International Journal of Mycobacteriology最新文献_第6页

Hepatic Safety of Bedaquiline, Delamanid, and Pretomanid: A Systematic Review and Meta-analysis. 贝达喹啉、Delamanid和Pretomanid的肝脏安全性：系统评价和荟萃分析。

IF 1.5

International Journal of Mycobacteriology Pub Date : 2025-10-01 Epub Date: 2025-12-18 DOI: 10.4103/ijmy.ijmy_97_25

Mohamad Faisal Said Al Omar, Izz Eddin Majed Alchikhsuliman, Sondos Mahmoud Awad, Numa Rajab, Yousef Mohammed Alawi, Leena Yousif Mohamed Ibrahim, Idris Sula, Muhammad Candragupta Jihwaprani, Nazmus Saquib

{"title":"Hepatic Safety of Bedaquiline, Delamanid, and Pretomanid: A Systematic Review and Meta-analysis.","authors":"Mohamad Faisal Said Al Omar, Izz Eddin Majed Alchikhsuliman, Sondos Mahmoud Awad, Numa Rajab, Yousef Mohammed Alawi, Leena Yousif Mohamed Ibrahim, Idris Sula, Muhammad Candragupta Jihwaprani, Nazmus Saquib","doi":"10.4103/ijmy.ijmy_97_25","DOIUrl":"10.4103/ijmy.ijmy_97_25","url":null,"abstract":"Novel anti-tuberculosis (TB) drugs have been shown to effectively treat drug-resistant TB (DR-TB). However, there is a risk of hepatotoxicity. We aimed to evaluate the incidence of hepatotoxicity in TB patients receiving bedaquiline (BDQ), delamanid (DLM), and/or pretomanid (Pa). This meta-analysis (PROSPERO: CRD42024564922) systematically explored electronic databases (i.e., Clinicaltrials.gov, Cochrane CENTRAL, Embase, PROQUEST, PubMed, ScienceDirect, and SinoMed) for clinical trials reporting the incidence of hepatotoxicity upon administering BDQ, DLM, and/or Pa. Primary endpoints were the overall incidence of elevated liver enzymes, particularly alanine transferase (ALT), aspartate transferase (AST), and gamma-glutamyl transferase (GGT). Proportion meta-analysis was performed for each outcome of interest. Sixteen trials with pooled 4086 participants. The combination of BDQ + Pa was associated with increased ALT (10.6%) and AST (10.4%). Among the individual drugs, Pa-containing regimens had the highest incidence of elevated liver enzymes (ALT [18.9%], AST [20.3%], and GGT [12.8%]). DLM-containing regimens had the lowest incidence (ALT [0.2%], AST [0.7%], and GGT [1%]). For BDQ-containing regimens, the incidence of elevated liver enzymes was similar to the standard of care (SOC): ALT (5.5%) vs. (6.9%) and AST (7.5%) vs. (10.8%), respectively. GGT elevation was more common among the groups receiving BDQ compared to SOC (10% vs. 3.1%). Overall, all the included trials were of high or fair quality. Among all the studied drugs, DLM alone demonstrated the highest hepatic safety, while regimens containing BDQ, Pa, or their combination showed higher hepatotoxic risks compared to SOC. We recommend regular liver function monitoring for DR-TB patients receiving these novel anti-TB drugs.","PeriodicalId":14133,"journal":{"name":"International Journal of Mycobacteriology","volume":"14 4","pages":"309-319"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-interferon-γ Autoantibody-mediated Adult-onset Immunodeficiency with Disseminated Mycobacterium abscessus Complex Infection: A Report of Three Cases. 抗干扰素γ自身抗体介导的成人发病免疫缺陷伴弥散性脓肿分枝杆菌复合体感染：附3例报告

IF 1.5

International Journal of Mycobacteriology Pub Date : 2025-10-01 Epub Date: 2025-12-18 DOI: 10.4103/ijmy.ijmy_191_25

Yonghao Deng, Naiyu Lin, Jiande Han, Rong Yin

{"title":"Anti-interferon-γ Autoantibody-mediated Adult-onset Immunodeficiency with Disseminated Mycobacterium abscessus Complex Infection: A Report of Three Cases.","authors":"Yonghao Deng, Naiyu Lin, Jiande Han, Rong Yin","doi":"10.4103/ijmy.ijmy_191_25","DOIUrl":"10.4103/ijmy.ijmy_191_25","url":null,"abstract":"Interferon-γ serves as the pivotal cytokine for macrophage activation. Anti-interferon-γ autoantibody (AIGA)-mediated adult-onset immunodeficiency (AOID) represents a phenocopy of primary immunodeficiency, characterized by recurrent disseminated infections predominantly caused by Mycobacterium abscessus complex (MABC) and other nontuberculous mycobacteria. Disseminated MABC (dMABC) in AOID poses significant therapeutic challenges, requiring long-term multidrug antimicrobial therapy combined with AIGA-targeted immunotherapy. This report details three cases of AOID with dMABC. All patients exhibited recurrent fevers, widespread cutaneous erythema, nodules, pustules, and painful multifocal lymphadenopathy over several months to 2 years. Serum AIGA testing was positive in all cases. MABC was isolated from skin and lymph node specimens through culture or next-generation sequencing. Radiologic studies confirmed systemic involvement, including pulmonary, lymphatic, and osteoarticular sites. A therapeutic regimen of combined antibiotics and low-to-medium-dose oral glucocorticoids (prednisone 20-30 mg/day initiated, tapered to 5 mg/day maintenance) was instituted, leading to clinical resolution in all patients. All were discharged successfully and remained disease-free on long-term follow-up.","PeriodicalId":14133,"journal":{"name":"International Journal of Mycobacteriology","volume":"14 4","pages":"407-411"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Immune Mechanisms in Leprosy: The Role of Serum Interleukin-17 and Tumor Necrosis Factor-alpha in the Immunopathogenesis of the Disease in Sudanese Patients. 探索麻风病的免疫机制：血清白细胞介素-17和肿瘤坏死因子- α在苏丹患者麻风病免疫发病机制中的作用

IF 1.5

International Journal of Mycobacteriology Pub Date : 2025-10-01 Epub Date: 2025-12-18 DOI: 10.4103/ijmy.ijmy_197_25

Hassan Gumaa Mustafa Hamid, Ogail Yousif Dawod, Amar Babikir Elhussein, Mariam Siddig Balla Ali, Omar Elteyb Fadlelseed, Soad Mohammed Alfadol, Husham E Homeida, Nahid Mahmoud Hassan Elamin, Salha Yahia Khalil, Abdullah Mohammed Qahl, Abdullah Shoei Sayd, Mashael Hakami, Rahika Ibrahim Zeleei, Abeer Omar Ahmed, Faisal Hassan Hakami, Fadia Abdalla Saeed Khairi, Aamir Abdullahi Hamzza, Mohammed Helmy Faris Shalayel

{"title":"Exploring Immune Mechanisms in Leprosy: The Role of Serum Interleukin-17 and Tumor Necrosis Factor-alpha in the Immunopathogenesis of the Disease in Sudanese Patients.","authors":"Hassan Gumaa Mustafa Hamid, Ogail Yousif Dawod, Amar Babikir Elhussein, Mariam Siddig Balla Ali, Omar Elteyb Fadlelseed, Soad Mohammed Alfadol, Husham E Homeida, Nahid Mahmoud Hassan Elamin, Salha Yahia Khalil, Abdullah Mohammed Qahl, Abdullah Shoei Sayd, Mashael Hakami, Rahika Ibrahim Zeleei, Abeer Omar Ahmed, Faisal Hassan Hakami, Fadia Abdalla Saeed Khairi, Aamir Abdullahi Hamzza, Mohammed Helmy Faris Shalayel","doi":"10.4103/ijmy.ijmy_197_25","DOIUrl":"https://doi.org/10.4103/ijmy.ijmy_197_25","url":null,"abstract":"Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. This study aimed to compare serum interleukin-17 (IL-17) and tumor necrosis factor-alpha (TNF-α) levels among Sudanese patients with and without leprosy to assess their impact on disease immunopathogenesis.Methods: A case-control cross-sectional study was conducted at Abu Rouf Leprosy Clinic and Khartoum Dermatology Teaching Hospital between August 2018 and October 2020. IL-17 and TNF-α levels were quantified using Sandwich enzyme-linked immunosorbent assay kits (Sunlong Biotech, China). Statistical analyses were performed in SPSS v21.Results: Leprosy patients had significantly lower mean IL-17 levels (1.6 ± 1.2 pg/ml) than healthy controls (5.5 ± 2.6 pg/ml, P < 0.001), whereas TNF-α was higher in patients (103.1 ± 25.5 ng/L) than controls (30.8 ± 15.1 ng/L, P < 0.001). IL-17 correlated negatively with disease duration, while TNF-α showed a positive correlation (r = 0.201, P = 0.037).Conclusion: Cytokine dysregulation, particularly reduced IL-17 and elevated TNF-α, reflects distinct immune pathways in leprosy pathogenesis. These biomarkers may aid in assessing disease activity and treatment response.","PeriodicalId":14133,"journal":{"name":"International Journal of Mycobacteriology","volume":"14 4","pages":"375-381"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coinfection of Pneumocystis jirovecii with Cytomegalovirus Pneumonia and Pulmonary Tuberculosis among Human Immunodeficiency Virus Patients at a Referral Hospital in Tehran. 德黑兰一家转诊医院人类免疫缺陷病毒患者中齐罗氏肺囊虫合并巨细胞病毒肺炎和肺结核的感染

IF 1.5

International Journal of Mycobacteriology Pub Date : 2025-10-01 Epub Date: 2025-12-18 DOI: 10.4103/ijmy.ijmy_128_25

Mitra Rezaei, Estatira Javadzade, Abdolreza Babamahmoodi, Alireza Eskandari, Seyed Mohammad Poorhosseini, Seyed Ali Ziai, Majid Marjani

{"title":"Coinfection of Pneumocystis jirovecii with Cytomegalovirus Pneumonia and Pulmonary Tuberculosis among Human Immunodeficiency Virus Patients at a Referral Hospital in Tehran.","authors":"Mitra Rezaei, Estatira Javadzade, Abdolreza Babamahmoodi, Alireza Eskandari, Seyed Mohammad Poorhosseini, Seyed Ali Ziai, Majid Marjani","doi":"10.4103/ijmy.ijmy_128_25","DOIUrl":"https://doi.org/10.4103/ijmy.ijmy_128_25","url":null,"abstract":"Background: Pneumocystis jirovecii pneumonia (PJP) is still a common opportunistic infection among patients with human immunodeficiency virus (HIV) infection, which has significant mortality if not diagnosed and treated in time.Methods: This study identified and compared demographic, clinical, and radiological characteristics between individuals with solitary PJP and those with concurrent pulmonary infections with other agents.Results: The medical records of 1040 HIV-positive patients with pulmonary diseases were analyzed, and 140 cases of PJP pneumonia were selected. The average age was 37.2 ± 9.2 years, 72% were male, and 52% were intravenous drug users. Most patients had low CD4+ cell counts (median: 25 cells/mm3), were new cases (65%), and antiretroviral drug-naïve (82%). Among confirmed PJP cases, 25.9% had concurrent infections, mainly tuberculosis (TB; 8 cases) and cytomegalovirus pneumonia (8 cases). The comparison showed that there were no significant differences between the two groups in terms of age, gender, history of antiretroviral treatment, history of PJP, history of TB, erythrocyte sedimentation rate, CD4 count, HIV viral load, and the pattern of lung involvement in computed tomography scan imaging. The mortality rates were 17.2% for patients solely infected with PJP and 44.7% for those with coinfections (P < 0.001).Conclusions: These results suggest that diagnosing coinfection of PJP and other pulmonary infections is essential, given the higher mortality.","PeriodicalId":14133,"journal":{"name":"International Journal of Mycobacteriology","volume":"14 4","pages":"334-339"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Detection of Mycobacterium tuberculosis and Nontuberculous Mycobacteria with Drug Resistance Profiling Using Line Probe Assay in Clinical Samples from Suspected Tuberculosis Patients in North Sumatra, Indonesia. 印尼北苏门答腊疑似结核患者临床标本中结核分枝杆菌和非结核分枝杆菌的分子检测及耐药谱分析

IF 1.5

International Journal of Mycobacteriology Pub Date : 2025-10-01 Epub Date: 2025-12-18 DOI: 10.4103/ijmy.ijmy_99_25

R Lia Kusumawati, Mirzan Hasibuan, Indah Nur Lestari, Delyuzar, Nisrina Tari

{"title":"Molecular Detection of Mycobacterium tuberculosis and Nontuberculous Mycobacteria with Drug Resistance Profiling Using Line Probe Assay in Clinical Samples from Suspected Tuberculosis Patients in North Sumatra, Indonesia.","authors":"R Lia Kusumawati, Mirzan Hasibuan, Indah Nur Lestari, Delyuzar, Nisrina Tari","doi":"10.4103/ijmy.ijmy_99_25","DOIUrl":"https://doi.org/10.4103/ijmy.ijmy_99_25","url":null,"abstract":"Background: Tuberculosis (TB) remains a major global health challenge. In addition to Mycobacterium tuberculosis (MTB), nontuberculous mycobacteria (NTM) are increasingly recognized as causative agents of mycobacterial infections. However, the limited access to rapid diagnostics often delays appropriate treatment. Accurate and timely differentiation is critical for selecting effective antibiotic regimens. In Indonesia, there is a lack of population-based data comparing MTB and NTM in TB-suspected cases. This study aimed to detect and differentiate MTB and NTM in clinical samples from suspected TB patients in North Sumatra and to assess their drug resistance profiles using a molecular diagnostic approach.Methods: We conducted a prospective cohort study using 56 clinical samples (45 smear-positive sputum and 11 fine-needle aspiration biopsies) from suspected TB patients in North Sumatra. DNA was extracted and analyzed using the Genoscholar™ NTM + multidrug-resistant TB (MDR-TB) II line probe assay (LPA) to detect MTB, NTM, and anti-TB drug resistance.Results: Of the 56 samples, 40 (71.4%) were positive for MTB, 2 (3.6%) for Mycobacterium avium, and 5 (8.9%) for other NTM species, while 9 (16.1%) were negative. MDR MTB was detected in 9 (28%) sputum samples and 1 (12.5%) biopsy sample. Both M. avium isolates were susceptible to rifampicin and isoniazid, while resistance profiles for the other NTM species could not be determined.Conclusion: LPA effectively differentiated MTB from NTM and identified drug resistance patterns in clinical samples. Implementation of this rapid diagnostic tool may strengthen TB management in high-burden areas such as North Sumatra, enabling earlier and more targeted treatment.","PeriodicalId":14133,"journal":{"name":"International Journal of Mycobacteriology","volume":"14 4","pages":"347-353"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simple Murine Model for Mycobacteria-induced Bone and Soft-tissue Damage by Wild-type and In vitro Selected Drug-resistant Strains. 野生型和体外筛选耐药菌株致小鼠骨和软组织损伤的简单模型。

IF 1.5

International Journal of Mycobacteriology Pub Date : 2025-10-01 Epub Date: 2025-12-18 DOI: 10.4103/ijmy.ijmy_95_25

Mahendra Kumar, Ramraju Ambati, Prachi J Urade, Anil H Lotke, Musti Venkata Krishnasastry

{"title":"Simple Murine Model for Mycobacteria-induced Bone and Soft-tissue Damage by Wild-type and In vitro Selected Drug-resistant Strains.","authors":"Mahendra Kumar, Ramraju Ambati, Prachi J Urade, Anil H Lotke, Musti Venkata Krishnasastry","doi":"10.4103/ijmy.ijmy_95_25","DOIUrl":"https://doi.org/10.4103/ijmy.ijmy_95_25","url":null,"abstract":"Background: Extrapulmonary tuberculosis (EPTB) constitutes 15%-20% of the entire tuberculosis (TB) cases worldwide. However, the lack of proper diagnostic methods, the absence of a reliable model system, and limited knowledge of its pathogenesis impair therapeutic efficacy and contribute to compromised treatment strategies. This study aims to evaluate the Mycobacterium marinum-murine infection model to study bone erosion induced by M. marinum and associated changes in the bone density and soft-tissue damage. A thorough understanding of the EPTB infection and the pathogenesis is necessary and requires a reliable in vivo animal model that mimics pathology similar to human infection.Methods: All studies involved random, stochastically selected healthy, equal weight and activity of C57BL/6 inbred mice for all experiments. All control mice were mock-injected with sterile phosphate-buffered saline in place of the infectious agent and are maintained in isolators having the same light and dark cycles. At the indicated days postinfection, tail lesions are measure and taken for MicroCT as described.Results: The M. marinum mice infection model presented here offers quantifiable pathological features as the infected tails exhibited infiltration of the immune cells, and the microcomputed tomography imaging showed bone erosion to the extent of the coccygeal vertebral loss. Infection of the mice with Isoniazid Resistant Population (IRP) and Ethambutol Resistant (EmbRP) of M. marinum also exhibited pathological features akin to wild-type M. marinum infection. At the same time, for EmbRP, the severity is significantly reduced.Conclusions: These findings advocate the use of the murine model of mycobacterium to understand the EPTB, precisely bone and spine TB.","PeriodicalId":14133,"journal":{"name":"International Journal of Mycobacteriology","volume":"14 4","pages":"360-369"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuberculosis and Leprosy in the Past. 过去的结核病和麻风病。

IF 1.5

International Journal of Mycobacteriology Pub Date : 2025-10-01 Epub Date: 2025-12-18 DOI: 10.4103/ijmy.ijmy_193_25

Malin Ridell, Margareta Eriksson

引用次数: 0

Isolated Muscular Tuberculosis of the External Compartment of the Leg: A Rare Presentation. 腿外隔室孤立性肌肉结核：一种罕见的表现。

IF 1.5

International Journal of Mycobacteriology Pub Date : 2025-10-01 Epub Date: 2025-12-18 DOI: 10.4103/ijmy.ijmy_228_24

Montassar El Ayachi, Mehdi Meddeb, Helmi Ernandes, Ahmed Mzid, Chedi Saadi, Khalil Habboubi, Ikbel Kooli, Mondher Mestiri

引用次数: 0

Coinfection between Pulmonary Tuberculosis and Systemic Lupus Erythematosus: A 20-year Bibliometric Study. 肺结核和系统性红斑狼疮合并感染：20年文献计量学研究。

IF 1.5

International Journal of Mycobacteriology Pub Date : 2025-10-01 Epub Date: 2025-12-18 DOI: 10.4103/ijmy.ijmy_171_25

John Barja-Ore, Alexandra Liñan-Bermudez, Brandon E Guillen-Calle, Zaida Zagaceta-Guevara, Luis Tello Davila

{"title":"Coinfection between Pulmonary Tuberculosis and Systemic Lupus Erythematosus: A 20-year Bibliometric Study.","authors":"John Barja-Ore, Alexandra Liñan-Bermudez, Brandon E Guillen-Calle, Zaida Zagaceta-Guevara, Luis Tello Davila","doi":"10.4103/ijmy.ijmy_171_25","DOIUrl":"https://doi.org/10.4103/ijmy.ijmy_171_25","url":null,"abstract":"Background: Pulmonary tuberculosis (PTB) has a major global impact and has been reported as one of the most relevant complications in patients with systemic lupus erythematosus (SLE). The aim of this study was to analyze the bibliometric parameters of the scientific literature indexed in Scopus regarding the coinfection between PTB and SLE.Methods: A bibliometric study was conducted using a search strategy with MeSH terms to identify articles indexed in Scopus. After screening, 122 articles were included in the study. Bibliometric tools (SciVal, VOSviewer, and Bibliometrix) were used to analyze publication metadata.Results: Scientific production showed an annual growth rate of 4.56%, with a mean of 22.4 citations per publication per year. Rheumatology International, ranked in Q2, was the most relevant journal in the field of PTB and SLE, followed by Clinical Rheumatology and the Indian Journal of Tuberculosis. India demonstrated the greatest growth, with approximately 125 articles, whereas Brazil ranked fifth with sustained productivity. National collaboration was most frequent (46.7%); however, articles with international authorship achieved greater impact, with 209.8 citations per publication and 148% more citations than expected.Conclusion: Scientific output on PTB and SLE has steadily increased over the past 20 years. India, China, and Brazil lead the field, with international cooperation playing an emerging but significant role. The main publication venues are journals ranked in Q2 and Q3.","PeriodicalId":14133,"journal":{"name":"International Journal of Mycobacteriology","volume":"14 4","pages":"354-359"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Treatment Outcomes of Shorter Regimen in Modified All Oral Regimen with Injectable in Patients Treated for Rifampicin-resistant/Multidrug-resistant Tuberculosis in Tanzania. 坦桑尼亚利福平耐药/耐多药结核病患者改良全口服方案与注射方案较短治疗方案的疗效比较

IF 1.5

International Journal of Mycobacteriology Pub Date : 2025-10-01 Epub Date: 2025-12-18 DOI: 10.4103/ijmy.ijmy_98_25

Happiness Cornel Mvungi, Peter Masunga Mbelele, Kassim Salim Msaji, Stellah George Mpagama, Hadija Hamis Semvua

{"title":"Comparative Treatment Outcomes of Shorter Regimen in Modified All Oral Regimen with Injectable in Patients Treated for Rifampicin-resistant/Multidrug-resistant Tuberculosis in Tanzania.","authors":"Happiness Cornel Mvungi, Peter Masunga Mbelele, Kassim Salim Msaji, Stellah George Mpagama, Hadija Hamis Semvua","doi":"10.4103/ijmy.ijmy_98_25","DOIUrl":"https://doi.org/10.4103/ijmy.ijmy_98_25","url":null,"abstract":"Background: Drug-resistant tuberculosis (TB), especially rifampicin-resistant/multidrug-resistant TB (RR/MDR-TB), remains difficult to treat due to toxic aminoglycosides. The World Health Organization recommended all-oral bedaquiline-based regimens, but evidence comparing their effectiveness to injectable-containing regimens is limited. This study evaluated treatment success between both approaches.Methods: This was a retrospective study, which included 114 adults aged 18 years and above with RR/MDR-TB treated at Kibong'oto Infectious Diseases Hospital with either a 9-11-month injectable-containing regimen from 2018 to 2019 or a modified all-oral bedaquiline regimen from June 2020 to May 2021. Patients were followed monthly for smear/culture conversion and clinical outcomes up to 12 months posttreatment. Analysis was performed using SPSS version 25.Results: Of 114 patients, 71 (62.3%) received an all-oral bedaquiline-containing regimen. Overall, 80 (70.2%) patients were male, with a median age of 37 years (interquartile range: 29-48); 27 (23.9%) patients were human immunodeficiency virus infected, and 37 (22.5%) had prior TB treatment. Culture conversion at month 2 occurred in all 43 patients on injectable regimens, compared to 63 (90%) patients on all-oral regimens (P = 0.03). Treatment success was higher in the all-oral group at 63 (94.4%), compared to 33 (76.7%) in the injectable group (P = 0.001). Mortality was 7 (14.0%) in the injectable group and 4 (5.6%) in the all-oral group (P = 0.004).Conclusion: All-oral bedaquiline regimens demonstrated higher treatment success and lower 12-month posttreatment mortality, while injectable regimens had faster culture conversion at month 2, but poorer overall outcomes, supporting the use of all-oral treatment.","PeriodicalId":14133,"journal":{"name":"International Journal of Mycobacteriology","volume":"14 4","pages":"340-346"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0