International Journal of Innovative Research in Medical Science最新文献

{"title":"Omental Infarction after Infectious Uterine Underwent Caesarian Section: A Case Report","authors":"Ahmad Reza Shahraki, Reza Abaee, Elham Shahraki","doi":"10.23958/ijirms/vol08-i12/1785","DOIUrl":"https://doi.org/10.23958/ijirms/vol08-i12/1785","url":null,"abstract":"Omental infarction is a rare disease that affects the entire omentum or a segment of the greater omentum. It presents as acute abdominal pain mainly in the right lower quadrant or right flank. Left-sided omental torsion is infrequent and it is rarely preoperatively diagnosed. Omental infarction is a differential diagnosis in the acute abdomen. As most cases of omental infarction can be adequately diagnosed via computed tomography, a conservative treatment strategy for patients without complications should be considered in order to avoid any unnecessary surgical intervention. Our case was a middle age woman with abdominal pain that surgery showed omental infarction after infectious cesarean section. After surgery patient discharged successfully. Although the classical treatment of omental infarction is surgery, more recently the conservative management has been suggested. Thus, we believe that the knowledge of the characteristic imaging findings is essential for establish a correct preoperative diagnosis, which can avoid unnecessary surgical intervention.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138973316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Disorders and their Relationship with Survival and Graft Rejection in Deceased Donor Kidney Transplant Recipients","authors":"Héctor Octavio Castañeda González, Mario García-Alanis, Judith González-Sánchez, Luis Morales-Buenrostro, Héctor Cabello-Rangel","doi":"10.23958/ijirms/vol08-i12/1786","DOIUrl":"https://doi.org/10.23958/ijirms/vol08-i12/1786","url":null,"abstract":"Introduction: A significant association has been documented between the severity of depression and renal graft loss in post-transplant patients. Objective: To determine the relationship between mental disorders during the pre-transplant period and outcomes of graft rejection, graft loss, and mortality. Method: A retrospective cohort study was conducted on deceased donor kidney transplant recipients to assess whether mental disorders modify the risk of experiencing adverse outcomes during the post-transplant period. Results: Psychiatric comorbidity is associated with a longer duration of the pre-transplant evaluation protocol and time on the waiting list. Renal transplant candidates with psychiatric histories are more likely to experience renal graft loss compared to those without such histories. Recipients diagnosed with anxiety disorders during the pre-transplant protocol experience an increased risk of graft rejection during the post-transplantation period. Conclusion: Identifying and treating psychiatric disorders in renal transplant recipients could help reduce the likelihood of adverse outcomes during the post-transplant period. The study's main limitation is the lack of standardized instruments to identify psychiatric diagnoses during the pre-transplant evaluation protocol.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"28 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139004890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-6 Levels to Identify Patients at Risk of Early Postoperative Complications after Open Radical Cystectomy: A Clinical Study","authors":"B. Horosz, Malgorzata Malec Milewska, Marek Jutel, P. Gajdanowicz, Dries Van Elst, Michał Pirożyński","doi":"10.23958/ijirms/vol08-i12/1784","DOIUrl":"https://doi.org/10.23958/ijirms/vol08-i12/1784","url":null,"abstract":"Background and Objective: Molecular data indicate that immune mechanisms are affected by surgical trauma. We performed a study to compare lymphocyte Th1/Th2 cytokine production profile in open cystectomy patients who developed early postoperative infectious and cardiac complications and patients whose postoperative course was uneventful. Methods: Perioperative and laboratory data of 54 patients who underwent elective open radical cystectomy with ileal conduit were assessed. Interleukin (IL)-2, IL-4, IL-5, IL-6, IL-10, IL-13, interferon - gamma (INF)-γ and tumor necrosis factor - alpha (TNF)-α concentrations were analysed at two points: before surgery and on postoperative day one (POD-1). Cardiac troponin levels on POD-1 were also analysed. Cytokine levels were determined using cytometric bead array and flow cytometry. Complications assessed as one composite outcome were pneumonia, surgical site infection and myocardial injury. Cytokine levels at two study points in patients with and without complications, as well as in patients with and without perioperative blood transfusion were compared. Results: Data from 54 cases (30% women) were analysed. Of eight assessed cytokines only IL-6 and IFN- γ levels differed at two study points. Seven patients developed infection and myocardial injury was diagnosed in six cases. Postoperative IL-6 levels increased postoperatively and were significantly higher in patients who developed complications (413.2 vs 250.2pg/ml, p=0.01), as well as in those transfused perioperatively (328.3 vs 160.2pg/ml, p=0.005). Conclusions: Open cystectomy results in major rise in proinflammatory IL-6, with higher levels in patients who develop postoperative complications and those requiring blood transfusion.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"45 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139007115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Oral Propranolol Accelerate Augmentation of Labour in Synergy with Oxytocin in Nulliparous Women? A Randomized Controlled Trial in Abakaliki, Nigeria","authors":"Ugoji DARLINTON-PETER CHIBUZOR, Chidi. O. Esike, J. Adebayo, Emmanuel Chijioke Uwakwe, P. C. Okoye, Chidubem Philip Osuagwu, Odidika UgochukwuJoannes Umeora","doi":"10.23958/ijirms/vol08-i12/1775","DOIUrl":"https://doi.org/10.23958/ijirms/vol08-i12/1775","url":null,"abstract":"Objective: Propranolol, a beta blocker has been documented in few studies to act in synergy with oxytocin to accelerate labour progress. The only available systematic review is inconclusive, hence, the need for this study. Methodology: This research is a clinical superiority open labeled randomized controlled trial that involved only nulliparous women who met the inclusion criteria and gave consent to the study. Participants were randomized from a pool of 82 participants divided into A and B. Group A received 20 mg of oral propranolol and oxytocin titration while group B received only oxytocin titration. Partograph was used to monitor their labour. SPSS software was used for analysis. Continuous variables were analyzed using students t-test while chi-square (χ2) test was used for categorical variables. A P-value of <0.05 was considered significant. Results: The total mean duration of labour was statistically significant (P<0.001). The mean duration of active phase of labour was also statistically significant (P = 0.001). However, there was no significant difference in the 2nd stage (P=0.491)} and 3rd stage of labour (P=0.753)}. Conclusion: Administration of 20mg oral propranolol prior to augmentation of labour with oxytocin accelerated the total duration of labour and active phase of labour.\u0000Clinical Trial. gov: - NCT05251610","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"277 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139012395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing Anesthesia Practice with AI-Assisted Referral Management","authors":"Baha Taha, Yusuf Alsharaf, Dr Meral Al-Ameer","doi":"10.23958/ijirms/vol08-i11/1781","DOIUrl":"https://doi.org/10.23958/ijirms/vol08-i11/1781","url":null,"abstract":"The article explores the burgeoning role of Artificial Intelligence (AI) in healthcare, particularly in anesthesia and surgical practices, with the ultimate aim of enhancing patient outcomes. It underscores the necessity for refining AI algorithms while addressing legal and ethical concerns. AI's potential applications in healthcare are manifold, including predicting perioperative risks, detecting intraoperative events, and identifying postoperative complications for early intervention. The integration of AI in the operating room (OR) aims to augment human capabilities rather than replace healthcare professionals, thereby improving surgical safety and outcomes. Significantly, AI is posited to enhance efficiency and quality of care in healthcare settings. This includes automating referral management in anesthesia clinics, which face challenges like referral backlogs and labor-intensive processes. AI can streamline these processes, reduce paperwork, alleviate patient anxiety, and provide real-time feedback for more accurate and timely interventions. The article also highlights various AI applications in anesthesia, such as personalized anesthetic management, vital sign monitoring, and trend analysis in anesthesia practice. Additionally, the article delves into AI's transformative potential in pharmaceutical research, particularly in Central Nervous System (CNS) therapeutics. It mentions a study named \"ADVENTURE\" by the University Hospital, Strasbourg, focusing on using AI for classifying and analyzing adverse events in anesthesia. Furthermore, the use of AI in pediatric anesthesia for preoperative assessment, risk stratification, and managing various intraoperative challenges is discussed. AI's impact on reducing MRI scan times and enhancing ultrasound-guided regional anesthesia is also highlighted. The article concludes with a discussion on the implementation of AI in healthcare. It emphasizes the need for accurate, diverse data sets and robust governance for successful AI integration. The goal is to streamline clinic operations, improve patient care quality, and increase patient satisfaction while ensuring AI's role as an aid, not a substitute, in clinical judgment.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139226574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Analysis of PTEN Alterations in Prostate Cancer: A cBioportal Study","authors":"Chidozie Ogbonnaya, Uzochukwu Alozie Ononuju","doi":"10.23958/ijirms/vol08-i11/1783","DOIUrl":"https://doi.org/10.23958/ijirms/vol08-i11/1783","url":null,"abstract":"Prostate cancer (PCa), a leading cause of cancer-related mortality among men, demands an intricate understanding of its molecular landscape for improved diagnostics and treatment strategies. This study investigates the prevalence and clinical significance of Phosphatase and tensin homolog (PTEN) alterations in prostate cancer using data sourced from cBioportal. Analysing 10,998 samples across 26 prostate cancer studies, our findings reveal that PTEN alterations occur in 19% of patients, with deep deletion (PTEN HOMODELETED) being the most significant genetic alteration. Notably, Metastatic Prostate Adenocarcinoma exhibits the highest prevalence of PTEN mutations, while Prostate Adenocarcinoma Organoids show the least. Correlation analyses unveil associations between PTEN deep deletion and age, particularly within the 42-72 age range, as well as with Pelvic Radiation Disease Local Treatment at Diagnosis and primary Sample Type. Survival analysis indicates a significantly lower median overall survival in months (95% CI) for patients with PTEN alterations (96.00 months, 95% CI: 65.36 - 113.98) compared to unaltered cases (120.0 months, 95% CI: 115.05 - 160.00), highlighting the clinical relevance of PTEN in PCa and its correlation with disease progression and remission. The study concludes by discussing the potential implications of these findings, recognizing limitations, and emphasizing the critical need for targeted therapeutic strategies based on PTEN status in PCa management.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139233739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Bilateral Anterior Shoulder Fracture Dislocation Following a Seizure: A Case Report and Review of Literature","authors":"Ayman Alrushaydan, M. Alsayed, Amer Alnefaie","doi":"10.23958/ijirms/vol08-i09/1746","DOIUrl":"https://doi.org/10.23958/ijirms/vol08-i09/1746","url":null,"abstract":"Simultaneous, Bilateral anterior fracture-dislocation of the shoulders is very rare complication of generalized seizures. most cases attributable to major trauma. Seizures and electric shock are a common cause of fractures and dislocations of shoulder although these are most commonly posterior injuries. We present interesting case report of diagnosis and treatment of a patient with bilateral anterior shoulder fracture dislocations following a seizure.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78797577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Coexistence of Inv(16) and T(9;22) in Patient with Chronic Myeloid Leukaemia Presenting as Blast Crisis","authors":"Aymen Abbas, Mutaz Kalas, E. Raidullah","doi":"10.23958/ijirms/vol08-i09/1747","DOIUrl":"https://doi.org/10.23958/ijirms/vol08-i09/1747","url":null,"abstract":"Chronic myeloid leukemia (CML) is associated with BCR-ABL1 fusion gene located on chromosome 22 as a result of a t(9;22)(q34;q11.2) translocation in about 90% of the patients. Also, coexistence of the t(9;22) and inv(16) chromosomal aberrations is a rare occurrence that has been described in CML (mainly the myeloid blast phase [CML-BP]), de novo AML, and a few cases of therapy-related AML (t-AML). We describe a 22 years old male in primary blast crisis of CML as initial presentation with coexistence of the t(9;22) and inv(16). Majority of cases, in which these abnormalities coexist are CML-BP, which is typically characterized by an aggressive clinical course rapid disease progression and resistance to chemotherapy.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77200794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Newborn Male Infant with Seizures, Cyanosis, Bradycardia, and Ischemic Stroke Due to Autosomal Dominant Hypocalcemia with a Missense Mutation in the CaSR Gene: A Case Report","authors":"Althea Samantha C. Agdamag, Alexander Maclennan, Brande M. Brown, Anjum Mohyuddin Ahmed, Abhinav Parikh, Levon Agdere, Nitin Ron","doi":"10.23958/ijirms/vol08-i09/1739","DOIUrl":"https://doi.org/10.23958/ijirms/vol08-i09/1739","url":null,"abstract":"Autosomal dominant hypocalcemia is commonly caused by a gain-of-function mutation in the CaSR gene and inhibits calcium reabsorption in the kidneys by suppressing the secretion of parathyroid hormone. Laboratory findings typically result in hypocalcemia, hyperphosphatemia, hypomagnesemia, hypercalciuria, and low to normal parathyroid hormone. Clinically, patient presentation varies from asymptomatic to life-threatening. We present a full-term baby boy who exhibited episodic right lower extremity stiffening, cyanosis, and bradycardia at day of life 2 with confirmed seizure activity. The patient’s course was significant for poor feeding, right vocal cord paralysis, and an ischemic stroke in the posterior division of the right middle cerebral artery. Genetic work-up revealed the unique CaSR heterozygous missense variant mutation c2495T>C (p.lle832Thr), and STX16 gene variation. This patient’s sibling also carries the same mutation however is asymptomatic. It is important to monitor these patients for clinical manifestations, as gain-of-function mutations in the CaSR gene may carry complications such as nephrocalcinosis, changes in bone mineral density, and a predilection for epilepsy later in life.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90979281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music, Language, and Autism: Neurological Insights for Enhanced Learning","authors":"Emanuel Luo, C. Pan, Xiujun Fan","doi":"10.23958/ijirms/vol08-i09/1743","DOIUrl":"https://doi.org/10.23958/ijirms/vol08-i09/1743","url":null,"abstract":"This comprehensive review thoroughly explores the intricate relationship between music and language, encompassing their historical, cognitive, and neural dimensions. It draws evidence from ancient Chinese civilizations dating back to 4500 BC to analyze the coexistence and parallel evolution of music and language for the first time. Comparative studies illuminate the shared and distinctive aspects of pitch, rhythm, and syntax inherent to music and language. The examination extends to the diverse impact of music, including second language acquisition, phonological awareness, pitch processing, memory, and cognitive skills. This influence is also observed among individuals with Autism Spectrum Disorder. The paper further examines the intricate neural connections, neural overlapping, networks, structural processing, bidirectional relationships, cross-modal transfer effects, and brain plasticity that underpin music and language. It reviews music interventions for enhancing language and cognitive abilities, particularly in the context of autism spectrum disorders. However, the precise role of music and its intricate neural mechanisms in shaping language-related outcomes within Autism spectrum disorder groups remains incompletely understood. Further interdisciplinary research integrating disciplines like neuroscience, psychology, sociology, and related fields is imperative to deepen our comprehension and unlock the precise neural mechanisms and interventions that can foster enhanced language and cognitive development in individuals with autism.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74389878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}