International Journal of Fertility & Sterility最新文献

{"title":"Research Performance in Reproductive Biomedicine: A National Scientometrics Study.","authors":"Zohreh Hashemian, Ahmad Vosough Dizaji, Mahdi Lotfipanah, Parvaneh Afsharian, Massoud Vosough","doi":"10.22074/ijfs.2023.1995671.1446","DOIUrl":"10.22074/ijfs.2023.1995671.1446","url":null,"abstract":"<p><p>Recent achievements in reproductive biomedicine have led to a revolution in infertility treatment. A comprehensive understanding of the current status of reproductive medicine is necessary for the development of a forward-looking plan by health policymakers, based on fundamental requirements. This study is a systematic review of the Scopus database to assess reproductive biomedicine publications within Iran and compared to the rest of the world from 1990 to 2020. The data were categorized by geographical distribution across five continents. National data were assessed in comparison with the world and with neighboring countries. Finally, prominent national research institutes in the field of reproductive biomedicine in Iran were identified, and their contributions to the field highlighted. Of the five continents, the highest number of publications and citations is from Europe (36% publications and 41.5% citations). Corresponding numbers for the other continents are 32 and 33% for America, and 26 and 18.4% for Asia respectively. The remaining publications and citations were from Australia (3.8 and 4.1%) and Africa (2.6 and 3.1%). In a national analysis, the highest-ranking institutes in reproductive biomedicine are in Tehran province (50.9% of all Iranian publications), Shiraz (8.8%), Yazd (7.8%), Isfahan (7.1%), and Tabriz (6.9%). More specifically, Tehran University of Medical Science (15.9%), the Royan Institute (12.2%), Shahid Beheshti Medical University (10.1%), Shahid Sadoughi University of Medical Sciences (6.9%), and Tarbiat Modares University (6.7%) account for more than 50% of all Iranian scientific publications. In recent decades, reproductive biomedical research has grown significantly in Iran. Reviewing publications in this field helps health policy decision makers to monitor the direction of research and adjust investment in the treatment of infertility. In addition, it is necessary to expand and organize inter-organizational and international collaborations to improve the research, gain the benefits of different experiences, and engage in international multicenter studies.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"18 1","pages":"1-6"},"PeriodicalIF":2.5,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on The Pedigrees of Three Cases of Whole-Arm Translocation in Hainan China and Literature Review: A Retrospective Study.","authors":"C Hen Yunchun, Lin Yao, Zhao Zhengmin, Huang Xuning, Kong Changying, Liang Chongnan","doi":"10.22074/ijfs.2023.548275.1257","DOIUrl":"10.22074/ijfs.2023.548275.1257","url":null,"abstract":"<p><p>In this study, in order to promote chromosome abnormality carriers eugenics, three patients with adverse pregnancy histories were examined by cytogenetics and their pedigrees further analyzed. In this retrospective study, approximately anticoagulant peripheral venous blood from the patients was collected for peripheral blood cell culture and chromosome analysis. Karyotypes were analyzed in the BEIONMED karyotype analysis system. The karyotypes of the three probands were all whole-arm translocations (WATs): case 1 (DatabaseNo.3591): 46, XY, t (7; 13) (p10; p10) dn, two years of marriage in which the spouse did not have pregnancy, with azoospermia; case 2 (Database No.3809): 46, XY, t(12; 17) (p10; q10), three spontaneous abortions within three years of marriage; case 3 (Database No.4914) 46, XX, t(2;6) (p10; q10) mat, 21ps+pat, a year of marriage without pregnancy. When the parents are carriers of WAT, the family should be considered to have a high reproductive risk, increasing the risk of producing offspring with chromosomal abnormalities. Three kinds of human chromosomal aberration karyotypes were reported for the first time providing an important basis for studying the occurrence and clinical consultation of chromosomal diseases.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"18 1","pages":"81-86"},"PeriodicalIF":2.5,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Experimental Study on The Oxidative Status and Inflammatory Levels of A Rat Model of Polycystic Ovary Syndrome Induced by Letrozole and A New High-Fat Diet.","authors":"Seyyede Fahimeh Mirseyyed, Saeed Zavareh, Meysam Nasiri, Hamid Hashemi-Moghaddam","doi":"10.22074/ijfs.2023.1972296.1391","DOIUrl":"10.22074/ijfs.2023.1972296.1391","url":null,"abstract":"<p><strong>Background: </strong>Although there are numerous animal models of polycystic ovary syndrome (PCOS), they often fail to accurately replicate the reproductive and metabolic phenotypes associated with PCOS. The objective of this study is to assess oxidative status and inflammatory levels in a rat model of PCOS subjected to a new high-fat diet (HFD) in combination with letrozole.</p><p><strong>Materials and methods: </strong>In this experimental study, mature, six-week-old female Sprague-Dawley rats (n=20) were divided into four groups: control (standard diet); letrozole (letrozole plus a standard diet); HFD; and letrozole+HFD. After 16 weeks, the rats underwent vaginal smear analysis, measurement of hormonal and lipid profiles, and an oral glucose tolerance test (OGTT). Ovarian tissue morphology, oxidative parameters, and inflammatory status were evaluated.</p><p><strong>Results: </strong>The experimental groups exhibited anoestrus profiles in the vaginal smears and abnormal ovarian morphology, which was not observed in the control group. Steroid hormone levels were significantly higher in the letrozole+HFD group compared to the other groups (P=0.00). The experimental groups also showed abnormal glucose levels and lipid metabolism. The relative expression levels of inflammatory genes were significantly elevated in the experimental groups compared to the control group (P=0.00), and the letrozole+HFD group exhibited the highest expression level (P=0.00). The HFD, letrozole, and letrozole+HFD groups demonstrated significantly increased levels of malondialdehyde (MDA) and reactive oxygen species (ROS), while the levels of enzymatic antioxidants were significantly reduced compared to the control group (P=0.00).</p><p><strong>Conclusion: </strong>The combination of a new HFD and letrozole treatment induces inflammation and oxidative stress (OS) in a rat model of PCOS. This model accurately exhibits abnormal metabolic phenotypes and disruptions in hormonal profiles associated with PCOS.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"18 1","pages":"45-53"},"PeriodicalIF":2.5,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy with Intrauterine Device Perforation: A Case Report.","authors":"S Hamsi Zare, Rozbeh Sohrabi, Hana Sohrabi","doi":"10.22074/ijfs.2023.1974526.1402","DOIUrl":"10.22074/ijfs.2023.1974526.1402","url":null,"abstract":"<p><p>Although intrauterine devices (IUDs) are known for their low failure rate in pregnancy prevention, potential risks associated with their use include uterine perforation and migration through the abdomen. In this particular case, the patient experienced simultaneous IUD failure and perforation, with the device becoming embedded in an omentum. A 28-year-old woman who was 39 weeks plus one day gestation presented for caesarean section. During the caesarean section, it was discovered that the IUD had entered the omentum through a hole in the posterior part of the uterus. The result of the birth was a live boy. IUD perforation is most commonly observed during the insertion procedure; however, it may rarely occur at a later stage. IUD perforations are frequently asymptomatic and remain undetected until follow-up assessments are conducted or clinical manifestations become apparent. The presence of gastrointestinal symptoms is commonly observed in cases with intraperitoneal migration of the IUD. Although the occurrence of abdominal pain, diarrhoea, and fever with a missing IUD are indicative, they may not always be present. Nonspecific signs and symptoms lead to misdiagnosis and the consequent delay in initiating appropriate treatment. In the present case, the co-occurrence of IUD embedded in the omentum and pregnancy posed a challenge due to the device's rapid and imprecise shift, which complicated its accurate localisation. In such scenarios, ultrasonographic guidance can serve as a valuable tool to enhance accuracy and decrease adverse outcomes.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"18 1","pages":"91-93"},"PeriodicalIF":2.5,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Total Testosterone and Dehydroepiandrosterone Sulfate Status in Noncritically Ill Hospitalized Patients with Coronavirus Disease 2019: A Cross-Sectional Study.","authors":"Hurjahan Banu, Md Shahed Morshed, Nusrat Sultana, Touhida Akter, Muhammad Abul Hasanat, Ahmed Abu Saleh, Mahmud Shohael Arafat","doi":"10.22074/ijfs.2023.1978415.1407","DOIUrl":"10.22074/ijfs.2023.1978415.1407","url":null,"abstract":"<p><strong>Background: </strong>In individuals with coronavirus disease 2019 (COVID-19), male subjects have consistently been linked to poor severity and prognosis. Data on sex hormones in non-critical COVID-19-infected patients are scarce. The aim of this study was to assess the status of total testosterone (TT) and dehydroepiandrosterone sulfate (DHEAS) among noncritical patients with COVID-19 according to sex and their associations with clinical and biochemical features.</p><p><strong>Materials and methods: </strong>This cross-sectional observational study was done in the COVID-19 unit of a University hospital during the period of September 2021 to February 2022 among 91 adults (18-65 years) with reverse transcriptase- polymerase chain reaction confirmed noncritical COVID-19 patients. Blood was drawn by venipuncture before receiving steroids between 07:00 to 09:00 a.m. in a fasting state to measure serum TT and DHEAS by chemiluminescent microparticle immunoassay. Diagnosis and classification of COVID-19 were done according to World Health Organization's interim guidance. Age- and sex-specific laboratory reference values were used to classify the TT and DHEAS status of the patients.</p><p><strong>Results: </strong>Only three males (8.1%) had low TT and the rest had normal TT. On the other hand, 15 (27.8%) of the females had high TT with normal levels in the rest. Similarly, 11 (29.7%) males had low DHEAS. Females had low, normal, and high DHEAS in four (7.4%), 48 (88.9%), and two (3.7%) cases respectively. Males with moderate severity of COVID-19 had significantly lower DHEAS (post hoc P=0.038) than the mild group. Both TT (P=0.008) and DHEAS (P=0.023) significantly correlated with neutrophils/lymphocytes ratio and only DHEAS with platelets/lymphocytes ratio (P=0.044) in males. In females, TT significantly correlated with serum sodium (P=0.034).</p><p><strong>Conclusion: </strong>In noncritical COVID-19 patients, substantial gender variations in TT and DHEAS were detected and correlated with severity markers in males.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"18 1","pages":"54-59"},"PeriodicalIF":2.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Immature Testicular Tissue and Cell Transplantation Results: Comparing Transplantation Sites and Scaffolds.","authors":"Alireza Anvari, Mansoureh Movahedin, Maedeh Hamzeh","doi":"10.22074/ijfs.2023.559999.1350","DOIUrl":"10.22074/ijfs.2023.559999.1350","url":null,"abstract":"<p><p>For patients who had testicular tissue cryopreserved before receiving gonadotoxic therapies, transplantation of testicular tissues and cells has been recommended as a potential therapeutic option. There are no studies that indicate the generation of sperm after human immature testicular tissue (ITT) or spermatogonial stem cells (SSCs) transplantation. The use of releasing scaffolds and localized drug delivery systems as well as the optimizing transplantation site can play an effective role in increasing the efficiency and improving the quality of testicular tissue and cell transplantation in animal models. Current research is focused on optimizing ITT and cell transplantation, the use of releasing scaffolds, and the selection of the right transplantation site that might restore sperm production or male infertility treatment. By searching the PubMed and Google Scholar databases, original and review papers were collected. Search terms were relevant for SSCs and tissue transplantation. In this review, we'll focus on the potential advantages of using scaffolds and choosing the right transplantation site to improve transplantation outcomes.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"18 1","pages":"12-19"},"PeriodicalIF":2.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of <i>Interleukin-17A</i> rs2275913 Polymorphism with Recurrent Miscarriage: A Systematic Review and Meta-Analysis Study.","authors":"Atoosa Keshavarz Motamed, Z Hina Zarei, Hosna Mirfakhraee, Fatemeh Shariatinia, Malihe Akbari, Sara Ziagham, Somayeh Igder, Neda Zarei","doi":"10.22074/ijfs.2023.546127.1248","DOIUrl":"10.22074/ijfs.2023.546127.1248","url":null,"abstract":"<p><p>Recurrent miscarriage (RM) is a condition defined as having three or more consecutive pregnancy losses before the 20 weeks of pregnancy. The present study was undertaken to investigate association of <i>Interleukin-17A (IL-17A)</i> rs2275913 polymorphism with RM. To this end, we searched the international databases (Web of Science, PubMed, Embase, and Scopus) and extracted studies investigating the association of <i>IL-17A</i> rs2275913 polymorphism with RM using the appropriate keywords. The collected data were analyzed with the random-effects model and STATA (version 14). A total of five studies met the eligibility criteria, and total sample size was 998 subjects. Mean age of the cases and controls were 31.41 ± 4.16 and 30.56 ± 3.5 years, respectively. Our results disclosed a significant relationship of the <i>IL-17A</i> rs2275913 AA genotype [odds ratio (OR)=1.68; 95% confidence interval (CI)=1.16- 2.43; I2=19; P=0.294) with RM. There was no statistically significant correlation between <i>IL-17A</i>rs2275913 GG genotype (OR=1.04; 95% CI=0.64-1.7; I²=59.5; P=0.042) and GA genotype (OR=0.85; 95% CI=0.65-1.1²; I²=19.1; P=0.293) with RM. Our findings revealed that the <i>IL-17A</i> rs2275913 polymorphism is associated with RM, and the AA genotype of this polymorphism increased possibility of being involved in RM.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"18 1","pages":"7-11"},"PeriodicalIF":2.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of SARS-Cov2 Infection on The Spermogram: A Prospective Study.","authors":"Farzad Allameh,&nbsp;Mahsa Kazemi,&nbsp;Mehrnaz Ajorlou,&nbsp;Saeed Soroush,&nbsp;Behzad Narouie,&nbsp;Alireza Fatemi,&nbsp;Mehdi Dadpour","doi":"10.22074/ijfs.2023.556335.1322","DOIUrl":"10.22074/ijfs.2023.556335.1322","url":null,"abstract":"<p><strong>Background: </strong>During the Coronavirus disease 2019 (COVID-19) pandemic, there was always concern about damage to different organs of the body. In this study, we aimed to determine if coronavirus 2 (SARS-CoV-2) could influence the sperm parameters in inpatient adult men with COVID-19.</p><p><strong>Materials and methods: </strong>In this prospective study during 2021, 22 patients with COVID-19 diagnosed with polymerase chain reaction (PCR) test and clinical symptoms and history of admission and 19 volunteer healthy men as the control group participated. They were asked to provide semen samples at 2 and 6 months after hospital discharge and the same time for the control group. The following parameters were measured in all semen samples and beside the demographic data, they compared between the two groups: volume (mL), sperm concentration (10⁶/mL), total motile sperm percentage, progressive percentage, normal morphology percentage, and DNA fragmentation index (DFI).</p><p><strong>Results: </strong>The mean ± SD age of the participants in the COVID and control groups was 46.36 ± 9.94 and 45.84 ± 10.21 years, respectively (P=0.869). The mean ± SD body mass index (BMIs) of the participants in the COVID and control groups were 28.6 ± 5.460 and 29.6 ± 6.092, respectively (P=0.579). The mean ± SD number of children was 1.41 ± 1.054 in the COVID group and 1.47 ± 1.073 in the control group (P=0.847). All the sperm parameters were significantly impaired after 2 months in the COVID group in comparison with the control group (P<0.05). After 4 months from first sampling, all the parameters were improved significantly (except normal morphology) but had not yet reached the level of the control group.</p><p><strong>Conclusion: </strong>SARS-CoV-2 affected semen parameters in patients admitted because of COVID-19, in the short term. It is expected that this will improve with time.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"17 4","pages":"259-263"},"PeriodicalIF":2.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d1/ec/Int-J-Fertil-Steril-17-259.PMC10439987.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10036601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint Modeling of <i>In Vitro</i> Fertilization Outcomes among A Population of Iranian Infertile Couples: A Historical Cohort.","authors":"Maryam Mohammadi,&nbsp;Amir Kavousi,&nbsp;Tahereh Madani,&nbsp;Payam Amini,&nbsp;Azadeh Ghaheri","doi":"10.22074/ijfs.2023.562653.1374","DOIUrl":"10.22074/ijfs.2023.562653.1374","url":null,"abstract":"<p><strong>Background: </strong>Women who undergo <i>in vitro</i> fertilization (IVF) cycles should successfully go via multiple stages (i.e., clinical pregnancy, no abortion under 12 weeks, no abortion under 20 weeks, and delivery) to achieve a live birth. In this study, data from multiple IVF cycles and its multiple stages were reanalyzed to illustrate the success factors associated with various stages of IVF cycles in a population of Iranian infertile women.</p><p><strong>Materials and methods: </strong>This historical cohort study includes 3676 assisted reproductive technology (ART) cycles. Covariates take into account in this study were women's age, type of infertility (primary, secondary), body mass index (BMI), cause of infertility, history of abortion, duration of infertility, number of oocytes, number of embryos, fertilization rate, semen factors (Spermogram) and having polycystic ovarian syndrome (PCOS) during IVF cycles. Joint modeling was fitted to apply informative cluster size.</p><p><strong>Results: </strong>Increasing age un women was associated with an increase in the BMI and a positive history of abortion and PCOS, and also, an increase in the number of treatment cycles, while in men was associated with the negative spermogram. With the increase in the number of treatment cycles, the result of the IVF success decreased, but with the increase in the number of embryos, fertilization rate and also, quality and / or quantity parameters of spermogram, we encountered with an increase in the IVF success rate.</p><p><strong>Conclusion: </strong>It seems that a joint model of the number of treatment cycles and the result of IVF is a valuable statistical model that does not ignore the significant effect of cycle numbers, while this issue is ignored usually in the univariate models.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"17 4","pages":"306-311"},"PeriodicalIF":2.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/e7/Int-J-Fertil-Steril-17-306.PMC10439996.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10036607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness of Polycystic Ovary Syndrome among Schoolgirls and Their Mothers: A Cross-Sectional Study.","authors":"Farideh Malekzadeh,&nbsp;Maryam Mohammadi,&nbsp;Behnaz Navid,&nbsp;Ashraf Moini,&nbsp;Reza Omani-Samani","doi":"10.22074/ijfs.2023.543119.1224","DOIUrl":"10.22074/ijfs.2023.543119.1224","url":null,"abstract":"<p><strong>Background: </strong>One of the most common endocrine disorders of reproductive age women is polycystic ovary syndrome (PCOS). Women with PCOS are at risk for infertility, endometrial cancer, metabolic disorders, and cardiovascular disease. Awareness of the signs and symptoms of PCOS can be effective in diagnosing early stage PCOS and promoting quality of life (QoL). This study assesses the awareness of PCOS in schoolgirls and their mothers.</p><p><strong>Materials and methods: </strong>This cross-sectional study was carried out on 1580 high school girls and 480 of their mothers in Tehran (capital of Iran) in 2017 and 2018. We used the stratified sampling method and divided Tehran into five geographic regions: north, south, east, west, and central. Schools were randomly selected from each of these regions. Students and their mothers separately answered a self-administered questionnaire that pertained to their knowledge of PCOS. Statistical analyses were carried out with SPSS, version 22 (Inc. Chicago, IL, USA) and R version 3.2.1.</p><p><strong>Results: </strong>Students had an average age of 16.97 ± 0.84 years and their mothers' average age was 45.19 ± 5.03 years. The average body mass index (BMI) of the students was 22.01 ± 5.54 kg/m2. The results of this study showed that only 48 students (3.2%) and 148 mothers (27%) had acceptable knowledge about PCOS. The knowledge of students about PCOS was positively related to their mothers' knowledge about PCOS (P<0.001).</p><p><strong>Conclusion: </strong>The level of PCOS awareness in Iranian women is insufficient and this may affect their QoL. Therefore, the health authorities should implement educational programs to challenge women's incorrect beliefs about PCOS and increase their awareness of this disease.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"17 4","pages":"299-305"},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/91/Int-J-Fertil-Steril-17-299.PMC10439986.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10036605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}