International Journal of Medical Sciences最新文献

{"title":"Role of the RBMS Family in Different Cancers and Research Progress.","authors":"Hanchi Wu, Rui Hou, Yuhan Zhang, Hanfang Fan, Junying Xu, Huiyu Wang","doi":"10.7150/ijms.118386","DOIUrl":"10.7150/ijms.118386","url":null,"abstract":"<p><p>RNA-binding proteins (RBPs), as posttranscriptional regulators, can modulate the activity and stability of target RNAs and participate in the whole life cycle of RNA processing, localization, modification and translation. RNA-binding motif single-stranded interacting proteins (RBMSs) comprise a critical subgroup within the RNA-binding protein (RBP) family, sharing the same domain characteristics as other RBPs. Several studies have shown that RBMSs can participate in tumorigenesis and tumor progression through mechanisms such as regulating the expression of oncogenes, growth factors and cell cycle proteins. In this paper, we reviewed the role of RBPs and related research progress in breast, prostate, lung, liver, gastric and colorectal cancers.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 3","pages":"804-814"},"PeriodicalIF":3.2,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12964577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.","authors":"Wu-Hsien Kuo, Ko-Shih Chang, Fu-Hsuan Kuo, Kuan-Po Cheng, Ru-Yin Tsai","doi":"10.7150/ijms.123717","DOIUrl":"10.7150/ijms.123717","url":null,"abstract":"<p><strong>Background: </strong>Cardiometabolic disorders, such as diabetes, hypertension, dyslipidemia, retinopathy, and non-alcoholic fatty liver disease, present significant health challenges globally. Recent evidence suggests that sesame (<i>Sesamum indicum L.</i>) supplementation may offer beneficial effects in modulating various cardiometabolic risk factors, although findings from clinical trials have been inconsistent.</p><p><strong>Objective: </strong>This meta-analysis aims to systematically assess the effects of sesame supplementation on multiple cardiometabolic parameters, including lipid profiles, blood pressure, glycemic control, liver enzyme levels, inflammatory biomarkers, body weight, and body mass index (BMI), with the goal of evaluating its potential as an adjunctive therapy for clinical retinopathy.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across multiple databases through July 2025 to identify randomized controlled trials (RCTs) that compared sesame supplementation with placebo or active controls on cardiometabolic outcomes.</p><p><strong>Results: </strong>Pooled effect sizes were calculated using a random-effects model. A total of 10 studies involving 441 participants were included in the meta-analysis. Sesame supplementation significantly reduced both systolic and diastolic blood pressure. Improvements were also observed in glycemic control, with reductions in fasting blood glucose and HbA1c levels. Further-more, sesame intake was associated with a significant reduction in liver enzyme levels, particularly alanine aminotransferase (ALT). Subgroup analyses revealed that the effects did not increase with longer durations of sesame supplementation.</p><p><strong>Conclusions: </strong>This meta-analysis provides evidence supporting the beneficial effects of sesame supplementation in improving various cardiometabolic risk factors. Incorporating sesame products into dietary strategies may offer a promising adjunctive intervention for managing cardiometabolic disorders and retinopathy associated with these disorders.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 3","pages":"788-803"},"PeriodicalIF":3.2,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12964580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cells ameliorate neurotrauma-induced visual disturbances and retinal degeneration via broad normalization of β-catenin-related signaling.","authors":"Shu-Chun Kuo, Chung-Hsin Tseng, Suan Hwang, Chia-Yi Lee, Ting-Feng Wu, Pi-Yu Chao, Anthony Lu, Ching-Ping Chang, Chung-Ching Chio","doi":"10.7150/ijms.123975","DOIUrl":"10.7150/ijms.123975","url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury (TBI) is associated with visual dysfunction and retinal degeneration, but the underlying mechanisms and therapeutic options remain limited. Mesenchymal stem cells (MSCs) have shown neuroprotective effects in various central nervous system injuries, including optic neuropathies.</p><p><strong>Objective: </strong>To investigate the protective effects and mechanisms of MSC therapy in TBI-induced retinal degeneration using <i>in vivo</i> and <i>in vitro</i> models.</p><p><strong>Methods: </strong>Repeated mild TBI was induced in adult male Wistar rats by lateral fluid percussion. On day 3 post-injury, rats received intravenous MSCs (4 × 10⁶ cells/ml/kg) or saline. Visual and neurological functions were assessed using the visual cliff test and modified neurological severity score (mNSS). Thirty-five days after TBI, retinal tissues were collected for histological and immunofluorescence analysis. <i>In vitro</i>, R28 retinal precursor cells underwent stretch injury (SI) and were then cocultured with MSCs. Cell viability, apoptosis, mitochondrial membrane potential, reactive oxygen species (ROS), and β-catenin signaling were evaluated.</p><p><strong>Results: </strong>TBI caused visual deficits, brain injury, retinal ganglion cell loss, thinning of the ganglion cell complex, increased neuronal apoptosis, and decreased β-catenin-positive neurons. <i>In vitro</i>, SI led to decreased cell viability, increased apoptosis and autophagy, mitochondrial dysfunction, ROS overproduction, and reduced β-catenin expression. MSC treatment ameliorated both <i>in vivo</i> and <i>in vitro</i> injuries, restoring visual function, preserving retinal structure, and normalizing β-catenin-related pathways.</p><p><strong>Conclusion: </strong>MSC therapy mitigates TBI-induced visual dysfunction and retinal degeneration, in association with β-catenin-related neuroprotective signaling, and may represent a promising strategy for treating TBI-related visual and retinal injury.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 3","pages":"758-779"},"PeriodicalIF":3.2,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12964567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LAP2 Isoform Profile in Heart Ageing and in Cardiac Cell Proliferation and Differentiation: Input From CRISPR-Cas9-mediated LAP2a Knockdown in H9C2.","authors":"Nathalie Vadrot, Maryline Moulin, Ana Ferreiro, Pascale Richard, Brigitte Buendia","doi":"10.7150/ijms.114095","DOIUrl":"10.7150/ijms.114095","url":null,"abstract":"<p><p>Haploinsufficiency of Lap2 alpha (LAP2a), a nuclear partner of Lamins A/C, has been associated with cardiac disease in rare cases, but LAP2a function remains largely unknown. To investigate the functional role of LAP2a in cardiomyocytes, we generated clones of embryonic myocardium-derived H9C2 cells in which LAP2a expression was specifically reduced through gene editing of the LAP2a gene <i>Tmpo</i> by CRISPR-Cas9. Downregulation (+/-) and absence (-/-) of LAP2a expression led to a decreased proliferation capacity of cardiomyocytes <i>in vitro</i>. Upon differentiation, the expression of myocardial markers (alpha cardiac Actin 1/<i>Actc1</i>, cardiac Troponin T2/<i>Tnnt2</i>, Myosin-2/<i>Myh2</i> and Myosin-7/<i>Myh7</i>) was higher in LAP2a -/- cells compared to LAP2a +/- or LAP2a +/+ cells, with consistently higher expression of their upstream regulator <i>Mef2c</i> in LAP2a-devoid cells. These results suggest that LAP2a promotes cardiomyocyte proliferation and negatively modulates cardiomyocyte differentiation, through mechanisms including <i>Mef2c</i> regulation. Accordingly, normal protein expression of LAP2a was downregulated upon cardiomyocyte differentiation, contrary to LAP2b and a LAP2b-related shorter isoform. The latter tended to increase upon differentiation in all cells, most significantly in the LAP2a -/- clone. In postnatal mouse hearts, LAP2a levels were higher in the right than in the left ventricle, and lowest in the septum. The LAP2a:LAP2b ratio was much lower in murine hearts than in H9C2 cells, and decreased significantly upon ageing, specifically in the left ventricle. Finally, our data show that expression of the nuclear envelope proteins LEMD2 and Lamin A might be influenced by LAP2a upon cardiac differentiation. Our results show that LAP2 expression is finely regulated upon cardiac differentiation <i>in vitro</i> and is dependent on age and heart compartment <i>in vivo.</i> They contribute to clarifying the potential impact of genetic LAP2a defects and their connection with heart disease, possibly including reduced cardiomyoblast proliferation, increased cardiomyocyte differentiation and altered nuclear envelope remodelling.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 3","pages":"741-757"},"PeriodicalIF":3.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12964562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Links between Air Pollution and Aortic Diseases: Current Evidence for Future Prevention and Treatment.","authors":"Chayatorn Chansakaow, Poon Apichartpiyakul, Siriporn C Chattipakorn, Nipon Chattipakorn","doi":"10.7150/ijms.124106","DOIUrl":"10.7150/ijms.124106","url":null,"abstract":"<p><p>This review examines the evidence linking air pollution, particularly fine particulate matter (PM2.5), to aortic diseases such as atherosclerosis, aneurysms, and dissections. Air pollution is a significant environmental risk factor for cardiovascular disease, and understanding its impact on the aorta is crucial for developing prevention strategies. We performed a comprehensive literature search of PubMed for articles published between December 2007 and May 2024, including <i>in vivo</i>, <i>in vitro</i>, and clinical studies that investigate the effects of air pollution on aortic pathophysiology. Findings indicate that exposure to PM2.5 and diesel exhaust particles accelerates aortic atherosclerosis, aneurysm formation, and dissection through mechanisms involving oxidative stress, inflammation, endothelial dysfunction, and vascular remodelling, with heightened effects in genetically predisposed models and high-fat diets. <i>In vitro</i> studies reveal that particles can cause cytotoxicity in human aortic endothelial cells, characterized by reduced nitric oxide production and cellular damage. Clinical data are mixed but suggest associations between air pollution and increased aortic calcification, arterial stiffness, and altered hemodynamics. Overall, air pollution influences the development and progression of aortic diseases via multiple biological pathways, emphasizing the need for further research to define dose-response relationships, identify molecular targets, and implement environmental interventions to reduce disease burden and protect public health.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 2","pages":"730-740"},"PeriodicalIF":3.2,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of new-onset glaucoma in people with carpal tunnel syndrome: a global-federated, multicenter retrospective cohort study.","authors":"Yu-Jung Su, Shuo-Yan Gau, Yow-Ling Shiue","doi":"10.7150/ijms.122874","DOIUrl":"10.7150/ijms.122874","url":null,"abstract":"<p><p><b>Background:</b> Carpal tunnel syndrome (CTS) is a common entrapment neuropathy involving chronic inflammation, while glaucoma is an optic neuropathy linked to neuroinflammation and vascular insufficiency. Shared pathogenic mechanisms have been hypothesized, but large-scale epidemiologic evidence is lacking. This study aims to evaluate whether CTS patients present an elevated risk of glaucoma compared to CTS-free individuals. <b>Materials and Methods:</b> We conducted a retrospective cohort study using the TriNetX global research network. Adults diagnosed with CTS were matched 1:1 with CTS-free controls based on demographics, comorbidities, and healthcare utilization. The primary outcome was new-onset glaucoma, with subtypes assessed separately. Cox proportional hazard models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). Sensitivity analyses included alternative matching algorithms, washout periods, and comparisons with autoimmune musculoskeletal diseases. <b>Results:</b> After matching (n = 733,997 per group), CTS was associated with an increased risk of glaucoma (HR = 1.57, 95% CI: 1.52-1.62). Risks were elevated across glaucoma subtypes, including open-angle glaucoma (HR = 1.55, 95% CI: 1.44-1.66) and angle-closure glaucoma (HR = 1.67, 95% CI: 1.38-2.02). Sensitivity analyses confirmed the robustness of the association across multiple models. When compared to patients with autoimmune musculoskeletal diseases, CTS patients had a higher risk of glaucoma than those with rheumatoid arthritis (HR = 1.73, 95% CI: 1.60-1.87) or ankylosing spondylitis (HR = 1.36, 95% CI: 1.20-1.53). <b>Conclusion:</b> Carpal tunnel syndrome is associated with a significantly increased risk of glaucoma. These findings support the involvement of shared inflammatory or vascular mechanisms and highlight the growing concern about ocular comorbidities in patients with CTS.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 2","pages":"661-669"},"PeriodicalIF":3.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic Omental Lymph Node Flap Transfer for Lower Extremity Lymphedema: Insights into Lymphangiogenesis and Clinical Outcomes.","authors":"Chakrit Eaimkijkarn, Nutthapon Kanasup, Oumyos Rattanamahattana, Peerawan Chochai, Pornthep Sirimahachaiyakul, Worapong Leethochavalit, Tanayos Suyabodha, Chamnong Chirawichada, Wuttichai Saengprakai, Amarit Tansawet, Suphakarn Techapongsatorn","doi":"10.7150/ijms.125568","DOIUrl":"10.7150/ijms.125568","url":null,"abstract":"<p><p><b>Background:</b> Lower extremity lymphedema is a chronic surgical disease marked by lymphatic obstruction, fibrosis, and recurrent infection. Conservative therapy is often inadequate in advanced cases. Vascularized lymph node transfer (VLNT) restores drainage through lymphangiogenesis and node regeneration. The omentum, rich in lymphoid tissue and VEGF-C secretion, is an underutilized donor site. This study evaluated the safety, efficacy, and mechanistic outcomes of laparoscopic omental lymph node flap transfer. <b>Methods:</b> This retrospective case series evaluated, twelve patients (14 limbs) with advanced lower extremity lymphedema underwent laparoscopic omental VLNT. Outcomes included limb circumference reduction, resolution of lymphangitis, lymphoscintigraphic improvement, and donor-site morbidity. Lymphoscintigraphy at 12 months assessed functional restoration and tracer uptake as surrogates of lymphangiogenesis. <b>Results:</b> At a mean follow-up of 27 (12-43) months, the mean circumference reduction was 29%, greatest in distal segments. All recurrent lymphangitis resolved, and chronic wounds healed within 3 months. Lymphoscintigraphy demonstrated enhanced drainage, reduced dermal backflow, and increased tracer uptake within transferred flaps, suggesting functional integration. Flap survival was 93%, with no gastrointestinal complications or donor-site hernia. Patients reported improved skin texture, reduced heaviness, and greater walking tolerance. <b>Conclusions:</b> Laparoscopic omental VLNT is a safe and effective option for refractory lower extremity lymphedema. Clinical improvements were supported by lymphoscintigraphic consistent with lymphangiogenesis and lymphatic restoration. This minimally invasive approach represents an important advancement in physiologic lymphedema surgery.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 2","pages":"720-729"},"PeriodicalIF":3.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acetaminophen is associated with improved survival in critically ill lung cancer patients: A propensity score-matched cohort study.","authors":"Chen Chen, Weijia Zeng, Yunyi Li, Zhihui Yang, Xue He","doi":"10.7150/ijms.122435","DOIUrl":"10.7150/ijms.122435","url":null,"abstract":"<p><p><b>Background:</b> Acetaminophen is widely used in intensive care units, yet its impact on mortality among critically ill patients with primary lung cancer remains unclear. Given the high disease burden and potential immunomodulatory effects of acetaminophen, robust evidence is needed to clarify its prognostic relevance in this population. <b>Methods:</b> We conducted a retrospective cohort study using the MIMIC-IV v2.2 database, including 1,127 critically ill patients with primary lung cancer. Baseline variables comprised demographics, comorbidities, illness severity scores (SOFA, APSIII, SAPSII, OASIS), and laboratory parameters. To minimize confounding, propensity score matching was applied. <b>Results:</b> A total of 1,127 critically ill patients with primary lung cancer were included, of whom 403 received acetaminophen. The 28-day mortality rate was 22.0% in the acetaminophen group compared to 37.5% in the non-acetaminophen group. After adjusting for baseline differences using inverse probability of treatment weighting (IPTW), acetaminophen exposure was associated with a significantly lower risk of 28-day mortality (HR=0.75, 95% CI: 0.60-0.93, <i>p</i>=0.015). In addition to 28-day mortality, acetaminophen use was consistently associated with reduced risks of ICU mortality, in-hospital mortality, 30-day mortality, 90-day mortality, and 365-day mortality. Subgroup analyses identified patients aged ≥65 years and those with a SOFA score ≥3 as particularly noteworthy subgroups. <b>Conclusion:</b> Acetaminophen use was associated with significantly reduced short- and long-term mortality in critically ill patients with primary lung cancer. These findings suggest a potential survival benefit beyond its conventional symptomatic use and underscore the need for prospective studies to validate its therapeutic role in this high-risk population.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 2","pages":"636-645"},"PeriodicalIF":3.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Mechanisms of Hyperbaric Oxygen Therapy in Cerebral Ischemia-Hypoxia Injury Following Cardiopulmonary Resuscitation.","authors":"Yifan Huang, Xiaopeng Liu, Xiaozhan Yang, Sisen Zhang","doi":"10.7150/ijms.123862","DOIUrl":"10.7150/ijms.123862","url":null,"abstract":"<p><p>Despite significant advancements in cardiopulmonary resuscitation (CPR) techniques, the global burden of sudden cardiac death remains high, with post-CPR survival rates persistently below 8%. Hypoxic-ischemic brain injury (HIBI) is the predominant cause of mortality, accounting for 68% of fatalities following resuscitation. Hyperbaric oxygen (HBO) therapy, which enhances oxygen dissolution in plasma, has demonstrated efficacy in focal cerebral ischemia conditions such as stroke. However, its potential in addressing global cerebral ischemia following CPR-a condition pathophysiologically distinct due to the absence of a salvageable ischemic penumbra and characterized by pan-cerebral energy failure-remains insufficiently explored. This review synthesizes emerging evidence from both focal and global ischemia models, highlighting the role of HBO in modulating key injury mechanisms common to both conditions, including oxidative stress, neuroinflammation, and ferroptosis. By integrating findings on HBO-induced upregulation of endogenous antioxidants, suppression of pro-inflammatory cytokines, and stabilization of mitochondrial function, we propose a combined therapeutic strategy that incorporates HBO with advanced CPR techniques and adjunctive therapies to mitigate HIBI.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 2","pages":"670-683"},"PeriodicalIF":3.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of dynamic changes in systemic inflammatory markers on mortality after liver transplantation: a retrospective cohort study.","authors":"Eun Jung Kim, Darhae Eum, Jin Ha Park, Seongwook Kang, Jin Sun Cho","doi":"10.7150/ijms.126883","DOIUrl":"10.7150/ijms.126883","url":null,"abstract":"<p><p><b>Purpose</b>: Liver transplantation (LT) is a risky but life-saving treatment for end-stage liver disease. Dynamic changes in systemic inflammation can inform disease progression and postoperative recovery. This retrospective study investigated the prognostic impact of these chronological changes in patients undergoing LT. <b>Methods</b>: Inflammatory statuses were assessed using the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) measured preoperatively (within 7 days before surgery) and postoperatively (between days 21 and 90, before any re-exploration). Their predictive performances for three-year postoperative mortality were evaluated. Using the best-performing index, the patients were stratified into normal (persistently low), elevated (low-to-high), normalized (high-to-low), and persistent (persistently high) groups, and associations with mortality were analyzed. <b>Results</b>: A total of 377 patients were included. Among inflammatory indices, the NLR had the highest mortality prediction accuracy. Patients grouped by pre- and postoperative NLR cutoffs (4.2 and 24.0) showed significant mortality differences, with stepwise risk increases from normal to normalized and persistent groups. The NLR-based group was an independent mortality predictor. Compared with the normal group, the normalized and persistent groups had higher mortality, prolonged ventilation, and longer intensive care unit (ICU) and hospital stays. <b>Conclusion</b>: Dynamic changes in systemic inflammation, reflected by pre- and postoperative NLR, were strongly associated with long-term mortality after LT. The NLR is a reliable, accessible inflammatory marker. Elevated preoperative NLR was associated with poor outcomes, with persistent postoperative elevation indicating a worse prognosis than normalization. NLR trajectory may help identify high-risk LT patients and guide postoperative care.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 2","pages":"711-719"},"PeriodicalIF":3.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}