International journal of MS care最新文献

{"title":"Perceptions of People With Multiple Sclerosis Who Practice Tai Chi and/or Qigong: A Mixed-Methods Study.","authors":"Lita Buttolph, Jamie Villanueva, Heena Manglani-Terranova, Tanya Snyder, Gloria Y Yeh, Lindsey Wooliscroft, Ryan Bradley, Heather Zwickey","doi":"10.7224/1537-2073.2024-107","DOIUrl":"10.7224/1537-2073.2024-107","url":null,"abstract":"<p><strong>Background: </strong>Exercise is important for people with multiple sclerosis (MS) to manage symptoms and improve quality of life. Tai chi and qigong (TCQ) are mind-body exercises shown to benefit physical, emotional, and cognitive health in many conditions, but research has been limited in people with MS. To understand potential benefits from regular TCQ practice and factors influencing feasibility, acceptability, and sustainability, we conducted a mixed-methods study through a survey and focus groups with people with MS who regularly practice TCQ.</p><p><strong>Methods: </strong>We conducted focus groups with people with MS from across the United States who regularly practice TCQ; the data from these groups were analyzed using reflexive thematic analysis. Participants also completed a brief survey that collected data on demographics, MS health history and symptoms, and TCQ practice (including opinions on content, dosage, and delivery).</p><p><strong>Results: </strong>Thirteen people with MS (85% female, 69% White) participated in the study. Reported TCQ benefits included physical (balance, strength), cognitive (memory), psychological (calming), and social (community building), with a dose-response gain over time. Challenges included learning and remembering movements, physical limitations (strength, endurance, fatigue), and transportation barriers. Adaptations specific to MS included tailoring TCQ content to meet individual needs and symptoms, appropriate pace, online delivery, and safety. Keys to sustainable practice included enjoyment, patience and self-compassion, viewing TCQ as medicine, and scheduling time for practice.</p><p><strong>Conclusions: </strong>Results suggest people with MS who maintain a TCQ practice may experience physical, emotional, cognitive, and social benefits, especially when specific practice details and facilitators are met. Future studies might investigate how these factors influence sustainable practice.</p>","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"28 1","pages":"40-47"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocrelizumab Wearing-Off Phenomenon: Prevalence, Predictors, and Outcomes After Intervention.","authors":"Alexandra Rincones, Marjorie Fitzsimmons, Avinash Kolli, Luis Compres Brugal, Derrick S Robertson, John R Ciotti","doi":"10.7224/1537-2073.2024-092","DOIUrl":"https://doi.org/10.7224/1537-2073.2024-092","url":null,"abstract":"<p><strong>Background: </strong>Studies have suggested a wearing-off phenomenon characterized by subjective worsening of symptoms prior to subsequent infusions in more than half of people with multiple sclerosis (MS) treated with ocrelizumab. This study assesses the prevalence, characteristics, predictive factors, and impacts of different interventions on wearing off in a large cohort of people with MS receiving ocrelizumab.</p><p><strong>Methods: </strong>Clinical records of people with MS receiving ocrelizumab were reviewed to collect demographic variables, clinical characteristics, comorbidities, presence of wearing off and its specific symptoms, and responses after interventions to wearing off. Logistic regression modeling was used to assess predictors of wearing off.</p><p><strong>Results: </strong>Wearing off was observed in 24.8% of 528 people with MS receiving ocrelizumab, most often characterized by worsening residual focal symptoms (79.4%) and fatigue (67.2%). Risk factors for wearing off included obesity (OR, 1.93; <i>P</i> = .013), fatigue (OR, 2.22; <i>P</i> < .001), and use of an assistive device for ambulation (OR, 2.16; <i>P</i> = .004). Any intervention, such as shortening ocrelizumab infusion intervals or switching therapies, improved or resolved wearing off in over 80% of participants (<i>P</i> < .001).</p><p><strong>Conclusions: </strong>Wearing off was observed in nearly a quarter of people with MS receiving ocrelizumab. Clinicians should be aware of predictive factors for wearing off with ocrelizumab and that interventions were generally effective at mitigating this phenomenon.</p>","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"27 4","pages":"304-311"},"PeriodicalIF":0.0,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head Rotation Impairs Balance and Walking in People With Mild to Moderate Multiple Sclerosis: A Pilot Study.","authors":"Marianne Rösner, Cintia Ramari, Juan Ma Vecin Villa-Real, Lousin Moumdjian, Peter Feys, Ingo Kleiter","doi":"10.7224/1537-2073.2024-095","DOIUrl":"https://doi.org/10.7224/1537-2073.2024-095","url":null,"abstract":"<p><strong>Background: </strong>People with multiple sclerosis (MS) have an increased risk of falls, which are often associated with changes in movement direction and preceded by head rotation (HR). We aimed to investigate the effects of HR on postural control and gait temporal parameters in people with MS compared with controls (Cs) and to quantify the number of strides required to correct gait after HR.</p><p><strong>Methods: </strong>Eighteen people with MS (44.4 ± 9.9 years; 3.1 ± 1.5 Expanded Disability Scale Score) and 10 Cs (43.6 ± 10.3 years) participated. Postural control during a standing task on a force plate was assessed and quantified by center of pressure displacement. Gait was assessed by 2D sagittal video analysis and analyzed with Kinovea. After30 seconds of unperturbed walking on a treadmill, participants were instructed to turn their head to the left and walk on, followed by a right HR. The 10 strides after the HR were compared with the mean of normal walking strides. Inter- and intragroup comparisons were performed using a mixed model for repeated measurements. Hierarchical testing was used for stride analysis.</p><p><strong>Results: </strong>While standing, people with MS performed worse in all conditions and increased center of pressure displacement after HR in comparison with Cs (<i>P</i> ≤ .05). While walking, both groups increased the relative stance phase after HR (<i>P</i> ≤ .05); however, people with MS reduced stride times (<i>P</i> ≤ .05), and Cs maintained them. After HR, people with MS needed 3 strides to normalize stride times back to baseline, versus 1 to none for Cs.</p><p><strong>Conclusions: </strong>People with MS have higher transient imbalance while walking and standing after an HR compared with Cs.</p>","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"27 4","pages":"295-303"},"PeriodicalIF":0.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Changes in Patient-Reported Outcome Measures in People With Multiple Sclerosis 55 Years and Older: Analysis From the New York State Multiple Sclerosis Consortium.","authors":"Dejan Jakimovski, Katelyn S Kavak, Patricia K Coyle, Andrew D Goodman, Malcolm H Gottesman, Bianca Weinstock-Guttman, New York State Multiple Sclerosis Consortium","doi":"10.7224/1537-2073.2024-067","DOIUrl":"https://doi.org/10.7224/1537-2073.2024-067","url":null,"abstract":"<p><strong>Background: </strong>Patient-reported outcome measures (PROMs) are increasingly utilized in observational and regulated studies of people with multiple sclerosis (MS). However, the impact of aging on PROMs for people with MS remains largely unknown. This study explores the cross-sectional characteristics and longitudinal trajectories of PROMs to determine their ability to predict clinical progression in a large group of people with MS 55 years and older.</p><p><strong>Methods: </strong>Included in the analysis were people with MS enrolled in the New York State Multiple Sclerosis Consortium (NYSMSC), 55 years or older, with at least 3 clinical visits recorded in the consortium database. All people in the NYSMSC complete PROMs through the LIFEware questionnaire. Additional clinical measures were also collected. The percentage of people with MS who reported severe limitations within each of the LIFEware domains was compared at their baseline visit (≥ 55 years) and at the most recent follow-up visit (average follow-up of 8.3 years). Comparisons between people with MS with stable or increasing disability were also performed.</p><p><strong>Results: </strong>Of 658 eligible people in the NYSMSC (mean age at most recent follow-up, 66.6 years), a greater percentage reported decreased ability since baseline in all physical PROMs domains (getting up from sofa, 38.4% to 48.8%, <i>P</i> < .001; standing for more than 30 minutes, 59.3% vs 66.9%, <i>P</i> < .001; and functional limitations in all extremities, <i>P</i> < .007). Contrarily, the group reported improvement in multiple psychosocial domains, including pessimism (<i>P</i> < .001), feeling tense (<i>P</i> < .001), feeling annoyed (<i>P</i> = .02), or having morbid thoughts (<i>P</i> = .018). People with increasing disability had significantly worse baseline physical PROMs when compared with people with stable MS.</p><p><strong>Conclusions: </strong>An increase in physical limitations does not necessarily contribute to a rise in psychosocial limitations. Instead, as people with MS age, they tend to report improvements in their mental health over time. PROMs can be a complementary predictive indicator of future disease progression as individuals with MS age.</p>","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"27 Suppl 2","pages":"T32-T45"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter From the Guest Editors - Multiple Sclerosis and Aging.","authors":"Yinan Zhang, Sarah A Morrow","doi":"10.7224/1537-2073.2025-096","DOIUrl":"https://doi.org/10.7224/1537-2073.2025-096","url":null,"abstract":"","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"27 Suppl 2","pages":"i"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation in Multiple Sclerosis (RiMS) Network Is Key to the World Health Organization's Rehabilitation 2030: A Call for Action for People With Multiple Sclerosis.","authors":"Lousin Moumdjian, Giampaolo Brichetto, Griet Gysemberg, Lars G Hvid, Letizia Leocani, Jana Pöttgen, Anders Guldhammer Skjerbæk, Roshan das Nair","doi":"10.7224/1537-2073.2025-014","DOIUrl":"https://doi.org/10.7224/1537-2073.2025-014","url":null,"abstract":"<p><p>Rehabilitation is essential for improving physical, cognitive, and psychological function; independence; and quality of life for people with multiple sclerosis (MS). Rehabilitation in Multiple Sclerosis (RiMS; www.rehabinms.org) is a professional international network for clinicians and researchers dedicated to advancing MS rehabilitation through research, education, and collaboration. With a focus on knowledge exchange and professional development, RiMS supports multidisciplinary rehabilitation efforts across Europe and internationally. Recognizing the persistent challenges in delivering, accessing, and evaluating rehabilitation, Rehabilitation 2030: A Call for Action from the World Health Organization (WHO) outlines key priorities to strengthen global rehabilitation systems. This editorial maps RiMS's activities and aligns it with the WHO's 10 priority areas, assessing its contributions and identifying gaps to enhance the understanding of RiMS' role in contributing to these priorities and to inform the adaptation of strategic action plans to ensure alignment with global priorities.</p>","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"27 4","pages":"290-294"},"PeriodicalIF":0.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the Unknown: A Qualitative Exploration of the Lived Experiences of People With Multiple Sclerosis During Pregnancy.","authors":"Vivian Chen, Suma Shah","doi":"10.7224/1537-2073.2024-071","DOIUrl":"https://doi.org/10.7224/1537-2073.2024-071","url":null,"abstract":"<p><strong>Background: </strong>People with multiple sclerosis (MS) face challenges in family planning and pregnancy due to the unpredictable nature of the disease and a lack of clear guidelines for approaching pregnancy-related care. The objective of this qualitative study was to explore the pregnancy experiences of people with MS, focusing on uncertainty and mental health.</p><p><strong>Methods: </strong>Semistructured interviews were conducted at the Duke Neurological Disorders Clinic (N = 10). Thematic analysis was conducted inductively to identify main themes.</p><p><strong>Results: </strong>Participants, aged 26 to 40 years, had a range of 1 to 12 years since MS diagnosis and an average of 2 pregnancies and 1.3 children per participant. Three main types of uncertainty were identified: (1) anticipation of the future (relapses, impact of MS on motherhood, health care factors); (2) experienced symptoms (differentiating MS from pregnancy, role of MS in peripartum challenges); and (3) availability of information (insufficient research, provider counseling, external support). These uncertainties negatively impacted mental health, with most participants reporting mental health challenges (n = 7, 70%) and utilizing mental health resources (n = 8, 80%), including talk therapy, psychiatric medications, and support groups.</p><p><strong>Conclusions: </strong>People with MS experience disease-related uncertainty during and around pregnancy. This study highlights the need for proactive counseling on medication safety, lactation, risks of infertility, and pregnancy complications. We also identify a need to address uncertainty and its impacts on the mental health of pregnant people with MS. Clear provider recommendations, timely communication, enhanced mental health screening, and augmented social support are likely to be beneficial in this setting.</p>","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"27 4","pages":"282-289"},"PeriodicalIF":0.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Quality, Dysfunctional Sleep Beliefs, and Health-Related Quality of Life and Functioning in People With Multiple Sclerosis.","authors":"Alaina G Tiani, Nicolas R Thompson, Alexa Kane, Alicia Roth, Michelle Drerup, Robert Bermel, Amy B Sullivan","doi":"10.7224/1537-2073.2024-050","DOIUrl":"https://doi.org/10.7224/1537-2073.2024-050","url":null,"abstract":"<p><strong>Background: </strong>People with multiple sclerosis (MS) are more prone to sleep disturbances than the general population. Poor sleep is associated with diminished health-related quality of life and functioning (HRQOL/F) in people with MS and may trigger unhelpful thoughts and beliefs about sleep. This study aimed to examine the relationship between self-reported sleep quality, dysfunctional sleep beliefs, and HRQOL/F in a sample of people with MS.</p><p><strong>Methods: </strong>Participants (N = 200) completed the Pittsburgh Sleep Quality Index (PSQI), the Dysfunctional Beliefs and Attitudes about Sleep Scale-16 (DBAS-16), and HRQOL/F patient-reported outcome measures (PROMs). Separate multivariable linear regressions were modeled, each including 1 PROM as the dependent variable. For each PROM, 2 models were fit: one with the PSQI score as the predictor and one with the DBAS-16 score. All models included demographic and/or clinical factors as covariates. Two-way interactions between each PSQI and DBAS-16 score and each demographic and/or clinical factor were added to the models. Mediation analysis was performed where each PROM was the outcome, the PSQI score was the predictor, and the DBAS-16 score was the mediator.</p><p><strong>Results: </strong>Worse self-reported sleep quality and a greater degree of dysfunctional sleep beliefs were significantly associated with worse <i>t</i> scores for global HRQOL/F physical and mental health outcomes and several Quality of Life in Neurological Disorders (Neuro-QoL) scales. Dysfunctional sleep beliefs significantly mediated the association between PSQI and HRQOL/F mental health outcomes and several Neuro-QoL scales, and significant interactions between PSQI, DBAS-16, and demographic/clinical factors were revealed.</p><p><strong>Conclusions: </strong>Sleep quality and dysfunctional sleep beliefs are important correlates of HRQOL/F in people with MS. In clinical settings, thorough assessment and intervention targeting these factors are warranted.</p>","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"27 3","pages":"268-281"},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Barriers to Effective Bone Health Management in People With Multiple Sclerosis.","authors":"Lisa B Grech, Luis A Jayanta, Nigel Caswell, L E Ohman, Alison Reece, Michelle Allan, Ernest Butler, Peter R Ebling, Ayse Zengin","doi":"10.7224/1537-2073.2024-073","DOIUrl":"https://doi.org/10.7224/1537-2073.2024-073","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of osteoporosis is higher in people with multiple sclerosis (MS) compared with the general population. Poor bone health, including higher rates of osteopenia and osteoporosis than in the general population, has been established in people with MS. This qualitative study examines how much a group of health care professionals (HCPs) knows about osteoporosis as an MS comorbidity, as well as current practices, barriers to effective bone health management in people with MS, and recommendations for improvement.</p><p><strong>Methods: </strong>Thirty-two Australian HCPs participated in qualitative interviews, including 4 neurologists, 8 endocrinologists, 9 MS nurses, 6 general practitioners, and 5 physiotherapists. Participants were recruited via email, phone calls, and network contacts. Due to a technical error with the recording of 1 interview, 31 interviews were transcribed using Otter.ai. They were reviewed for accuracy and analyzed through NVivo using framework analysis.</p><p><strong>Results: </strong>Most clinicians lacked specific knowledge regarding bone health in people with MS. While the heightened osteoporosis risk in people with MS was presumed, participants perceived current practices as insufficient or were uncertain about their adequacy. Lack of awareness and education about bone health in people with MS emerged as primary barriers, as did insufficient interdisciplinary communication, role delegation, funding, and resources, which were deemed essential for better management.</p><p><strong>Conclusions: </strong>Clinicians advocated for specific guidelines, enhanced education for HCPs, increased resources for patients and clinicians, and improved access to bone health screening for people with MS. These findings underscore the need for comprehensive strategies, emphasizing collaboration, education, and resource allocation, to address the complexities of bone health in individuals with MS.</p>","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"27 3","pages":"256-265"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New/Enlarging T2 Lesions in a Progressive Multiple Sclerosis Trial Cohort: Computer vs Human Detection.","authors":"Alexandra J White, Stephen E Jones, Jay Costantini, Douglas L Arnold, Colm Elliott, Robert J Fox","doi":"10.7224/1537-2073.2024-051","DOIUrl":"https://doi.org/10.7224/1537-2073.2024-051","url":null,"abstract":"<p><strong>Background: </strong>Although detection of new/enlarging multiple sclerosis (MS) lesions is a key metric in clinical practice and research, little is known about how human and automated detection methods compare. We compared findings made by a neuroradiologist to simulate routine practice to those made with a computer-aided technique as used in a clinical trial.</p><p><strong>Methods: </strong>MRIs from a 96-week, progressive MS clinical trial with 255 participants were evaluated for new/enlarging T2 lesions by both a neuroradiologist and a semiautomated method. Readings from 887 paired scans were compared using a paired <i>t</i> test and inter-rater reliability κ. Selected discordant reads were subsequently reviewed by a second neuroradiologist.</p><p><strong>Results: </strong>The semiautomated method identified new/enlarging lesions on 19.7% of the paired scans, while the neuroradiologist identified lesions on 5.7%. Of the 185 paired scans with new/enlarging T2 lesions by either method, the semiautomated method detected a mean of 3.4 new lesions, while the neuroradiologist detected 0.4. Overall κ was 0.18 (poor agreement); the κ of only scans with new/enlarging lesions by either method was -0.06. When scans were categorized as active or inactive, κ was 0.18. Unblinded neuroradiologist overread of selected discordant scans found more lesions when using advanced radiology tools such as coregistration.</p><p><strong>Conclusions: </strong>A large discordance was found between new/enlarging MS lesions identified by a neuroradiologist and a semiautomated identification method. These findings may explain clinical trials reporting new lesions in patients on highly effective therapies, while they are less common in clinical practice. These findings have implications for treatment decision algorithms using MRI. Advanced radiology tools such as coregistration may improve lesion detection in routine clinical practice.</p>","PeriodicalId":14150,"journal":{"name":"International journal of MS care","volume":"27 3","pages":"251-255"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}