International Journal of Heart Failure最新文献

{"title":"A Case of Multiple Myeloma Presenting with High-Output Heart Failure That Improved with Anti-angiogenesis Therapy.","authors":"Bo Eun Park, Dong Heon Yang, Hyeon Jeong Kim, Yoon Jung Park, Hong Nyun Kim, Se Yong Jang, Myung Hwan Bae, Jang Hoon Lee, Hun Sik Park, Yongkeun Cho, Shung Chull Chae","doi":"10.36628/ijhf.2020.0014","DOIUrl":"https://doi.org/10.36628/ijhf.2020.0014","url":null,"abstract":"albumin of 4.1 g/dL, and calcium of 8.7 mg/dL. Her electrocardiogram demonstrated","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"2 3","pages":"204-208"},"PeriodicalIF":0.0,"publicationDate":"2020-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/23/ijhf-2-204.PMC9536680.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40668100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Coronary Flow Reserve Is Associated with Impaired Ventricular-vascular Interaction in Patients with Obstructive Sleep Apnea.","authors":"Hyemoon Chung,&nbsp;Sung Wan Kim,&nbsp;Hyung Oh Kim,&nbsp;Jung Myung Lee,&nbsp;Jong Shin Woo,&nbsp;Jin Bae Kim,&nbsp;Soo Joong Kim,&nbsp;Weon Kim,&nbsp;Kwon Sam Kim,&nbsp;Woo-Shik Kim","doi":"10.36628/ijhf.2020.0005","DOIUrl":"https://doi.org/10.36628/ijhf.2020.0005","url":null,"abstract":"<p><strong>Background and objectives: </strong>Obstructive sleep apnea (OSA) is associated with cardiac and arterial damage and adverse cardiovascular outcomes. We aimed to determine whether coronary flow reserve (CFR), which represents microvascular dysfunction, might be associated with the ventricular-vascular coupling index (VVI), which represents the afterload-adjusted contractility in patients with OSA.</p><p><strong>Methods: </strong>We enrolled 281 patients (257 males; mean age, 43±11 years) with newly diagnosed OSA. Transthoracic echocardiography was performed, and adenosine-associated CFR was measured in the left anterior descending coronary artery. We evaluated the differences between the patients with normal CFR ≥2.5 and reduced CFR <2.5. VVI was calculated using the effective arterial elastance (Ea) and left ventricular (LV) end-systolic elastance (Ees) as follows: 10×Ea/Ees.</p><p><strong>Results: </strong>The normal CFR group (n=214) showed increased Ees (7.28±2.31 vs. 8.14±2.33 mmHg/mL, p=0.016) and preserved VVI (3.17±1.53 vs. 2.78±1.20, p=0.044) compared with the reduced CFR group (n=67). There were no differences in LV dimension, LV ejection fraction, left atrial-volume index, E/e', left atrial strain and LV global longitudinal strain between the 2 groups (all p>0.05). CFR was significantly correlated to Ees (r=0.139; p=0.023) and VVI (r=-0.137; p=0.025).</p><p><strong>Conclusions: </strong>Reduced CFR is associated with decreased Ees and impaired VVI in OSA patients. It suggests the necessity of more intensive observation in OSA patients with reduced CFR to improve cardiovascular outcomes.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"2 3","pages":"195-203"},"PeriodicalIF":0.0,"publicationDate":"2020-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/96/2d/ijhf-2-195.PMC9536679.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40668105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Hospital Outcome in Patients Underwent Extracorporeal Membrane Oxygenation in Life-Threatening High-Risk Pulmonary Embolism.","authors":"Jung Hyun Choi,&nbsp;Sang Yeub Lee,&nbsp;Yong Hyun Park,&nbsp;Jae-Hyeong Park,&nbsp;Kye Hun Kim","doi":"10.36628/ijhf.2020.0006","DOIUrl":"https://doi.org/10.36628/ijhf.2020.0006","url":null,"abstract":"<p><strong>Background and objectives: </strong>Acute pulmonary embolism(PE) has high mortality and morbidity. Although reperfusion therapies can be used in high-risk PE patients, a few patients remain in a highly hemodynamically unstable state. In these patients, extracorporeal membrane oxygenation (ECMO) can be used to restore tissue oxygenation and improve their hemodynamic status. We retrospectively assessed the outcomes of ECMO in patients with high-risk PE.</p><p><strong>Methods: </strong>We retrospectively screened all acute PE patients from January 2010 to December 2019 in 5 university hospitals in Korea. We reviewed their medical records and clinical outcomes.</p><p><strong>Results: </strong>During the study period, we screened total 3,572 patients with PE and found 33 high-risk PE patients with ECMO (17 women, 58.3±14.7 years old) whose data were analyzed. Common causes of acute PE included limited mobility (8, 24.2%), a recent operation (6, 18.2%) and a recent hospitalization for medical diseases (3, 9.1%). Among the patients, 25 (75.0%) had a history of cardiopulmonary resuscitation. Nineteen patients had received primary therapy (intravenous thrombolysis in 10, thrombectomy in 8 and catheter-based thrombolysis in 1). The mean duration of ECMO was 5.0 days (range, 1-23 days). The in-hospital mortality rate was 51.5%. Twenty-two patients (66.7%) had ECMO related complications (15 [46.9%] had bleeding, 10 [31.3%] had an infection, and 5 [15.6%] had vascular complications). Of 15 cases with bleeding, 13 of them had mild bleeding associated with catheter insertion, and 2 had moderate multiorgan bleeding.</p><p><strong>Conclusions: </strong>ECMO can be used as an additional or alternative circulatory support method in high-risk PE patients. However, physicians should keep in mind a high incidence of complications related to ECMO.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"2 3","pages":"187-194"},"PeriodicalIF":0.0,"publicationDate":"2020-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bf/da/ijhf-2-187.PMC9536677.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40668103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor Heart Utilization in Korea.","authors":"In-Cheol Kim, Jong-Chan Youn, Sang Eun Lee, Sung-Ho Jung, Jae-Joong Kim","doi":"10.36628/ijhf.2020.0011","DOIUrl":"10.36628/ijhf.2020.0011","url":null,"abstract":"<p><strong>Background and objectives: </strong>Donor heart utilization patterns in Korea are not well known. We aimed to analyze the current utilization rate of donor heart and to evaluate the reason for non-utilization in Korea.</p><p><strong>Methods: </strong>Brain death donors were identified from the Korean Network for Organ Sharing registry from November 2009 to December 2019. Baseline characteristics and heart transplant related parameters were compared between transplanted and discarded donor hearts.</p><p><strong>Results: </strong>Among 4,401 donors, 1,383 (31.4%) hearts were utilized. Hearts from younger, male donors without history of hypertension or diabetes mellitus were utilized more frequently. The most common blood type in the transplanted group was O, while blood type A was the most common blood type in the discarded group. The ejection fraction in the discarded group were significantly lower (57.0 ± 13.5% vs. 61.7 ± 7.0%, p<0.001). Reasons for non-utilization were as follows: medical condition (34.4%), old age (31.8%), refused by all candidates (22.5%), refused to donate (11.0%), and others (0.2%). The most common cause of brain death was cerebrovascular disease in both the transplanted and discarded groups, but the incidence was significantly higher in the discarded group (46.8% vs. 37.5%, p<0.001). In multivariate analysis, old age, small body surface area, rapid heart rate, blood type other than O, abnormal echocardiography findings were independent predictors for non-utilization.</p><p><strong>Conclusions: </strong>Average donor heart utilization rate was 31.4% and it improved to 42.9% in 2019. However, substantial numbers of donor hearts are still discarded. A strategic approach to improve donor heart utilization is necessary.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"2 4","pages":"254-263"},"PeriodicalIF":0.0,"publicationDate":"2020-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/af/ijhf-2-254.PMC9536728.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40556715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rate of Rehospitalization in 60 Days of Discharge and It's Determinants in Patients with Heart Failure with Reduced Ejection Fraction in a Tertiary Care Centre in India.","authors":"Kakasaheb H Bhosale,&nbsp;Ranjit Kumar Nath,&nbsp;Neeraj Pandit,&nbsp;Puneet Agarwal,&nbsp;Shripad Khairnar,&nbsp;Balram Yadav,&nbsp;Sulabh Chandrakar","doi":"10.36628/ijhf.2020.0007","DOIUrl":"https://doi.org/10.36628/ijhf.2020.0007","url":null,"abstract":"<p><strong>Background and objectives: </strong>Identifying the patients with acute heart failure (HF) at high risk for rehospitalization after hospital discharge will enable proper optimization of treatment. This study is aimed to evaluate the rehospitalization rate at 60 days of discharge and their predictors in patients of chronic heart failure with reduced ejection fraction (HFrEF).</p><p><strong>Methods: </strong>This prospective observational study enrolled patients with left ventricle ejection fraction (LVEF) <40%, who were admitted because of acute decompensation. Patients were followed for 60 days to analyze rehospitalization rate and its predictors.</p><p><strong>Results: </strong>Of 103 HFrEF patients (74% male; mean age 55.8 years) enrolled, 7 patients died during index admission and 3 patients lost to follow up. The 60-day rehospitalization rate was 37% (34/93). We studied 23 clinical and 9 biochemical predictors of rehospitalization. Out of 34 events of rehospitalization, 79.41% (n=28) was due to cardiac cause followed by respiratory 5.8% (n=2), renal 5.8% (n=2) and others 5.8% (n=2). Among all the parameters, on logistic regression analysis having longer length of index hospital stay (>7 days) (52.8% vs. 28.8%; odds ratio [OR], 1.79; confidence interval [CI], 1.2-7.25; p=0.040) and chronic kidney disease (CKD) (26.5% vs. 8.5%; OR, 3.06; CI, 1.1-57.04; p=0.050) independently increased the risk of rehospitalization at 60 days of discharge. Further higher haemoglobin level (11.3 vs. 9.9 gm/dL; OR, 0.71; CI, 0.48-0.97; p=0.050) and higher LVEF at index admission (30.4% vs. 26.5%; OR, 0.87; CI, 0.75-0.99; p=0.049) were associated with decreased the risk of rehospitalization.</p><p><strong>Conclusions: </strong>Our study reveals that patients with HFrEF have significantly higher rehospitalization rate (37%) and in-hospital mortality rates (6.78%) of any chronic cardiac disease conditions. Correction of low hemoglobin and special care in those who are having very low LVEF, CKD and longer length of stay, including tailored therapy and frequent visits may play an important role in preventing future rehospitalization in these patients.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"2 2","pages":"131-144"},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/b2/ijhf-2-131.PMC9536659.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40657156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Acute Heart Failure during an Early Phase.","authors":"Koji Takagi,&nbsp;Antoine Kimmoun,&nbsp;Naoki Sato,&nbsp;Alexandre Mebazaa","doi":"10.36628/ijhf.2019.0014","DOIUrl":"https://doi.org/10.36628/ijhf.2019.0014","url":null,"abstract":"<p><p>Acute heart failure (AHF), a global pandemic with high morbidity and mortality, exerts a considerable economic burden. AHF includes a broad spectrum of clinical presentations ranging from new-onset heart failure to cardiogenic shock. Key elements of the management rely on the clinical diagnosis confirmed on, both, increased natriuretic peptides and echocardiography, and on the prompt initiation of oxygen therapy, including non-invasive positive pressure ventilation, vasodilators, and diuretics. A care pathway is essential, specifically when an acute coronary syndrome is suspected or in the case of cardiogenic shock. Association or increasing doses of vasopressors despite an adequate volume status are markers of progression toward a refractory cardiogenic shock state. For the latter, mechanical circulatory support should be initiated early, optimally before the onset of renal or liver failure. Thus, a tertiary care center is recommended for the management of patients with AHF who require percutaneous coronary intervention or mechanical circulatory support. This narrative review provides multidisciplinary guidance for the management of AHF and cardiogenic shock from pre-hospital to intensive care unit/cardiac care unit, based on contemporary evidence and expert opinion.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"2 2","pages":"91-110"},"PeriodicalIF":0.0,"publicationDate":"2020-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b7/71/ijhf-2-91.PMC9536658.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40657160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and Gender Differences in Heart Failure.","authors":"Vera Regitz-Zagrosek","doi":"10.36628/ijhf.2020.0004","DOIUrl":"https://doi.org/10.36628/ijhf.2020.0004","url":null,"abstract":"<p><p>Heart failure (HF) phenotypes differ according to sex. HF preserved ejection fraction (EF) has a greater prevalence in women and HF reduced EF (HFrEF) in men. Women with HF survive longer than men and have a lower risk of sudden death. Ischemia is the most prominent cause in men, whereas hypertension and diabetes contribute to a greater extent in women. Women with HF have a greater stiffness of the smaller left ventricle and a higher EF than men. This higher stiffness of women's hearts may be based on an increase in fibrosis at old age. In younger women estrogen reduces collagen production in female cardiac fibroblasts, but stimulates it in males. Lipid and energy metabolism is better maintained in female than in male stressed hearts. Pulse pressure is a key determinant of outcome in HF women but not in men. Takotsubo and peripartum cardiomyopathy are rare diseases affecting predominantly or exclusively women. Sudden cardiac arrest affects more men than women, but women are less adequately treated. New findings in HF therapy indicate that women with HFrEF need lower doses of beta-blockers and angiotensin-converting enzyme inhibitors than men for optimal effects. The combined neprilysin inhibitor/angiotensin II receptor blockers sacubitril-valsartan led to a significant reduction in event rate versus valsartan in women, which was not observed in men. Unfortunately, only less than 10% of recent randomized controlled trial report effects and adverse drug reactions for women and men separately. More research on sex differences in pathophysiology and therapy of HF is needed.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"2 3","pages":"157-181"},"PeriodicalIF":0.0,"publicationDate":"2020-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/f3/ijhf-2-157.PMC9536682.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40668106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 - Implications for Patients with Heart Failure: The Korean Society of Heart Failure's Clinical Recommendations.","authors":"Dong-Hyuk Cho,&nbsp;Byung-Su Yoo,&nbsp;Jung-Woo Son,&nbsp;In-Cheol Kim,&nbsp;Seong-Mi Park,&nbsp;Dong-Ju Choi","doi":"10.36628/ijhf.2020.0015","DOIUrl":"https://doi.org/10.36628/ijhf.2020.0015","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).1) After first being identified in 2019 in Wuhan, China, COVID-19 has spread rapidly to other countries, resulting in the ongoing 2019–2020 coronavirus pandemic (Table 1, Figure 1).2-4) It has become a global health problem with severe socio-economic impact.3) According to the World Health Organization (WHO) report, people over the age of 60 years are considered a high-risk group if they have an underlying disease, including cardiovascular, respiratory, and metabolic disease.1)2)5) However, patients in the high-risk group often avoid the use of medical facilities or have difficulties due to concerns about COVID-19.4)6) In April 2020, the Korean Society of Heart Failure released clinical recommendations regarding COVID-19 infection in heart failure (HF) patients.","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"2 2","pages":"111-114"},"PeriodicalIF":0.0,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/0f/ijhf-2-111.PMC9536661.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40574371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Prolonged QRS in Patients with Heart Failure and Cardiogenic Shock.","authors":"Se Yong Jang, Dong Heon Yang","doi":"10.36628/ijhf.2020.0013","DOIUrl":"10.36628/ijhf.2020.0013","url":null,"abstract":"","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"2 2","pages":"118-120"},"PeriodicalIF":0.0,"publicationDate":"2020-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/49/ijhf-2-118.PMC9536662.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40657158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paradigm Shifts of Heart Failure Therapy: Do We Need Another Paradigm?","authors":"Hae-Young Lee,&nbsp;Byung-Hee Oh","doi":"10.36628/ijhf.2020.0010","DOIUrl":"https://doi.org/10.36628/ijhf.2020.0010","url":null,"abstract":"<p><p>Heart failure (HF) is a progressive condition with intermittent acute decompensation leading to poor prognosis despite established guideline-directed therapy. A paradigm of HF therapy has been shifted over last four decades. Until the early 1970s, HF was empirically managed, then was managed with the hemodynamic concept until the early 1980s. According to the results of large randomized clinical trials, HF therapy has been shifted to the neurohormonal paradigm since the late 1980s until recently. Korean Acute Heart Failure (KorAHF) registry is a multi-center registry that recruited a total of 5625 admitted patients with acute HF from 2011 to 2014 and followed until 2019. Through KorAHF registry, we could obtain invaluable information or messages in various fields such as epidemiology, clinical characteristics, and treatment of acute HF in Korea and also had opportunities to fill the gap between guideline-directed care and real-world practice. Considering significant unmet needs in HF therapy even at this moment, we do need another paradigm shift for HF therapy, such as molecular and regenerative paradigm using gene, stem cells, mechanical support as well as novel pharmacological agents.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"2 3","pages":"145-156"},"PeriodicalIF":0.0,"publicationDate":"2020-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a5/b7/ijhf-2-145.PMC9536678.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40668104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}