含5-氯-2-甲氧基苯基基团的新型1,3,4-恶二唑的合成及体外抗菌评价

International Journal of Medicinal Chemistry Pub Date : 2013-01-01 Epub Date: 2013-03-31 DOI:10.1155/2013/725673

Basavapatna N Prasanna Kumar, Kikkeri N Mohana, Lingappa Mallesha, Kikkeri P Harish

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引用次数: 6

摘要

以5-氯-2-甲氧基苯甲酸为原料，与不同的芳香羧酸反应，合成了一系列含有5-氯-2-甲氧基苯并肼的1,3,4-恶二唑衍生物4(A -h)。这些新合成的化合物通过FT-IR， (1)H NMR，质谱和元素分析进行了表征。对所有新合成的化合物进行了抗菌和抗真菌活性筛选。抗菌研究表明，化合物4c、4f和4g对试验菌株具有显著的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis and In Vitro Antimicrobial Evaluation of New 1,3,4-Oxadiazoles Bearing 5-Chloro-2-methoxyphenyl Moiety.

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Synthesis and In Vitro Antimicrobial Evaluation of New 1,3,4-Oxadiazoles Bearing 5-Chloro-2-methoxyphenyl Moiety.

A series of new 1,3,4-oxadiazole derivatives, 4(a-h), containing 5-chloro-2-methoxy benzohydrazide moiety were synthesized by the reaction of 5-chloro-2-methoxybenzoate with different aromatic carboxylic acids. These newly synthesized compounds were characterized by FT-IR, (1)H NMR, mass spectra, and also by elemental analysis. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial studies revealed that compounds 4c, 4f, and 4g showed significant activity against tested strains.

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来源期刊

International Journal of Medicinal Chemistry CHEMISTRY, MEDICINAL-

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期刊介绍： International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis. International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis.