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Informatics-driven unsupervised learning of comorbidity clusters for COVID-19 reinfection risk: A finite mixture modeling approach COVID-19再感染风险共病集群的信息驱动无监督学习:一种有限混合建模方法
Informatics in Medicine Unlocked Pub Date : 2025-01-01 DOI: 10.1016/j.imu.2025.101649
Grant B. Morgan , Andreas Stamatis , Chelsea C. Yager , Ali Boolani
{"title":"Informatics-driven unsupervised learning of comorbidity clusters for COVID-19 reinfection risk: A finite mixture modeling approach","authors":"Grant B. Morgan ,&nbsp;Andreas Stamatis ,&nbsp;Chelsea C. Yager ,&nbsp;Ali Boolani","doi":"10.1016/j.imu.2025.101649","DOIUrl":"10.1016/j.imu.2025.101649","url":null,"abstract":"<div><h3>Purpose</h3><div>This study applied an informatics-focused, unsupervised learning framework (finite mixture modeling) to determine whether distinct clusters of coexisting conditions among patients with coronavirus disease 2019 (COVID-19) are associated with multiple (reinfection) versus single infections.</div></div><div><h3>Methods</h3><div>We analyzed 42,974 patient records containing COVID-19 diagnoses using an machine learning classification algorithm to identify comorbidity profiles. Of nearly 850 recorded conditions, 29 were retained if they occurred in at least 5 % of the sample. We then compared patients with single versus multiple COVID-19 diagnoses within each profile.</div></div><div><h3>Results</h3><div>Three comorbidity profiles emerged. The first profile (Minimal Comorbidity) was the largest (67 % of sample) and was characterized by few additional conditions. Patients classified into this profile were also 20–30 years younger, on average, than members of the other profiles. The second (Elevated Select Comorbidity) profile consisted of 24 % of the sample and was characterized by moderate-risk factors such as hypertension, hyperlipidemia, and acute respiratory failure. The third (High Comorbidity Burden) third was represented by 9 % of the sample and was characterized by conditions related to cardiovascular, renal, endocrine, and respiratory systems. Among the high-burden group, 30 % experienced reinfection, versus only 9 % in the minimal group. Overall, patients with more extensive cardiometabolic or pulmonary conditions were more likely to experience repeated infection.</div></div><div><h3>Conclusions</h3><div>By identifying and characterizing comorbidity clusters, this informatics-based approach offers deeper insight into COVID-19 reinfection dynamics. The findings may support targeted prevention, data-driven resource allocation, and precision medicine strategies by highlighting subgroups at elevated risk. Moreover, the unsupervised modeling framework is potentially adaptable to other multifactorial conditions, underscoring its broader utility in medical informatics.</div></div>","PeriodicalId":13953,"journal":{"name":"Informatics in Medicine Unlocked","volume":"55 ","pages":"Article 101649"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of machine learning in infectious disease early detection and prediction in the MENA region: A systematic review 机器学习在中东和北非地区传染病早期检测和预测中的作用:系统综述
Informatics in Medicine Unlocked Pub Date : 2025-01-01 DOI: 10.1016/j.imu.2025.101651
Radwan Qasrawi , Ghada Issa , Suliman Thwib , Razan AbuGhoush , Malak Amro , Raghad Ayyad , Stephanny Vicuna , Eman Badran , Yousef Khader , Raeda Al Qutob , Faris Al Bakri , Hana Trigui , Elie Sokhn , Emmanuel Musa , Jude Dzevela Kong
{"title":"The role of machine learning in infectious disease early detection and prediction in the MENA region: A systematic review","authors":"Radwan Qasrawi ,&nbsp;Ghada Issa ,&nbsp;Suliman Thwib ,&nbsp;Razan AbuGhoush ,&nbsp;Malak Amro ,&nbsp;Raghad Ayyad ,&nbsp;Stephanny Vicuna ,&nbsp;Eman Badran ,&nbsp;Yousef Khader ,&nbsp;Raeda Al Qutob ,&nbsp;Faris Al Bakri ,&nbsp;Hana Trigui ,&nbsp;Elie Sokhn ,&nbsp;Emmanuel Musa ,&nbsp;Jude Dzevela Kong","doi":"10.1016/j.imu.2025.101651","DOIUrl":"10.1016/j.imu.2025.101651","url":null,"abstract":"<div><div>This systematic review analyzes the implementation and effectiveness of machine learning (ML) approaches for infectious disease surveillance and prediction across the Middle East and North Africa (MENA) region. Adhering to PRISMA guidelines, studies published between 2016 and 2024 were examined to assess model structures, performance metrics, and dataset characteristics. The findings reveal a predominance of deep learning approaches, particularly Convolutional Neural Networks (CNNs), achieving mean accuracy rates of 96.3 % in pathogen detection from medical imaging. Random Forest algorithms demonstrated superior performance in disease outbreak prediction, with mean ACC scores of 0.85. Iran, Saudi Arabia, and Egypt emerged as regional leaders, collectively contributing 54 % of the analyzed studies. The temporal analysis showed peak research output in 2022 (n = 30 studies), followed by a 25 % decline in 2023. Despite promising performance, challenges such as data quality, infrastructural limitations, and algorithmic bias persist. This review highlights the need for standardized protocols, enhanced digital infrastructure, and collaborative efforts to realize the full potential of ML in enhancing public health interventions across the region. Future research directions should prioritize multi-center validation studies, standardized reporting frameworks, and integration of diverse data modalities to enhance model robustness and clinical applicability.</div></div>","PeriodicalId":13953,"journal":{"name":"Informatics in Medicine Unlocked","volume":"56 ","pages":"Article 101651"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hybrid attention-enhanced MobileNetV2 with particle swarm optimization for endometrial cancer classification in CT images 混合注意增强MobileNetV2与粒子群优化用于子宫内膜癌CT图像分类
Informatics in Medicine Unlocked Pub Date : 2025-01-01 DOI: 10.1016/j.imu.2025.101662
Omar F. Altal , Amer Mahmoud Sindiani , Mohammad Amin , Hamad Yahia Abu Mhanna , Raneem Hamad , Hasan Gharaibeh , Hanan Fawaz Akhdar , Salem Alhatamleh , Rawan Eimad Almahmoud , Omar H. Abu-azzam , Mohammad Balaw , Bashar Haj Hamoud , Fatimah Maashey , Latifah Alghulayqah
{"title":"Hybrid attention-enhanced MobileNetV2 with particle swarm optimization for endometrial cancer classification in CT images","authors":"Omar F. Altal ,&nbsp;Amer Mahmoud Sindiani ,&nbsp;Mohammad Amin ,&nbsp;Hamad Yahia Abu Mhanna ,&nbsp;Raneem Hamad ,&nbsp;Hasan Gharaibeh ,&nbsp;Hanan Fawaz Akhdar ,&nbsp;Salem Alhatamleh ,&nbsp;Rawan Eimad Almahmoud ,&nbsp;Omar H. Abu-azzam ,&nbsp;Mohammad Balaw ,&nbsp;Bashar Haj Hamoud ,&nbsp;Fatimah Maashey ,&nbsp;Latifah Alghulayqah","doi":"10.1016/j.imu.2025.101662","DOIUrl":"10.1016/j.imu.2025.101662","url":null,"abstract":"<div><div>Endometrial cancer is a form of uterine cancer that is known to be deadly and shows a strong therapeutic response if diagnosed at an early stage. The inability of traditional endometrial cancer methods to provide timely and cost-effective diagnosis has been transformed with the introduction of computational techniques driven by oncologists and data scientists. Deep learning, the most important branch of artificial intelligence, has found increasing importance in diagnosing endometrial cancer. This paper presents a novel methodology for accurate diagnosis of endometrial cancer computed tomography (CT) images, based on the use of a hybrid deep learning framework to develop a novel methodology that automates hyperparameter optimization and enhances feature recognition by integrating dual attention and particle swarm optimization (PSO) techniques. The pre-trained MobileNetV2 backbone uses geometric transformations (rotations, translations, and reflections) while extracting hierarchical features from CT slices to mitigate data scarcity. PSO is used to enhance the hyperparameters governing the attention and regularization modules. The method combines efficient swarm-based optimization and adaptive attention mechanisms, improving the discrimination between different images and establishing a reproducible pipeline for medical imaging applications with less illustrative data. The performance of the model was validated using a new dataset, collected from King Abdullah University Hospital in Jordan by physicians, and the proposed model achieved an accuracy of 86.07 %, a precision of 86.75 %, a sensitivity of 86.02 %, a specificity of 91.45 %, and an AUC of 97.33 %. , outperforming all previously trained models (MobileNetV2, VGG16, VGG19, ResNets50, NASNetMobile, and InceptionV3), on the King Abdullah University Hospital Endometrial Cancer Computed Tomography (KAUH-ECCTD) dataset. PSO optimization enabled effective tuning of key hyperparameters (learning rate, dropout rate, L2 regularization, number of neurons), directly enhancing model generalization and discrimination capability. The validated model, trained on a dataset collected from King Abdullah University Hospital (KAUH-ECCTD), has strong potential for real-world clinical applications as part of AI-assisted diagnostic tools and clinical decision support systems for oncologists. The proposed approach can enhance early detection, personalized treatment planning, and continuous monitoring in endometrial cancer management, thereby facilitating collaborative research between oncologists, biomedical engineers, and data scientists.</div></div>","PeriodicalId":13953,"journal":{"name":"Informatics in Medicine Unlocked","volume":"57 ","pages":"Article 101662"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing users and intention to use online health information resources: A comprehensive study 用户特征和使用在线健康信息资源的意向:一项综合研究
Informatics in Medicine Unlocked Pub Date : 2025-01-01 DOI: 10.1016/j.imu.2025.101640
André Michaud , Virginie Blanchette , François Boudreau , Sarah Lafontaine , Denis Leroux , Paule Miquelon , Michel Vallée , Joany Rousseau-Bédard , Lyne Cloutier
{"title":"Characterizing users and intention to use online health information resources: A comprehensive study","authors":"André Michaud ,&nbsp;Virginie Blanchette ,&nbsp;François Boudreau ,&nbsp;Sarah Lafontaine ,&nbsp;Denis Leroux ,&nbsp;Paule Miquelon ,&nbsp;Michel Vallée ,&nbsp;Joany Rousseau-Bédard ,&nbsp;Lyne Cloutier","doi":"10.1016/j.imu.2025.101640","DOIUrl":"10.1016/j.imu.2025.101640","url":null,"abstract":"","PeriodicalId":13953,"journal":{"name":"Informatics in Medicine Unlocked","volume":"55 ","pages":"Article 101640"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electronic health records in non-hospital settings of developing economies: A systematic review on enablers and barriers 发展中经济体非医院环境中的电子健康记录:对促进因素和障碍的系统审查
Informatics in Medicine Unlocked Pub Date : 2025-01-01 DOI: 10.1016/j.imu.2025.101634
Bejie Rodriguez , Joenelyn Kaye Demoral , Jan Jacob Carpio , Alan Napoleon Gultia , Gloria Shiela Coyoca , Cecilio Garciano Jr. , Lemuel Clark Velasco
{"title":"Electronic health records in non-hospital settings of developing economies: A systematic review on enablers and barriers","authors":"Bejie Rodriguez ,&nbsp;Joenelyn Kaye Demoral ,&nbsp;Jan Jacob Carpio ,&nbsp;Alan Napoleon Gultia ,&nbsp;Gloria Shiela Coyoca ,&nbsp;Cecilio Garciano Jr. ,&nbsp;Lemuel Clark Velasco","doi":"10.1016/j.imu.2025.101634","DOIUrl":"10.1016/j.imu.2025.101634","url":null,"abstract":"<div><div>In recent years, rapid advancements in Information and Communications Technology (ICT) have greatly transformed the healthcare landscape by streamlining health data management and providing decision-makers with secure and convenient access to health records. In developing economies, limited resources hinder healthcare access. Implementing EHRs in non-hospital settings is essential for enhancing healthcare quality and accessibility. While existing literature supports EHR use, further research is needed to pinpoint specific barriers and enablers. Using PRISMA guidelines, 18 relevant articles were systematically analyzed with the Human, Organization, and Technology Fit (HOT-fit) framework to examine these factors in non-hospital settings within developing economies. This study found that human factors take precedence in both enablers and barriers. The first two barriers emphasize the human element, highlighting the critical importance of addressing individual user challenges. However, organizational issues take on a supporting role, highlighting the possibility that the prominence of user-centric challenges stems from the lack of devolution of governance and leadership in non-hospital settings. Additionally, the findings indicate that prioritizing robust IT infrastructure, which meets both functional and usability requirements, remains a fundamental concern for EHR implementation. By focusing on the enablers and barriers of EHR implementation, this study highlights the research gaps that can be explored as well as the potential and challenges that are faced by healthcare systems within the non-hospital settings of -developing economies. From these findings, we infer that further research is needed to identify specific training components for EHR systems to enable individuals for effective system use in non-hospital settings.</div></div>","PeriodicalId":13953,"journal":{"name":"Informatics in Medicine Unlocked","volume":"54 ","pages":"Article 101634"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal asphyxia prediction using features extracted from cardiotocography data by explainable artificial intelligence 利用可解释人工智能从心动图数据中提取的特征预测新生儿窒息
Informatics in Medicine Unlocked Pub Date : 2025-01-01 DOI: 10.1016/j.imu.2025.101636
Hayato Kinoshita , Hiroaki Fukunishi , Chihiro Shibata , Toyofumi Hirakawa , Kohei Miyata , Fusanori Yotsumoto
{"title":"Neonatal asphyxia prediction using features extracted from cardiotocography data by explainable artificial intelligence","authors":"Hayato Kinoshita ,&nbsp;Hiroaki Fukunishi ,&nbsp;Chihiro Shibata ,&nbsp;Toyofumi Hirakawa ,&nbsp;Kohei Miyata ,&nbsp;Fusanori Yotsumoto","doi":"10.1016/j.imu.2025.101636","DOIUrl":"10.1016/j.imu.2025.101636","url":null,"abstract":"<div><h3>Background and objective</h3><div>Developing Artificial Intelligence (AI)-assisted technology for cardiotocography (CTG) monitoring system is highly anticipated in the field of obstetrics. This study developed a neonatal asphyxia prediction model to assist obstetricians and practitioners in making early treatment decisions in clinical practice.</div></div><div><h3>Methods</h3><div>Using 32,711 CTG records, features based on fetal heart rate (FHR) were extracted following Japanese Society of Obstetrics and Gynecology (JSOG) guidelines. The machine learning algorithm LightGBM was adopted to construct a binary prediction model of normal and abnormal states for newborns after delivery. To address the data imbalance between normal and abnormal samples, multiple prediction models were constructed using the underbagging technique. Furthermore, features impacting neonatal asphyxia were analyzed using the SHapley Additive exPlanations (SHAP), an explainable artificial intelligence (XAI) technique.</div></div><div><h3>Results</h3><div>The best prediction model used the Apgar score as the outcome variable and 13 FHR-based features + maternal age as the feature set, with an area under the curve of 0.759. This performance is reliable because this study used 32,711 CTG records, whereas most prior studies used datasets with only a few hundred records. When risk factors were analyzed via SHAP, the top three features were mean FHR, frequency of acceleration, and frequency of marked variability. The relationship between many of the features and abnormal risk corresponded to the CTG interpretation of the JSOG guidelines.</div></div><div><h3>Conclusions</h3><div>This study demonstrated reliable prediction performance using a large dataset along with the rationale behind its prediction. These results will facilitate the use of AI-assisted technology in clinical practice. In the future, it is expected that XAI technology will be integrated into real-time CTG monitoring systems, and that the display of associated risk factors will occur simultaneously with risk alerts.</div></div>","PeriodicalId":13953,"journal":{"name":"Informatics in Medicine Unlocked","volume":"54 ","pages":"Article 101636"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the accuracy of neural networks for blood pressure prediction in the ICU 探讨神经网络在ICU血压预测中的准确性
Informatics in Medicine Unlocked Pub Date : 2025-01-01 DOI: 10.1016/j.imu.2025.101635
Charles J. Gillan, Bartosz Gorecki
{"title":"Investigating the accuracy of neural networks for blood pressure prediction in the ICU","authors":"Charles J. Gillan,&nbsp;Bartosz Gorecki","doi":"10.1016/j.imu.2025.101635","DOIUrl":"10.1016/j.imu.2025.101635","url":null,"abstract":"<div><div>This paper reports on research which investigates the viability of artificial neural networks, used in an ICU environment, for predicting both systolic and diastolic blood pressure up to 1 h ahead. In this environment, patients often receive pharmacological intervention to increase or decrease blood pressure. The physiological state of an ICU patient is therefore quite different to a hyper or hypotensive patient outside hospital, suggesting that predicting blood pressure in this environment is more challenging The work investigates whether building neural network architectures with multivariate input data is capable of predicting blood pressures in this environment. Our work uses skin temperature and heart rate readings in addition to systolic and diastolic blood pressure. Two types of neural network are explored are explored in this paper: an encoder-decoder long short-term memory architecture and, separately, a convolutional neural network architecture. The top-performing configuration, when using a 70 %–30 % train-test split of data, is a convolutional neural network model. This predicted systolic and diastolic blood pressures for a patient with an error of approximately <sub>3<em>.</em>4 %</sub>. These results are at the same level of accuracy as work on blood pressure prediction outside the ICU environment. Our work shows that neural networks are a viable tool for short term prediction of arterial blood pressures in an ICU context.</div></div>","PeriodicalId":13953,"journal":{"name":"Informatics in Medicine Unlocked","volume":"55 ","pages":"Article 101635"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early detection of gynecological malignancies using ensemble deep learning models: ResNet50 and inception V3 使用集成深度学习模型早期检测妇科恶性肿瘤:ResNet50和inception V3
Informatics in Medicine Unlocked Pub Date : 2025-01-01 DOI: 10.1016/j.imu.2025.101620
Chetna Vaid Kwatra , Harpreet Kaur , Monika Mangla , Arun Singh , Swapnali N. Tambe , Saiprasad Potharaju
{"title":"Early detection of gynecological malignancies using ensemble deep learning models: ResNet50 and inception V3","authors":"Chetna Vaid Kwatra ,&nbsp;Harpreet Kaur ,&nbsp;Monika Mangla ,&nbsp;Arun Singh ,&nbsp;Swapnali N. Tambe ,&nbsp;Saiprasad Potharaju","doi":"10.1016/j.imu.2025.101620","DOIUrl":"10.1016/j.imu.2025.101620","url":null,"abstract":"<div><h3>Background and objective</h3><div>Improving patient outcomes and lowering death rates depend on the early identification of gynecological cancers. This work intends to improve the accuracy and dependability of early gynecological tumor diagnosis by means of a hybrid deep learning model combining ResNet50 and Inception v3 architectures.</div></div><div><h3>Methods</h3><div>The proposed ensemble model combines multi-scale feature extraction of Inception v3 with the deep residual learning capability of ResNet50. A significant number of gynecological images were employed for training, testing, and assessment of the proposed model. By entailing accuracy, sensitivity, specificity, and F1 score, among other parameters the performance of the model was assessed.</div></div><div><h3>Results</h3><div>The first experiment depicted displays that the ensemble model performed better than single models with a training accuracy of 99.80 %, a validation accuracy of 99.80 %, and a test accuracy of 99.80 %. Comparing the two studies done in the current research, the model has shown to have a high sensitivity of 99 %, specificity of 99 %, and F1 score of 0.99, making it better in the identification of gynecological cancers and significantly reducing low true negatives and low true positives.</div></div><div><h3>Conclusions</h3><div>Ensembling of ResNet50 with Inception v3 for early diagnosis of gynecological cancers is promising and reproducible. Thus, according to the presented results, this method can contribute to the diagnoses of diseases by doctors quickly and accurately and, therefore, improve the treatment outcomes and the patient's health</div></div>","PeriodicalId":13953,"journal":{"name":"Informatics in Medicine Unlocked","volume":"53 ","pages":"Article 101620"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of breast cancer classification and segmentation techniques: A comprehensive review 乳腺癌分类和分割技术分析:综述
Informatics in Medicine Unlocked Pub Date : 2025-01-01 DOI: 10.1016/j.imu.2025.101642
Malaya Kumar Nath, Kohilavani Sundararajan, Shanmathi Mathivanan, Bhagyashree Thandapani
{"title":"Analysis of breast cancer classification and segmentation techniques: A comprehensive review","authors":"Malaya Kumar Nath,&nbsp;Kohilavani Sundararajan,&nbsp;Shanmathi Mathivanan,&nbsp;Bhagyashree Thandapani","doi":"10.1016/j.imu.2025.101642","DOIUrl":"10.1016/j.imu.2025.101642","url":null,"abstract":"<div><div>Breast cancer (BC) is caused by the mutation of breast cells and their uncontrolled proliferation, making diagnosis critical at the chronic stage. Early cancer detection can help plan treatment and reduce its severity and mortality rate. It can be confirmed by the biopsy test. Due to technological advancements, it can be effectively detected by various modalities, such as X-rays, ultrasound, MRI scans, histopathology images, etc. Development in machine learning (ML), data mining, sensors, and signal processing techniques gained popularity in early breast cancer detection and grading. However, these techniques must be improved for better prediction, localization, and grading of cancer tissues. This manuscript discusses the tissue variation due to the propagation of cancer and its havoc in life, along with various AI-based techniques for early identification with their limitations. Publicly available breast cancer databases and performance evaluation metrics used by the researchers have been summarized. Based on the limitations and potential strengths of various techniques, a deep learning (DL) model for multi-class classification of breast cancer for the whole slide image (WSI) is proposed. This study identifies ongoing issues essential for driving future advancements in BC detection and segmentation to improve clinical outcomes.</div></div>","PeriodicalId":13953,"journal":{"name":"Informatics in Medicine Unlocked","volume":"56 ","pages":"Article 101642"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated lumbar intervertebral disc identification and herniation detection in MR images using cascade CNN architecture 利用级联CNN架构在MR图像中自动识别腰椎间盘和检测突出症
Informatics in Medicine Unlocked Pub Date : 2025-01-01 DOI: 10.1016/j.imu.2025.101648
Md Abu Sayed , Ashiqur Rahman , Sadman Mohammad Nasif , Sudipto Halder , Akram Hossain , Hasan Ahmed , Muhammad Abdul Kadir
{"title":"Automated lumbar intervertebral disc identification and herniation detection in MR images using cascade CNN architecture","authors":"Md Abu Sayed ,&nbsp;Ashiqur Rahman ,&nbsp;Sadman Mohammad Nasif ,&nbsp;Sudipto Halder ,&nbsp;Akram Hossain ,&nbsp;Hasan Ahmed ,&nbsp;Muhammad Abdul Kadir","doi":"10.1016/j.imu.2025.101648","DOIUrl":"10.1016/j.imu.2025.101648","url":null,"abstract":"<div><h3>Objective</h3><div>Identifying herniated discs in MRI scans is inherently challenging due to the small size, irregular shape, and complex appearance of the affected regions. Conventional approaches typically rely on semi-automated region-of-interest (ROI) selection and single-model classification using either axial or sagittal views, limiting diagnostic performance. This study aims to develop an automated, accurate, and efficient system for the detection and classification of lumbar intervertebral disc herniation using deep learning models applied to axial and sagittal MR images.</div></div><div><h3>Methods</h3><div>A YOLO-based framework was developed to automatically identify lumbar intervertebral discs (IVD<sub>1-5</sub>) and extract ROIs from MR images. Attention-enhanced and fine-tuned VGG19 and ResNet50 models were employed to analyze axial and sagittal images for herniation detection. A decision fusion strategy was used to combine the classification probabilities from both models to further enhance accuracy. The dataset underwent extensive preprocessing and augmentation to improve model robustness and generalization.</div></div><div><h3>Results</h3><div>The proposed approach demonstrated exceptional performance in detection and classification tasks. For detection, the model achieved mAP50 scores of 95.18 % (axial IVD<sub>1-5</sub>), 99.50 % (lumbar regions), and 94.87 % (sagittal IVD<sub>1-5</sub>). Classification accuracy reached 97.05 % for axial images and 97.45 % for sagittal images, increasing to 98.09 % with decision fusion.</div></div><div><h3>Conclusion</h3><div>Designed to assist physicians, especially during high-demand periods such as pandemics, this approach has the potential to improve diagnostic efficiency and reduce clinical workload.</div></div>","PeriodicalId":13953,"journal":{"name":"Informatics in Medicine Unlocked","volume":"55 ","pages":"Article 101648"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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