strong>Methods: </strong>In this cross-sectional study, we describe the frequency of comorbidities and their correlation with MS disability progression in a Brazilian population by reviewing the medical records of patients from a single MS center in Brazil. Preexisting comorbidities and those present at the time of MS diagnosis were screened. We assessed the prevalence of comorbidities, their prevalence ratios (PR) and the association between them, their number, and the confirmed disability worsening (CDW) that emerged during the follow-up visits.</p><p><strong>Results: </strong>Comorbidities were present in 68.9% of individuals. The most prevalent comorbidities included cardiovascular diseases (19.3%), migraine (13.3%), psychiatric disorders (12.4%), smoking (12.4%), autoimmune diseases (12.0%), respiratory diseases (10.3%), and neoplasms (5.6%). Patients with 1 comorbidity and those with multiple comorbidities (≥ 3) had a significant PR for CDW (2.67, <i>P</i> = .01; 1.25, <i>P</i> = .03, respectively). Cardiovascular and autoimmune diseases presented significant PR for CDW (2.28, <i>P</i> = .03; 4.2, <i>P</i> = .004, respectively).</p><p><strong>Conclusions: </strong>Comorbidities are more prevalent among Brazilian individuals with MS than in the general population and are associated with disease progression. Identifying and managing them may mitigate their adverse effects on disease course.</p>","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"26 Q3","pages":"239-246"},"PeriodicalIF":0.0,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LETTER FROM THE EDITOR.","authors":"Francois Bethoux","doi":"10.7224/1537-2073-26.2.viii","DOIUrl":"https://doi.org/10.7224/1537-2073-26.2.viii","url":null,"abstract":"","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"26 2","pages":"viii"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10930807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognition, Description, and Variability of Spasticity in Individuals With Multiple Sclerosis and Potential Barriers to Clinician-Patient Dialogue: Results From SEEN-MSS, a Large-Scale, Self-Reported Survey.","authors":"Ben Thrower, Scott D Newsome, Barry Hendin, Sherry Danese, Jenifer Patterson, Robert Chinnapongse","doi":"10.7224/1537-2073.2022-115","DOIUrl":"10.7224/1537-2073.2022-115","url":null,"abstract":"<p><strong>Background: </strong>The experience with spasticity varies among individuals with multiple sclerosis and spasticity (MSS), as they may not recognize it as spasticity or have the language to describe their symptoms. This can lead to potential delays in diagnosis and treatment.</p><p><strong>Methods: </strong>Symptoms and Emotions Exploration Needed in Multiple Sclerosis Spasticity was an online survey completed by 1177 individuals with MSS in 2021. It sought to capture symptoms of spasticity, variability of symptoms, specific spasticity triggers, and how conversations with physicians were initiated.</p><p><strong>Results: </strong>The mean age of the cohort was 56.8 years and it was 78% women. Prior to spasticity onset, 65% of respondents felt minimally prepared or unprepared for possibly developing spasticity and were unaware that spasticity manifests as part of MS. Eighty percent experienced spasticity daily, which was variable in severity and duration. Spasticity was triggered by a range of factors and 90% of those surveyed were unable to predict when it would occur or its severity. Day-to-day variability of spasticity prevented 65% of respondents from doing things they wished to do. Sixty percent were confused by their symptoms, not recognizing them as spasticity. Although 91% reported experiencing muscle spasms, only 69% used \"muscle spasms\" to describe their symptoms. Other descriptors included \"muscle tightness,\" \"stiffness,\" \"cramping,\" and \"pain.\" After recognizing spasticity, 78% proactively initiated discussions with their physicians, 52% wished they had done so sooner, and 42% delayed the conversation by up to or more than a year.</p><p><strong>Conclusions: </strong>Results emphasize the variable nature of spasticity and the lack of a common language to describe symptoms, underscoring the importance of education, earlier recognition, and customized treatments tailored to the severity and duration of spasticity symptoms.</p>","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":" ","pages":"75-80"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10930809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42222782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity in Individuals Newly Diagnosed With Multiple Sclerosis Through the Lens of the COM-B Model.","authors":"Trinh L T Huynh, Whitney N Neal, Elizabeth A Barstow, Robert W Motl","doi":"10.7224/1537-2073.2022-095","DOIUrl":"10.7224/1537-2073.2022-095","url":null,"abstract":"<p><strong>Background: </strong>Physical activity (PA) is a promising intervention for disease modification and symptom management in multiple sclerosis (MS); however, there is a lack of research focusing on PA behavior change interventions for persons newly diagnosed with MS. Such PA behavior change interventions should be developed based on a strong empirical foundation of understanding the behavior and its determinants (ie, what to target for changes to occur). To that end, this qualitative study examined factors explaining PA in persons newly diagnosed with MS and identified potential targets for future behavior change intervention development based on the Capability-Opportunity-Motivation-Behavior (COM-B) model.</p><p><strong>Methods: </strong>Twenty individuals diagnosed with MS within the past 2 years underwent one-on-one semistructured interviews using questions developed based on the COM-B model. Data were analyzed using reflective thematic analysis, and the identified themes were then mapped with the COM-B model.</p><p><strong>Results: </strong>Factors explaining PA in the study sample were identified across the COM-B components. The typical factors include knowledge and skills to sufficiently engage in PA with appropriate approaches, ability to adapt and navigate through new environmental and social difficulties after diagnosis, and motivation resulting from a combination of factors, such as outcome expectation, belief of capabilities, role/identity, reinforcement, and emotions.</p><p><strong>Conclusions: </strong>The COM-B model was applied successfully in this study to understand PA behavior and identify potential targets for behavior change in individuals newly diagnosed with MS. Future behavior change interventions should consider addressing these factors to generate effective PA behavior change in this population.</p>","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":" ","pages":"49-56"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10930808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47663210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Long-Arm Serial Casting to Manage Multiple Sclerosis Spasticity: A Case Report","authors":"Christine Hampton","doi":"10.7224/1537-2073.2023-024","DOIUrl":"https://doi.org/10.7224/1537-2073.2023-024","url":null,"abstract":"\u0000 Spasticity is common among individuals with multiple sclerosis (MS) and can have negative implications. Casting is a treatment intervention that is used to manage spasticity. The use of casting has been studied in individuals with brain injury and stroke, but no publications were found for its use in persons with MS. An individual with MS with upper extremity spasticity participated in long-arm serial casting, bivalve cast fabrication, and additional targeted therapeutic interventions over the course of 17 visits. Spasticity, pain, strength, passive range of motion (PROM), skin, and function were assessed. Spasticity and PROM improved. Increased strength was found in shoulder flexion, elbow flexion/extension, and supination. Active range of motion with resistance was possible and pain-free after the intervention for abduction, horizontal abduction, horizontal adduction, and external rotation. Furthermore, increased functional use including feeding, dressing, and bathing was achieved.","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"331 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking and Health-Related Quality of Life in Patients With Multiple Sclerosis From Latin America","authors":"E. Carnero Contentti, Juan I. Rojas, S. Giachello, Paula Henestroza, Pablo A Lopez","doi":"10.7224/1537-2073.2023-053","DOIUrl":"https://doi.org/10.7224/1537-2073.2023-053","url":null,"abstract":"\u0000 \u0000 \u0000 Tobacco smoking is an important, modifiable, environmental risk factor for multiple sclerosis (MS) with a relevant impact on health-related quality of life (HRQOL). We aimed to assess the use of tobacco in individuals with MS from Latin America (LATAM), and its impact on HRQOL.\u0000 \u0000 \u0000 \u0000 We conducted a cross-sectional study based on a LATAM web-based survey. Demographics, social and clinical data, information on physical disability, and HRQOL scores were collected using the MS Impact Scale-29 (MSIS-29), the Fatigue Severity Scale (FSS), and the Hospital Anxiety and Depression Scale-Anxiety (HADS-A). Individuals with MS were classified at the time of the survey as follows: never-smokers (ie, patients who reported they had never smoked), past smokers (those who had smoked tobacco but not during the past year), or current smokers. For the analysis, groups were compared.\u0000 \u0000 \u0000 \u0000 425 patients (74.6% female) from 17 LATAM countries were included, mean age 43.6 ± 11 years and median Expanded Disability Status Scale score 2. There were 122 (28.7%) current smokers, 178 (41.9%) past smokers, and 125 (30.4%) never-smokers. Current smokers had significantly higher MSIS-29 physical (physical worsening), FSS (fatigue), and HADS-A (anxiety) scores compared with past and never-smokers after being adjusted for covariables. No significant differences were observed in any of the other analyzed demographic, clinical, and therapeutic variables. Thirty percent of the current and past smokers groups had never had their neurologists discuss smoking cessation with them.\u0000 \u0000 \u0000 \u0000 Individuals with MS who were current smokers had higher fatigue and anxiety scores and worse HRQOL compared with past and never-smokers.\u0000","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"21 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140436451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of COVID-19 on Fatigue in Multiple Sclerosis","authors":"Zade Abou-Rass, Jennie Feldpausch, Prudence Plummer, Nora E. Fritz","doi":"10.7224/1537-2073.2023-031","DOIUrl":"https://doi.org/10.7224/1537-2073.2023-031","url":null,"abstract":"\u0000 \u0000 \u0000 Although the COVID-19 quarantine required everyone to make lifestyle changes, it may have had especially profound implications for individuals who experience multiple sclerosis (MS)-related fatigue. Individuals with MS who suffer from fatigue are already predisposed to inactivity and social isolation and are at risk of worsening symptoms. The objective of this study was to examine the impact of the COVID-19 national quarantine and related restrictions on the mental, emotional, and physical fatigue in persons with MS in the United States.\u0000 \u0000 \u0000 \u0000 We conducted a survey open to all adults (> 18 years) with MS within the United States. The survey gathered demographic information and asked how the COVID-19 pandemic impacted their physical, mental, and emotional fatigue.\u0000 \u0000 \u0000 \u0000 The survey was completed by 600 individuals, 478 with relapsing MS and 122 with progressive MS. There was a significant 2-way interaction for time by fatigue type; both physical and emotional fatigue significantly increased during the pandemic (P < .01) and remained significantly higher after the pandemic than prior to the pandemic (P < .01). Mental fatigue increased significantly during the pandemic (P < .01) and although it remained higher, on average, after the pandemic, it was not significantly different than prepandemic.\u0000 \u0000 \u0000 \u0000 Individuals with MS experienced increases in physical, mental, and emotional fatigue over the course of the COVID-19 quarantine. Even after the lifting of quarantine restrictions, these levels have not returned to baseline. To adequately address fatigue, it is critical that health care professionals inquire about all types of fatigue in persons with MS.\u0000","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"43 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139775734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of COVID-19 on Fatigue in Multiple Sclerosis","authors":"Zade Abou-Rass, Jennie Feldpausch, Prudence Plummer, Nora E. Fritz","doi":"10.7224/1537-2073.2023-031","DOIUrl":"https://doi.org/10.7224/1537-2073.2023-031","url":null,"abstract":"\u0000 \u0000 \u0000 Although the COVID-19 quarantine required everyone to make lifestyle changes, it may have had especially profound implications for individuals who experience multiple sclerosis (MS)-related fatigue. Individuals with MS who suffer from fatigue are already predisposed to inactivity and social isolation and are at risk of worsening symptoms. The objective of this study was to examine the impact of the COVID-19 national quarantine and related restrictions on the mental, emotional, and physical fatigue in persons with MS in the United States.\u0000 \u0000 \u0000 \u0000 We conducted a survey open to all adults (> 18 years) with MS within the United States. The survey gathered demographic information and asked how the COVID-19 pandemic impacted their physical, mental, and emotional fatigue.\u0000 \u0000 \u0000 \u0000 The survey was completed by 600 individuals, 478 with relapsing MS and 122 with progressive MS. There was a significant 2-way interaction for time by fatigue type; both physical and emotional fatigue significantly increased during the pandemic (P < .01) and remained significantly higher after the pandemic than prior to the pandemic (P < .01). Mental fatigue increased significantly during the pandemic (P < .01) and although it remained higher, on average, after the pandemic, it was not significantly different than prepandemic.\u0000 \u0000 \u0000 \u0000 Individuals with MS experienced increases in physical, mental, and emotional fatigue over the course of the COVID-19 quarantine. Even after the lifting of quarantine restrictions, these levels have not returned to baseline. To adequately address fatigue, it is critical that health care professionals inquire about all types of fatigue in persons with MS.\u0000","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"748 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139835258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Traditional and Complementary Medicine Among Patients With Multiple Sclerosis in Morocco","authors":"Rachid Lotfi, Mourad Chikhaoui, Abdessamad Elmourid, F. Chigr","doi":"10.7224/1537-2073.2022-116","DOIUrl":"https://doi.org/10.7224/1537-2073.2022-116","url":null,"abstract":"\u0000 \u0000 \u0000 Multiple sclerosis (MS) is an acquired chronic, autoimmune, and neurodegenerative disease of the central nervous system. In addition to conventional MS therapy, patients are interested in traditional and complementary medicine (T&CM). Our study aims to describe the use of T&CM in a cohort of Moroccan patients with MS.\u0000 \u0000 \u0000 \u0000 A quantitative descriptive study was adopted to study this subject. For data collection, we opted for an anonymous questionnaire for 98 patients with MS. We gathered data via an electronic survey, using multivariable analysis to examine the effect of specific factors on T&CM use. Data collection took place from March to June 2022.\u0000 \u0000 \u0000 \u0000 The results show that 52% of patients use T&CM. Of those, 29.6% use cupping, 23.5% recite the Holy Quran, 15.3% use phytotherapy, 13.2% use apitherapy, and 10.2% use acupuncture. In addition, 66.3% of the surveyed respondents stated that alternative medicine positively affects their health. Finally, 49.1% of surveyed patients who use alternative medicine are between 30 and 40 years old. The results also show that the rate of T&CM use is higher in patients with progressive MS (OR = 2.540) and patients without financial access to disease-modifying therapy (OR = 2.100).\u0000 \u0000 \u0000 \u0000 This study invites us to consider societal, cultural, and economic factors when studying the use of T&CM among people with MS. Further research is needed to understand the motivations for using T&CM.\u0000","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"32 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139863299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Traditional and Complementary Medicine Among Patients With Multiple Sclerosis in Morocco","authors":"Rachid Lotfi, Mourad Chikhaoui, Abdessamad Elmourid, F. Chigr","doi":"10.7224/1537-2073.2022-116","DOIUrl":"https://doi.org/10.7224/1537-2073.2022-116","url":null,"abstract":"\u0000 \u0000 \u0000 Multiple sclerosis (MS) is an acquired chronic, autoimmune, and neurodegenerative disease of the central nervous system. In addition to conventional MS therapy, patients are interested in traditional and complementary medicine (T&CM). Our study aims to describe the use of T&CM in a cohort of Moroccan patients with MS.\u0000 \u0000 \u0000 \u0000 A quantitative descriptive study was adopted to study this subject. For data collection, we opted for an anonymous questionnaire for 98 patients with MS. We gathered data via an electronic survey, using multivariable analysis to examine the effect of specific factors on T&CM use. Data collection took place from March to June 2022.\u0000 \u0000 \u0000 \u0000 The results show that 52% of patients use T&CM. Of those, 29.6% use cupping, 23.5% recite the Holy Quran, 15.3% use phytotherapy, 13.2% use apitherapy, and 10.2% use acupuncture. In addition, 66.3% of the surveyed respondents stated that alternative medicine positively affects their health. Finally, 49.1% of surveyed patients who use alternative medicine are between 30 and 40 years old. The results also show that the rate of T&CM use is higher in patients with progressive MS (OR = 2.540) and patients without financial access to disease-modifying therapy (OR = 2.100).\u0000 \u0000 \u0000 \u0000 This study invites us to consider societal, cultural, and economic factors when studying the use of T&CM among people with MS. Further research is needed to understand the motivations for using T&CM.\u0000","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"21 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139803615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}