International Journal of Morphology最新文献

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Impacto de un Programa de Recuperación Funcional en Músculos Ventilatorios y Apendiculares en Pacientes Post-ventilación Mecánica por COVID-19 COVID-19机械通气后患者通气和阑尾肌肉功能恢复方案的影响
4区 医学
International Journal of Morphology Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501485
María Fernanda del-Valle-Valdés, Constanza Díaz-Canales, Mariano del Sol, Máximo Escobar-Cabello, Jorge Valenzuela-Vásquez, Rodrigo Muñoz-Cofré
{"title":"Impacto de un Programa de Recuperación Funcional en Músculos Ventilatorios y Apendiculares en Pacientes Post-ventilación Mecánica por COVID-19","authors":"María Fernanda del-Valle-Valdés, Constanza Díaz-Canales, Mariano del Sol, Máximo Escobar-Cabello, Jorge Valenzuela-Vásquez, Rodrigo Muñoz-Cofré","doi":"10.4067/s0717-95022023000501485","DOIUrl":"https://doi.org/10.4067/s0717-95022023000501485","url":null,"abstract":"","PeriodicalId":14023,"journal":{"name":"International Journal of Morphology","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiologıcal Evaluation of Volar Cortical Angle in the Anatolian Population 安那托利亚人群掌侧皮质角的影像学评价
4区 医学
International Journal of Morphology Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501508
Asrın Nalbant, Eren Ismailoglu, Ebru Turhan, Özden Bedre Duygu
{"title":"Radiolog&amp;#305;cal Evaluation of Volar Cortical Angle in the Anatolian Population","authors":"Asrın Nalbant, Eren Ismailoglu, Ebru Turhan, Özden Bedre Duygu","doi":"10.4067/s0717-95022023000501508","DOIUrl":"https://doi.org/10.4067/s0717-95022023000501508","url":null,"abstract":"Distal radius fractures are the most common fractures of the upper limb. The most commonly used method in the repair of these fractures is volar locking plates. Recently, the frequency of removal of volar locking plates after surgery has increased. There are many factors in its reduction. Anatomically, incompatibility of the distal end of the radius with volar locking plates is one of them. In previous studies, different volar cortical angle (VCA) values were found in other races. For this reason, this study aimed to determine the mean values by making VCA measurements of the Anatolian population. The study was designed retrospectively. In the study, measurements were made on computed tomography (CT) images of the distal end of the radius of 53 men and 28 women. Radial width, intermediate volar angle, and radial volar angle were measured in the images. On average, the radius width was 23.35±1.96 mm, and the intermediate volar angle was 26.02±.3.83°, radial volar angle was 24±3.07°. Radial width, intermediate volar angle, and radial volar angle differed significantly by gender (p<0.001). A significant correlation was found between radius width, intermediate volar angle, and radial volar angle values (p<0.001). It has been determined that the Anatolian population has a different VCA value than the European, Asian, and other populations. When using volar locking plates in distal radius fracture surgery, volar locking plates should be selected by considering the average values of the races.","PeriodicalId":14023,"journal":{"name":"International Journal of Morphology","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136161243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Wrist Morphology Through Hamate and Lunate Bone Variations in Anatolian Population Using Plain Radiography 利用x线平片分析安纳托利亚人群钩骨和月骨的腕部形态变化
4区 医学
International Journal of Morphology Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501343
Ahmet Savran
{"title":"Analysis of Wrist Morphology Through Hamate and Lunate Bone Variations in Anatolian Population Using Plain Radiography","authors":"Ahmet Savran","doi":"10.4067/s0717-95022023000501343","DOIUrl":"https://doi.org/10.4067/s0717-95022023000501343","url":null,"abstract":"The present study aimed to evaluate wrist (lunate) anatomy in terms of the incidence of lunatum morphology on plain-radiographs among the Anatolian (Turkey) population, accompanied by demographic analysis. We obtained all the patients’ data regarding demographical features, diagnosis, and posteroanterior (PA) X-ray imaging. Two radiograph-reviewers repeated the analysis twice, one month later, blinded to their findings before the previous review. The lunatum structure was determined as Type-1 (n:293) and Type-2 (n:207) for each radiograph. Most of the 500 wrists' radiographs [n:293 (58.6 %)] were type-I lunate. The mean age was 36.7±13.3 (range:18-90) years. Sex distribution was as follows: 185 (63.1 %) males to 108 (36.9 %) females. Type-2 lunate was seen in 207 participants (41.4 %). The mean age for type-2 was 41.6±15.2 (18-88) years. 142 (68.6 %) participants were male sex, while 65 (31.4 %) were females. The mean age of subjects with type-I showed a difference with type-II (p=0.007). There was no relationship in terms of sex (p=0.206) between the groups. In the Anatolian region, type-1 lunate was dominant compared to type-2. The incidence rate of lunate type in Anatolian population was similar to the Arab population.","PeriodicalId":14023,"journal":{"name":"International Journal of Morphology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136127514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methodological Proposal for the Adequate Use of the Osteotechnics Technique 充分使用骨技术的方法学建议
4区 医学
International Journal of Morphology Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501281
J. Stephan Sánchez-Torrijos, G. L Serrano-González, L. A San-Martín-Martínez, G Mejía-Medina, L Valencia-Caballero
{"title":"Methodological Proposal for the Adequate Use of the Osteotechnics Technique","authors":"J. Stephan Sánchez-Torrijos, G. L Serrano-González, L. A San-Martín-Martínez, G Mejía-Medina, L Valencia-Caballero","doi":"10.4067/s0717-95022023000501281","DOIUrl":"https://doi.org/10.4067/s0717-95022023000501281","url":null,"abstract":"Osteotechnics is one of the different anatomical preservation techniques and can be defined as the technique designed to prepare, clean, obtain and preserve bone structures that can be used in the teaching, museographic or research field. The osteotechnical technique procedure consists of the following phases: debulk and disjoint, maceration, cooking, cleaning, degreasing, bleaching, and labeling to obtain bone material. Seven phases will be explained in detail, as well as the materials, instruments, quantities of the substances used, and the time required to obtain human bone material. We consider that this article can serve as a guide, given that all the experimentation was carried out with human biological material. This methodological proposal could be consolidated and established based on the experience acquired during the creation of the contemporary skeletal collection of the department of innovation in human biological material (DIMBIH). Therefore, the purpose of our proposal is to provide tools that facilitate the work of those who carry out this work and fundamentally to avoid irreversible or irreparable damage to the osteological material, since it is of great value and difficult to acquire for disciplines as anatomy, veterinary, physical and forensic anthropology, medicine, dentistry and biology.","PeriodicalId":14023,"journal":{"name":"International Journal of Morphology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136127515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anthropometric Similarities and Differences in Children of Aymara and Non-Aymara Descent in Northern Chile: Implications for Health and Development 智利北部艾马拉和非艾马拉后裔儿童的人体测量相似性和差异性:对健康和发展的影响
4区 医学
International Journal of Morphology Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501411
Luis A Barrio-Mateu, Dayneri León-Valladares, Josivaldo de-Souza-Lima, Rodrigo Yáñez-Sepúlveda, Yaiza Cordero-Rodríguez, Fernanda Borges-Silva, Ernesto Ponce, Daniel Ponce, Muriel Ponce
{"title":"Anthropometric Similarities and Differences in Children of Aymara and Non-Aymara Descent in Northern Chile: Implications for Health and Development","authors":"Luis A Barrio-Mateu, Dayneri León-Valladares, Josivaldo de-Souza-Lima, Rodrigo Yáñez-Sepúlveda, Yaiza Cordero-Rodríguez, Fernanda Borges-Silva, Ernesto Ponce, Daniel Ponce, Muriel Ponce","doi":"10.4067/s0717-95022023000501411","DOIUrl":"https://doi.org/10.4067/s0717-95022023000501411","url":null,"abstract":"This study aims to assess the nutritional status of Aymara and non-Aymara children in Arica, comparing anthropometric measurements of boys and girls aged 4-10 to inform interventions for child health and development. We conducted a non-experimental, quantitative, cross-sectional study in Arica, Chile. The sample included 458 children, with equal representation of Aymara and non-Aymara children from diverse socioeconomic backgrounds. Trained research assistants collected anthropometric data using standardized techniques. IBM SPSS statistical software was used for data analysis, including Student's t-test and the Levene test. Both Aymara and non-Aymara children showed high prevalence of overweight and obesity. Boys had a meso-endomorph somatotype, while girls had an endomorph somatotype. Among 8-year-olds, non-Aymara children had a slightly higher mean body weight (35.87, SD 4.50) compared to Aymara children (32.27, SD 4.31), but the difference was not statistically significant (p>0.05). However, 10-year-old Aymara girls had a significantly higher mean body mass index (22.34, SD 4.21) than non-Aymara girls (20.10, SD 3.58) (p=0.05). Regarding body fat percentage, 10-year- old non-Aymara girls had a slightly higher mean (31.01, SD 5.64) than Aymara girls (26.12, SD 5.63), but the difference was not statistically significant (p>0.05). The study found high levels of overweight and obesity in children from northern Chile, increasing with age for both Aymara and non-Aymara groups. The somatotype patterns were consistent across both groups. Although the differences between Aymara and non-Aymara children were not statistically significant, the Aymara group showed slightly higher levels of overweight and obesity. Further research with a larger sample size is needed to confirm these results and identify potential trends. Efforts should focus on promoting healthy nutrition and physical activity to address the growing problem of overweight and obesity in this region.","PeriodicalId":14023,"journal":{"name":"International Journal of Morphology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136127717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histomorphological, Histochemical and Ultrastructural Studies on the Healthy Liver of Yemen Veiled Chameleon (Chamaeleo calyptratus) in Southern Saudi Arabia 沙特阿拉伯南部也门面纱变色龙健康肝脏的组织形态学、组织化学和超微结构研究
4区 医学
International Journal of Morphology Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501513
Amin A Al-Doaiss, Mohammed A Alshehri, Ali A Shati, Mohammad Y Alfaifi, Mohammed A Al-Kahtani, Ahmed Ezzat Ahmed, Refaat A Eid, Laila A Al-Shuraym, Fahd A Al-Mekhlafi, Mohammed Al-Zahrani, Mohammed Mubarak
{"title":"Histomorphological, Histochemical and Ultrastructural Studies on the Healthy Liver of Yemen Veiled Chameleon (Chamaeleo calyptratus) in Southern Saudi Arabia","authors":"Amin A Al-Doaiss, Mohammed A Alshehri, Ali A Shati, Mohammad Y Alfaifi, Mohammed A Al-Kahtani, Ahmed Ezzat Ahmed, Refaat A Eid, Laila A Al-Shuraym, Fahd A Al-Mekhlafi, Mohammed Al-Zahrani, Mohammed Mubarak","doi":"10.4067/s0717-95022023000501513","DOIUrl":"https://doi.org/10.4067/s0717-95022023000501513","url":null,"abstract":"The livers of reptiles are being studied as a model for the link between the environment and hepatic tissue. There have been few investigations on the histology of reptile livers, and very few or no studies have examined the histology of liver of veiled chameleon (Chamaeleo calyptratus). This paper describes the histomorphological, histochemical and ultrastructural characterization of the liver of veiled chameleons in southern Saudi Arabia. Seven Chamaeleo calyptratus were captured in the summer season in Abha City, Aseer region, southern Saudi Arabia. Chamaeleon liver samples were processed for histomorphology, histochemistry and ultrastructure analyses. Morphologically liver of Chamaeleo calyptratus was observed as a large dark brown organ with lighter speckles, which represent melanin deposits. It located at the ventral part of abdominal cavity forward of the stomach. Its dimensions approximately were 3.7 x 2 cm. The liver was a bilobed organ divided into two lobes, right and left lobes. The right one was bigger than the others. The gallbladder was well developed and had an elongated shape, situated between the two lobes and contained the bile for the digestion. Microscopically, the liver was found to be covered by a thick layer of connective tissue, which formed the hepatic capsule. Hepatic parenchyma probably appeared in cross sections as hepatic glandular-like alveoli “acini” or follicular structures with various diameters, each acinus contains approximately four to six hepatocytes, surrounded by sinusoidal capillaries filled with abundant melanomacrophages, which are absent in birds and mammals. Melanomacrophages are common in the hepatic parenchyma's perisinusoidal areas, particularly near portal spaces. Hepatocytes are polyhedral or pyramidal with and mostly contained large, rounded nuclei mostly peripherally located, with prominent dark oval nucleoli. Some of nuclei are eccentric or central position. The cytoplasm appeared spongy or vacuolated and more eosinophilic when stained by hematoxylin-eosin and strongly reactive to PAS staining technique, indicating abundant glycogen content. The reticular fibers that surround hepatocytes, blood arteries, and sinusoids supported the hepatic parenchyma. The blood sinusoids are seen interspersed among hepatocytes of varying sizes. The sinusoidal lumen was bordered by flattened endothelial cells and includes elliptical nucleated erythrocytes and liver macrophages as phagocytes, which are also known as Kupffer cells. Branches of the portal vein, hepatic artery, small bile duct, and lymph vessels were detected in the hepatic portal area “tract” or triad which made up of connective. Hematopoietic tissue was observed in subcapsular region and portal triads. Ultrastructurally, the hepatocyte appeared polyhedric containing a single large rounded basal or eccentric vesicular nucleus with prominent nucleolus. Extensive network of rough endoplasmic reticulum (RER) often arranged in an array parallel","PeriodicalId":14023,"journal":{"name":"International Journal of Morphology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136127872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dissectional Orientation: Morphological Variations of Teres Minor Muscle and its Nerve Supply 解剖取向:小圆肌形态变化及其神经供应
4区 医学
International Journal of Morphology Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501445
Chutikan Kaensa, Sirinush Sricharoenvej, Passara Lanlua, Sani Baimai
{"title":"Dissectional Orientation: Morphological Variations of Teres Minor Muscle and its Nerve Supply","authors":"Chutikan Kaensa, Sirinush Sricharoenvej, Passara Lanlua, Sani Baimai","doi":"10.4067/s0717-95022023000501445","DOIUrl":"https://doi.org/10.4067/s0717-95022023000501445","url":null,"abstract":".","PeriodicalId":14023,"journal":{"name":"International Journal of Morphology","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Assessment of Contact Osteogenesis at the Titanium Implant-Bone Junction in Male Rabbits with Dissimilar Femoral Defects 不同股骨缺损雄性兔钛植入骨接口处接触成骨的比较评价
4区 医学
International Journal of Morphology Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501317
V. Duma, A. F Gal, V Rus, Maria-Catalina Matei-Latiu, C Ratiu, B. C Alexandru, C Latiu, C Martonos, L. I Oana
{"title":"Comparative Assessment of Contact Osteogenesis at the Titanium Implant-Bone Junction in Male Rabbits with Dissimilar Femoral Defects","authors":"V. Duma, A. F Gal, V Rus, Maria-Catalina Matei-Latiu, C Ratiu, B. C Alexandru, C Latiu, C Martonos, L. I Oana","doi":"10.4067/s0717-95022023000501317","DOIUrl":"https://doi.org/10.4067/s0717-95022023000501317","url":null,"abstract":"Traumatized bone tissue has the capacity to repair itself so that it eventually regains its almost original form, even in the case of artificially inserted implants. The process that stays at the base of the regeneration is represented by osteogenesis or remote osteogenesis. The major difference between the two types of bone formation is the location of the cement line, which is located on the surface of the implant for contact osteogenesis and on the surface of the bone defect for remote osteogenesis. The aim of the present study was to assess the contact osteogenesis in the case of inserted titanium screws in holes with diameters of 1.8 mm and 1 mm respectively. The obtained results show, in the case of the groove with 1.8 mm that the newly proliferated bone represents 73.85 % of the total area, while in the case of the groove with 1 mm in diameter the value of the newly proliferated bone is 26.15 %. In conclusion, the insertion of titanium screws by self-tapping into the hole smaller than the core of the screw is accompanied by bone proliferation by contact osteogenesis much more modest than in the case of insertion into the hole larger than the core of the screw.","PeriodicalId":14023,"journal":{"name":"International Journal of Morphology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136127504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Digastric Muscle: Its Anatomy and Functions Revisited 二腹肌:解剖与功能重访
4区 医学
International Journal of Morphology Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501501
Jae-Heon Kim, Hye-Jung Yoon, Soyeon Kim, Wanki Lee, Young-Seok Park
{"title":"The Digastric Muscle: Its Anatomy and Functions Revisited","authors":"Jae-Heon Kim, Hye-Jung Yoon, Soyeon Kim, Wanki Lee, Young-Seok Park","doi":"10.4067/s0717-95022023000501501","DOIUrl":"https://doi.org/10.4067/s0717-95022023000501501","url":null,"abstract":"As one of the suprahyoid muscles, the digastric muscle is characterized by two separate bellies of different embryologic origins. The origin of the anterior belly is the digastric fossa, while the origin of the posterior belly is the mastoid notch. They share a common insertion: the intermediate tendon. When the digastric muscle contracts, the hyoid bone is raised. Opening of the jaw and swallowing of food boli are associated with digastric muscle activity. This review discusses the general anatomic features of the digastric muscle and its variation, primary functions, and clinical implications focused on surgical reconstruction and rejuvenation.","PeriodicalId":14023,"journal":{"name":"International Journal of Morphology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136127875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective Effects and Mechanisms of Huangqi Decoction Against Radiation-Induced Bystander Effects 黄芪汤对辐射诱导的旁观者效应的保护作用及其机制
4区 医学
International Journal of Morphology Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501527
Fangyu An, Chunlu Yan, Jiajin Li, Xueying Lv, Caixia Wang, Jie Deng, Biao Shi, Jinlong Zhang, Wenxuan Che, Wenrui Zheng
{"title":"Protective Effects and Mechanisms of Huangqi Decoction Against Radiation-Induced Bystander Effects","authors":"Fangyu An, Chunlu Yan, Jiajin Li, Xueying Lv, Caixia Wang, Jie Deng, Biao Shi, Jinlong Zhang, Wenxuan Che, Wenrui Zheng","doi":"10.4067/s0717-95022023000501527","DOIUrl":"https://doi.org/10.4067/s0717-95022023000501527","url":null,"abstract":"The 12C6+ heavy ion beam irradiation can cause bystander effects. The inflammatory cytokines, endocrine hormones and apoptotic proteins may be involved in 12C6+ irradiation-induced bystander effects. This study characterized the protective effects and mechanisms of Huangqi decoction (HQD) against 12C6+ radiation induced bystander effects. Wistar rats were randomly divided into control, 12C6+ heavy ion irradiation model, and high-dose/medium-dose/low-dose HQD groups. HE staining assessed the pathological changes of brain and kidney. Peripheral blood chemical indicators as well as inflammatory factors and endocrine hormones were detected. Apoptosis was measured with TUNEL. Proliferating cell nuclear antigen (PCNA) expression was determined with real-time PCR and Western blot.Irradiation induced pathological damage to the brain and kidney tissues. After irradiation, the numbers of white blood cells (WBC) and monocyte, and the expression of interleukin (IL)-2, corticotropin-releasing hormone (CRH) and PCNA decreased. The damage was accompanied by increased expression of IL-1β, IL-6, corticosterone (CORT) and adrenocorticotropic hormone (ACTH) as well as increased neuronal apoptosis. These effects were indicative of radiation-induced bystander effects. Administration of HQD attenuated the pathological damage to brain and kidney tissues, and increased the numbers of WBC, neutrophils, lymphocyte and monocytes, as well as the expression of IL-2, CRH and PCNA. It also decreased the expression of IL-1β, IL-6, CORT and ACTH as well as neuronal apoptosis. HQD exhibits protective effects against 12C6+ radiation-induced bystander effects. The underlying mechanism may involve the promotion of the production of peripheral blood cells, inhibition of inflammatory factors and apoptosis, and regulation of endocrine hormones.","PeriodicalId":14023,"journal":{"name":"International Journal of Morphology","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136128350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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