{"title":"Age estimation in children: insights from a new Bosnian-Herzegovinian formula.","authors":"Emina Dervišević, Aida Selmanagić, Kenan Šehić","doi":"10.1007/s00414-025-03478-2","DOIUrl":"https://doi.org/10.1007/s00414-025-03478-2","url":null,"abstract":"<p><p>In recent years, the use of precise age assessment methods on living individuals has become increasingly important in the forensic field. The aim of this study was to develop, for the first time, a Bosnian and Herzegovinian-specific formula based on our local dataset, utilizing the LASSO model to uncover and leverage the unique characteristics of the Bosnian-Herzegovinian population. This research is undertaken to address the need for a Bosnia-Herzegovina-specific equation capable of accurately predicting a child's age using local data. The dataset covering the details of 205 Bosnian boys and girls, spanning from 7 to 13 years, to maintain representativeness and reduce potential age-related biases. Three distinct models were considered, each inspired by existing approaches but adapted to the specifics of the local dataset. The first model, based on the Belgrade equation, incorporated predictors x3, x7, and N0. The second model extended the European equation by including N0, x5, s, and the interaction term s⋅N0. The third model adopted a linear regression framework with Lasso regularization, which used all available predictors (x1, x2, x3, x4, x5, x6, x7, s, N0, s⋅N0). It would be recommended that in the future the BH equation that has the form of the European one that specifically uses the x5 tooth with gender, sum and product be used. A linear model with fewer parameters is generally preferred, as the results between Lasso and such models are ultimately negligible. In this study, we explored the use of Lasso model as a method to identify which teeth contribute most to dental age estimation within a linear modeling framework. By comparing Lasso's performance to the customized European formula for the Bosnian-Herzegovinian population, we found that the results were similar, and in some cases, Lasso even performed slightly better. Given that the European formula relies on fewer features, it presents a practical and efficient alternative as a final model for Bosnian-Herzegovinian dental age estimation.</p>","PeriodicalId":14071,"journal":{"name":"International Journal of Legal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katerina Grusova, Tomas Vojtisek, Rexson Tse, Tomas Kalinka
{"title":"Postmortem morphology of honeybee stings induced fatal anaphylaxis.","authors":"Katerina Grusova, Tomas Vojtisek, Rexson Tse, Tomas Kalinka","doi":"10.1007/s00414-025-03483-5","DOIUrl":"https://doi.org/10.1007/s00414-025-03483-5","url":null,"abstract":"<p><p>Despite numerous case reports in the literature, high-quality postmortem images of honeybee sting are scant in postmortem literature. We report a case of a fatal anaphylactic death from honeybee stings with detailed high-quality annotated macroscopic and microscopic morphological images. A woman in her mid-60's was found dead in her garden cabin unexpectedly after mowing the lawn near her beehives in late evening hours. She passed away despite resuscitation efforts. External examination showed multiple honeybee stings on the body. A number of them had a nidus near the center in which a stinger was confirmed by subsequent histology. Postmortem examination and ancillary testing showed features of anaphylaxis.</p>","PeriodicalId":14071,"journal":{"name":"International Journal of Legal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chia-Tzu Hsu, Li-Chin Tsai, Kuo-Lan Liu, Yu-Chih Lin, Nu-En Huang, James Chun-I Lee, Adrian Linacre, Hsing-Mei Hsieh
{"title":"Identification of menstrual blood and vaginal fluid using a 4-plex MSRE-PCR system applicable to alleged sexual assault cases.","authors":"Chia-Tzu Hsu, Li-Chin Tsai, Kuo-Lan Liu, Yu-Chih Lin, Nu-En Huang, James Chun-I Lee, Adrian Linacre, Hsing-Mei Hsieh","doi":"10.1007/s00414-025-03471-9","DOIUrl":"https://doi.org/10.1007/s00414-025-03471-9","url":null,"abstract":"<p><p>Menstrual blood and vaginal fluid are frequently encountered in conjunction with semen in alleged sexual assault cases. There are few tests with high specificity for these two body fluids and here we report on a 4-plex MSRE-PCR system for the detection of menstrual blood and vaginal fluid. The assay uses four markers in a multiplex PCR: a positive control (PC), digestive control (DC), menstrual blood-specific (MB) marker and vaginal fluid-specific (VF) marker. Menstrual blood and vaginal fluid samples were identified by the MB and VF markers as expected. Additionally, the results using samples from saliva, semen and blood were also correctly identified, with an absence of both the MB and VF markers as expected, even though MB and VF signals can occur within a few non-target body fluids (urine, nasal fluid and skin). It was found that the methylation levels at the markers for both menstrual blood and vaginal fluid have differences between individuals. The methylation level of the marker for menstrual blood was affected by the day during the menstruation cycle, which also affected the sensitivity of the test. DNA required for correct identification of menstrual blood increased from 1 ng at day 1 to 1.5 ng for day 5. The sensitivity of the assay using samples from vaginal fluid was at least 0.5 ng of DNA for confident identification. Menstrual blood samples deposited on seven types of materials frequently encountered in forensic investigations were all correctly assigned. Also, samples of simulated mixed menstrual blood and vaginal fluid were tested and the results were all concordant as expected. These data help to verify the applicability of the 4-plex MSRE-PCR system in forensic casework.</p>","PeriodicalId":14071,"journal":{"name":"International Journal of Legal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joanna M Glengarry, Ben Thompson, Maria Pricone, Melanie S Archer, Hans H de Boer
{"title":"Post-mortem urine dipstick analysis for hyperglycemia and ketoacidosis: observer agreement and diagnostic value.","authors":"Joanna M Glengarry, Ben Thompson, Maria Pricone, Melanie S Archer, Hans H de Boer","doi":"10.1007/s00414-025-03477-3","DOIUrl":"https://doi.org/10.1007/s00414-025-03477-3","url":null,"abstract":"<p><p>The post-mortem diagnosis of hyperglycemia and/or ketoacidosis is challenging and usually requires costly ancillary testing of vitreous humor or serum samples. A screening tool that would help to determine whether ancillary testing is needed is therefore desirable. The aim of this study was to add to the literature testing the validity and diagnostic utility of post-mortem dipstick urinalysis. More specifically, we determined inter-observer agreement of visual dipstick assessment, the correlation between glucose and ketone urine dipstick scores and formal laboratory testing results, and the diagnostic value of specific dipstick scores expressed with likelihood ratios. Results demonstrate almost perfect interobserver agreement for 108 glucose dipstick scores (Fleiss' kappa 0.914) but only moderate interobserver agreement for 96 ketones dipstick scores (Fleiss' kappa 0.467). Dipstick glucose scores correlated strongly with vitreous humor glucose levels (Spearman's rank correlation coefficient of 0.841, n = 107). Correlation between ketone dipstick scores and serum levels of beta-hydroxybutyrate (BHB) and blood acetone was also positive but much weaker (0.317, n = 91; and 0.411, n = 92, respectively). The diagnostic value of specific dipstick scores was determined by calculating likelihood ratios for substantial hyperglycemia (vitreous humor glucose > 10 mmol/L), substantial ketoacidosis (serum BHB > 2.50 mmol/L) and elevated blood acetone (> 20 mg/L). Our results suggest substantial screening potential of dipstick urinalysis for glucose, especially when scores are at the lower and higher end of the spectrum. Overall, dipstick analysis results for ketones must be interpreted with great caution. A sub analysis of the data showed that a serum BHB above 2.50 mmol/L was only seen in 1.8% of cases without demonstrable acetone (> 20 mg/L).</p>","PeriodicalId":14071,"journal":{"name":"International Journal of Legal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlo Previderè, Serena Bonin, Calogero Cuttaia, Gianmarco Argentiero, Tommaso Livieri, Giovanni Cecchetto, Antonio Oliva, Paolo Fattorini
{"title":"Are pre-analytical factors fully considered in forensic FFPE molecular analyses? A systematic review reveals the need for standardised procedures.","authors":"Carlo Previderè, Serena Bonin, Calogero Cuttaia, Gianmarco Argentiero, Tommaso Livieri, Giovanni Cecchetto, Antonio Oliva, Paolo Fattorini","doi":"10.1007/s00414-025-03480-8","DOIUrl":"https://doi.org/10.1007/s00414-025-03480-8","url":null,"abstract":"<p><p>The need for molecular analyses has become increasingly common in the forensic sciences, particularly in forensic pathology, to better shape the causes of death. This approach is called the \"molecular autopsy,\" where conventional medico-legal findings are often enhanced with specific molecular tests to provide reliable clinical and forensic diagnoses. In this context, FFPE (Formalin-Fixed Paraffin-Embedded) tissue samples collected during forensic autopsies are the only available specimens in retrospective studies for molecular DNA and/or RNA analyses. It is well known that pre-analytical parameters such as the agonal time, the PMI (Post-Mortem Interval), the fixation procedures, and the FFPE ageing and storage conditions can deeply impact the quality and quantity of the recovered nucleic acids, thus influencing the reliability of the downstream molecular tests. In the present study, we reviewed the recent forensic literature to establish whether these parameters are reported. Our survey showed that up to 34.9% and 40.5% of the 50 selected studies on DNA and RNA, respectively, reported the pre-analytical parameters mentioned above. Many publications did not report the length of agony (if any), which is an important parameter in RNA-based studies and estimations of the PMI; in addition, even relevant information on formalin tissue fixation procedures was often missing, thus impairing any critical evaluation of the PCR-based results. To address these issues, we propose the use of a simple form we set up to be filled out by Forensic Pathologists, where each pre-analytical step concerning the tissue samples collected during autopsy is accurately described and reported. In our opinion, this standardization will help the forensic community compare and evaluate the results of different molecular tests, thus increasing the reliability of the molecular results in forensics.</p>","PeriodicalId":14071,"journal":{"name":"International Journal of Legal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ugo Da Broi, Francesco Simonit, Maurizio Perogio, Daniela Visentini, Federico Reccardini, Rexson Tse, Jack Garland, Benjamin Ondruschka, Lorenzo Desinan
{"title":"Fatal anaphylactic shock due to hymenoptera venom in a farmer suffering from indolent systemic mastocytosis. The comparative diagnostic relevance of perimortem serum tryptase levels.","authors":"Ugo Da Broi, Francesco Simonit, Maurizio Perogio, Daniela Visentini, Federico Reccardini, Rexson Tse, Jack Garland, Benjamin Ondruschka, Lorenzo Desinan","doi":"10.1007/s00414-025-03487-1","DOIUrl":"https://doi.org/10.1007/s00414-025-03487-1","url":null,"abstract":"<p><p>Hymenoptera anaphylaxis led to the death of a bee and wasp venom sensitized 41-year-old man suffering from systemic indolent mastocytosis. While at work in a vineyard, the man suffered a serious anaphylactic crisis and cardiovascular arrest; despite ongoing attempts of resuscitation, he died in hospital 12 h after being stung. Autopsy confirmed that death was due to post-anoxic brain damage, cardiovascular shock, disseminated intravascular coagulation (DIC) and multi-organ failure (MOF). ICU blood samples drawn before the patient's death from the distal extremity of the pulmonary catheter revealed central blood tryptase levels of 8955 ng/mL; samples drawn 6 days after death, at autopsy, confirmed anaphylaxis diagnostic central blood total tryptase levels (4977 ng/mL) and peripheral blood levels (319 ng/mL); IgE levels in ICU blood sample suggested that the farmer was a responder to venom immunoteraphy (VIT) for Apis Mellifera (IgE 0.44 kUI/L) but not for Polistes Dominulus (IgE 3.13 kUI/L) yet. The comparison of perimortem laboratory results was crucial, in association with autopsy findings and circumstantial data, in ascertaining that death was caused by a wasp venom anaphylactic reaction, with key findings being: 1) Significantly high pre-mortem (8955 ng/mL) and post-mortem (4977 ng/mL) central blood tryptase levels. 2) High post-mortem peripheral blood tryptase levels (319 ng/mL). 3) High pre-mortem central blood IgE antibodies against Polistes Dominulus.</p>","PeriodicalId":14071,"journal":{"name":"International Journal of Legal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katarzyna Palacz-Ziółek, Monika Krzyżanowska, Marcin Kadej
{"title":"A multi-level overview of the hair decomposition process.","authors":"Katarzyna Palacz-Ziółek, Monika Krzyżanowska, Marcin Kadej","doi":"10.1007/s00414-025-03474-6","DOIUrl":"https://doi.org/10.1007/s00414-025-03474-6","url":null,"abstract":"<p><p>The process of hair fibre degradation is still not well studied. The first group of decompositional alterations are those caused by an external factor - the action of other organisms or environment. The main groups degrading this biological material include microorganisms such as bacteria, Micromycetes and invertebrates. The mechanism of post-mortem root banding is not well known. It is presumed to be caused by external factors (microorganisms, staining by decaying body), but also internal factors (decomposition of the hair matrix). Other degradative changes described in the literature include the breakdown of proteins (mainly keratin - the main building block of hair), photodegradation, which occurs due to the excitation of melanin radicals and elemental composition during hair decomposition. The aim of this research is to extend and systematise the knowledge of hair decomposition, in particular regarding these degradative changes, and to identify gaps and new directions for research in this field. The publications cited in this study, along with the analyses performed, indicate that hair is a promising biological material with potential applications in various fields, including forensics, archaeology, industry, and ecology. In particular, hair can be valuable for estimating post-mortem interval (PMI), as well as for genetic studies, toxicology, and life history analysis. However, key research gaps remain, notably the lack of comprehensive studies on hair decomposition and the absence of standardized, validated methods that could be widely implemented in forensic laboratories and industry.</p>","PeriodicalId":14071,"journal":{"name":"International Journal of Legal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katarzyna Michaud, Cristina Basso, Hans H de Boer, Tony Fracasso, Monica de Gaspari, Carla Giordano, Xiaofei Li, Joaquin Lucena, Pilar Molina, Sarah Parsons, Mary N Sheppard, Allard C van der Wal
{"title":"Ischemic and non-ischemic myocardial injuries at autopsy- an overview for forensic pathologists.","authors":"Katarzyna Michaud, Cristina Basso, Hans H de Boer, Tony Fracasso, Monica de Gaspari, Carla Giordano, Xiaofei Li, Joaquin Lucena, Pilar Molina, Sarah Parsons, Mary N Sheppard, Allard C van der Wal","doi":"10.1007/s00414-025-03479-1","DOIUrl":"https://doi.org/10.1007/s00414-025-03479-1","url":null,"abstract":"<p><p>Cardiovascular diseases are major causes of morbidity and death worldwide, and most cardiac deaths are related to ischemic injury of the myocardium (myocardial infarction). As underlined in the current clinical definition and classification of myocardial infarctions, not all myocardial injuries are due to ischemia: irreversible injury, ending in necrosis, can be induced also by various other factors, such as infections, immune disorders, physical and chemical agents, and trauma. This is supported by clinical studies showing that elevated serum levels of cardiac troponins, as a measure of myocardial damage, are also a common finding in the non-ischemic types of myocardial injury. Forensic pathologists confronted with autopsy findings suggestive of myocardial injury should therefore realize that both ischemic and non-ischemic forms of myocardial death can be observed, and not only in natural but also non-natural deaths (intoxications, asphyxia, traumatic and iatrogenic deaths, and others). Distinguishing these different types of injuries and underlying diseases or circumstances of death is critical, not only to determine the cause and mechanism of death, but also to help investigate often challenging medico-legal scenarios. This article reviews the broad spectrum of ischemic and non-ischemic myocardial injuries in natural and violent deaths. From this perspective we propose a diagnostic approach to myocardial injuries in a forensic pathology context.</p>","PeriodicalId":14071,"journal":{"name":"International Journal of Legal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabiano Riva, Daan Wintermans, Stefan Schaufelbühl, Nadine Fuchs, Wim Kerkhoff
{"title":"From digital to physical model: the use of 3D-printed models in wound ballistic reconstruction.","authors":"Fabiano Riva, Daan Wintermans, Stefan Schaufelbühl, Nadine Fuchs, Wim Kerkhoff","doi":"10.1007/s00414-025-03475-5","DOIUrl":"https://doi.org/10.1007/s00414-025-03475-5","url":null,"abstract":"<p><p>Synthetic models (also called \"surrogates\") simulating human tissues are widely used in wound ballistics. Although there are a large number of commercial models showing interesting properties, these are limited to generic shapes. The result of the interaction between the projectile and the target varies based on several parameters; therefore, using a case-specific, custom-shaped synthetic model would enhance the accuracy of the findings. For this purpose, the authors created, based on Post-Mortem Computed Tomography (PMCT) measurements, case specific 3D-printed synthetic models. The first ballistic tests were performed on simple plates printed with different materials and compared against polyurethan Synbone® products in order to select the most suited materials for synthetic head models. Further tests were realised on head models printed with PLA (polylactic acid), PETG (polyethylene terephthalate glycol-modified) and TPU (thermoplastic polyurethane) polymers as well as on two head models composed of powder and resin. The bullet's behaviour, its deformation, the wound channel and other qualitative aspects were directly compared to the findings of the real case reported in Riva et al in Int J Legal Med 135:2567-2579, 2021, as well as to the \"open shape\" head model created by Riva et al in Forensic Sci Int 294:150-159, 2019. Finally, although the results of this study did not completely fulfil the requirements to simulate human bones, its concept in reproducing case specific head models with easily available 3D printing materials, is very promising.</p>","PeriodicalId":14071,"journal":{"name":"International Journal of Legal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nelly Alexandra Gómez, Ana Patricia Robles Nieto, Ginna Chacón, Rocio Lizarazo, Thore Egeland
{"title":"A crime case involving a mixture of three individuals solved using a sample from the daughter of the person of interest.","authors":"Nelly Alexandra Gómez, Ana Patricia Robles Nieto, Ginna Chacón, Rocio Lizarazo, Thore Egeland","doi":"10.1007/s00414-025-03472-8","DOIUrl":"https://doi.org/10.1007/s00414-025-03472-8","url":null,"abstract":"<p><p>A forensic genetics laboratory may well receive requests that are out of the ordinary and pose challenges like the one presented in this case. A mixture from three individuals was analysed from a crime scene. Reference samples were obtained from two individuals. The Person Of Interest (POI) was not available, only a putative daughter. The analysis of Y and X-STR markers indicated that the contributors to the bloodstain mixture were two males and one female. The hypotheses for the calculation of the Likelihood Ratio (LR) were specified and evaluated using autosomal STR markers. The calculations were done using the open and freely available programs relMix and EuroFormix. The software relMix can deal with arbitrary family relationships between contributors while EuroFormix only accommodates pairwise relationships. In this case both programs were applicable. EuroFormix models peak heights resulting in higher LR, as expected. Ultimately, results from both programs identified the POI, leading to the resolution of the case.</p>","PeriodicalId":14071,"journal":{"name":"International Journal of Legal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}