International Journal of Medicinal Chemistry最新文献

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Catalyst-free synthesis of highly biologically active 5-arylidene rhodanine and 2,4-thiazolidinedione derivatives using aldonitrones in polyethylene glycol. 在聚乙二醇中使用醛丙酮无催化剂合成高生物活性的5-芳基罗丹宁和2,4-噻唑烷二酮衍生物。
International Journal of Medicinal Chemistry Pub Date : 2013-01-01 Epub Date: 2013-02-14 DOI: 10.1155/2013/273534
Dhruva Kumar, Suresh Narwal, Jagir S Sandhu
{"title":"Catalyst-free synthesis of highly biologically active 5-arylidene rhodanine and 2,4-thiazolidinedione derivatives using aldonitrones in polyethylene glycol.","authors":"Dhruva Kumar,&nbsp;Suresh Narwal,&nbsp;Jagir S Sandhu","doi":"10.1155/2013/273534","DOIUrl":"https://doi.org/10.1155/2013/273534","url":null,"abstract":"<p><p>A green, efficient synthesis of 5-arylidene rhodanine and 2,4-thiazolidinedione derivatives without using any external catalyst in polyethylene glycol (PEG) at 80°C has been described. Reaction procedure is very simple, short, and obtained yields are very high. </p>","PeriodicalId":14082,"journal":{"name":"International Journal of Medicinal Chemistry","volume":"2013 ","pages":"273534"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/273534","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32795669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Synthesis and In Vitro Antimicrobial Evaluation of New 1,3,4-Oxadiazoles Bearing 5-Chloro-2-methoxyphenyl Moiety. 含5-氯-2-甲氧基苯基基团的新型1,3,4-恶二唑的合成及体外抗菌评价
International Journal of Medicinal Chemistry Pub Date : 2013-01-01 Epub Date: 2013-03-31 DOI: 10.1155/2013/725673
Basavapatna N Prasanna Kumar, Kikkeri N Mohana, Lingappa Mallesha, Kikkeri P Harish
{"title":"Synthesis and In Vitro Antimicrobial Evaluation of New 1,3,4-Oxadiazoles Bearing 5-Chloro-2-methoxyphenyl Moiety.","authors":"Basavapatna N Prasanna Kumar,&nbsp;Kikkeri N Mohana,&nbsp;Lingappa Mallesha,&nbsp;Kikkeri P Harish","doi":"10.1155/2013/725673","DOIUrl":"https://doi.org/10.1155/2013/725673","url":null,"abstract":"<p><p>A series of new 1,3,4-oxadiazole derivatives, 4(a-h), containing 5-chloro-2-methoxy benzohydrazide moiety were synthesized by the reaction of 5-chloro-2-methoxybenzoate with different aromatic carboxylic acids. These newly synthesized compounds were characterized by FT-IR, (1)H NMR, mass spectra, and also by elemental analysis. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial studies revealed that compounds 4c, 4f, and 4g showed significant activity against tested strains. </p>","PeriodicalId":14082,"journal":{"name":"International Journal of Medicinal Chemistry","volume":"2013 ","pages":"725673"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/725673","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32795673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Synthesis and evaluation of some novel chromone based dithiazoles as antimicrobial agents. 新型铬基二噻唑类抗菌药物的合成与评价。
International Journal of Medicinal Chemistry Pub Date : 2013-01-01 Epub Date: 2013-11-27 DOI: 10.1155/2013/815453
Naureen Aggarwal, Vishal Sharma, Harpreet Kaur, Mohan Paul Singh Ishar
{"title":"Synthesis and evaluation of some novel chromone based dithiazoles as antimicrobial agents.","authors":"Naureen Aggarwal,&nbsp;Vishal Sharma,&nbsp;Harpreet Kaur,&nbsp;Mohan Paul Singh Ishar","doi":"10.1155/2013/815453","DOIUrl":"https://doi.org/10.1155/2013/815453","url":null,"abstract":"<p><p>Novel substituted 1,2,4-dithiazolylchromones 3a-j were synthesized by the reaction of 3-formylchromones (1a-j) with two equivalents of p-chlorothiobenzamide (2) in dry xylene and characterized spectroscopically (IR, (1)H and (13)C NMR, mass) and elemental analysis. All synthesized compounds were screened for in vitro antimicrobial activity against various pathogenic bacterial and fungal strains and were found to possess good to moderate inhibitory potential against all tested strains. Antimicrobial results reveal that compounds bearing lipophilic electron withdrawing groups such as chloro and bromo displayed significant inhibitory potential against both bacterial and fungal strains. Particularly, compound 3c displayed significant inhibitory against bacterial strains and compound 3h exhibits significant inhibitory potential in comparison to standard drug fluconazole against fungal strain S. cerevisiae. </p>","PeriodicalId":14082,"journal":{"name":"International Journal of Medicinal Chemistry","volume":"2013 ","pages":"815453"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/815453","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32799713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Microwave-assisted synthesis and biological evaluation of dihydropyrimidinone derivatives as anti-inflammatory, antibacterial, and antifungal agents. 微波辅助合成及抗炎、抗菌和抗真菌二氢嘧啶衍生物的生物学评价。
International Journal of Medicinal Chemistry Pub Date : 2013-01-01 Epub Date: 2013-04-15 DOI: 10.1155/2013/197612
Anjna Bhatewara, Srinivasa Rao Jetti, Tanuja Kadre, Pradeep Paliwal, Shubha Jain
{"title":"Microwave-assisted synthesis and biological evaluation of dihydropyrimidinone derivatives as anti-inflammatory, antibacterial, and antifungal agents.","authors":"Anjna Bhatewara,&nbsp;Srinivasa Rao Jetti,&nbsp;Tanuja Kadre,&nbsp;Pradeep Paliwal,&nbsp;Shubha Jain","doi":"10.1155/2013/197612","DOIUrl":"https://doi.org/10.1155/2013/197612","url":null,"abstract":"A simple protocol for the efficient preparation of aryl and heteroaryl substituted dihydropyrimidinone has been achieved via initial Knoevenagel, subsequent addition, and final cyclization of aldehyde, ethylcyanoacetate, and guanidine nitrate in the presence of piperidine as a catalyst in solvent-free under microwave irradiation. The synthesized compounds showed a good anti-inflammatory, antibacterial, and antifungal activity.","PeriodicalId":14082,"journal":{"name":"International Journal of Medicinal Chemistry","volume":"2013 ","pages":"197612"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/197612","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32844355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Recent pharmacological developments on rhodanines and 2,4-thiazolidinediones. 罗丹宁和 2,4-噻唑烷二酮类化合物的最新药理学发展。
International Journal of Medicinal Chemistry Pub Date : 2013-01-01 Epub Date: 2013-05-02 DOI: 10.1155/2013/793260
Ravinder Singh Bhatti, Sakshi Shah, Suresh, Pawan Krishan, Jagir S Sandhu
{"title":"Recent pharmacological developments on rhodanines and 2,4-thiazolidinediones.","authors":"Ravinder Singh Bhatti, Sakshi Shah, Suresh, Pawan Krishan, Jagir S Sandhu","doi":"10.1155/2013/793260","DOIUrl":"10.1155/2013/793260","url":null,"abstract":"<p><p>Thiazolidines are five-member heterocyclic having sulfur, nitrogen, and oxygen atoms in their ring structure and exhibiting potent as well as wide range of pharmacological activities. In this minireview, recent updates on synthesis and pharmacological evaluations of molecules based on 2,4-thiazolidine and rhodanine are discussed. </p>","PeriodicalId":14082,"journal":{"name":"International Journal of Medicinal Chemistry","volume":"2013 ","pages":"793260"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32799712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Silico Inhibition Studies of Jun-Fos-DNA Complex Formation by Curcumin Derivatives. 姜黄素衍生物对Jun-Fos-DNA复合物形成的硅抑制研究。
International Journal of Medicinal Chemistry Pub Date : 2012-01-01 Epub Date: 2012-12-06 DOI: 10.1155/2012/316972
Anil Kumar, Utpal Bora
{"title":"In Silico Inhibition Studies of Jun-Fos-DNA Complex Formation by Curcumin Derivatives.","authors":"Anil Kumar,&nbsp;Utpal Bora","doi":"10.1155/2012/316972","DOIUrl":"https://doi.org/10.1155/2012/316972","url":null,"abstract":"<p><p>Activator protein-1 (AP1) is a transcription factor that consists of the Jun and Fos family proteins. It regulates gene expression in response to a variety of stimuli and controls cellular processes including proliferation, transformation, inflammation, and innate immune responses. AP1 binds specifically to 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive element 5'-TGAG/CTCA-3' (AP1 site). It has been found constitutively active in breast, ovarian, cervical, and lung cancers. Numerous studies have shown that inhibition of AP1 could be a promising strategy for cancer therapeutic applications. The present in silico study provides insights into the inhibition of Jun-Fos-DNA complex formation by curcumin derivatives. These derivatives interact with the amino acid residues like Arg155 and Arg158 which play a key role in binding of Jun-Fos complex to DNA (AP1 site). Ala151, Ala275, Leu283, and Ile286 were the residues present at binding site which could contribute to hydrophobic contacts with inhibitor molecules. Curcumin sulphate was predicted to be the most potent inhibitor amongst all the natural curcumin derivatives docked. </p>","PeriodicalId":14082,"journal":{"name":"International Journal of Medicinal Chemistry","volume":"2012 ","pages":"316972"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/316972","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32797272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Room temperature synthesis and antibacterial activity of new sulfonamides containing n,n-diethyl-substituted amido moieties. 含n,n-二乙基取代氨基的新型磺胺类化合物的室温合成及其抗菌活性。
International Journal of Medicinal Chemistry Pub Date : 2012-01-01 Epub Date: 2012-10-17 DOI: 10.1155/2012/367815
Olayinka O Ajani, Oluwole B Familoni, Feipeng Wu, Johnbull O Echeme, Zheng Sujiang
{"title":"Room temperature synthesis and antibacterial activity of new sulfonamides containing n,n-diethyl-substituted amido moieties.","authors":"Olayinka O Ajani,&nbsp;Oluwole B Familoni,&nbsp;Feipeng Wu,&nbsp;Johnbull O Echeme,&nbsp;Zheng Sujiang","doi":"10.1155/2012/367815","DOIUrl":"https://doi.org/10.1155/2012/367815","url":null,"abstract":"Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities. We have synthesized a series of α-tolylsulfonamide, 1–11 and their substituted N,N-diethyl-2-(phenylmethylsulfonamido) alkanamide derivatives, 12–22 in improved and excellent yields in aqueous medium at room temperature through highly economical synthetic routes. The chemical structures of the synthesized compounds 1–22 were confirmed by analytical and spectral data such as IR, 1H- and 13C-NMR, and mass spectra. The in vitro antibacterial activity of these compounds along with standard clinical reference, streptomycin, was investigated on two key targeted organisms. It was observed that 1-(benzylsulfonyl)pyrrolidine-2-carboxylic acid, 2 emerged as the most active compound against Staphylococcus aureus at MIC value of 1.8 μg/mL while 4-(3-(diethylamino)-3-oxo-2-(phenylmethylsulfonamido) propyl)phenyl phenylmethanesulfonate, 22 was the most active sulfonamide scaffold on Escherichia coli at MIC value of 12.5 μg/mL.","PeriodicalId":14082,"journal":{"name":"International Journal of Medicinal Chemistry","volume":"2012 ","pages":"367815"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/367815","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32797273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Synthesis and biological evaluation of achiral indole-substituted titanocene dichloride derivatives. 非手性吲哚取代二氯化二茂钛衍生物的合成及生物学评价。
International Journal of Medicinal Chemistry Pub Date : 2012-01-01 Epub Date: 2012-06-12 DOI: 10.1155/2012/905981
Anthony Deally, Frauke Hackenberg, Grainne Lally, Matthias Tacke
{"title":"Synthesis and biological evaluation of achiral indole-substituted titanocene dichloride derivatives.","authors":"Anthony Deally,&nbsp;Frauke Hackenberg,&nbsp;Grainne Lally,&nbsp;Matthias Tacke","doi":"10.1155/2012/905981","DOIUrl":"https://doi.org/10.1155/2012/905981","url":null,"abstract":"<p><p>Six new titanocene compounds have been isolated and characterised. These compounds were synthesised from their fulvene precursors using Super Hydride (LiBEt3H) followed by transmetallation with titanium tetrachloride to yield the corresponding titanocene dichloride derivatives. These complexes are bis-[((1-methyl-3-diethylaminomethyl)indol-2-yl)methylcyclopentadienyl] titanium (IV) dichloride (5a), bis-[((5-methoxy-1-methyl,3-diethylaminomethyl)indol-2-yl)methylcyclopentadienyl] titanium (IV) dichloride (5b), bis-[((1-methyl,3-diethylaminomethyl)indol-4-yl)methylcyclopentadienyl] titanium (IV) dichloride (5c), bis-[((5-bromo-1-methyl)indol-3-yl)methylcyclopentadienyl] titanium (IV) dichloride (5d), bis-[((5-chloro-1-methyl)indol-3-yl)methylcyclopentadienyl] titanium (IV) dichloride (5e), and bis-[((5-fluoro-1-methyl)indol-3-yl)methylcyclopentadienyl] titanium (IV) dichloride (5f). All six titanocenes 5a-5f were tested for their cytotoxicity through MTT-based in vitro tests on CAKI-1 cell lines using DMSO and Soluphor P as solubilising agents in order to determine their IC50 values. Titanocenes 5a-5f were found to have IC50 values of 10 (±2), 21 (±3), 29 (±4), 140 (±6), and 450 (±10) μM when tested using DMSO. </p>","PeriodicalId":14082,"journal":{"name":"International Journal of Medicinal Chemistry","volume":"2012 ","pages":"905981"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/905981","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33287295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Pharmacophore Modelling and 3D-QSAR Studies on N(3)-Phenylpyrazinones as Corticotropin-Releasing Factor 1 Receptor Antagonists. 促肾上腺皮质激素释放因子1受体拮抗剂N(3)-苯吡嗪酮的药效团建模和3D-QSAR研究。
International Journal of Medicinal Chemistry Pub Date : 2012-01-01 Epub Date: 2012-05-31 DOI: 10.1155/2012/452325
Paramjit Kaur, Vikas Sharma, Vipin Kumar
{"title":"Pharmacophore Modelling and 3D-QSAR Studies on N(3)-Phenylpyrazinones as Corticotropin-Releasing Factor 1 Receptor Antagonists.","authors":"Paramjit Kaur,&nbsp;Vikas Sharma,&nbsp;Vipin Kumar","doi":"10.1155/2012/452325","DOIUrl":"https://doi.org/10.1155/2012/452325","url":null,"abstract":"<p><p>Pharmacophore modelling-based virtual screening of compound is a ligand-based approach and is useful when the 3D structure of target is not available but a few known active compounds are known. Pharmacophore mapping studies were undertaken for a set of 50 N(3)-phenylpyrazinones possessing Corticotropin-releasing Factor 1 (CRF 1) antagonistic activity. Six point pharmacophores with two hydrogen bond acceptors, one hydrogen bond donor, two hydrophobic regions, and one aromatic ring as pharmacophoric features were developed. Amongst them the pharmacophore hypothesis AADHHR.47 yielded a statistically significant 3D-QSAR model with 0.803 as R (2) value and was considered to be the best pharmacophore hypothesis. The developed pharmacophore model was externally validated by predicting the activity of test set molecules. The squared predictive correlation coefficient of 0.91 was observed between experimental and predicted activity values of test set molecules. The geometry and features of pharmacophore were expected to be useful for the design of selective CRF 1 receptor antagonists. </p>","PeriodicalId":14082,"journal":{"name":"International Journal of Medicinal Chemistry","volume":"2012 ","pages":"452325"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/452325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33187158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors. 一种新型TrkA受体酪氨酸激酶抑制剂的鉴定。
International Journal of Medicinal Chemistry Pub Date : 2012-01-01 Epub Date: 2012-05-02 DOI: 10.1155/2012/412614
Stéphane L Raeppel, Frédéric Gaudette, Hannah Nguyen, Normand Beaulieu, James Wang, Christiane Maroun, Jeffrey M Besterman, Arkadii Vaisburg
{"title":"Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors.","authors":"Stéphane L Raeppel,&nbsp;Frédéric Gaudette,&nbsp;Hannah Nguyen,&nbsp;Normand Beaulieu,&nbsp;James Wang,&nbsp;Christiane Maroun,&nbsp;Jeffrey M Besterman,&nbsp;Arkadii Vaisburg","doi":"10.1155/2012/412614","DOIUrl":"https://doi.org/10.1155/2012/412614","url":null,"abstract":"<p><p>A novel series of N-(3-(6-substituted-aminopyridin-3-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting TrkA receptor tyrosine kinase was identified. SAR study of the series allowed us to design and synthesize compounds possessing inhibitory activity of TrkA kinase enzyme in the low nanomolar range with low residual activity against c-Met and with no significant activity against VEGFR2. </p>","PeriodicalId":14082,"journal":{"name":"International Journal of Medicinal Chemistry","volume":"2012 ","pages":"412614"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/412614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33287291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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