International Journal of Fertility & Sterility最新文献

{"title":"Association between Serum HLA-G Levels in The First Trimester of Pregnancy and The Onset of Preeclampsia: A Systematic Review and Meta-analysis Study.","authors":"Salome Maghsudlu,&nbsp;Mohamad Ghazanfari Hashemi,&nbsp;Vahid Talebi,&nbsp;Elham Vahabi,&nbsp;Sanaz Sharifpour,&nbsp;Ramtin Hajibeygi,&nbsp;Farajolah Maleki","doi":"10.22074/ijfs.2023.559787.1349","DOIUrl":"10.22074/ijfs.2023.559787.1349","url":null,"abstract":"<p><p>Human leukocyte antigen G (HLA-G) levels are among the biomarkers suggested for pre-eclampsia (PE). This study is aimed at determining the possible relationship between low soluble HLA-G (sHLA-G) levels in maternal blood at the beginning of pregnancy and subsequent PE. We searched the international scientific databases of Web of Science, Embase, PubMed, Cochrane, and Scopus. We extracted the studies investigating the relationship between the serum levels of HLA-G in the first trimester of pregnancy and the onset of PE using the appropriate keywords. The collected data were analyzed using the random-effects meta-analysis model and STATA (version 14). A total of 5 studies met the eligibility criteria, and the total sample size was 668 subjects. The mean and SD age of case subjects was 31.41 ± 4.16 years, while it was 30.56 ± 3.5 for control subjects. According to the findings, there was an inverse relationship between HLA-G serum level in the first trimester of pregnancy and the subsequent onset of PE, standard mean difference (SMD)=-1.51 [95% confidence interval (CI): -2.26, -0.75, I2=90.8%, P=0.000]. Based on these results, low sHLA-G level in early pregnancy has a positive correlation with subsequent PE, and the significant role of sHLA-G in the early stages of placentation can be proven.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"17 4","pages":"231-235"},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/26/e3/Int-J-Fertil-Steril-17-231.PMC10439989.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10043623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-6 as A Useful Predictor of Endometriosis-Associated Infertility: A Systematic Review.","authors":"Giosue Giordano Incognito,&nbsp;Federica Di Guardo,&nbsp;Ferdinando Antonio Gulino,&nbsp;Fortunato Genovese,&nbsp;Domenico Benvenuto,&nbsp;Chiara Lello,&nbsp;Marco Palumbo","doi":"10.22074/ijfs.2023.557683.1329","DOIUrl":"10.22074/ijfs.2023.557683.1329","url":null,"abstract":"<p><p>Endometriosis is a chronic inflammatory disease defined by the presence of endometrial-like tissue outside the uterine cavity. Several authors have reported on the association between changes in inflammatory marker levels and the maintenance or progression of endometriosis and associated infertility. Interleukin-6 (IL-6) is the most studied cytokine in endometriosis and has important functions in reproductive physiology. The aim of this study is to review systematically available evidence about altered IL-6 concentrations in endometriosis-related infertility. This is a systematic review including all studies until December 2022 in which IL-6 in serum, peritoneal fluid, follicular fluid, or endometrial biopsy specimens was measured and that correlated their findings with endometriosis- associated infertility. Fifteen studies were included in the systematic review. There seems to be a correlation between elevated serum and peritoneal fluid IL-6 concentrations and the occurrence of endometriosis-associated infertility. IL-6 may be a potential diagnostic or biomarker tool for the prediction of endometriosis-related infertility. However, the numerous biases affecting the available studies, and challenges in endometriosis research reproducibility must be considered. Future investigations should pay attention to factors that may affect the results, such as the choice of suitable control groups, and carefully consider other pathological conditions affecting the patients, endometriosis stage, and type of lesion.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"17 4","pages":"226-230"},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/73/aa/Int-J-Fertil-Steril-17-226.PMC10439985.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10043624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin and Body Mass Index Predicts <i>In Vitro</i> Fertilization Oocyte Maturation Rate: A Cross-Sectional Study.","authors":"Budi Wiweko,&nbsp;Ervan Surya,&nbsp;Vita Silvana,&nbsp;Mila Maidarti,&nbsp;Achmad Kemal Harzif,&nbsp;Gita Pratama,&nbsp;Kanadi Sumapraja,&nbsp;R Muharam,&nbsp;Andon Hestiantoro","doi":"10.22074/ijfs.2023.555467.1315","DOIUrl":"10.22074/ijfs.2023.555467.1315","url":null,"abstract":"<p><strong>Background: </strong><i>In vitro</i> fertilization (IVF) remains a main treatment for infertility cases. Post-injection human chorionic gonadotropin (hCG) level is an essential factor in determining oocyte maturation rate in IVF. This study aimed to determine the relationship between 12 hours post-injection serum hCG level and oocyte maturation rate among IVF participants.</p><p><strong>Materials and methods: </strong>A cross-sectional study on IVF participants was done at a tertiary hospital in Indonesia from January 2020 to December 2021. Subjects were injected with 250 μg of recombinant-hCG (r-hCG) subcutaneously. Twelve hours post-injection serum hCG levels and oocyte maturation rate data were retrieved and analyzed accordingly.</p><p><strong>Results: </strong>Twenty-eight subjects were recruited into the study. Higher 12 hours post-injection serum hCG was related to oocyte maturation rate (P=0.046). The cut-off point of 12 hours post-injection serum hCG to predict better oocyte maturation rate was 90.15 mIU/mL (sensitivity 68.2%, specificity 83.3%). Oocyte maturation rate may be predicted using body mass index (BMI) and 12 hours post-injection serum hCG.</p><p><strong>Conclusion: </strong>Higher 12 hours post-injection serum hCG was associated with a higher oocyte maturation rate in IVF subjects.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"17 4","pages":"264-267"},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/18/Int-J-Fertil-Steril-17-264.PMC10439995.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10043627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Expression Levels of <i>CSF-1</i> and <i>CSF-1R</i> Endometrial under The Influence of Prolactin Level in Unexplained Miscarriage: A Case-Control Study.","authors":"Zahra Sadeghi Jam,&nbsp;Zahra Tahmasebi Fard","doi":"10.22074/ijfs.2023.555588.1316","DOIUrl":"10.22074/ijfs.2023.555588.1316","url":null,"abstract":"<p><strong>Background: </strong>Hormones such as prolactin, by influencing expression of the endometrial genes, play a pivotal role in embryo implantation and development. The present study aimed to evaluate serum level of prolactin and its effect on altering expression level of colony-stimulating factor-1 (<i>CSF-1</i>) and colony-stimulating factor-1 receptor (<i>CSF-1R</i>) genes in endometrial tissue during <i>in vitro</i> fertilization (IVF) pregnancy in the infertile women and recurrent pregnancy loss (RPL), compared to fertile women, who lost their pregnancies at gestational age <20 weeks.</p><p><strong>Materials and methods: </strong>In this case-control study, 40 infertile women, 40 IVF pregnant women with RPL and 40 fertile women who lost their pregnancies at <20 weeks of gestation for unknown reasons were selected. Prolactin serum level was assessed using ELISA technique and expression of <i>CSF-1</i> and <i>CSF-1R</i> genes was determined in endometrial tissue, using quantitative reverse transcription polymerase chain reaction (qRT-PCR).</p><p><strong>Results: </strong>Mean prolactin level of the infertile group was 24.38 ± 1.43 ng/mL and it had statistically significant relationship with the fertile group (P<0.001). Expression level of the CSF-1 and CSF-1R genes were higher in the fertile than infertile groups by 2.88 times (P<0.0001) and 2.64 times (P<0.0001), while it was respectively 2.28 (P<0.0001) and 1.69 (P<0.0001) times higher compared to the RPL group. Risk factors for pregnancy loss, such as aging, increased body mass index (BMI), smoking and diabetes caused decreasing changes in gene expression (<i>CSF-1</i> and <i>CSF-1R</i> ) and the differences were statistically significant, except in the infertile group.</p><p><strong>Conclusion: </strong>The present study showed a significant relationship of <i>CSF-1</i> and <i>CSF-1R</i> expression levels with pregnancy loss. Risk factors such as aging, obesity, smoking and diabetes decreased both genes expression levels.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"17 4","pages":"236-241"},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/a6/Int-J-Fertil-Steril-17-236.PMC10439994.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10048274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Microbial Profile in Patients with Polycystic Ovary Syndrome and Periodontal Disease: A Case-Control Study.","authors":"Reshma Achu Joseph,&nbsp;Supraja Ajitkumar,&nbsp;Subbusamy Kanakasabapathy Balaji,&nbsp;Muthukumar Santhanakrishnan","doi":"10.22074/ijfs.2023.550187.1272","DOIUrl":"10.22074/ijfs.2023.550187.1272","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) and oral health are found to share a reciprocal link. Previous substantiating evidences suggest that PCOS may have a confounding effect on periodontal health and may quantitatively modify the composition of the oral microbiome. To analyze the role of PCOS as a risk factor in causing periodontal disease, we compared and evaluated the levels of <i>Porphyromonas gingivalis</i> and <i>Fusobacterium nucleatum</i> in patients with polycystic ovary syndrome, polycystic ovary syndrome, chronic periodontitis, polycystic ovary syndrome, and gingivitis, and healthy controls.</p><p><strong>Materials and methods: </strong>In this case-control study, 40 female participants are enrolled and grouped into four groups which included healthy female individuals, patients with PCOS, patients with PCOS and gingivitis, and patients with PCOS and periodontitis. Periodontal examination is assessed primarily on all the participants using a UNC-15 probe. Dental plaque is then collected using a sterile curette in one stroke and transferred into an Eppendorf tube containing TE Buffer (Tris-EDTA buffer) solution. The level of <i>Porphyromonas gingivalis</i> and <i>Fusobacterium nucleatum</i> nucleatum was estimated by real-time polymerase chain reaction (PCR).</p><p><strong>Results: </strong>The levels of <i>Fusobacterium nucleatum</i> were observed to be significantly higher in group with patients with PCOS and periodontitis.</p><p><strong>Conclusion: </strong>PCOS may have an impact on the composition of oral microflora causing repercussions in periodontal health.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"17 4","pages":"248-253"},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/f3/Int-J-Fertil-Steril-17-248.PMC10439991.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10036602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Altered <i>Mucin1, FGF2,</i> and <i>HBEGF</i> Gene Expression at The Ectopic Implantation Site and Endometrial Tissues in The Tubal Pregnancy Pathogenesis: A Case-Control Study.","authors":"Nadia Noghrehalipour,&nbsp;Reza Aflatoonian,&nbsp;Ali Rahimipour,&nbsp;Samaneh Aghajanpour,&nbsp;Aida Najafian,&nbsp;Zahra Chekini,&nbsp;Firouzeh Ghaffari,&nbsp;Faranak Kazerouni","doi":"10.22074/ijfs.2023.1972252.1390","DOIUrl":"10.22074/ijfs.2023.1972252.1390","url":null,"abstract":"<p><strong>Background: </strong>Ectopic pregnancy (EP) is defined as implantation and development of an embryo outside of the uterine tissue. Women undergoing assisted reproductive technologies (ART), particularly frozen embryo transfer (FET), are in high-risk populations for EP. <i>Mucin1 (MUC1)</i>, fibroblast growth factor-2 <i>(FGF2)</i>, and Heparin-binding epidermal growth factor <i>(HBEGF)</i> genes are involved in the endometrial receptivity pathway, leading to normal eutopic implantation; Although, their relevance in the tubal pregnancy after FET is unknown. We aimed evaluation of <i>Mucin1, FGF2,</i> and <i>HBEGF</i> expression fold as endometrial receptive markers in the EP patients following the FET cycle.</p><p><strong>Materials and methods: </strong>A case-control study was conducted on ten patients (five EP patients and five women in the pseudo-pregnancy group, as the control samples). Pseudo-pregnancy group was established in women who were candidates for hysterectomy for benign diseases. Fallopian tube biopsies and corresponding endometrial tissues from these patients were taken during the hysterectomy. However, the fallopian tube and endometrial tissues of EP patients were obtained during salpingectomy. The mRNA expressions of <i>Mucin1, FGF2,</i> and <i>HBEGF</i> genes in the fallopian tube and endometrial tissues were measured by real-time polymerase chain reaction (PCR) assay.</p><p><strong>Results: </strong>MUC1 mRNA expression level in the endometrium of the case group was higher than in the control group (P=0.04); however, its mRNA expression in the fallopian samples of the case group in comparison with the control group was significantly decreased (P=0.001). The <i>HBEGF</i> mRNA expression level was not significantly different between the case and control endometrium, whereas its expression was significantly increased in the case fallopian samples compared with the control ones (P=0.001). The same pattern was observed for <i>FGF2</i> mRNA expression level in the fallopian samples of the case group but was significantly reduced in the endometrial samples in comparison with the control samples (P=0.03).</p><p><strong>Conclusion: </strong><i>Mucin1, FGF2,</i> and <i>HBEGF</i> gene mRNA expression changes may explain the embryo rejection from the uterus and the establishment of a receptive phenotype in fallopian cells.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"17 4","pages":"242-247"},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d1/e1/Int-J-Fertil-Steril-17-242.PMC10439997.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10048273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Roles of lncRNAs in Recurrent Pregnancy Loss: A Review Study.","authors":"Shirin Azizidoost,&nbsp;Mahrokh Abouali Gale Dari,&nbsp;Farhoodeh Ghaedrahmati,&nbsp;Zahra Razani,&nbsp;Mona Keivan,&nbsp;Razieh Mohammad Jafari,&nbsp;Mahin Najafian,&nbsp;Maryam Farzaneh","doi":"10.22074/ijfs.2022.559132.1339","DOIUrl":"10.22074/ijfs.2022.559132.1339","url":null,"abstract":"<p><p>Recurrent pregnancy loss (RPL) or recurrent miscarriage is the failure of pregnancy before 20-24 weeks that influences around 2-5% of couples. Several genetic, immunological, environmental and physical factors may influence RPL. Although various traditional methods have been used to treat post-implantation failures, identifying the mechanisms underlying RPL may improve an effective treatment. Recent evidence suggested that gene expression alterations presented essential roles in the occurrence of RPL. It has been found that long non-coding RNAs (lncRNAs) play functional roles in pregnancy pathologies, such as recurrent miscarriage. lncRNAs can function as dynamic scaffolds, modulate chromatin function, guide and bind to microRNAs (miRNAs) or transcription factors. lncRNAs, by targeting various miRNAs and mRNAs, play essential roles in the progression or suppression of RPL. Therefore, targeting lncRNAs and their downstream targets might be a suitable strategy for diagnosis and treatment of RPL. In this review, we summarized emerging roles of several lncRNAs in stimulation or suppression of RPL.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"17 4","pages":"218-225"},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/b2/Int-J-Fertil-Steril-17-218.PMC10439990.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10048272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Body Mass Index, Metal Elements, and Antioxidant Capacity of Semen on The Human Sperm Chromatin.","authors":"Shiva Roshankhah,&nbsp;Neda Barani,&nbsp;Mohammad Reza Salahshoor,&nbsp;Leila Rezakhani,&nbsp;Mozafar Khazaei","doi":"10.22074/ijfs.2023.563577.1379","DOIUrl":"10.22074/ijfs.2023.563577.1379","url":null,"abstract":"<p><strong>Background: </strong>Sperm chromatin abnormalities are defects in nuclear maturation and DNA integrity. These defects originated from defective spermatogenesis due to a lack of DNA repair during chromatin remodeling. Changes in semen elements can cause damage to chromatin. There is little information about the relationship between changes in trace metal elements and total antioxidant capacity (TAC) with sperm chromatin damage. The present study was conducted to determine the relationship between Selenium (Se), Iron (Fe), Zinc (Zn), Copper (Cu) and the TAC of semen with the status of human sperm chromatin.</p><p><strong>Materials and methods: </strong>In this experimental study, semen samples (n=30) were collected from healthy men referred to Kermanshah Motazadi Hospital and stored in liquid nitrogen; after thawing and centrifugation, sperm were separated. The atomic absorption method was used to measure the concentration of metal elements. The TAC was evaluated using the ferric-reducing antioxidant capacity of the plasma method. Furthermore, the integrity of sperm chromatin was measured using the sperm DNA fragmentation (SDF) method.</p><p><strong>Results: </strong>The status of sperm chromatin had a non-significant correlation with body mass index (BMI, P=0.25, r=0.21) and a non-significant negative correlation with sperm count (P=0.71, r=-0.71) and motility (P=0.75, r=0.61). In addition, there was no significant relationship between sperm chromatin and the TAC of semen (P=0.92, r=0.01). Additionally, there was no significant correlation between Se, Zn, or Cu concentration (P>0.05) and Fe concentration, which had a partially positive relationship with the chromatin state of sperm (P=0.24, r=0.20).</p><p><strong>Conclusion: </strong>The trace metal elements in the seminal fluid did not play a significant role in the status of sperm chromatin.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"17 4","pages":"287-291"},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/a4/Int-J-Fertil-Steril-17-287.PMC10439988.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10043628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forskolin Improves Male Reproductive Complications Caused by Hyperglycemia in Type 2 Diabetic Rats.","authors":"Mehran Naghibi,&nbsp;Hamid Tayefi Nasrabadi,&nbsp;Jafar Soleimani Rad,&nbsp;Alireza Garjani,&nbsp;Mohammad Sadegh Gholami Farashah,&nbsp;Daryoush Mohammadnejad","doi":"10.22074/ijfs.2022.544368.1235","DOIUrl":"10.22074/ijfs.2022.544368.1235","url":null,"abstract":"<p><strong>Background: </strong>In many diabetic patients, spermatogenesis complications are frequent causing infertility problems. This study aimed to demonstrate the effect of Forskolin on male reproductive dysfunction caused by type 2 diabetes.</p><p><strong>Materials and methods: </strong>In this experimental study, type 2 diabetes was induced by a high-fat diet (HFD) for one month and then a low single dose injection (35 mg/kg) of streptozotocin (STZ) in Wistar rats. After 72 hours, rats with more than 200 mg/dl of blood glucose were considered type 2 diabetic rats. Forty rats (200-250 g) were divided into four groups (n=10) including group 1 (G1): rats with normal diet and buffer citrate (STZ solvent) injection, group 2 (G2): control type 2 diabetic rats with HFD and STZ injection, group 3 (G3): type 2 diabetic rats received phosphate buffer saline (PBS) as Forskolin solvent, and group 4 (G4): Forskolin treated diabetic rats (10 mg/kg) for 1 month.</p><p><strong>Results: </strong>In comparison to control group, in diabetic groups (G2 and G3) some parameters are increased significantly: The blood glucose (P=0.00078), testicular malondialdehyde (MDA) level and body weight (P=0.00009) and Bax gene expression (P=0.00007). Unlike, some parameters are decreased significantly: The serum level of testosterone (P=0.0009), testicular superoxide dismutase (SOD, P=0.00007) and glutathione peroxidase (GPX) levels (P=0.00008), sperm concentration (P=0.00008), motility (P=0.00009), normal morphological sperm (P=0.00008) and <i>Bcl-2</i> gene expression (P=0.00009). However, in Forskolin treated group (G4) the parameters stayed close to control values that was significantly (P=0.00007) higher than in G2 and G3 groups. Therefore, treatment with Forskolin significantly improved these abnormal changes in Forskolin-treated group.</p><p><strong>Conclusion: </strong>Our study demonstrates that Forskolin is an effective antidiabetic agent, which significantly improves sperm concentration, testosterone levels, and antioxidant activity in diabetic rats.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"17 4","pages":"268-275"},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/2f/Int-J-Fertil-Steril-17-268.PMC10439998.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10043626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Marital Relationship Quality in Emotional Disturbance and Personal Growth of Women with Infertility: A Cross-Sectional Study.","authors":"S Hiva Shafierizi,&nbsp;Seddigheh Esmaelzadeh,&nbsp;Faezeh Ghofrani,&nbsp;Hemmat Gholinia,&nbsp;Mahbobeh Faramarzi","doi":"10.22074/ijfs.2022.551247.1281","DOIUrl":"https://doi.org/10.22074/ijfs.2022.551247.1281","url":null,"abstract":"<p><strong>Background: </strong>Infertility is a stressful condition that can lead to either emotional disturbance or personal growth. Marital relationship is one of the factors affecting the consequences of infertility. This study aimed to explore the role of marital relationship quality in development of women's personal growth after experiencing infertility.</p><p><strong>Materials and methods: </strong>In the cross-sectional study, 122 infertile women (mean age 28.79 ± 6.3) were invited to complete the survey, including ENRICH Marital Satisfaction Scale, Posttraumatic Growth, Fertility problem inventory, State-Trait Anxiety Inventory, and Beck Inventory Depression.</p><p><strong>Results: </strong>Higher scores of quality of marital relationships were a protective factor against infertility stress and state/ trait anxiety. Additionally, infertility stress was a strong negative predictor of personal growth. Furthermore, infertile women with a high level of marital relationships may have more chances to experience personal growth rather than stress in infertility treatments.</p><p><strong>Conclusion: </strong>The study suggests that high quality of marital relationships may provide positive opportunities for women's personal growth after experiencing infertility.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"17 3","pages":"174-180"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/f8/Int-J-Fertil-Steril-17-174.PMC10189161.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9731804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}